{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:26:25Z","timestamp":1789133185244,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.joen.2012.12.030","type":"journal-article","created":{"date-parts":[[2013,2,10]],"date-time":"2013-02-10T05:02:29Z","timestamp":1360472549000},"page":"643-647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Outcome of Periapical Lesions in a Rat Model of Type 2 Diabetes: Refractoriness to Systemic Antioxidant Therapy"],"prefix":"10.1016","volume":"39","author":[{"given":"Carlos Frederico B.","family":"Wolle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana A.","family":"Zollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia O.","family":"Bairros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Etges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda B.","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2012.12.030_bib1","series-title":"Adult Dental Health Survey Oral Health in the United Kingdom 1998","author":"Kelly","year":"2000"},{"key":"10.1016\/j.joen.2012.12.030_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1479-666X(03)80019-7","article-title":"Dentistry and the medically compromised patient","volume":"1","author":"Seymour","year":"2003","journal-title":"Surgeon"},{"key":"10.1016\/j.joen.2012.12.030_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1601-0825.2004.01019.x","article-title":"Update on diabetes mellitus and related oral diseases","volume":"10","author":"Manfredi","year":"2004","journal-title":"Oral Dis"},{"issue":"Suppl","key":"10.1016\/j.joen.2012.12.030_bib4","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.14219\/jada.archive.2008.0364","article-title":"Diabetes mellitus: considerations for dentistry","volume":"139","author":"Kidambi","year":"2008","journal-title":"J Am Dent Assoc"},{"issue":"Suppl","key":"10.1016\/j.joen.2012.12.030_bib5","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.14219\/jada.archive.2008.0363","article-title":"The relationship between oral health and diabetes mellitus","volume":"139","author":"Lamster","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2012.12.030_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd2476","article-title":"Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials","volume":"8","author":"Calcutt","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.joen.2012.12.030_bib7","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1210\/er.2003-0019","article-title":"Oxidative stress in the pathogenesis of diabetic neuropathy","volume":"25","author":"Vincent","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.joen.2012.12.030_bib8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2337\/diacare.28.2.379","article-title":"Chronic vascular inflammation in patients with type 2 diabetes: endothelial biopsy and RT-PCR analysis","volume":"28","author":"Feng","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.joen.2012.12.030_bib9","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2522\/ptj.20080020","article-title":"Epidemiology of diabetes and diabetes-related complications","volume":"88","author":"Deshpande","year":"2008","journal-title":"Phys Ther"},{"key":"10.1016\/j.joen.2012.12.030_bib10","first-page":"779","article-title":"The patient with diabetes mellitus: etiology, epidemiology, principles of medical management, oral disease burden, and principles of dental management","volume":"36","author":"Miley","year":"2005","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2012.12.030_bib11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00004770-200306000-00001","article-title":"Diabetes mellitus and the dental pulp","volume":"29","author":"Bender","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.joen.2008.07.010","article-title":"Diabetes induces metabolic alterations in dental pulp","volume":"34","author":"Leite","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib13","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.14219\/jada.archive.2001.0059","article-title":"Dental management considerations for the patient with diabetes mellitus","volume":"132","author":"Lalla","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2012.12.030_bib14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1902\/annals.1998.3.1.51","article-title":"Periodontal disease and diabetes mellitus: a two-way relationship","volume":"3","author":"Grossi","year":"1998","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.joen.2012.12.030_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2010.08.054","article-title":"Impact of diabetes mellitus, hypertension, and coronary artery disease on tooth extraction after nonsurgical endodontic treatment","volume":"37","author":"Wang","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.joen.2011.01.002","article-title":"Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a cross-sectional study","volume":"37","author":"Lopez-Lopez","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib17","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.joen.2006.03.007","article-title":"Endodontic treatment in an American Indian population: a 10-year retrospective study","volume":"32","author":"Mindiola","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib18","doi-asserted-by":"crossref","first-page":"e12622","DOI":"10.1371\/journal.pone.0012622","article-title":"Kinin B1 receptor enhances the oxidative stress in a rat model of insulin resistance: outcome in hypertension, allodynia and metabolic complications","volume":"5","author":"Dias","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2012.12.030_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.joen.2011.11.007","article-title":"Effects of the antioxidant agent tempol on periapical lesions in rats with doxorubicin-induced cardiomyopathy","volume":"38","author":"Wolle","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(01)01566-7","article-title":"Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats","volume":"436","author":"Nassar","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.joen.2012.12.030_bib21","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.freeradbiomed.2007.02.030","article-title":"The chemistry and biology of nitroxide compounds","volume":"42","author":"Soule","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.joen.2012.12.030_bib22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/154405910308200416","article-title":"The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes","volume":"82","author":"Iwama","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2012.12.030_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1590\/S1678-77572006000500013","article-title":"Development of periradicular lesions in normal and diabetic rats","volume":"14","author":"Armada-Dias","year":"2006","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2012.12.030_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10006-010-0235-8","article-title":"Isotretinoin effect on alveolar repair after exodontia: a study in rats","volume":"15","author":"Bergoli","year":"2011","journal-title":"Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2012.12.030_bib25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1365-2591.2010.01707.x","article-title":"In\u00a0vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan-induced diabetic rats","volume":"43","author":"Leite","year":"2010","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2012.12.030_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2008.05.006","article-title":"Blockade of sensory abnormalities and kinin B(1) receptor expression by N-acetyl-L-cysteine and ramipril in a rat model of insulin resistance","volume":"589","author":"Ismael","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.joen.2012.12.030_bib27","doi-asserted-by":"crossref","first-page":"E1220","DOI":"10.1152\/ajpendo.00378.2011","article-title":"Delayed bone regeneration and low bone mass in a rat model of insulin-resistant type 2 diabetes mellitus is due to impaired osteoblast function","volume":"301","author":"Hamann","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.joen.2012.12.030_bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00394-011-0228-x","article-title":"Metabolic and behavioural effects of sucrose and fructose\/glucose drinks in the rat","volume":"51","author":"Sheludiakova","year":"2012","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.joen.2012.12.030_bib29","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0099-2399(96)80243-3","article-title":"Periapical lesions in rats with streptozotocin-induced diabetes","volume":"22","author":"Kohsaka","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.joen.2008.09.010","article-title":"The effect of hyperglycemia on pulpal healing in rats","volume":"35","author":"Garber","year":"2009","journal-title":"J Endod"},{"issue":"Suppl 1","key":"10.1016\/j.joen.2012.12.030_bib31","doi-asserted-by":"crossref","first-page":"s5","DOI":"10.2337\/diacare.27.2007.S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","author":"American Diabetes Association","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.joen.2012.12.030_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.joen.2011.11.001","article-title":"Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population","volume":"38","author":"Marotta","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.7326\/0003-4819-122-6-199503150-00002","article-title":"Bone density in non-insulin-dependent diabetes mellitus: the Rotterdam Study","volume":"122","author":"van Daele","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joen.2012.12.030_bib34","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2337\/diacare.22.7.1196","article-title":"Bone mineral density in patients with type 1 and type 2 diabetes","volume":"22","author":"Tuominen","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.joen.2012.12.030_bib35","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1600-051X.2009.01445.x","article-title":"Association between type 1 and type 2 diabetes with periodontal disease and tooth loss","volume":"36","author":"Kaur","year":"2009","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2012.12.030_bib36","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.2337\/diabetes.54.7.2219","article-title":"Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats","volume":"54","author":"Banday","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.joen.2012.12.030_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pharmthera.2010.01.003","article-title":"Effects of tempol and redox-cycling nitroxides in models of oxidative stress","volume":"126","author":"Wilcox","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.joen.2012.12.030_bib38","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1600-051X.2005.00818.x","article-title":"Effects of tempol, a membrane-permeable radical scavenger, in a rodent model periodontitis","volume":"32","author":"Di Paola","year":"2005","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2012.12.030_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF02785889","article-title":"Protective effect of 4-hydroxy-TEMPO, a low molecular weight superoxide dismutase mimic, on free radical toxicity in experimental pancreatitis","volume":"18","author":"Sledzinski","year":"1995","journal-title":"Int J Pancreatol"},{"key":"10.1016\/j.joen.2012.12.030_bib40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1079-2104(03)00034-9","article-title":"Periradicular radiographic assessment in diabetic and control individuals","volume":"96","author":"Britto","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib41","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tripleo.2005.06.007","article-title":"Increased number of anaerobic bacteria in the infected root canal in type 2 diabetic rats","volume":"101","author":"Iwama","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib42","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.joen.2012.03.016","article-title":"The levels of vascular endothelial growth factor and bone morphogenetic protein 2 in dental pulp tissue of healthy and diabetic patients","volume":"38","author":"Ilic","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.030_bib43","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.joen.2012.03.010","article-title":"Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand\/osteoprotegerin","volume":"38","author":"Liu","year":"2012","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239913000204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239913000204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:46:27Z","timestamp":1758829587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239913000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0099239913000204"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2012.12.030","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcome of Periapical Lesions in a Rat Model of Type 2 Diabetes: Refractoriness to Systemic Antioxidant Therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2012.12.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}