{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:56:25Z","timestamp":1787162185798,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.joen.2013.08.032","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T18:31:21Z","timestamp":1381948281000},"page":"1498-1503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["MicroRNAs: New Insights into the Pathogenesis of Endodontic Periapical Disease"],"prefix":"10.1016","volume":"39","author":[{"given":"Linda T.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsar Raza","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jezrom","family":"Self-Fordham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Nares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2013.08.032_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.semcancer.2008.01.005","article-title":"MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation","volume":"18","author":"Sonkoly","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.joen.2013.08.032_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.joen.2013.08.032_bib3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc2867","article-title":"Genetic variation in microRNA networks: the implications for cancer research","volume":"10","author":"Ryan","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.joen.2013.08.032_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.joen.2013.08.032_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/cvr\/cvn137","article-title":"MicroRNAs: novel regulators in cardiac development and disease","volume":"79","author":"Thum","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.joen.2013.08.032_bib6","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1038\/emboj.2011.327","article-title":"microRNA-34c is a novel target to treat dementias","volume":"30","author":"Zovoilis","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.joen.2013.08.032_bib7","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.joca.2008.09.012","article-title":"The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-\u03b1 and MMP13","volume":"17","author":"Jones","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joen.2013.08.032_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mrfmmm.2011.03.004","article-title":"Extracellular microRNA: a new source of biomarkers","volume":"717","author":"Etheridge","year":"2011","journal-title":"Mutat Res"},{"key":"10.1016\/j.joen.2013.08.032_bib9","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.joen.2013.08.032_bib10","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joen.2013.08.032_bib11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.joen.2013.08.032_bib12","first-page":"253","article-title":"MicroRNAs: their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics","volume":"2","author":"Ladomery","year":"2011","journal-title":"Int J Mol Epidemiol Genet"},{"key":"10.1016\/j.joen.2013.08.032_bib13","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/0022034512456551","article-title":"MicroRNAs and their target genes in gingival tissues","volume":"91","author":"Stoecklin-Wasmer","year":"2012","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2013.08.032_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/0022034511425045","article-title":"MicroRNA modulation in obesity and periodontitis","volume":"91","author":"Perri","year":"2012","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2013.08.032_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4248\/IJOS11046","article-title":"Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues","volume":"3","author":"Xie","year":"2011","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.joen.2013.08.032_bib16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.joen.2012.02.020","article-title":"Differential expression of microRNAs in normal and inflamed human pulps","volume":"38","author":"Zhong","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.08.032_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.joen.2013.08.032_bib18","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.3168\/jds.2011-5173","article-title":"Bioinformatics analysis of microRNA and putative target genes in bovine mammary tissue infected with Streptococcus uberis","volume":"95","author":"Naeem","year":"2012","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.joen.2013.08.032_bib19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1582-4934.2011.01282.x","article-title":"Functional analysis of microRNAs in human hepatocellular cancer stem cells","volume":"16","author":"Meng","year":"2012","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.joen.2013.08.032_bib20","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jcb.22592","article-title":"Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system","volume":"110","author":"Dave","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joen.2013.08.032_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12576-012-0230-y","article-title":"Angiotensin II induced differentially expressed microRNAs in adult rat cardiac fibroblasts","volume":"63","author":"Jiang","year":"2013","journal-title":"J Physiol Sci"},{"key":"10.1016\/j.joen.2013.08.032_bib22","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/onc.2009.468","article-title":"TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3","volume":"29","author":"Wang","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.joen.2013.08.032_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.immuni.2009.06.024","article-title":"The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs","volume":"31","author":"Androulidaki","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.joen.2013.08.032_bib24","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.immuni.2013.02.021","article-title":"The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis","volume":"38","author":"Henao-Mejia","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.joen.2013.08.032_bib25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1479-5876-9-195","article-title":"MicroRNA modulation in complex regional pain syndrome","volume":"9","author":"Orlova","year":"2011","journal-title":"J Transl Med"},{"key":"10.1016\/j.joen.2013.08.032_bib26","first-page":"1973","article-title":"MicroRNA-181b regulates NF-kappaB-mediated vascular inflammation","volume":"122","author":"Sun","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2013.08.032_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1752-0509-4-51","article-title":"Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma","volume":"4","author":"Liu","year":"2010","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.joen.2013.08.032_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013669","article-title":"Regulation of miRNA transcription in macrophages in response to Candida albicans","volume":"5","author":"Monk","year":"2010","journal-title":"PLoS One"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239913007619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239913007619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:45:50Z","timestamp":1758829550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239913007619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0099239913007619"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2013.08.032","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNAs: New Insights into the Pathogenesis of Endodontic Periapical Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2013.08.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}