{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:28:55Z","timestamp":1791206935278,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.joen.2013.10.005","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T07:39:44Z","timestamp":1385019584000},"page":"670-677","source":"Crossref","is-referenced-by-count":101,"title":["New Bacterial Composition in Primary and Persistent\/Secondary Endodontic Infections with Respect to Clinical and\u00a0Radiographic Findings"],"prefix":"10.1016","volume":"40","author":[{"given":"Christian","family":"Tennert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Fuhrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Wittmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamprini","family":"Karygianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Altenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Hellwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Al-Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2013.10.005_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1601-1546.2005.00152.x","article-title":"Mechanical preparation of root canals: shaping goals, techniques and means","volume":"10","author":"Hulsmann","year":"2005","journal-title":"Endod Top"},{"key":"10.1016\/j.joen.2013.10.005_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.joen.2007.11.003","article-title":"Treatment outcome in endodontics: the Toronto study\u2014phases 3 and 4: orthograde retreatment","volume":"2","author":"de Chevigny","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2591.2001.00411.x","article-title":"Isolation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis","volume":"6","author":"Peciuliene","year":"2001","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2013.10.005_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1079-2104(98)90404-8","article-title":"Microbiologic analysis of teeth with failed endodontic treatment and the outcome of conservative re-treatment","volume":"1","author":"Sundqvist","year":"1998","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.joen.2009.09.017","article-title":"The effects of antimicrobials on endodontic biofilm bacteria","volume":"1","author":"Chavez de Paz","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.joen.2005.10.027","article-title":"Killing of Enterococcus faecalis by MTAD and chlorhexidine digluconate with or without cetrimide in the presence or absence of dentine powder or BSA","volume":"2","author":"Portenier","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1177\/0022034509346549","article-title":"Diversity of endodontic microbiota revisited","volume":"11","author":"Siqueira","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2013.10.005_bib8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1034\/j.1399-302X.2001.160603.x","article-title":"Microbial flora of root canal-treated teeth associated with asymptomatic periapical radiolucent lesions","volume":"6","author":"Cheung","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2013.10.005_bib9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.joen.2006.11.004","article-title":"Redefining the persistent infection in root canals: possible role of biofilm communities","volume":"6","author":"Chavez de Paz","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib10","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/01.don.0000164133.04548.26","article-title":"Enterococcus spp. in endodontically treated teeth with and without periradicular lesions","volume":"12","author":"Kaufman","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib11","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1128\/JCM.00388-09","article-title":"Occurrence, population structure, and antimicrobial resistance of enterococci in marginal and apical periodontitis","volume":"7","author":"Sun","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joen.2008.10.024","article-title":"New bacterial compositions in root-filled teeth with periradicular lesions","volume":"2","author":"Schirrmeister","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib13","doi-asserted-by":"crossref","first-page":"e49576","DOI":"10.1371\/journal.pone.0049576","article-title":"Comprehensive analysis of secondary dental root canal infections: a combination of culture and culture-independent approaches reveals new insights","volume":"11","author":"Anderson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2013.10.005_bib14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.joen.2007.01.012","article-title":"Detection and eradication of microorganisms in root-filled teeth associated with periradicular lesions: an in\u00a0vivo study","volume":"5","author":"Schirrmeister","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-9657.1995.tb00673.x","article-title":"Microbial flora of sinus tracts and root canals of non-vital teeth","volume":"1","author":"Weiger","year":"1995","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2013.10.005_bib16","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.joen.2008.08.021","article-title":"Prevalence and clonal analysis of Porphyromonas gingivalis in primary endodontic infections","volume":"11","author":"Siqueira","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib17","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1097\/00004770-200311000-00012","article-title":"Pseudoramibacter alactolyticus in primary endodontic infections","volume":"11","author":"Siqueira","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2591.1996.tb01164.x","article-title":"Associations of endodontic symptoms and signs with particular combinations of specific bacteria","volume":"2","author":"Gomes","year":"1996","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2013.10.005_bib19","first-page":"216","article-title":"Detection of Enterococcus faecalis in necrotic teeth root canals by culture and polymerase chain Reaction Methods","volume":"4","author":"Cogulu","year":"2007","journal-title":"Eur J Dent"},{"key":"10.1016\/j.joen.2013.10.005_bib20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.tripleo.2004.10.002","article-title":"Disinfection of gutta-percha cones with chlorhexidine and sodium hypochlorite","volume":"4","author":"Gomes","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2591.2008.01537.x","article-title":"The mysterious appearance of enterococci in filled root canals","volume":"4","author":"Zehnder","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2013.10.005_bib22","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2147\/IJGM.S36919","article-title":"Moraxella osloensis: an unusual cause of central venous catheter infection in a cancer patient","author":"Hadano","year":"2012","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.joen.2013.10.005_bib23","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1432-2277.2008.00727.x","article-title":"Moraxella osloensis bacteremia in a kidney transplant recipient","volume":"10","author":"Sifri","year":"2008","journal-title":"Transpl Int"},{"key":"10.1016\/j.joen.2013.10.005_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3346\/jkms.2010.25.3.501","article-title":"Three cases of Moraxella osloensis meningitis: a difficult experience in species identification and determination of clinical significance","volume":"3","author":"Roh","year":"2010","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.joen.2013.10.005_bib25","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1128\/JCM.00531-12","article-title":"Characterization of microbiota of root canal-treated teeth with posttreatment disease","volume":"5","author":"Rocas","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.joen.2008.01.016","article-title":"Microbial analysis of canals of root-filled teeth with periapical lesions using polymerase chain reaction","volume":"5","author":"Gomes","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib27","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.joen.2012.06.035","article-title":"Effectiveness of endodontic disinfecting solutions against young and old Enterococcus faecalis biofilms in dentin canals","volume":"10","author":"Wang","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib28","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/154411130401500506","article-title":"Virulence factors of Enterococcus faecalis: relationship to endodontic disease","volume":"5","author":"Kayaoglu","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2013.10.005_bib29","first-page":"115","article-title":"Identification of dominant pathogens in periapical lesions associated with persistent apical periodontitis","volume":"2","author":"Zhang","year":"2010","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.joen.2013.10.005_bib30","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.joen.2008.05.008","article-title":"Microorganisms in root canal-treated teeth from a German population","volume":"8","author":"Rocas","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib31","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1128\/JCM.43.7.3314-3319.2005","article-title":"Uncultivated phylotypes and newly named species associated with primary and persistent endodontic infections","volume":"7","author":"Siqueira","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The biofilm matrix","volume":"9","author":"Flemming","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib33","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.joen.2011.05.026","article-title":"Analysis of symptomatic and asymptomatic primary root canal infections in adult Norwegian patients","volume":"9","author":"Rocas","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1365-2591.2011.01974.x","article-title":"Investigation of six selected bacterial species in endo-periodontal lesions","volume":"3","author":"Didilescu","year":"2012","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2013.10.005_bib35","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.joen.2010.07.001","article-title":"Apical root canal microbiota as determined by reverse-capture checkerboard analysis of cryogenically ground root samples from teeth with apical periodontitis","volume":"10","author":"Rocas","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib36","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.joen.2011.06.020","article-title":"Molecular characterization of the microbial flora residing at the apical portion of infected root canals of human teeth","volume":"10","author":"Chugal","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib37","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.joen.2011.04.007","article-title":"Exploring bacterial diversity of endodontic microbiota by cloning and sequencing 16S rRNA","volume":"7","author":"Ribeiro","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1099\/jmm.0.46280-0","article-title":"Overestimation of Streptococcus mutans prevalence by nested PCR detection of the 16S rRNA gene","volume":"55","author":"Al-Ahmad","year":"2006","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00284-008-9182-0","article-title":"Characterization of the first oral vagococcus isolate from a root-filled tooth with periradicular lesions","volume":"3","author":"Al-Ahmad","year":"2008","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib40","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1902\/jop.2011.110063","article-title":"Detection and clonal analysis of anaerobic bacteria associated to endodontic-periodontal lesions","volume":"12","author":"Pereira","year":"2011","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2013.10.005_bib41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1097\/01.don.0000157990.86638.49","article-title":"Exploiting molecular methods to explore endodontic infections: part 2\u2014redefining the endodontic microbiota","volume":"7","author":"Siqueira","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib42","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.tripleo.2009.01.044","article-title":"Community as the unit of pathogenicity: an emerging concept as to the microbial pathogenesis of apical periodontitis","volume":"6","author":"Siqueira","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2013.10.005_bib43","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v1i0.2009","article-title":"Distinctive features of the microbiota associated with different forms of apical periodontitis","author":"Siqueira","year":"2009","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.joen.2013.10.005_bib44","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1399-302x.2004.00170.x","article-title":"Investigation of bacterial communities associated with asymptomatic and symptomatic endodontic infections by denaturing gradient gel electrophoresis fingerprinting approach","volume":"6","author":"Siqueira","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2013.10.005_bib45","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1128\/MMBR.50.4.452-457.1986","article-title":"Encapsulated anaerobic bacteria in synergistic infections","volume":"4","author":"Brook","year":"1986","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.joen.2013.10.005_bib46","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1128\/IAI.25.2.685-693.1979","article-title":"Capacity of anaerobic bacteria from necrotic dental pulps to induce purulent infections","volume":"2","author":"Sundqvist","year":"1979","journal-title":"Infect Immun"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239913009011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239913009011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:01:08Z","timestamp":1597050068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239913009011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0099239913009011"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2013.10.005","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}