{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:54:25Z","timestamp":1791896065929,"version":"4.3.4"},"reference-count":96,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.joen.2014.01.021","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T23:32:07Z","timestamp":1396308727000},"page":"S46-S51","source":"Crossref","is-referenced-by-count":284,"special_numbering":"S","title":["Inflammation and Regeneration in the Dentin-Pulp Complex: A Double-edged Sword"],"prefix":"10.1016","volume":"40","author":[{"given":"Paul R.","family":"Cooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Holder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2014.01.021_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000016495","article-title":"A light microscopic study of odontoblastic and non-odontoblastic cells involved in tertiary dentinogenesis in well-defined cavitated carious lesions","volume":"33","author":"Bj\u00f8rndal","year":"1999","journal-title":"Caries Res"},{"key":"10.1016\/j.joen.2014.01.021_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000016431","article-title":"Thylstrup. A quantitative light microscopic study of the odontoblast and subodontoblastic reactions to active and arrested enamel caries without cavitation","volume":"32","author":"Bj\u00f8rndal","year":"1998","journal-title":"Caries Res"},{"key":"10.1016\/j.joen.2014.01.021_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jdent.2010.05.016","article-title":"Inflammation-regeneration interplay in the dentine-pulp complex","volume":"38","author":"Cooper","year":"2010","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2014.01.021_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/0022034511405390","article-title":"Pattern-recognition receptors in pulp defense","volume":"23","author":"Staquet","year":"2011","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1399-302X.2007.00310.x","article-title":"Differential regulation of immune responses by odontoblasts","volume":"22","author":"Veerayutthwilai","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2014.01.021_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2172-12-9","article-title":"Caries induced cytokine network in the odontoblast layer of human teeth","volume":"12","author":"Horst","year":"2011","journal-title":"BMC Immunol"},{"key":"10.1016\/j.joen.2014.01.021_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1159\/000159604","article-title":"Caries ecology revisited: microbial dynamics and the caries process","volume":"42","author":"Takahashi","year":"2008","journal-title":"Caries Res"},{"key":"10.1016\/j.joen.2014.01.021_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.joen.2014.01.021_bib9","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood-2006-06-028704","article-title":"Toll-like receptors and their ligands control mesenchymal stem cell functions","volume":"109","author":"Pevsner-Fischer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.joen.2014.01.021_bib10","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1177\/154405910508401105","article-title":"NF-kappaB activation in human dental pulp stem cells by TNF and LPS","volume":"84","author":"Chang","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbrc.2006.06.055","article-title":"TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications","volume":"347","author":"Zampetaki","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joen.2014.01.021_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jez.b.21259","article-title":"Odontoblasts in the dental pulp immune response","volume":"312B","author":"Farges","year":"2009","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"10.1016\/j.joen.2014.01.021_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.imbio.2010.08.006","article-title":"Cytokine production by human odontoblast-like cells upon Toll-like receptor-2 engagement","volume":"216","author":"Farges","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.joen.2014.01.021_bib14","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.joen.2011.06.008","article-title":"Up-regulation of nucleotide-binding oligomerization domain 1 in inflamed human dental pulp","volume":"37","author":"Lee","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/0022034509341779","article-title":"Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts","volume":"88","author":"Hirao","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib16","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.joen.2009.03.047","article-title":"Expression of nucleotide-binding oligomerization domain 2 in normal human dental pulp cells and dental pulp tissues","volume":"35","author":"Lin","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5213\/inj.2012.16.1.2","article-title":"The role of NLR-related protein 3 inflammasome in host defense and inflammatory diseases","volume":"16","author":"Yang","year":"2012","journal-title":"Int Neurourol J"},{"key":"10.1016\/j.joen.2014.01.021_bib18","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.joen.2012.09.023","article-title":"NLRP3 Is expressed in human dental pulp cells and tissues","volume":"38","author":"Song","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1749-6632.1988.tb18814.x","article-title":"Hematopoietic, lymphopoietic, and pro-inflammatory cytokines produced by human and murine keratinocytes","volume":"548","author":"Kupper","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.joen.2014.01.021_bib20","first-page":"229","article-title":"Chemokines inflammation and the immune system","volume":"1","author":"Taub","year":"1994","journal-title":"Ther Immunol"},{"key":"10.1016\/j.joen.2014.01.021_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2591.2007.01215.x","article-title":"Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp","volume":"40","author":"Kokkas","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.021_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbadis.2005.03.007","article-title":"Gene expression profiling of pulpal tissue reveals the molecular complexity of dental caries","volume":"1741","author":"McLachlan","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joen.2014.01.021_bib23","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.72.7.4102-4108.2004","article-title":"S100 and cytokine expression in caries","volume":"72","author":"McLachlan","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.joen.2014.01.021_bib24","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.archoralbio.2009.06.008","article-title":"Phenotype and behaviour of dental pulp cells during expansion culture","volume":"54","author":"Patel","year":"2009","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib25","article-title":"Cytokine release from human dentine","volume":"86(B)","author":"Graham","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib26","first-page":"127","article-title":"Dentine regeneration: key roles for stem cells and molecular signalling","volume":"2","author":"Smith","year":"2005","journal-title":"Oral Biosci Med"},{"key":"10.1016\/j.joen.2014.01.021_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0099-2399(89)80093-7","article-title":"A study of T and B cells in pulpal pathosis","volume":"15","author":"Hahn","year":"1989","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0003-9969(95)00024-J","article-title":"Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth","volume":"40","author":"Izumi","year":"1995","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00441-011-1231-5","article-title":"In situ proliferation and differentiation of macrophages in dental pulp","volume":"346","author":"Iwasaki","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.joen.2014.01.021_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0898-6568(00)00149-2","article-title":"LPS induction of gene expression in human monocytes","volume":"13","author":"Guha","year":"2001","journal-title":"Cell Signal"},{"key":"10.1016\/j.joen.2014.01.021_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1524-475X.2005.00079.x","article-title":"Age-dependent response of primary human dermal fibroblasts to oxidative stress: cell survival, pro-survival kinases, and entrance into cellular senescence","volume":"13","author":"Gurjala","year":"2005","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.joen.2014.01.021_bib32","first-page":"273","article-title":"Reactionary dentinogenesis","volume":"39","author":"Smith","year":"1995","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib33","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.joen.2008.04.001","article-title":"Regenerative potential of dental pulp","volume":"34","author":"Trope","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib34","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/dev.109.2.461","article-title":"Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity","volume":"109","author":"Byers","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.joen.2014.01.021_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/08959374010150011201","article-title":"Molecular regulation of odontoblast activity under dentin injury","volume":"15","author":"Magloire","year":"2001","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.archoralbio.2008.09.008","article-title":"VEGF and odontoblast-like cells: stimulation by low frequency ultrasound","volume":"54","author":"Scheven","year":"2009","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib37","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/154405910308200612","article-title":"Lipotechoic acid up-regulates VEGF expression in macrophages and pulp cells","volume":"82","author":"Telles","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.joen.2007.01.003","article-title":"Vascular endothelial growth factor and its relationship with the dental pulp","volume":"33","author":"Grando Mattuella","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib39","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1177\/0022034509341946","article-title":"Angiogenic signalling triggered by cariogenic bacteria in pulp cells","volume":"88","author":"Soden","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib40","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/0022034509357556","article-title":"MAPK signalling is required for LPS-induced VEGF in pulp stem cells","volume":"89","author":"Botero","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00004770-200201000-00005","article-title":"Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps","volume":"28","author":"Artese","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib42","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/154405910608500908","article-title":"Role of human pulp fibroblasts in angiogenesis","volume":"85","author":"Tran-Hung","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1600-0722.1998.tb02158.x","article-title":"NGF, BDNF, NT3, NT4 and GDNF in tooth development","volume":"106","author":"Nosrat","year":"1998","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2014.01.021_bib44","first-page":"195","article-title":"Neurotrophins in odontogenesis","volume":"39","author":"Mitsiadis","year":"1995","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1097-0177(199911)216:3<299::AID-DVDY8>3.0.CO;2-B","article-title":"Nerve growth factor (NGF) supports tooth morphogenesis in mouse first branchial arch explants","volume":"216","author":"Amano","year":"1999","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joen.2014.01.021_bib46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jcb.22006","article-title":"Nerve growth factor promotes differentiation of odontoblast-like cells","volume":"106","author":"Arany","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joen.2014.01.021_bib47","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1177\/0022034511417443","article-title":"Effects of glial cell line-derived neurotrophic factor on dental pulp cells","volume":"90","author":"Gale","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib48","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1172\/JCI114932","article-title":"Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution","volume":"86","author":"Wakefield","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2014.01.021_bib49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s00223-009-9248-4","article-title":"TGF-beta\/extracellular matrix interactions in dentin matrix: a role in regulating sequestration and protection of bioactivity","volume":"85","author":"Baker","year":"2009","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.joen.2014.01.021_bib50","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0003-9969(96)00115-X","article-title":"Comparative analysis of transforming growth factor-beta isoforms 1-3 in human and rabbit dentine matrices","volume":"42","author":"Cassidy","year":"1997","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib51","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0003-9969(00)00075-3","article-title":"Angiogenic growth factors in human dentine matrix","volume":"45","author":"Roberts-Clark","year":"2000","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.archoralbio.2011.07.008","article-title":"Dentine as a bioactive extracellular matrix","volume":"57","author":"Smith","year":"2012","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib53","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1042\/BC20090122","article-title":"Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralisation","volume":"102","author":"Musson","year":"2010","journal-title":"Biol Cell"},{"key":"10.1016\/j.joen.2014.01.021_bib54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cyto.2012.11.009","article-title":"Hepatocyte growth factor is sequestered in dentine matrix and promotes regeneration-associated events in dental pulp cells","volume":"61","author":"Tomson","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.joen.2014.01.021_bib55","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1016\/j.biomaterials.2005.12.020","article-title":"The effect of calcium hydroxide on solubilisation of bio-active dentine matrix","volume":"27","author":"Graham","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2014.01.021_bib56","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jdent.2007.04.008","article-title":"Dissolution of bio-active dentine matrix components by mineral trioxide aggregate","volume":"35","author":"Tomson","year":"2007","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2014.01.021_bib57","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/etp.12036","article-title":"Molecular mediators of pulp inflammation and regeneration","volume":"28","author":"Cooper","year":"2013","journal-title":"Endod Top"},{"key":"10.1016\/j.joen.2014.01.021_bib58","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.joen.2009.09.019","article-title":"The MAP kinase pathway is involved in odontoblast stimulation via p38 phosphorylation","volume":"36","author":"Simon","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib59","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0030-4220(65)90166-0","article-title":"The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats","volume":"20","author":"Kakehashi","year":"1965","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2014.01.021_bib60","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0030-4220(69)90030-9","article-title":"The exposed germ-free pulp: effects of topical corticosteroid medication and restoration","volume":"27","author":"Kakehashi","year":"1969","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2014.01.021_bib61","first-page":"35","article-title":"An experimental study on wound healing of surgically exposed dental pulp in germ-free rats","volume":"28","author":"Tsuji","year":"1987","journal-title":"Bull Tokyo Dent Coll"},{"key":"10.1016\/j.joen.2014.01.021_bib62","first-page":"183","article-title":"Repair dentinogenesis following transplantation into normal and germ-free animals","volume":"88","author":"Inoue","year":"1992","journal-title":"Proc Finn Dent Soc"},{"key":"10.1016\/j.joen.2014.01.021_bib63","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0099-2399(81)80122-7","article-title":"Inflammatory response of the dental pulp to bacterial irritation","volume":"7","author":"Bergenholtz","year":"1981","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib64","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1034\/j.1600-0722.2000.108003202.x","article-title":"Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7","volume":"108","author":"Rutherford","year":"2000","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2014.01.021_bib65","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/00004770-200103000-00014","article-title":"The anti-inflammatory effects of human recombinant copper-zinc superoxide dismutase on pulp inflammation","volume":"27","author":"Baumgardner","year":"2001","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib66","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.archoralbio.2005.03.004","article-title":"Smad protein mediated transforming growth factor beta1 induction of apoptosis in the MDPC-23 odontoblast-like cell line","volume":"50","author":"He","year":"2005","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.01.021_bib67","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2008.05.013","article-title":"Inflammatory and immunological aspects of dental pulp repair","volume":"58","author":"Goldberg","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.joen.2014.01.021_bib68","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0022034509334070","article-title":"TNF-alpha promotes an odontoblastic phenotype in dental pulp cells","volume":"88","author":"Paula-Silva","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10565-006-0018-z","article-title":"Effects of hydrogen peroxide (H2O2) on alkaline phosphatase activity and matrix mineralization of odontoblast and osteoblast cell lines","volume":"22","author":"Lee","year":"2006","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.joen.2014.01.021_bib70","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1369\/0022155411403314","article-title":"The expression of GM-CSF and osteopontin in immunocompetent cells precedes the odontoblast differentiation following allogenic tooth transplantation in mice","volume":"59","author":"Saito","year":"2011","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.joen.2014.01.021_bib71","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/0022034513487377","article-title":"Pulp progenitor cell recruitment is selectively guided by a C5a gradient","volume":"92","author":"Chmilewsky","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib72","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-065X.2000.17715.x","article-title":"CXCR4: chemokine receptor extraordinaire","volume":"177","author":"Murdoch","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1016\/j.joen.2014.01.021_bib73","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jneuroim.2008.04.008","article-title":"CXCR4 signaling in the regulation of stem cell migration and development","volume":"198","author":"Miller","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.joen.2014.01.021_bib74","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2591.2007.01329.x","article-title":"Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: a randomized controlled trial","volume":"41","author":"Nair","year":"2008","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.021_bib75","first-page":"887","article-title":"Dentinobilteration der Wurzelkanale nach Behandlung mit calcium","volume":"30","author":"Hermann","year":"1930","journal-title":"Zahnarzti Rdsch"},{"key":"10.1016\/j.joen.2014.01.021_bib76","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/002203458506400407","article-title":"Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation","volume":"64","author":"Schr\u00f6der","year":"1985","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib77","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1600-9657.1998.tb00821.x","article-title":"Odontoblast differentiation: a response to environmental calcium?","volume":"14","author":"Kardos","year":"1998","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.021_bib78","first-page":"66","article-title":"Bioactive molecules and the future of pulp therapy","volume":"16","author":"Goldberg","year":"2003","journal-title":"Am J Dent"},{"key":"10.1016\/j.joen.2014.01.021_bib79","first-page":"379","article-title":"Early reaction of intact human teeth to calcium hydroxide following experimental pulpotomy and its significance to the development of hard tissue barrier","volume":"22","author":"Schr\u00f6der","year":"1971","journal-title":"Odontol Revy"},{"key":"10.1016\/j.joen.2014.01.021_bib80","series-title":"Seltzer and Bender\u2019s Dental Pulp","first-page":"309","article-title":"Calcium hydroxide and vital pulp therapy","author":"Stanley","year":"2002"},{"key":"10.1016\/j.joen.2014.01.021_bib81","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1002\/art.21273","article-title":"RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3","volume":"52","author":"Brentano","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joen.2014.01.021_bib82","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/eji.200939712","article-title":"Nuclear retention of IL-1alpha by necrotic cells: a mechanism to dampen sterile inflammation","volume":"39","author":"Luheshi","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.joen.2014.01.021_bib83","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-3083.2008.02155.x","article-title":"Differential dependence of the ingestion of necrotic cells and TNF-alpha\/IL-1beta production by murine macrophages on lipid rafts","volume":"68","author":"Acosta-P\u00e9rez","year":"2008","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.joen.2014.01.021_bib84","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1590\/S0074-02762005000500017","article-title":"Participation of cytokines in the necrotic-inflammatory lesions in the heart and skeletal muscles of Calomys callosus infected with Trypanosoma cruzi","volume":"100","author":"Magalh\u00e3es-Santos","year":"2005","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.joen.2014.01.021_bib85","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/154405910808700417","article-title":"N-acetyl cysteine (NAC)-assisted detoxification of PMMA resin","volume":"87","author":"Yamada","year":"2008","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib86","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1177\/0022034511406919","article-title":"HDACi: cellular effects, opportunities for restorative dentistry","volume":"90","author":"Duncan","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib87","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.joen.2011.12.014","article-title":"Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells","volume":"38","author":"Duncan","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.021_bib88","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.yexcr.2013.02.022","article-title":"Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells","volume":"319","author":"Duncan","year":"2013","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.joen.2014.01.021_bib89","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1177\/0022034512460404","article-title":"Interplay between mesenchymal stem cells and lymphocytes: implications for immunotherapy and tissue regeneration","volume":"91","author":"Wang","year":"2012","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib90","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/156652412800619950","article-title":"Immunosuppressive properties of mesenchymal stem cells: advances and applications","volume":"12","author":"De Miguel","year":"2012","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.joen.2014.01.021_bib91","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2591.2012.02028.x","article-title":"Interactions between immune system and mesenchymal stem cells in dental pulp and periapical tissues","volume":"45","author":"Leprince","year":"2012","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.021_bib92","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/odi.12086","article-title":"Immunomodulatory properties of dental tissue-derived mesenchymal stem cells","volume":"20","author":"Li","year":"2014","journal-title":"Oral Dis"},{"key":"10.1016\/j.joen.2014.01.021_bib93","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/scd.2010.0145","article-title":"Immunomodulatory properties of mesenchymal stem cells derived from dental pulp and dental follicle are susceptible to activation by toll-like receptor agonists","volume":"20","author":"Tomic","year":"2011","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.joen.2014.01.021_bib94","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1177\/0022034512456040","article-title":"Effects of red light-emitting diode irradiation on dental pulp cells","volume":"91","author":"Holder","year":"2012","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.021_bib95","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1258\/ebm.2012.012180","article-title":"Mechanisms of action for light therapy: a review of molecular interactions","volume":"237","author":"Prindeze","year":"2012","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.joen.2014.01.021_bib96","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1177\/0022034510393967","article-title":"Infection, inflammation, and bone regeneration: a paradoxical relationship","volume":"90","author":"Thomas","year":"2011","journal-title":"J Dent Res"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991400082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991400082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T02:34:22Z","timestamp":1746153262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923991400082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":96,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S009923991400082X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2014.01.021","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}