{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:58:13Z","timestamp":1775685493541,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.joen.2014.01.031","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T10:45:14Z","timestamp":1397645114000},"page":"1132-1138","source":"Crossref","is-referenced-by-count":59,"title":["EZH2, a Potential Regulator of Dental Pulp Inflammation and Regeneration"],"prefix":"10.1016","volume":"40","author":[{"given":"Tianqian","family":"Hui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"A","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuedong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2014.01.031_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jez.b.21259","article-title":"Odontoblasts in the dental pulp immune response","volume":"312B","author":"Farges","year":"2009","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"10.1016\/j.joen.2014.01.031_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2008.05.013","article-title":"Inflammatory and immunological aspects of dental pulp repair","volume":"58","author":"Goldberg","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.joen.2014.01.031_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jdent.2010.05.016","article-title":"Inflammation-regeneration interplay in the dentine-pulp complex","volume":"38","author":"Cooper","year":"2010","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2014.01.031_bib4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/154405910308200611","article-title":"Dentin-induced in\u00a0vivo inflammatory response and in\u00a0vitro activation of murine macrophages","volume":"82","author":"Lara","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.031_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0022034509334070","article-title":"TNF-alpha promotes an odontoblastic phenotype in dental pulp cells","volume":"88","author":"Paula-Silva","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.031_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0099-2399(98)80203-3","article-title":"Cytokines stimulate matrix metalloproteinase production by human pulp cells during long-term culture","volume":"24","author":"O'Boskey","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.031_bib7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.joen.2011.12.014","article-title":"Histone deacetylase inhibitors induced differentiation and accelerated mineralization of pulp-derived cells","volume":"38","author":"Duncan","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.031_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(02)01080-2","article-title":"Cellular memory and the histone code","volume":"111","author":"Turner","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.joen.2014.01.031_bib9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/embor.2009.102","article-title":"Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes","volume":"10","author":"Shaw","year":"2009","journal-title":"EMBO Rep"},{"key":"10.1016\/j.joen.2014.01.031_bib10","doi-asserted-by":"crossref","first-page":"201371","DOI":"10.4061\/2011\/201371","article-title":"Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation","volume":"2011","author":"Teven","year":"2011","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.joen.2014.01.031_bib11","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1089\/scd.2012.0711","article-title":"Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived intermediate odontogenic progenitor populations","volume":"22","author":"Gopinathan","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.joen.2014.01.031_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gde.2004.02.001","article-title":"The functions of E(Z)\/EZH2-mediated methylation of lysine 27 in histone H3","volume":"14","author":"Cao","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.joen.2014.01.031_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/bcr2871","article-title":"EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells","volume":"13","author":"Stefansson","year":"2011","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.joen.2014.01.031_bib14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nrc1991","article-title":"Polycomb silencers control cell fate, development and cancer","volume":"6","author":"Sparmann","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.joen.2014.01.031_bib15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1101\/gad.1742509","article-title":"Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a\/Arf expression and regeneration in diabetes mellitus","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.joen.2014.01.031_bib16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/jcb.24463","article-title":"The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response","volume":"114","author":"Turgeon","year":"2013","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joen.2014.01.031_bib17","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1101\/gad.1524107","article-title":"Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells","volume":"21","author":"Tan","year":"2007","journal-title":"Genes Dev"},{"key":"10.1016\/j.joen.2014.01.031_bib18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2119\/molmed.2011.00069","article-title":"Inhibition of histone deacetylases in inflammatory bowel diseases","volume":"17","author":"Glauben","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.joen.2014.01.031_bib19","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/ard.2011.154211","article-title":"Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay","volume":"71","author":"Grabiec","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joen.2014.01.031_bib20","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.joen.2006.01.007","article-title":"HGF enhanced proliferation and differentiation of dental pulp cells","volume":"32","author":"Ye","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.031_bib21","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.joen.2012.06.011","article-title":"JNK\/P38 mitogen-activated protein kinase used for hepatocyte growth factor-induced proliferation, differentiation, and migration in human dental papilla cells","volume":"38","author":"Su","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.031_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4161\/epi.2.3.4897","article-title":"Lifelong circadian and epigenetic drifts in metabolic syndrome","volume":"2","author":"Gallou-Kabani","year":"2007","journal-title":"Epigenetics"},{"key":"10.1016\/j.joen.2014.01.031_bib23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.5144\/0256-4947.2012.262","article-title":"The effect of prostate tissue inflammation in benign prostatic hyperplasia on enhancer of zeste homolog 2 ribonucleic acid expression","volume":"32","author":"Al-Maghrebi","year":"2012","journal-title":"Ann Saudi Med"},{"key":"10.1016\/j.joen.2014.01.031_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4248\/IJOS10015","article-title":"Multilineage differentiation of dental pulp stem cells from green fluorescent protein transgenic mice","volume":"2","author":"Grottkau","year":"2010","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.joen.2014.01.031_bib25","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.cell.2008.12.043","article-title":"Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells","volume":"136","author":"Ezhkova","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.joen.2014.01.031_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2012.04.009","article-title":"Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs","volume":"11","author":"Ye","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.joen.2014.01.031_bib27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.stem.2010.08.013","article-title":"TNF\/p38alpha\/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration","volume":"7","author":"Palacios","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.joen.2014.01.031_bib28","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.1000031107","article-title":"Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis","volume":"107","author":"Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joen.2014.01.031_bib29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4248\/BR201301005","article-title":"Bone remodeling and energy metabolism: new perspectives","volume":"1","author":"de Paula","year":"2013","journal-title":"Bone Research"},{"key":"10.1016\/j.joen.2014.01.031_bib30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ijos.2013.77","article-title":"KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells","volume":"5","author":"Xu","year":"2013","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.joen.2014.01.031_bib31","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.joen.2012.09.008","article-title":"Lipopolysaccharide induces the migration of human dental pulp cells by up-regulating miR-146a","volume":"38","author":"Wang","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.031_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.lungcan.2012.08.003","article-title":"Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells","volume":"78","author":"Kikuchi","year":"2012","journal-title":"Lung Cancer"},{"key":"10.1016\/j.joen.2014.01.031_bib33","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.joen.2012.07.009","article-title":"Effects of homeobox gene distal-less 3 on proliferation and odontoblastic differentiation of human dental pulp cells","volume":"38","author":"Li","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.031_bib34","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.1038\/sj.onc.1206558","article-title":"Cell cycle regulation and neural differentiation","volume":"22","author":"Galderisi","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.joen.2014.01.031_bib35","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1158\/1078-0432.CCR-12-2505","article-title":"Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation","volume":"19","author":"Gannon","year":"2013","journal-title":"Clin Cancer Res"}],"updated-by":[{"DOI":"10.1016\/j.joen.2017.02.012","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000}}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239914000922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239914000922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T12:00:51Z","timestamp":1565352051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239914000922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0099239914000922"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2014.01.031","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.joen.2017.02.012","asserted-by":"object"}]},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}