{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:19:10Z","timestamp":1791814750953,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.joen.2014.01.032","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T05:31:51Z","timestamp":1394170311000},"page":"606-612","source":"Crossref","is-referenced-by-count":132,"title":["Traumatized Immature Teeth Treated with 2 Protocols of Pulp Revascularization"],"prefix":"10.1016","volume":"40","author":[{"given":"Juliana Yuri","family":"Nagata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Paula","family":"Figueiredo de Almeida Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Farias","family":"Rocha Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Saori","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Elaine","family":"de Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Rocha","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"de Souza-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana de Jesus","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2014.01.032_bib1","series-title":"Textbook and Color Atlas of Traumatic Injuries to the Teeth","first-page":"411","year":"2007"},{"key":"10.1016\/j.joen.2014.01.032_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.joen.2008.03.001","article-title":"The hidden treasure in apical papilla: the potential role in pulp\/dentin regeneration and bioroot engineering","volume":"34","author":"Huang","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-9657.2011.01103.x","article-title":"International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 1\u2014fractures and luxations of permanent teeth","volume":"28","author":"Diangelis","year":"2012","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1600-9657.2010.00924.x","article-title":"A retrospective study of 889 injured permanent teeth","volume":"26","author":"Hecova","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib5","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1111\/j.1600-9657.2008.00745.x","article-title":"The use of calcium hydroxide and mineral trioxide aggregate on apexification of a replanted tooth: a case report","volume":"25","author":"Jacobovitz","year":"2009","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib6","first-page":"165","article-title":"Apexification with a new intra-canal medicament: a multidisciplinary case report","volume":"7","author":"de Jesus Soares","year":"2012","journal-title":"Iran Endod J"},{"key":"10.1016\/j.joen.2014.01.032_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.17796\/jcpd.36.3.02354g044271t152","article-title":"Apexification of anterior teeth: a comparative evaluation of mineral trioxide aggregate and calcium hydroxide paste","volume":"36","author":"Damle","year":"2012","journal-title":"J Clin Pediatr Dent"},{"key":"10.1016\/j.joen.2014.01.032_bib8","first-page":"200","article-title":"Avalia\u00e7\u00e3o de dentes reimplantados submetidos a um novo protocolo terap\u00eautico","volume":"66","author":"Buck","year":"2012","journal-title":"Rev Assoc Paul Cir Dent"},{"key":"10.1016\/j.joen.2014.01.032_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.joen.2008.05.001","article-title":"Efficacy of revascularization to induce apexification\/apexogensis in infected, nonvital, immature teeth: a pilot clinical study","volume":"34","author":"Shah","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/0970-9290.79977","article-title":"Regenerative endodontics: a state of the art","volume":"22","author":"Bansal","year":"2011","journal-title":"Indian J Dent Res"},{"key":"10.1016\/j.joen.2014.01.032_bib11","first-page":"47","article-title":"Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature","volume":"29","author":"Thibodeau","year":"2007","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2014.01.032_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.joen.2011.12.003","article-title":"Revitalization procedures in two traumatized incisors with different biological outcomes","volume":"38","author":"Lenzi","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib13","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/iej.12107","article-title":"Revascularization of an immature tooth with a necrotic pulp using platelet-rich fibrin: a case report","volume":"46","author":"Keswani","year":"2013","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.032_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-9657.2010.00963.x","article-title":"Revascularization of an immature permanent tooth with periradicular abscess after luxation","volume":"27","author":"Iwaya","year":"2011","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib15","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.joen.2011.05.033","article-title":"Regenerative endodontic treatment (revascularization) of immature necrotic molars medicated with calcium hydroxide: a case series","volume":"37","author":"Cehreli","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.joen.2008.02.029","article-title":"Regenerative treatment of an immature, traumatized tooth with apical periodontitis: report of a case","volume":"34","author":"Cotti","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1034\/j.1600-9657.2002.00097.x","article-title":"Long-term calcium hydroxide as a root canal dressing may increase risk of root fracture","volume":"18","author":"Andreasen","year":"2002","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00004770-200404000-00003","article-title":"Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?","volume":"30","author":"Banchs","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.joen.2012.10.005","article-title":"Pulp revascularization after root canal decontamination with calcium hydroxide and 2% chlorhexidine gel","volume":"39","author":"Soares Ade","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1834-7819.2010.01268.x","article-title":"Regenerative endodontics: biologically-based treatment for immature permanent teeth\u2014a case report and review of the literature","volume":"55","author":"Thomson","year":"2010","journal-title":"Aust Dent J"},{"key":"10.1016\/j.joen.2014.01.032_bib21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.joen.2011.01.011","article-title":"Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial","volume":"37","author":"Nosrat","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-9657.1998.tb00824.x","article-title":"Effectiveness of four chemical solutions in eliminating Bacillus subtilis spores on gutta-percha cones","volume":"14","author":"Siqueira","year":"1998","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2591.1996.tb01173.x","article-title":"In\u00a0vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline","volume":"29","author":"Hoshino","year":"1996","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.032_bib24","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.joen.2011.08.027","article-title":"Dentin conditioning codetermines cell fate in regenerative endodontics","volume":"37","author":"Galler","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1600-9657.2012.01133.x","article-title":"Pattern of traumatic dental injuries in the permanent dentition among children, adolescents, and adults","volume":"28","author":"Lauridsen","year":"2012","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib26","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0099-2399(85)80080-7","article-title":"A histological study of the effect of diameter enlargement of the apical portion of the root canal","volume":"11","author":"Benatti","year":"1985","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0030-4220(87)90157-5","article-title":"Influence of the enlargement of the apical foramen in periapical repair of contaminated teeth of dog","volume":"64","author":"de Souza Filho","year":"1987","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2014.01.032_bib28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1902\/jop.1986.57.6.370","article-title":"Chlorhexidine: an adjunct to periodontal therapy","volume":"57","author":"Greenstein","year":"1986","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.01.032_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0099-2399(06)80815-0","article-title":"A comparison of 2.0% chlorhexidine gluconate and 5.25% sodium hypochlorite as antimicrobial endodontic irrigants","volume":"20","author":"Jeansonne","year":"1994","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib30","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.joen.2011.05.013","article-title":"Effect of irrigants on the survival of human stem cells of the apical papilla in a platelet-rich plasma scaffold in human root tips","volume":"37","author":"Trevino","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib31","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.joen.2007.04.001","article-title":"Interaction between sodium hypochlorite and chlorhexidine gluconate","volume":"33","author":"Basrani","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib32","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/j.1365-2591.2009.01633.x","article-title":"One step pulp revascularization treatment of an immature permanent tooth with chronic apical abscess: a case report","volume":"42","author":"Shin","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.032_bib33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2591.2008.01467.x","article-title":"Pulp revascularization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discoloration: a case report","volume":"42","author":"Reynolds","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.032_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-9657.1999.tb00795.x","article-title":"Effect of chelating agents on the molecular composition and extent of decalcification at cervical, middle and apical root dentin locations","volume":"15","author":"Verdelis","year":"1999","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib35","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/00004770-200211000-00003","article-title":"Microbial susceptibility to calcium hydroxide pastes and their vehicles","volume":"28","author":"Gomes","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1590\/S0103-64402005000300001","article-title":"In\u00a0vitro evaluation of the susceptibility of endodontic pathogens to calcium hydroxide combined with different vehicles","volume":"16","author":"Vianna","year":"2005","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2014.01.032_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1590\/S0103-64402008000100005","article-title":"Antimicrobial effect and pH of chlorhexidine gel and calcium hydroxide alone and associated with other materials","volume":"19","author":"de Souza-Filho","year":"2008","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2014.01.032_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jdent.2008.09.009","article-title":"Antimicrobial action of intracanal medicaments on the external root surface","volume":"37","author":"Gomes","year":"2009","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2014.01.032_bib39","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.joen.2009.06.021","article-title":"A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures","volume":"35","author":"Bose","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib40","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.joen.2012.06.018","article-title":"Direct effect of intracanal medicaments on survival of stem cells of the apical papilla","volume":"38","author":"Ruparel","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib41","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.joen.2010.03.031","article-title":"Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report","volume":"36","author":"Kim","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/etp.12040","article-title":"An update on clinical regenerative endodontics","volume":"28","author":"Diogenes","year":"2013","journal-title":"Endodontic Topics"},{"key":"10.1016\/j.joen.2014.01.032_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3329\/bjdre.v2i2.16248","article-title":"Pulpal diagnosis of primary teeth: guidelines for clinical practice","volume":"2","author":"Mohammad","year":"2012","journal-title":"Bangladesh Journal of Dental"},{"key":"10.1016\/j.joen.2014.01.032_bib44","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1399-302X.1993.tb00661.x","article-title":"In\u00a0vitro antimicrobial susceptibility to combinations of drugs on bacteria from carious and endodontic lesions of human deciduous teeth","volume":"8","author":"Sato","year":"1993","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2014.01.032_bib45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.joen.2008.10.019","article-title":"Regenerative endodontic treatment for necrotic immature permanent teeth","volume":"35","author":"Chueh","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joen.2007.11.021","article-title":"Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study","volume":"34","author":"Sonoyama","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.joen.2014.01.032_bib48","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/edt.12000","article-title":"Periodontal healing complications following extrusive and lateral luxation in the permanent dentition: a longitudinal cohort study","volume":"28","author":"Hermann","year":"2012","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.01.032_bib49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/dvdy.10404","article-title":"Role of Hertwig's epithelial root sheath cells in tooth root development","volume":"228","author":"Zeichner-David","year":"2003","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joen.2014.01.032_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/856087","article-title":"Vital pulp therapy: current progress of dental pulp regeneration and revascularization","volume":"28","author":"Zhang","year":"2010","journal-title":"Int J Dent"},{"key":"10.1016\/j.joen.2014.01.032_bib51","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0099-2399(81)80308-1","article-title":"Solvent effect of various dilutions of sodium hypochlorite on vital and necrotic tissue","volume":"7","author":"Gordon","year":"1981","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib52","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.joen.2012.06.028","article-title":"Mahidol study 1: comparison of radiographic and survival outcomes of immature teeth treated with either regenerative endodontic or apexification methods\u2014a retrospective study","volume":"38","author":"Jeeruphan","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.032_bib53","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.joen.2007.03.001","article-title":"Pulp revascularization of immature dog teeth with apical periodontitis","volume":"33","author":"Thibodeau","year":"2007","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239914000934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239914000934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T02:45:54Z","timestamp":1597545954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239914000934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0099239914000934"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2014.01.032","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}