{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:46Z","timestamp":1789016326278,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.joen.2014.01.034","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T16:02:34Z","timestamp":1397404954000},"page":"1139-1144","source":"Crossref","is-referenced-by-count":44,"title":["Blood Profile and Histology in Oral Infections Associated with Diabetes"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-7846","authenticated-orcid":false,"given":"Luciano Tavares Angelo","family":"Cintra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aguinaldo C\u00e2ndido","family":"da Silva Facundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelise Katrine Carrara","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ris Hissako","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Gustavo","family":"Narciso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suely Regina","family":"Mogami Bomfim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleverson Oliveira","family":"e Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloi","family":"Dezan-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Eduardo","family":"Gomes-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2014.01.034_bib1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/154405910608501104","article-title":"Lesions of endodontic origin and risk of coronary heart disease","volume":"85","author":"Caplan","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.034_bib2","first-page":"211","article-title":"Oral health and dental treatment of patients with renal disease","volume":"38","author":"Vesterinen","year":"2007","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2014.01.034_bib3","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1097\/SCS.0b013e318231e585","article-title":"Brain abscess of odontogenic origin","volume":"22","author":"Antunes","year":"2011","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.joen.2014.01.034_bib4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1177\/154405910808700418","article-title":"Oral health and mortality risk from pneumonia in the elderly","volume":"87","author":"Awano","year":"2008","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.034_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/154405910808700403","article-title":"Osteoporosis and oral infection: independent risk factors for oral bone loss","volume":"87","author":"Brennan-Calanan","year":"2008","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.034_bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2174\/157339911797579205","article-title":"Diabetes and periodontal diseases: interplay and links","volume":"7","author":"Lakschevitz","year":"2011","journal-title":"Curr Diabetes Rev"},{"key":"10.1016\/j.joen.2014.01.034_bib7","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1902\/jop.2011.110349","article-title":"Periodontal disease decreases insulin sensitivity and insulin signaling","volume":"83","author":"Colombo","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.01.034_bib8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.joen.2012.12.031","article-title":"Periapical lesions decrease insulin signal and cause insulin resistance","volume":"39","author":"Astolphi","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib9","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00784-012-0853-7","article-title":"Pulpal and periodontal diseases increase triglyceride levels in diabetic rats","volume":"17","author":"Cintra","year":"2013","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.joen.2014.01.034_bib10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/iej.12072","article-title":"Diabetes mellitus and inflammatory pulpal and periapical disease: a review","volume":"46","author":"Lima","year":"2013","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.034_bib11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.diabres.2011.10.029","article-title":"IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030","volume":"94","author":"Whiting","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.joen.2014.01.034_bib12","doi-asserted-by":"crossref","first-page":"758921","DOI":"10.1155\/2012\/758921","article-title":"Epidemiological survey on the prevalence of periodontitis and diabetes mellitus in Uyghur adults from rural Hotan area in Xinjiang","volume":"2012","author":"Awuti","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.joen.2014.01.034_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.joen.2011.11.001","article-title":"Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population","volume":"38","author":"Marotta","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tripleo.2010.10.035","article-title":"Prevalence of apical periodontitis relative to endodontic treatment in an adult Dutch population: a repeated cross-sectional study","volume":"111","author":"Peters","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/j.0022-0337.2003.67.4.tb03647.x","article-title":"Diabetes mellitus as a modulating factor of endodontic infections","volume":"67","author":"Fouad","year":"2003","journal-title":"J Dent Educ"},{"key":"10.1016\/j.joen.2014.01.034_bib16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/154405910308200416","article-title":"The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes","volume":"82","author":"Iwama","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.034_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2334\/josnusd.48.195","article-title":"Diabetes and its effects on dental pulp","volume":"48","author":"Catanzaro","year":"2006","journal-title":"Oral Sci"},{"key":"10.1016\/j.joen.2014.01.034_bib18","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.joen.2008.07.010","article-title":"Diabetes induces metabolic alterations in dental pulp","volume":"34","author":"Leite","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib19","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.tripleo.2005.06.007","article-title":"Increased number of anaerobic bacteria in the infected root canal in type 2 diabetic rats","volume":"101","author":"Iwama","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00004770-200306000-00001","article-title":"Diabetes mellitus and the dental pulp","volume":"29","author":"Bender","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib21","doi-asserted-by":"crossref","first-page":"e13405","DOI":"10.1371\/journal.pone.0013405","article-title":"Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies","volume":"5","author":"Gkrania-Klotsas","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2014.01.034_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/iej.12136","article-title":"Relationships between oral infections and blood glucose concentrations or HbA1c levels in normal and diabetic rats","volume":"47","author":"Cintra","year":"2014","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.01.034_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00004770-200201000-00003","article-title":"Periapical lesion progression with controlled microbial inoculation in a type I diabetic mouse model","volume":"28","author":"Fouad","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/154405910708600403","article-title":"Chemokines in oral inflammatory diseases: apical periodontitis and periodontal disease","volume":"86","author":"Silva","year":"2007","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.01.034_bib25","doi-asserted-by":"crossref","first-page":"e1320","DOI":"10.1371\/journal.pone.0001320","article-title":"Alloxan-induced diabetes triggers the development of periodontal disease in rats","volume":"2","author":"Claudino","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2014.01.034_bib26","first-page":"35","article-title":"Histometric assessment of the effect of diabetes mellitus on experimentally induced periodontitis in rats","volume":"14","author":"Pepelassi","year":"2012","journal-title":"J Int Acad Periodontol"},{"key":"10.1016\/j.joen.2014.01.034_bib27","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00784-011-0628-6","article-title":"Hematological features in adolescents with periodontitis","volume":"16","author":"L\u00f3pez","year":"2012","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.joen.2014.01.034_bib28","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1902\/jop.2010.100211","article-title":"Relationship between decrease of erythrocyte count and progression of periodontal disease in a rural Japanese population","volume":"82","author":"Yamamoto","year":"2011","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.01.034_bib29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/08923970903490486","article-title":"Immunomodulatory, beta-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes","volume":"32","author":"Hamden","year":"2010","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.joen.2014.01.034_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/CH-2010-1303","article-title":"Gender differences of blood rheological parameters in laboratory animals","volume":"45","author":"Nemeth","year":"2010","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.joen.2014.01.034_bib31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.COC.0000071464.83271.08","article-title":"Effect of capecitabine on mean corpuscular volume in patients with metastatic breast cancer","volume":"27","author":"Karvellas","year":"2004","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.joen.2014.01.034_bib32","first-page":"283","article-title":"Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats","volume":"10","author":"Azeez","year":"2010","journal-title":"Afr Health Sci"},{"key":"10.1016\/j.joen.2014.01.034_bib33","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1902\/jop.2012.110681","article-title":"Tooth and periodontal clinical attachment loss are associated with hyperglycemia in diabetic patients","volume":"83","author":"Botero","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.01.034_bib34","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.joen.2012.03.010","article-title":"Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand\/osteoprotegerin","volume":"38","author":"Liu","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.01.034_bib35","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joen.2012.12.030","article-title":"Outcome of periapical lesions in a rat model of type 2 diabetes: refractoriness to systemic antioxidant therapy","volume":"39","author":"Wolle","year":"2013","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239914000958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239914000958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T19:00:53Z","timestamp":1597690853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239914000958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0099239914000958"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2014.01.034","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}