{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:31:46Z","timestamp":1789648306979,"version":"4.0.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"German Academic Exchange Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.joen.2014.07.010","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T20:41:12Z","timestamp":1413319272000},"page":"45-49","source":"Crossref","is-referenced-by-count":37,"title":["Effects of Alendronate on Osteoclast Formation and Activity In\u00a0Vitro"],"prefix":"10.1016","volume":"41","author":[{"given":"Caroline A.","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Leyhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Geurtsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2014.07.010_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-9657.2009.00818.x","article-title":"Contradictions in the treatment of traumatic dental injuries and ways to proceed in dental trauma research","volume":"26","author":"Andreasen","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1034\/j.1601-1546.2002.10106.x","article-title":"Root Resorption due to dental trauma","volume":"1","author":"Trope","year":"2002","journal-title":"Endod Topics"},{"key":"10.1016\/j.joen.2014.07.010_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-9657.1995.tb00462.x","article-title":"Replantation of 400 avulsed permanent incisors. Factors related to pulpal healing","volume":"11","author":"Andreasen","year":"1995","journal-title":"Endod Dent Traumatol"},{"issue":"suppl","key":"10.1016\/j.joen.2014.07.010_bib4","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1652::AID-CNCR15>3.0.CO;2-Z","article-title":"Overview of bisphosphonates [review]","volume":"80","author":"Rogers","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.joen.2014.07.010_bib5","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1258\/0004563011901037","article-title":"Bisphosphonates: an overview with special reference to alendronate","volume":"38","author":"Vasikaran","year":"2001","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.joen.2014.07.010_bib6","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1172\/JCI115539","article-title":"Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure","volume":"88","author":"Sato","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2014.07.010_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joen.2014.07.010_bib8","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s00198-009-1129-1","article-title":"Alendronate reduces osteoclast precursors in osteoporosis","volume":"21","author":"D'Amelio","year":"2010","journal-title":"Osteoporos Int"},{"issue":"12 Suppl","key":"10.1016\/j.joen.2014.07.010_bib9","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/1097-0142(20000615)88:12+<2961::AID-CNCR12>3.0.CO;2-L","article-title":"Cellular and molecular mechanisms of action of bisphosphonates [review]","volume":"88","author":"Rogers","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.joen.2014.07.010_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1600-9657.2005.00370.x","article-title":"Cytotoxicity analysis of alendronate on cultured endothelial cells and subcutaneous tissue. A pilot study","volume":"21","author":"Moreira","year":"2005","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-9657.2005.00434.x","article-title":"Cytotoxicity evaluation of sodium alendronate on cultured human periodontal ligament fibroblasts","volume":"22","author":"Correia","year":"2006","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-0765.2010.01306.x","article-title":"Effect of bisphosphonates on human gingival fibroblast production of mediators of osteoclastogenesis: RANKL, osteoprotegerin and interleukin-6","volume":"46","author":"Tipton","year":"2011","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.joen.2014.07.010_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1034\/j.1600-9657.2001.017003120.x","article-title":"Effect of topical alendronate on root resorption of dried replanted dog teeth","volume":"17","author":"Levin","year":"2001","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1006\/ijom.2002.0472","article-title":"The effect of alendronate on resorption of the alveolar bone following tooth extraction","volume":"33","author":"Altundal","year":"2004","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2014.07.010_bib15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-9657.2006.00417.x","article-title":"Evaluation of the topical effect of alendronate on the root surface of extracted and replanted teeth. Microscopic analysis on rats' teeth","volume":"22","author":"Lustosa-Pereira","year":"2006","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-9657.2008.00631.x","article-title":"Intracanal bisphosphonate does not inhibit replacement resorption","volume":"25","author":"Thong","year":"2009","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib17","series-title":"Fosamax (Sodium Alendronate) Package Insert and Prescription Information","year":"2013"},{"key":"10.1016\/j.joen.2014.07.010_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/BF02968579","article-title":"Bioequivalence and pharmacokinetics of 70 mg alendronate sodium tablets by measuring alendronate in plasma","volume":"29","author":"Yun","year":"2006","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.joen.2014.07.010_bib19","first-page":"475","article-title":"Adverse effects of bisphosphonates: current issues","volume":"5","author":"Diel","year":"2007","journal-title":"J Support Oncol"},{"key":"10.1016\/j.joen.2014.07.010_bib20","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.joen.2009.07.020","article-title":"A retrospective clinical and radiographic study on healing of periradicular lesions in patients taking oral bisphosphonates","volume":"35","author":"Hsiao","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.07.010_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.tripleo.2008.03.036","article-title":"The effects of bisphosphonates on osteoblasts in\u00a0vitro","volume":"106","author":"Naidu","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2014.07.010_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S8756-3282(97)00270-6","article-title":"Effect of alendronate on cultured normal human osteoblasts","volume":"22","author":"Garc\u00eda-Moreno","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.joen.2014.07.010_bib23","first-page":"153","article-title":"RANKL-mediated osteoclast formation from murine RAW 264.7 cells","volume":"80","author":"Collin-Osdoby","year":"2003","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.joen.2014.07.010_bib24","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1210\/endo.142.3.8031","article-title":"Receptor activator of nuclear factor-kappa b ligand activates nuclear factor-kappa b in osteoclast precursors","volume":"142","author":"Wei","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.joen.2014.07.010_bib25","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1359\/jbmr.1998.13.11.1721","article-title":"Human osteoclast formation and activity in\u00a0vitro: effects of alendronate","volume":"13","author":"Breuil","year":"1998","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2014.07.010_bib26","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1194\/jlr.M600151-JLR200","article-title":"Conjugated linoleic acid inhibits osteoclast differentiation of RAW264.7 cells by modulating RANKL signaling","volume":"47","author":"Rahman","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.joen.2014.07.010_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1136\/mp.55.2.65","article-title":"Acid phosphatases","volume":"55","author":"Bull","year":"2002","journal-title":"Mol Pathol"},{"key":"10.1016\/j.joen.2014.07.010_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S8756-3282(01)00655-X","volume":"30","author":"Van Beek","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.joen.2014.07.010_bib29","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1074\/jbc.M805280200","article-title":"Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption","volume":"284","author":"Wilson","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2014.07.010_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/030097498441155","article-title":"Bisphosphonates inhibit IL-6 production by human osteoblast-like cells","volume":"27","author":"Giuliani","year":"1998","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib31","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1016\/j.biomaterials.2005.04.059","article-title":"Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells","volume":"26","author":"von Knoch","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2014.07.010_bib32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12020-009-9306-8","article-title":"The effect of the alendronate on OPG\/RANKL system in differentiated primary human osteoblasts","volume":"37","author":"Enjuanes","year":"2010","journal-title":"Endocrine"},{"key":"10.1016\/j.joen.2014.07.010_bib33","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.biomaterials.2003.11.024","article-title":"Osteoblast proliferation and maturation by bisphosphonates","volume":"25","author":"Im","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2014.07.010_bib34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-9657.2006.00437.x","article-title":"Morphometric and microscopic evaluation of the effect of a solution of alendronate as an intracanal therapeutic agent","volume":"23","author":"Mori","year":"2007","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2014.07.010_bib35","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-9657.2011.01023.x","article-title":"Intracanal dressing and root canal filling materials in tooth replantation: a literature review","volume":"28","author":"Panzarini","year":"2012","journal-title":"Dent Traumatol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991400644X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991400644X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T05:40:16Z","timestamp":1565934016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923991400644X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S009923991400644X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2014.07.010","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}