{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:08:30Z","timestamp":1787857710713,"version":"build-2784847793"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["1090461"],"award-info":[{"award-number":["1090461"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["1120138"],"award-info":[{"award-number":["1120138"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.joen.2014.12.021","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T01:00:11Z","timestamp":1425430811000},"page":"464-469","source":"Crossref","is-referenced-by-count":32,"title":["C-Reactive Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with\u00a0Interleukin-6"],"prefix":"10.1016","volume":"41","author":[{"given":"Mauricio","family":"Garrido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dezerega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Bordagaray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Vernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Melgar-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00eda","family":"Ciuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Garc\u00eda-Sesnich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ahumada-Montalva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2014.12.021_bib1","first-page":"3","article-title":"Review of osteoimmunology and the host response in endodontic and periodontal lesions","author":"Graves","year":"2011","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.joen.2014.12.021_bib2","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.joen.2009.09.028","article-title":"Identify and define all diagnostic terms for periapical\/periradicular health and disease states","volume":"35","author":"Gutmann","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.joen.2013.06.020","article-title":"High levels of CXC ligand 12\/stromal cell-derived factor 1 in apical lesions of endodontic origin associated with mast cell infiltration","volume":"39","author":"Cavalla","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1902\/jop.2013.130156","article-title":"Gingival crevicular fluid matrix metalloproteinase-8 levels predict treatment outcome among smokers with chronic periodontitis","volume":"85","author":"Leppilahti","year":"2014","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.tripleo.2007.12.002","article-title":"Gelatinolytic activity in gingival crevicular fluid from teeth with periapical lesions","volume":"105","author":"Belmar","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib6","first-page":"38210","article-title":"Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions","volume":"2007","author":"Prso","year":"2007","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2014.12.021_bib7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/iej.12196","article-title":"The role of IL-6 on apical periodontitis: a systematic review","volume":"47","author":"Azuma","year":"2014","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.12.021_bib8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.joen.2013.06.014","article-title":"Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis","volume":"39","author":"Gomes","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib9","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-051X.2009.01506.x","article-title":"Local and systemic biomarkers in gingival crevicular fluid increase odds of periodontitis","volume":"37","author":"Fitzsimmons","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1600-051X.2010.01603.x","article-title":"C-reactive protein in gingival crevicular fluid may be indicative of systemic inflammation","volume":"37","author":"Megson","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib11","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1902\/jop.2007.070150","article-title":"Evaluation of gingival crevicular fluid and serum levels of high-sensitivity C-reactive protein in chronic periodontitis patients with or without coronary artery disease","volume":"78","author":"Tuter","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib12","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.archoralbio.2011.04.010","article-title":"Increased expression of C-reactive protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-6","volume":"56","author":"Maekawa","year":"2011","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2014.12.021_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1600-051X.2010.01600.x","article-title":"Human gingiva is another site of C-reactive protein formation","volume":"37","author":"Lu","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.joen.2013.10.026","article-title":"Association between chronic apical periodontitis and coronary artery disease","volume":"40","author":"Costa","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib15","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1902\/jop.2010.100054","article-title":"Periodontal ligament fibroblasts sustain destructive immune modulators of chronic periodontitis","volume":"81","author":"El-Awady","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2591.2007.01272.x","article-title":"Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses","volume":"40","author":"de Sa","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2014.12.021_bib17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.joen.2012.02.021","article-title":"Correlation between clinical\/radiographic features and inflammatory cytokine networks produced by macrophages stimulated with endodontic content","volume":"38","author":"Martinho","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib18","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1079-2104(03)00067-2","article-title":"Immunolocalization of interleukin 4, interleukin 6, and lymphotoxin alpha in dental granulomas","volume":"96","author":"de Sa","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib19","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1210\/endo.139.3.5818","article-title":"Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption","volume":"139","author":"Kusano","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.joen.2014.12.021_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1067\/moe.2001.115025","article-title":"Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice","volume":"92","author":"Huang","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2014.12.021_bib21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/154405910608500113","article-title":"Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk","volume":"85","author":"Taylor","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2014.12.021_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s007840000095","article-title":"Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment","volume":"5","author":"Minczykowski","year":"2001","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2014.12.021_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/cvr\/cvp249","article-title":"C-reactive protein impairs the endothelial glycocalyx resulting in endothelial dysfunction","volume":"84","author":"Devaraj","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"8 Suppl","key":"10.1016\/j.joen.2014.12.021_bib24","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1902\/jop.2008.080249","article-title":"Inflammation, C-reactive protein, and atherothrombosis","volume":"79","author":"Ridker","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2014.12.021_bib25","doi-asserted-by":"crossref","first-page":"e554","DOI":"10.1161\/01.CIR.0000148982.95775.BF","article-title":"CDC\/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the population science discussion group","volume":"110","author":"Fortmann","year":"2004","journal-title":"Circulation"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991401231X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991401231X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T12:34:24Z","timestamp":1566390864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923991401231X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S009923991401231X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2014.12.021","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}