{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:46Z","timestamp":1789016326266,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2012\/08722-2"],"award-info":[{"award-number":["2012\/08722-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pro-Rector for Research of UNESP"},{"name":"Foundation for the Development of UNESP"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.joen.2015.04.002","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T09:32:33Z","timestamp":1432891953000},"page":"1305-1310","source":"Crossref","is-referenced-by-count":15,"title":["Periapical Lesions Decrease Insulin Signaling in Rat Skeletal\u00a0Muscle"],"prefix":"10.1016","volume":"41","author":[{"given":"Rafael Dias","family":"Astolphi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane Machado","family":"Curbete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Yamamoto","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Tavares Angelo","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max Sander de Oliveira","family":"da Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Antoniali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9a Adas Saliba","family":"Garbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-229X","authenticated-orcid":false,"given":"Doris Hissako","family":"Sumida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.joen.2015.04.002_bib1","first-page":"S64","article-title":"Diagnosis and classification of diabetes mellitus","volume":"35","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.joen.2015.04.002_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/A:1006806722619","article-title":"The IRS-signalling system: a network of docking proteins that mediate insulin action","volume":"182","author":"White","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.joen.2015.04.002_bib3","doi-asserted-by":"crossref","first-page":"8302","DOI":"10.1016\/S0021-9258(18)92976-5","article-title":"Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase","volume":"266","author":"Rothenberg","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2015.04.002_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/352073a0","article-title":"Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein","volume":"352","author":"Sun","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.joen.2015.04.002_bib5","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1002\/j.1460-2075.1992.tb05426.x","article-title":"Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation","volume":"11","author":"Backer","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.joen.2015.04.002_bib6","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","article-title":"Mechanism of activation of protein kinase B by insulin and IGF-1","volume":"15","author":"Alessi","year":"1996","journal-title":"EMBO J"},{"issue":"Pt 3","key":"10.1016\/j.joen.2015.04.002_bib7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1042\/bj3000631","article-title":"Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin","volume":"300","author":"Clarke","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.joen.2015.04.002_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cmet.2006.04.005","article-title":"Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda\/zeta","volume":"3","author":"Taniguchi","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.joen.2015.04.002_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1210\/edrv.23.2.0461","article-title":"Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes","volume":"23","author":"Lewis","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.joen.2015.04.002_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2337\/diabetes.50.1.24","article-title":"Serine\/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation","volume":"50","author":"Pederson","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.joen.2015.04.002_bib11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nm724","article-title":"Diet-induced insulin resistance in mice lacking adiponectin\/ACRP30","volume":"8","author":"Maeda","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.joen.2015.04.002_bib12","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1902\/jop.2011.110349","article-title":"Periodontal disease decreases insulin sensitivity and insulin signaling","volume":"83","author":"Colombo","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2015.04.002_bib13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.joen.2012.12.031","article-title":"Periapical lesions decrease insulin signal and cause insulin resistance","volume":"39","author":"Astolphi","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.04.002_bib14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/iej.12136","article-title":"Relationships between oral infections and blood glucose concentrations or HbA1c levels in normal and diabetic rats","volume":"47","author":"Cintra","year":"2014","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2015.04.002_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0030-4220(94)90044-2","article-title":"Pathogenesis of induced rat periapical lesions","volume":"78","author":"Stashenko","year":"1994","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2015.04.002_bib16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.archoralbio.2008.09.016","article-title":"Effects of induced periapical abscesses on rat pregnancy outcomes","volume":"54","author":"Bain","year":"2009","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2015.04.002_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.archoralbio.2010.09.008","article-title":"Effects of gender on serum biomarkers of systemic inflammation coincident to experimentally-induced periapical lesions","volume":"56","author":"Zhang","year":"2011","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2015.04.002_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0029-1212086","article-title":"Mechanisms of TNF-alpha-induced insulin resistance","volume":"107","author":"Hotamisligil","year":"1999","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.joen.2015.04.002_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-051X.2010.01644.x","article-title":"Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia","volume":"38","author":"Fento\u011flu","year":"2011","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2015.04.002_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jtemb.2004.12.001","article-title":"Effect of bis[curcumino]oxovanadium complex on non-diabetic and streptozotocin-induced diabetic rats","volume":"18","author":"Majithiya","year":"2005","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.joen.2015.04.002_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tripleo.2010.10.035","article-title":"Prevalence of apical periodontitis relative to endodontic treatment in an adult Dutch population: a repeated cross-sectional study","volume":"111","author":"Peters","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2015.04.002_bib22","first-page":"47","article-title":"Association between chronic periodontitis and serum lipid levels","volume":"48","author":"Taleghani","year":"2010","journal-title":"Acta Med Iran"},{"key":"10.1016\/j.joen.2015.04.002_bib23","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00784-012-0853-7","article-title":"Pulpal and periodontal diseases increase triglyceride levels in diabetic rats","volume":"17","author":"Cintra","year":"2013","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2015.04.002_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1210\/endo.137.1.8536607","article-title":"Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats","volume":"137","author":"Carvalho","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.joen.2015.04.002_bib25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/jmf.2011.0306","article-title":"Effects of parboiled rice diet on oxidative stress parameters in kidney of rats with streptozotocin-induced diabetes","volume":"15","author":"Finamor","year":"2012","journal-title":"J Med Food"},{"key":"10.1016\/j.joen.2015.04.002_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/000456326900600108","article-title":"Quantitative determination of triglyceride using GPO-PAP method","volume":"6","author":"Trinder","year":"1969","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.joen.2015.04.002_bib27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2337\/diabetes.47.5.721","article-title":"Short-term exposure to tumor necrosis factor-alpha does not affect insulin-stimulated glucose uptake in skeletal muscle","volume":"47","author":"Nolte","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.joen.2015.04.002_bib28","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/diabetes.54.10.2939","article-title":"Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation","volume":"54","author":"Plomgaard","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.joen.2015.04.002_bib29","doi-asserted-by":"crossref","first-page":"35375","DOI":"10.1074\/jbc.M806480200","article-title":"S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2","volume":"283","author":"Zhang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2015.04.002_bib30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.joen.2011.11.001","article-title":"Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population","volume":"38","author":"Marotta","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.04.002_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jfluchem.2011.12.006","article-title":"NaF treatment increases TNF-\u03b1 and resistin concentrations and reduces insulin signal in rats","volume":"136","author":"Chiba","year":"2012","journal-title":"J Fluor Chem"},{"key":"10.1016\/j.joen.2015.04.002_bib32","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00004770-200306000-00001","article-title":"Diabetes mellitus and the dental pulp","volume":"29","author":"Bender","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.04.002_bib33","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.joen.2011.01.002","article-title":"Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a cross-sectional study","volume":"37","author":"L\u00f3pez-L\u00f3pez","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.04.002_bib34","first-page":"6","article-title":"Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride","volume":"43","author":"Chiba","year":"2010","journal-title":"Fluoride"},{"key":"10.1016\/j.joen.2015.04.002_bib35","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1210\/en.2006-0518","article-title":"The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats","volume":"147","author":"Cho","year":"2006","journal-title":"Endocrinology"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915003374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915003374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:42:02Z","timestamp":1652143322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239915003374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0099239915003374"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2015.04.002","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}