{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:39:40Z","timestamp":1776209980876,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["MOST 103-2314-B-010-022"],"award-info":[{"award-number":["MOST 103-2314-B-010-022"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.joen.2015.08.031","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T15:58:31Z","timestamp":1445702311000},"page":"1991-1996","source":"Crossref","is-referenced-by-count":19,"title":["Unfinished Root Canal Treatments and the Risk of Cardiovascular Disease"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-4558","authenticated-orcid":false,"given":"Po-Yen","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Liong","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Ji","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Yang","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2015.08.031_bib1","series-title":"Global Status Report on Noncommunicable Diseases 2010","year":"2011"},{"key":"10.1016\/j.joen.2015.08.031_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijcard.2010.08.011","article-title":"Can a chronic dental infection be considered a cause of cardiovascular disease? A review of the literature","volume":"148","author":"Cotti","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.joen.2015.08.031_bib3","first-page":"207","article-title":"Role of infectious and immune factors in coronary and cerebrovascular arteriosclerosis","volume":"9","author":"Stollberger","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.joen.2015.08.031_bib4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.atherosclerosis.2006.02.022","article-title":"Effects of chronic microbial infection on atherosclerosis","volume":"187","author":"Abbas","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.joen.2015.08.031_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/hc0102.101362","article-title":"Impact of infectious burden on extent and long-term prognosis of atherosclerosis","volume":"105","author":"Espinola-Klein","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2015.08.031_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ahj.2007.06.037","article-title":"The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis","volume":"154","author":"Bahekar","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.joen.2015.08.031_bib7","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s11606-008-0787-6","article-title":"Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis","volume":"23","author":"Humphrey","year":"2008","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.joen.2015.08.031_bib8","first-page":"197","article-title":"Periodontal diseases and cardiovascular events: meta-analysis of observational studies","volume":"59","author":"Blaizot","year":"2009","journal-title":"Int Dent J"},{"key":"10.1016\/j.joen.2015.08.031_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.joen.2005.10.039","article-title":"Pulpal inflammation and incidence of coronary heart disease","volume":"32","author":"Joshipura","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.14219\/jada.archive.2009.0311","article-title":"The relationship between self-reported history of endodontic therapy and coronary heart disease in the Atherosclerosis Risk in Communities Study","volume":"140","author":"Caplan","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2015.08.031_bib11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0099-2399(96)80215-9","article-title":"Production of interleukin-1 by polymorphonuclear leukocytes resident in periradicular tissue","volume":"22","author":"Miller","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-9657.1999.tb00744.x","article-title":"Detection of interleukin-6 in human dental pulp and periapical lesions","volume":"15","author":"Barkhordar","year":"1999","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2015.08.031_bib13","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0099-2399(98)80118-0","article-title":"Host mediators in endodontic exudates. I. Indicators of inflammation and humoral immunity","volume":"24","author":"Kuo","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2591.1992.tb01154.x","article-title":"Influence of surgical treatment of periapical lesions on serum and blood levels of inflammatory mediators","volume":"25","author":"Marton","year":"1992","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2015.08.031_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00784-012-0710-8","article-title":"The role of unfinished root canal treatment in odontogenic maxillofacial infections requiring hospital care","volume":"17","author":"Gronholm","year":"2013","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2015.08.031_bib16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.joen.2006.11.022","article-title":"An epidemiologic study of tooth retention after nonsurgical endodontic treatment in a large population in Taiwan","volume":"33","author":"Chen","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2010.08.054","article-title":"Impact of diabetes mellitus, hypertension, and coronary artery disease on tooth extraction after nonsurgical endodontic treatment","volume":"37","author":"Wang","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib18","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.joen.2014.07.007","article-title":"The effect of rubber dam usage on the survival rate of teeth receiving initial root canal treatment: a nationwide population-based study","volume":"40","author":"Lin","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.amjmed.2011.10.034","article-title":"The association of tooth scaling and decreased cardiovascular disease: a nationwide population-based study","volume":"125","author":"Chen","year":"2012","journal-title":"Am J Med"},{"key":"10.1016\/j.joen.2015.08.031_bib20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/STROKEAHA.111.000076","article-title":"Dental prophylaxis and periodontal treatment are protective factors to ischemic stroke","volume":"44","author":"Lee","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.joen.2015.08.031_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2004.05.021","article-title":"Secular trends in coronary heart disease mortality, hospitalization rates, and major cardiovascular risk factors in Taiwan, 1971-2001","volume":"100","author":"Cheng","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.joen.2015.08.031_bib22","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/01.STR.0000206458.58142.f3","article-title":"Influence of metabolic syndrome and general obesity on the risk of ischemic stroke","volume":"37","author":"Chen","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.joen.2015.08.031_bib23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2010.10.010","article-title":"Genetic variants of connexin37 are associated with carotid intima-medial thickness and future onset of ischemic stroke","volume":"214","author":"Leu","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.joen.2015.08.031_bib24","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.amjcard.2010.01.348","article-title":"Risk of adverse outcomes in Taiwan associated with concomitant use of clopidogrel and proton pump inhibitors in patients who received percutaneous coronary intervention","volume":"105","author":"Huang","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.joen.2015.08.031_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0099-2399(83)80253-2","article-title":"The survivability of F43 strain of Streptococcus sanguis in root canals filled with gutta-percha and Procosol cement","volume":"9","author":"Delivanis","year":"1983","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0300-5712(95)00042-9","article-title":"Clinical significance of dental root canal microflora","volume":"24","author":"Gomes","year":"1996","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2015.08.031_bib27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1399-302X.2006.00270.x","article-title":"Molecular analysis of bacteria in asymptomatic and symptomatic endodontic infections","volume":"21","author":"Sakamoto","year":"2006","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2015.08.031_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/154411130401500604","article-title":"Pathogenesis of apical periodontitis and the causes of endodontic failures","volume":"15","author":"Nair","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2015.08.031_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1399-302X.1988.tb00091.x","article-title":"Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment","volume":"3","author":"Marton","year":"1988","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2015.08.031_bib30","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.joen.2011.09.006","article-title":"Association of endodontic infection with detection of an initial lesion to the cardiovascular system","volume":"37","author":"Cotti","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib31","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/154405910608501104","article-title":"Lesions of endodontic origin and risk of coronary heart disease","volume":"85","author":"Caplan","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2015.08.031_bib32","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.joen.2012.08.013","article-title":"Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults","volume":"38","author":"Pasqualini","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.08.031_bib33","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.joen.2009.01.012","article-title":"Association between chronic dental infection and acute myocardial infarction","volume":"35","author":"Willershausen","year":"2009","journal-title":"J Endod"},{"issue":"suppl 3","key":"10.1016\/j.joen.2015.08.031_bib34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1875-595X.2003.tb00771.x","article-title":"Update on general health risk of periodontal disease","volume":"53","author":"Slots","year":"2003","journal-title":"Int Dent J"},{"key":"10.1016\/j.joen.2015.08.031_bib35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1600-0765.1999.tb02263.x","article-title":"Association of periodontal infections with atherosclerotic and pulmonary diseases","volume":"34","author":"Scannapieco","year":"1999","journal-title":"J Periodontal Res"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915007979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915007979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T06:58:46Z","timestamp":1537253926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239915007979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0099239915007979"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2015.08.031","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}