{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:24:59Z","timestamp":1773923099226,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.joen.2015.10.003","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T23:44:02Z","timestamp":1447890242000},"page":"131-134","source":"Crossref","is-referenced-by-count":12,"title":["Age-related Changes in the Alkaline Phosphatase Activity of\u00a0Healthy and Inflamed Human Dental Pulp"],"prefix":"10.1016","volume":"42","author":[{"given":"Eda E.","family":"Aslantas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Dogan","family":"Buzoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senem Pinar","family":"Karapinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer C.","family":"Cehreli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevda","family":"Muftuoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pergin","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2015.10.003_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.joen.2005.10.041","article-title":"Effects of pH on mineralization ability of human dental pulp cells","volume":"32","author":"Okabe","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib2","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.joen.2009.07.016","article-title":"Effect of age and extrinsic microenvironment on the proliferation and osteogenic differentiation of rat dental pulp stem cells in\u00a0vitro","volume":"35","author":"Ma","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/0022034511405386","article-title":"Dental pulp stem cells, niches, and notch signaling in tooth injury","volume":"23","author":"Mitsiadis","year":"2011","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2015.10.003_bib4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.joen.2009.05.026","article-title":"Microarray evaluation of age-related changes in human dental pulp","volume":"35","author":"Tranasi","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0030-4220(71)90306-9","article-title":"Functional and geriatric changes of the human pulp","volume":"32","author":"Quigley","year":"1971","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2015.10.003_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/0022034510387794","article-title":"Molecular inflammation as an underlying mechanism of the aging process and age-related diseases","volume":"90","author":"Chung","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2015.10.003_bib7","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0030-4220(91)90019-9","article-title":"Age-related changes of the dental pulp complex and their relationship to systemic aging","volume":"72","author":"Morse","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2015.10.003_bib8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1067\/moe.2002.120974","article-title":"Age-related odontometric changes of human teeth","volume":"93","author":"Murray","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S8756-3282(00)00310-0","article-title":"Expression of the small leucine-rich proteoglycan osteoadherin\/osteomodulin in human dental pulp and developing rat teeth","volume":"27","author":"Buchaille","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.joen.2015.10.003_bib10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jbmr.5650090212","article-title":"Temporal changes in matrix protein synthesis and mRNA expression during mineralized tissue formation by adult rat bone marrow cells in culture","volume":"9","author":"Yao","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2015.10.003_bib11","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0020-711X(92)90064-8","article-title":"Phosphotransferase activity associated with rat osseous plate alkaline phosphatase: a possible role in biomineralization","volume":"24","author":"Pizauro","year":"1992","journal-title":"Int J Biochem"},{"key":"10.1016\/j.joen.2015.10.003_bib12","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1177\/40.8.1619283","article-title":"Histochemical studies of acid and alkaline phosphatases in rat tooth germs with undecalcified resin-embedded specimens","volume":"40","author":"Tenorio","year":"1992","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.joen.2015.10.003_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.joen.2012.10.031","article-title":"Aging of in\u00a0vitro pulp illustrates change of inflammation and dentinogenesis","volume":"39","author":"Lee","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib14","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1177\/00220345900690031601","article-title":"Properties of alkaline phosphate of the human dental pulp","volume":"69","author":"Goseki","year":"1990","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2015.10.003_bib15","first-page":"7","article-title":"Osteogenic activity of cells from dental pulp, periodontal ligament, bone marrow and muscle in\u00a0vitro; an ultrasutructural study and alkaline-phosphatase activity","volume":"33","author":"Inoue","year":"1992","journal-title":"Bull Tokyo Dent Coll"},{"key":"10.1016\/j.joen.2015.10.003_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00004770-200301000-00003","article-title":"Proliferative ability and alkaline phosphatase activity with in\u00a0vivo cellular aging in human pulp cells","volume":"29","author":"Shiba","year":"2003","journal-title":"J Endod"},{"issue":"suppl","key":"10.1016\/j.joen.2015.10.003_bib17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1902\/jop.1992.63.12s.1117","article-title":"The host response in gingival crevicular fluid: potential applications in periodontitis clinical trials","volume":"63","author":"Lamster","year":"1992","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2015.10.003_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00004770-200103000-00010","article-title":"Alkaline phosphatase activity in normal and inflamed dental pulps","volume":"27","author":"Spoto","year":"2001","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.joen.2015.10.003_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1741-2358.2012.00623.x","article-title":"Pulp sensibility test in elderly patients","volume":"29","author":"Farac","year":"2012","journal-title":"Gerodontology"},{"key":"10.1016\/j.joen.2015.10.003_bib21","first-page":"93","article-title":"Geriatric endodontics","volume":"30","author":"Newton","year":"1981","journal-title":"J Mass Dent Soc"},{"key":"10.1016\/j.joen.2015.10.003_bib22","first-page":"262","article-title":"Age-induced changes in the teeth and their attachment apparatus","volume":"33","author":"Ketterl","year":"1983","journal-title":"Int Dent J"},{"key":"10.1016\/j.joen.2015.10.003_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0030-4220(86)90203-3","article-title":"The effect of aging on tooth morphology: a study on impacted teeth","volume":"61","author":"Nitzan","year":"1986","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2015.10.003_bib24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1524-475X.2005.00079.x","article-title":"Age-dependent response of primary human dermal fibroblasts to oxidative stress: cell survival, pro-survival kinases, and entrance into cellular senescence","volume":"13","author":"Gurjala","year":"2005","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.joen.2015.10.003_bib25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jdent.2010.05.016","article-title":"Inflammation-regeneration interplay in the dentine-pulp complex","volume":"38","author":"Cooper","year":"2010","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2015.10.003_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2008.05.013","article-title":"Inflammatory and immunological aspects of dental pulp repair","volume":"58","author":"Goldberg","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.joen.2015.10.003_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.joen.2006.11.008","article-title":"Relationships between caries bacteria, host responses, and clinical signs and symptoms of pulpitis","volume":"33","author":"Hahn","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.003_bib28","first-page":"273","article-title":"Reactionary dentinogenesis","volume":"39","author":"Smith","year":"1995","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.joen.2015.10.003_bib29","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/dbio.1995.1229","article-title":"Effects of basic fibroblast growth factor on proliferation, the expression of osteonectin (SPARC) and alkaline phosphatase, and calcification in cultures of human pulp cells","volume":"170","author":"Shiba","year":"1995","journal-title":"Dev Biol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915009012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915009012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T20:57:45Z","timestamp":1620853065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239915009012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0099239915009012"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2015.10.003","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}