{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:49:58Z","timestamp":1791377398934,"version":"4.3.2"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.joen.2015.10.020","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T14:16:04Z","timestamp":1450966564000},"page":"190-197","source":"Crossref","is-referenced-by-count":69,"title":["A Prospective Clinical Pilot Study on the Level of Matrix Metalloproteinase-9 in Dental Pulpal Blood as a Marker for\u00a0the State of Inflammation in the Pulp Tissue"],"prefix":"10.1016","volume":"42","author":[{"given":"Johannes","family":"Mente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Gehrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rampf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sch\u00fcrz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Pfefferle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Saure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Erber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2015.10.020_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1834-7819.2007.tb00522.x","article-title":"A clinical classification of the status of the pulp and the root canal system","volume":"52","author":"Abbott","year":"2007","journal-title":"Aust Dent J"},{"key":"10.1016\/j.joen.2015.10.020_bib2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.bdj.4811641","article-title":"Endodontics: Part 3. Treatment of endodontic emergencies","volume":"197","author":"Carrotte","year":"2004","journal-title":"Br Dent J"},{"key":"10.1016\/j.joen.2015.10.020_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF03262577","article-title":"Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries","volume":"8","author":"Qudeimat","year":"2007","journal-title":"Eur Arch Paediatr Dent"},{"key":"10.1016\/j.joen.2015.10.020_bib4","first-page":"547","article-title":"Long-term radiologic pulp evaluation after partial pulpotomy in young permanent molars","volume":"42","author":"Mass","year":"2011","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2015.10.020_bib5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-9657.1993.tb00279.x","article-title":"Partial pulpotomy in young permanent teeth with deep carious lesions","volume":"9","author":"Mejare","year":"1993","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2015.10.020_bib6","series-title":"Pathways of the Pulp","first-page":"822","article-title":"Pediatrics: endodontic treatment for the primary and young permanent dentition","author":"Camp","year":"2006"},{"key":"10.1016\/j.joen.2015.10.020_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1747-4477.2000.tb00144.x","article-title":"Reversible and irreversible painful pulpitides: diagnosis and treatment","volume":"26","author":"Bender","year":"2000","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2015.10.020_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00004770-200003000-00012","article-title":"Pulpal pain diagnosis\u2013a review","volume":"26","author":"Bender","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1046\/j.1365-2591.2002.00579.x","article-title":"Is pulpitis painful?","volume":"35","author":"Michaelson","year":"2002","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2015.10.020_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.22203\/eCM.v018a08","article-title":"MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem\/progenitor cell","volume":"18","author":"Chaussain","year":"2009","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.joen.2015.10.020_bib11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2591.2012.02016.x","article-title":"Diagnosis of the condition of the dental pulp: a systematic review","volume":"45","author":"Mej\u00e0re","year":"2012","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2015.10.020_bib12","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.joen.2014.08.010","article-title":"Correlation between clinical and histologic pulp diagnoses","volume":"40","author":"Ricucci","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib13","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0099-2399(96)80017-3","article-title":"A clinical study of direct pulp capping applied to carious-exposed pulps","volume":"22","author":"Matsuo","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib14","first-page":"474","article-title":"Role of matrix metalloproteinases in human periodontal diseases","volume":"64","author":"Birkedal-Hansen","year":"1993","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2015.10.020_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1034\/j.1600-0757.2000.2240110.x","article-title":"Regulators of tissue destruction and homeostasis as diagnostic aids in periodontology","volume":"24","author":"Kinane","year":"2000","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.joen.2015.10.020_bib16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/07853890600800103","article-title":"Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation","volume":"38","author":"Sorsa","year":"2006","journal-title":"Ann Med"},{"key":"10.1016\/j.joen.2015.10.020_bib17","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1046\/j.1365-2591.2002.00587.x","article-title":"Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates","volume":"35","author":"Wahlgren","year":"2002","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2015.10.020_bib18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00004770-200111000-00007","article-title":"Regulation of matrix metalloproteinase-2 production by cytokines and pharmacological agents in human pulp cell cultures","volume":"27","author":"Chang","year":"2001","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib19","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.joen.2009.01.004","article-title":"Cholinoceptor modulation on nitric oxide regulates prostaglandin E(2) and metalloproteinase-3 production in experimentally induced inflammation of rat dental pulp","volume":"35","author":"De Couto Pita","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00004770-200103000-00012","article-title":"Induction of dental pulp fibroblast matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 gene expression by interleukin-1alpha and tumor necrosis factor-alpha through a prostaglandin-dependent pathway","volume":"27","author":"Lin","year":"2001","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0099-2399(06)80070-1","article-title":"Comparison of human polymorphonuclear neutrophil elastase, polymorphonuclear neutrophil cathepsin-G, and alpha 2-macroglobulin levels in healthy and inflamed dental pulps","volume":"20","author":"Rauschenberger","year":"1994","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1043-4666(03)00116-9","article-title":"Cytokine gene expression\u2013part of host defence in pulpitis","volume":"22","author":"Zehnder","year":"2003","journal-title":"Cytokine"},{"key":"10.1016\/j.joen.2015.10.020_bib23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0099-2399(06)81717-6","article-title":"Human polymorphonuclear granule components: relative levels detected by a modified enzyme-linked immunosorbent assay in normal and inflamed dental pulps","volume":"17","author":"Rauschenberger","year":"1991","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1034\/j.1600-0722.2002.21347.x","article-title":"Matrix metalloproteinase levels and gelatinolytic activity in clinically healthy and inflamed human dental pulps","volume":"110","author":"Gusman","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2015.10.020_bib25","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.don.0000164851.55389.4e","article-title":"The upregulation of matrix metalloproteinase-9 in inflamed human dental pulps","volume":"31","author":"Tsai","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joen.2010.10.003","article-title":"A first study on the usefulness of matrix metalloproteinase 9 from dentinal fluid to indicate pulp inflammation","volume":"37","author":"Zehnder","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00016350600963640","article-title":"The role of matrix metalloproteinases in the oral environment","volume":"65","author":"Hannas","year":"2007","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.joen.2015.10.020_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.joen.2015.10.020_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.joen.2015.10.020_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-9657.1986.tb00119.x","article-title":"The periapical index: a scoring system for radiographic assessment of apical periodontitis","volume":"2","author":"\u00d8rstavik","year":"1986","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2015.10.020_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.joen.2015.10.020_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-9657.1987.tb00619.x","article-title":"Tissue response to dental caries","volume":"3","author":"Langeland","year":"1987","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2015.10.020_bib33","series-title":"Endodontology: An Integrated Biological and Clinical View","first-page":"19","article-title":"Pulp response to caries and restorative procedures","author":"Ricucci","year":"2013"},{"key":"10.1016\/j.joen.2015.10.020_bib34","series-title":"Seltzer and Bender's Dental Pulp","first-page":"323","article-title":"Caries, restorative dentistry, and the pulp","author":"Tay","year":"2012"},{"key":"10.1016\/j.joen.2015.10.020_bib35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.joen.2005.12.008","article-title":"A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth","volume":"32","author":"Barrieshi-Nusair","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib36","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/iej.12225","article-title":"Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars","volume":"47","author":"Chailertvanitkul","year":"2014","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2015.10.020_bib37","series-title":"Dental Pulp","first-page":"227","article-title":"Histology of pulpal inflammation","author":"Trowbridge","year":"2002"},{"key":"10.1016\/j.joen.2015.10.020_bib38","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/0030-4220(63)90323-2","article-title":"The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp","volume":"16","author":"Seltzer","year":"1963","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2015.10.020_bib39","first-page":"4629","article-title":"Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases","volume":"60","author":"Attiga","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.joen.2015.10.020_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.brainres.2011.07.022","article-title":"Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C epsilon-mediated metalloproteinase 2 and 9 levels in beta-amyloid infused Alzheimer's disease rat model","volume":"1412","author":"Zara","year":"2011","journal-title":"Brain Res"},{"key":"10.1016\/j.joen.2015.10.020_bib41","series-title":"Pulp-Dentin Biology in Restorative Dentistry","first-page":"39","article-title":"Pulpal inflammation and its sequelae","author":"Heyeraas","year":"2002"},{"key":"10.1016\/j.joen.2015.10.020_bib42","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.joen.2014.07.019","article-title":"Treatment outcome of mineral trioxide aggregate or calcium hydroxide direct pulp capping: long-term results","volume":"40","author":"Mente","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib43","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.14219\/jada.archive.2006.0116","article-title":"The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study","volume":"137","author":"Al-Hiyasat","year":"2006","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2015.10.020_bib44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004770-200009000-00010","article-title":"Pulp capping of carious exposures: treatment outcome after 5 and 10 years: a retrospective study","volume":"26","author":"Barthel","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2015.10.020_bib45","first-page":"251","article-title":"Long term clinical assessment of direct pulp capping","volume":"31","author":"Baume","year":"1981","journal-title":"Int Dent J"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915009875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239915009875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T16:24:55Z","timestamp":1537115095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239915009875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0099239915009875"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2015.10.020","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}