{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:16:12Z","timestamp":1788480972252,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.joen.2016.06.015","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T16:16:05Z","timestamp":1469722565000},"page":"1314-1319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Comparison of the Anesthetic Efficacy of\u00a0Mepivacaine and Lidocaine in Patients with\u00a0Irreversible Pulpitis: A Double-blind Randomized Clinical Trial"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-1097","authenticated-orcid":false,"given":"Renata Pieroni","family":"Visconti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Peixoto","family":"Tortamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas Aparecida","family":"Buscariolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2016.06.015_bib1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: a clinical study","volume":"19","author":"Cohen","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.joen.2015.12.025","article-title":"Anesthetic success of an inferior alveolar nerve block and supplemental articaine buccal infiltration for molars and premolars in patients with symptomatic irreversible pulpitis","volume":"42","author":"Fowler","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib3","first-page":"254","article-title":"Diagnosis and managing pulpitis: reversible or irreversible?","volume":"19","author":"Piattelli","year":"2007","journal-title":"Pract Proced Aesthet Dent"},{"key":"10.1016\/j.joen.2016.06.015_bib4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joen.2007.09.014","article-title":"Quantification of neural protein in extirpated tooth pulp","volume":"34","author":"Warren","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib5","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.joen.2015.07.001","article-title":"Does articaine provide an advantage over lidocaine in patients with symptomatic irreversible pulpitis? a systematic review and meta-analysis","volume":"41","author":"Kung","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.joen.2009.04.012","article-title":"Anesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine after an inferior alveolar nerve block in patients with irreversible pulpitis","volume":"35","author":"Aggarwal","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.joen.2008.10.020","article-title":"A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis","volume":"35","author":"Tortamano","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib8","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.tripleo.2009.06.012","article-title":"Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar","volume":"108","author":"Fan","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib9","first-page":"25","article-title":"A clinical evaluation of the electric pulp tester as an indicator of local anesthesia","volume":"21","author":"Certosimo","year":"1996","journal-title":"Oper Dent"},{"key":"10.1016\/j.joen.2016.06.015_bib10","first-page":"14","article-title":"Local anesthetics: special considerations in endodontics","volume":"83","author":"Jeske","year":"2003","journal-title":"J Tenn Dent Assoc"},{"key":"10.1016\/j.joen.2016.06.015_bib11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/01.DON.0000125317.21892.8F","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis","volume":"30","author":"Claffey","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tripleo.2009.11.016","article-title":"Efficacy of combining a buccal infiltration with an inferior alveolar nerve block for mandibular molars with irreversible pulpitis","volume":"109","author":"Parirokh","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0011-8532(02)00020-4","article-title":"Local anesthesia: advances in agents and techniques","volume":"46","author":"Hawkins","year":"2002","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joen.2016.06.015_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joen.2006.09.006","article-title":"Anesthetic efficacy of lidocaine\/meperidine for inferior alveolar nerve blocks in patients with irreversible pulpitis","volume":"33","author":"Bigby","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib15","first-page":"372","article-title":"Anesthetic efficacy of different volumes of lidocaine with epinephrine for inferior alveolar nerve blocks","volume":"50","author":"Nusstein","year":"2002","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2016.06.015_bib16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.joen.2012.10.012","article-title":"Efficacy of articaine versus lidocaine in block and infiltration anesthesia administered in teeth with irreversible pulpitis: a prospective, randomized, double-blind study","volume":"39","author":"Ashraf","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib17","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.tripleo.2005.12.003","article-title":"Evaluation of mandibular block using a standardized method","volume":"102","author":"Lai","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib18","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.joen.2015.05.015","article-title":"A comparison of different volumes of articaine for inferior alveolar nerve block for molar teeth with symptomatic irreversible pulpitis","volume":"41","author":"Abazarpoor","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S1079-2104(97)90372-3","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis","volume":"84","author":"Reisman","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-9657.1999.tb00782.x","article-title":"Failure of inferior alveolar nerve block in endodontics","volume":"15","author":"Potocnik","year":"1999","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2016.06.015_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.joen.2007.11.001","article-title":"Anesthetic efficacy of 1.8 mL and 3.6 mL of 2% lidocaine with 1:100,000 epinephrine for maxillary infiltrations","volume":"34","author":"Mikesell","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0099-2399(98)80053-8","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis","volume":"24","author":"Nusstein","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib23","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.4317\/jced.51617","article-title":"Comparison of anesthetic efficacy of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:80,000 epinephrine for inferior alveolar nerve block in patients with irreversible pulpitis","volume":"6","author":"Sood","year":"2014","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.joen.2016.06.015_bib24","first-page":"1","article-title":"Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial","volume":"6","author":"Rodr\u00edguez-Wong","year":"2015","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.06.015_bib25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joen.2012.01.008","article-title":"Comparison of the anesthetic efficacy between bupivacaine and lidocaine in patients with irreversible pulpitis of mandibular molar","volume":"38","author":"Sampaio","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib26","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.joen.2013.04.007","article-title":"Is a volume of 3.6 mL better than 1.8 mL for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis?","volume":"39","author":"Fowler","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.joen.2012.02.003","article-title":"Comparative evaluation of 1.8 mL and 3.6 mL of 2% lidocaine with 1:200,000 epinephrine for inferior alveolar nerve block in patients with irreversible pulpitis: a prospective, randomized single-blind study","volume":"38","author":"Aggarwal","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.don.0000140576.36513.cb","article-title":"A comparison of articaine and lidocaine for inferior alveolar nerve blocks","volume":"31","author":"Mikesell","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0099-2399(06)80510-8","article-title":"An evaluation of 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block","volume":"19","author":"McLean","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib30","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.tripleo.2007.04.017","article-title":"Injection pain of the inferior alveolar nerve block in patients with irreversible pulpitis","volume":"104","author":"McCartney","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00004770-200304000-00009","article-title":"Tissue levels of immunoreactive substance P are increased in patients with irreversible pulpitis","volume":"29","author":"Bowles","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib32","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2591.2006.01093.x","article-title":"Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp","volume":"39","author":"Caviedes-Bucheli","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.06.015_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.joen.2008.12.020","article-title":"The effect of different vasoconstrictors and local anesthetic solutions on substance P expression in human dental pulp","volume":"35","author":"Caviedes-Bucheli","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.06.015_bib34","series-title":"Caminhos da Polpa","first-page":"16","author":"Cohen","year":"2007"},{"key":"10.1016\/j.joen.2016.06.015_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.14219\/jada.archive.2011.0219","article-title":"The pulpal anesthetic efficacy of articaine versus lidocaine in dentistry: a meta-analysis","volume":"142","author":"Brandt","year":"2011","journal-title":"J Am Dent Assoc"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239916303703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239916303703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T01:53:25Z","timestamp":1536544405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239916303703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0099239916303703"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2016.06.015","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the Anesthetic Efficacy of\u00a0Mepivacaine and Lidocaine in Patients with\u00a0Irreversible Pulpitis: A Double-blind Randomized Clinical Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2016.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}