{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:42:30Z","timestamp":1773088950718,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.joen.2016.07.002","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T01:00:21Z","timestamp":1474419621000},"page":"1453-1457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["How Effective Is Supplemental Intraseptal Anesthesia in Patients with Symptomatic Irreversible Pulpitis?"],"prefix":"10.1016","volume":"42","author":[{"suffix":"Jr.","given":"Stephen","family":"Webster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Drum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al","family":"Reader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Nusstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2016.07.002_bib1","series-title":"Successful Local Anesthesia for Restorative Dentistry and Endodontics","first-page":"134","author":"Reader","year":"2011"},{"key":"10.1016\/j.joen.2016.07.002_bib2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00784-009-0352-7","article-title":"Intraseptal vs. periodontal ligament anaesthesia for maxillary tooth extraction: quality of local anaesthesia and haemodynamic response","volume":"14","author":"Brkovic","year":"2010","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2016.07.002_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00784-012-0724-2","article-title":"Efficacy and safety of intraseptal and periodontal ligament anesthesia achieved by computer-controlled articaine + epinephrine delivery: a dose-finding study","volume":"17","author":"Biocanin","year":"2013","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2016.07.002_bib4","first-page":"19","article-title":"[Intraceptal anesthesia of lower and upper teeth]","volume":"88","author":"Borodina","year":"2009","journal-title":"Stomatologiia"},{"key":"10.1016\/j.joen.2016.07.002_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1308\/135576111795162848","article-title":"An audit of the use of intra-septal local anaesthesia in a dental practice in the South of England","volume":"18","author":"Doman","year":"2011","journal-title":"Prim Dent Care"},{"key":"10.1016\/j.joen.2016.07.002_bib6","first-page":"204","article-title":"Intraseptal anesthesia in the general dental practice","volume":"8","author":"Marin","year":"1987","journal-title":"Compendium"},{"key":"10.1016\/j.joen.2016.07.002_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.14219\/jada.archive.1985.0111","article-title":"Intraseptal anesthesia in periodontal surgery","volume":"111","author":"Saadoun","year":"1985","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2016.07.002_bib8","first-page":"418","article-title":"Intraseptal anesthesia: a review of a relevant injection technique","volume":"53","author":"Woodmansey","year":"2005","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2016.07.002_bib9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/00220345690480041801","article-title":"Development of a dental anxiety scale","volume":"48","author":"Corah","year":"1969","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2016.07.002_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3959(84)90835-2","article-title":"An experimental basis for revising the graphic rating scale for pain","volume":"19","author":"Heft","year":"1984","journal-title":"Pain"},{"key":"10.1016\/j.joen.2016.07.002_bib11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.joen.2011.02.015","article-title":"Effect of preoperative ibuprofen\/acetaminophen on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis","volume":"37","author":"Simpson","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.joen.2012.02.010","article-title":"Effect of nitrous oxide on the efficacy of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis","volume":"38","author":"Stanley","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib13","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.joen.2015.02.022","article-title":"Effect of buffered 4% lidocaine on the success of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, randomized, double-blind study","volume":"41","author":"Schellenberg","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.joen.2009.12.030","article-title":"Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis","volume":"36","author":"Oleson","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib15","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.joen.2008.07.013","article-title":"Effect of sublingual triazolam on the success of inferior alveolar nerve block in patients with irreversible pulpitis","volume":"34","author":"Lindemann","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2013.09.009","article-title":"Effect of preoperative acetaminophen\/hydrocodone on the efficacy of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, randomized, double-blind, placebo-controlled Study","volume":"40","author":"Fullmer","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joen.2014.09.010","article-title":"Evaluation of the Gow-Gates and Vaziarani-Akinosi techniques in patients with symptomatic irreversible pulpitis: a prospective randomized study","volume":"41","author":"Click","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.joen.2015.01.029","article-title":"Incidence of missed inferior alveolar nerve blocks in vital asymptomatic subjects and in patients with symptomatic irreversible pulpitis","volume":"5","author":"Fowler","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib19","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joen.2012.08.006","article-title":"A prospective, randomized single-blind evaluation of effect of injection speed on anesthetic efficacy of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis","volume":"38","author":"Aggarwal","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/iej.12157","article-title":"Comparison of the anaesthetic efficacy of epinephrine concentrations (1:80,000 and 1:200,000) in 2% lidocaine for inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized, double-blind clinical trial","volume":"47","author":"Aggarwal","year":"2014","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.07.002_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/iej.12463","article-title":"Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial","volume":"49","author":"Rodr\u00edguez-Wong","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.07.002_bib22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.joen.2013.12.022","article-title":"Efficacy of articaine versus lidocaine as a supplemental buccal infiltration in mandibular molars with irreversible pulpitis: a prospective, randomized, double-blind study","volume":"40","author":"Rogers","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/iej.12283","article-title":"Comparison of the anaesthetic efficacy of different volumes of 4% articaine (1.8 and 3.6 mL) as a supplemental buccal infiltration after failed inferior alveolar nerve block","volume":"48","author":"Singla","year":"2015","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.07.002_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.joen.2011.12.006","article-title":"A prospective randomized trial of different supplementary local anesthetic techniques after failure of inferior alveolar nerve block in patients with irreversible pulpitis in mandibular teeth","volume":"38","author":"Kanaa","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2344\/15-00019.1","article-title":"Effect of preoperative pain on inferior alveolar nerve block","volume":"62","author":"Aggarwal","year":"2015","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2016.07.002_bib26","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.joen.2013.04.007","article-title":"Is a volume of 3.6 mL better than 1.8 mL for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis?","volume":"39","author":"Fowler","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.joen.2015.12.025","article-title":"Anesthetic success of an inferior alveolar nerve block and supplemental articaine buccal infiltration for molars and premolars in patients with symptomatic irreversible pulpitis","volume":"42","author":"Fowler","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/iej.12293","article-title":"4% articaine buccal infiltration versus 2% lidocaine inferior alveolar nerve block for emergency root canal treatment in mandibular molars with irreversible pulpitis: a randomized clinical study","volume":"48","author":"Monteiro","year":"2015","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.07.002_bib29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.joen.2008.11.025","article-title":"Articaine for supplemental buccal mandibular infiltration anesthesia in patients with irreversible pulpitis when the inferior alveolar nerve block fails","volume":"35","author":"Matthews","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib30","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/01.DON.0000140565.88940.60","article-title":"Anesthetic effectiveness of the supplemental intraligamentary injection, administered with a computer-controlled local anesthetic delivery system, in patients with irreversible pulpitis","volume":"31","author":"Nusstein","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: a clinical study","volume":"19","author":"Cohen","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0099-2399(98)80053-8","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis","volume":"24","author":"Nusstein","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/0972-0707.108202","article-title":"Anesthetic efficacy of X-tip intraosseous injection using 2% lidocaine with 1:80,000 epinephrine in patients with irreversible pulpitis after inferior alveolar nerve block: a clinical study","volume":"16","author":"Verma","year":"2013","journal-title":"J Conserv Dent"},{"key":"10.1016\/j.joen.2016.07.002_bib34","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00004770-200311000-00010","article-title":"Anesthetic efficacy of the supplemental X-tip\u2122 intraosseous injection in patients with irreversible pulpitis","volume":"29","author":"Nusstein","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.07.002_bib35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tripleo.2004.11.009","article-title":"Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system","volume":"99","author":"Berlin","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239916303958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239916303958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T04:01:46Z","timestamp":1536379306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239916303958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0099239916303958"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2016.07.002","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"How Effective Is Supplemental Intraseptal Anesthesia in Patients with Symptomatic Irreversible Pulpitis?","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2016.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}