{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:44:39Z","timestamp":1791092679393,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.joen.2016.11.008","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T18:46:22Z","timestamp":1486665982000},"page":"514-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Association between Systemic Diseases and Endodontic Outcome: A Systematic Review"],"prefix":"10.1016","volume":"43","author":[{"given":"Anita","family":"Aminoshariae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Kulild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Mickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf F.","family":"Fouad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2016.11.008_bib1","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/CIR.0b013e31825719f3","article-title":"Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? a scientific statement from the American Heart Association","volume":"125","author":"Lockhart","year":"2012","journal-title":"Circulation"},{"issue":"Suppl","key":"10.1016\/j.joen.2016.11.008_bib2","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.14219\/jada.archive.2002.0377","article-title":"Does chronic periodontitis cause coronary heart disease? a review of the literature","volume":"133","author":"Hujoel","year":"2002","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2016.11.008_bib3","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.ahj.2007.06.037","article-title":"The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis","volume":"154","author":"Bahekar","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.joen.2016.11.008_bib4","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.joen.2016.07.007","article-title":"Association between systemic diseases and apical periodontitis","volume":"42","author":"Khalighinejad","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/iej.12072","article-title":"Diabetes mellitus and inflammatory pulpal and periapical disease: a review","volume":"46","author":"Lima","year":"2013","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.11.008_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.14219\/jada.archive.2003.0016","article-title":"The effect of diabetes mellitus on endodontic treatment outcome: data from an electronic patient record","volume":"134","author":"Fouad","year":"2003","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2016.11.008_bib7","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.joen.2006.03.007","article-title":"Endodontic treatment in an American Indian population: a 10-year retrospective study","volume":"32","author":"Mindiola","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.joen.2005.10.039","article-title":"Pulpal inflammation and incidence of coronary heart disease","volume":"32","author":"Joshipura","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/j.0022-0337.2003.67.4.tb03647.x","article-title":"Diabetes mellitus as a modulating factor of endodontic infections","volume":"67","author":"Fouad","year":"2003","journal-title":"J Dent Educ"},{"key":"10.1016\/j.joen.2016.11.008_bib10","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joen.2016.11.008_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0528.2010.00584.x","article-title":"An appraisal of the quality of published qualitative dental research","volume":"39","author":"Masood","year":"2011","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.joen.2016.11.008_bib12","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.joen.2016.11.008_bib13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1365-2591.2011.01873.x","article-title":"A prospective study of the factors affecting outcomes of non-surgical root canal treatment: part 2\u2014tooth survival","volume":"44","author":"Ng","year":"2011","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.11.008_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2010.08.054","article-title":"Impact of diabetes mellitus, hypertension, and coronary artery disease on tooth extraction after nonsurgical endodontic treatment","volume":"37","author":"Wang","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1079-2104(03)00034-9","article-title":"Periradicular radiographic assessment in diabetic and control individuals","volume":"96","author":"Britto","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.joen.2006.12.025","article-title":"Factors affecting outcomes for single-tooth implants and endodontic restorations","volume":"33","author":"Doyle","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2591.2005.00996.x","article-title":"High prevalence of apical periodontitis amongst type 2 diabetic patients","volume":"38","author":"Segura-Egea","year":"2005","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2016.11.008_bib18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.joen.2011.01.002","article-title":"Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a cross-sectional study","volume":"37","author":"L\u00f3pez-L\u00f3pez","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.joen.2011.11.001","article-title":"Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population","volume":"38","author":"Marotta","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.20344\/amp.2089","article-title":"[Diabetes mellitus and its influence on the success of endodontic treatment: a retrospective clinical study]","volume":"27","author":"Ferreira","year":"2014","journal-title":"Acta Med Port"},{"key":"10.1016\/j.joen.2016.11.008_bib21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.joen.2014.12.024","article-title":"Glycated hemoglobin levels and prevalence of apical periodontitis in type 2 diabetic patients","volume":"41","author":"S\u00e1nchez-Dom\u00ednguez","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/01.don.0000157985.88883.81","article-title":"The effect of human immunodeficiency virus on endodontic treatment outcome","volume":"31","author":"Quesnell","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib23","first-page":"155","article-title":"Comparison of the success of root canal therapy in HIV\/AIDS patients and non-infected controls","volume":"56","author":"Alley","year":"2008","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2016.11.008_bib24","first-page":"322","article-title":"A comparison of endodontic treatment outcomes between HIV-positive and HIV-negative patients","volume":"67","author":"Tootla","year":"2012","journal-title":"SADJ"},{"key":"10.1016\/j.joen.2016.11.008_bib25","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.joen.2009.07.020","article-title":"A retrospective clinical and radiographic study on healing of periradicular lesions in patients taking oral bisphosphonates","volume":"35","author":"Hsiao","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib26","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.joen.2016.11.008_bib27","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.joen.2011.09.006","article-title":"Association of endodontic infection with detection of an initial lesion to the cardiovascular system","volume":"37","author":"Cotti","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib28","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.joen.2013.06.014","article-title":"Can apical periodontitis modify systemic levels of inflammatory markers? a systematic review and meta-analysis","volume":"39","author":"Gomes","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib29","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joen.2015.01.037","article-title":"Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women","volume":"41","author":"Cotti","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-051X.2009.01498.x","article-title":"Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes","volume":"37","author":"Correa","year":"2010","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2016.11.008_bib31","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.bone.2008.01.003","article-title":"Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis","volume":"42","author":"Rizzoli","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.joen.2016.11.008_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14219\/jada.archive.2009.0019","article-title":"Oral bisphosphonate use and the prevalence of osteonecrosis of the jaw: an institutional inquiry","volume":"140","author":"Sedghizadeh","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2016.11.008_bib33","first-page":"397","article-title":"Success of root canal therapy in HIV-positive patients","volume":"54","author":"Shetty","year":"2006","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2016.11.008_bib34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0099-2399(85)80230-2","article-title":"Identification and relative concentration of B and T lymphocytes in human chronic periapical lesions","volume":"11","author":"Torabinejad","year":"1985","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5005\/jcdp-7-1-1","article-title":"Retrospective clinical and radiologic evaluation of nonsurgical endodontic treatment in human immunodeficiency virus (HIV) infection","volume":"7","author":"Suchina","year":"2006","journal-title":"J Contemp Dent Pract"},{"key":"10.1016\/j.joen.2016.11.008_bib36","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.tripleo.2004.06.065","article-title":"Factors affecting the outcome of orthograde root canal therapy in a general dentistry hospital practice","volume":"99","author":"Marending","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2016.11.008_bib37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/iej.12429","article-title":"The Tennessee study: factors affecting treatment outcome and healing time following nonsurgical root canal treatment","volume":"49","author":"Azim","year":"2016","journal-title":"Int Endod J"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239916309025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239916309025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T05:15:45Z","timestamp":1601615745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239916309025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0099239916309025"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2016.11.008","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between Systemic Diseases and Endodontic Outcome: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2016.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}