{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:50:02Z","timestamp":1791377402992,"version":"4.3.2"},"reference-count":102,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.joen.2017.02.009","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T15:16:57Z","timestamp":1495034217000},"page":"1033-1051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":174,"title":["Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review"],"prefix":"10.1016","volume":"43","author":[{"given":"Marjorie","family":"Zanini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2017.02.009_bib1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0099-2399(89)80191-8","article-title":"Reduction in tooth stiffness as a result of endodontic and restorative procedures","volume":"15","author":"Reeh","year":"1989","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1600-0501.2009.01907.x","article-title":"Complication and failure rates in patients treated for chronic periodontitis and restored with single crowns on teeth and\/or implants","volume":"21","author":"Schmidlin","year":"2010","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.joen.2017.02.009_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-0722.2010.00731.x","article-title":"Treatment of deep caries lesions in adults: randomized clinical trials comparing stepwise vs direct complete excavation, and direct pulp capping vs partial pulpotomy","volume":"118","author":"Bj\u00f8rndal","year":"2010","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2017.02.009_bib4","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.joen.2015.02.024","article-title":"Outcome of direct pulp capping with mineral trioxide aggregate: a prospective study","volume":"41","author":"Marques","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1365-2591.2008.01433.x","article-title":"Evaluation of a new laboratory model for pulp healing: preliminary study","volume":"41","author":"Simon","year":"2008","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib6","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.joen.2012.04.018","article-title":"Biodentine induces immortalized murine pulp cell differentiation into odontoblast-like cells and stimulates biomineralization","volume":"38","author":"Zanini","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joen.2013.01.005","article-title":"Response of human dental pulp capped with biodentine and mineral trioxide aggregate","volume":"39","author":"Nowicka","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2008.05.013","article-title":"Inflammatory and immunological aspects of dental pulp repair","volume":"58","author":"Goldberg","year":"2008","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.joen.2017.02.009_bib9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0030-4220(52)90073-X","article-title":"Thoughts on the physiologic pathology of regressive and reparative changes in the dentine and dental pulp","volume":"5","author":"Shroff","year":"1952","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2017.02.009_bib10","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/0030-4220(59)90297-X","article-title":"The healing powers of the dental pulp","volume":"12","author":"Shroff","year":"1959","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2017.02.009_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00004770-200003000-00012","article-title":"Pulpal pain diagnosis: a review","volume":"26","author":"Bender","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1747-4477.2000.tb00144.x","article-title":"Reversible and irreversible painful pulpitides: diagnosis and treatment","volume":"26","author":"Bender","year":"2000","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib13","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.joen.2009.09.029","article-title":"AAE Consensus Conference on Diagnostic Terminology: background and perspectives","volume":"35","author":"Glickman","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0030-4220(63)90201-9","article-title":"The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp","volume":"16","author":"Seltzer","year":"1963","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2017.02.009_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2591.1980.tb00834.x","article-title":"Clinical signs and symptoms in pulp disease","volume":"13","author":"Dummer","year":"1980","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib16","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/00220345650440041301","article-title":"Dental pulp hemogram","volume":"44","author":"Guthrie","year":"1965","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.02.009_bib17","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/00016358309162331","article-title":"Vascular reactions in the dental pulp during inflammation","volume":"41","author":"T\u00f8nder","year":"1983","journal-title":"Acta Odontol Scand"},{"issue":"Suppl 1","key":"10.1016\/j.joen.2017.02.009_bib18","first-page":"387","article-title":"Effects of selected inflammatory mediators on blood flow and vascular permeability in the dental pulp","volume":"88","author":"Kim","year":"1992","journal-title":"Proc Finn Dent Soc"},{"key":"10.1016\/j.joen.2017.02.009_bib19","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0003-9969(95)00024-J","article-title":"Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth","volume":"40","author":"Izumi","year":"1995","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/0022034511405389","article-title":"Mediators of inflammation and regeneration","volume":"23","author":"Cooper","year":"2011","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2017.02.009_bib21","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib22","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1002\/eji.1830270805","article-title":"Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10","volume":"27","author":"Buelens","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib23","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1128\/IAI.72.7.4102-4108.2004","article-title":"S100 and cytokine expression in caries","volume":"72","author":"McLachlan","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.joen.2017.02.009_bib24","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.joen.2017.02.009_bib25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.joen.2016.02.018","article-title":"Critical assessment of search strategies in systematic reviews in endodontics","volume":"42","author":"Yaylali","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0099-2399(06)81717-6","article-title":"Human polymorphonuclear granule components: relative levels detected by a modified enzyme-linked immunosorbent assay in normal and inflamed dental pulps","volume":"17","author":"Rauschenberger","year":"1991","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0003-9969(77)90086-3","article-title":"Immune components in normal and inflamed human dental pulp","volume":"22","author":"Pulver","year":"1977","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib28","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1177\/00220345700490043101","article-title":"Localization of plasma proteins in the human dental pulp","volume":"49","author":"Honjo","year":"1970","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.02.009_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0003-9969(84)90046-3","article-title":"Substance P-like immunoreactivity in the pulp-dentine zone of human molar teeth demonstrated by indirect immunofluorescence","volume":"29","author":"Wakisaka","year":"1984","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib30","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0099-2399(06)80070-1","article-title":"Comparison of human polymorphonuclear neutrophil elastase, polymorphonuclear neutrophil cathepsin-G, and alpha 2-macroglobulin levels in healthy and inflamed dental pulps","volume":"20","author":"Rauschenberger","year":"1994","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1023\/A:1003852409574","article-title":"TGF-beta receptor expression in human odontoblasts and pulpal cells","volume":"38","author":"Sloan","year":"1999","journal-title":"Histochem J"},{"key":"10.1016\/j.joen.2017.02.009_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1023\/A:1004007202404","article-title":"Transforming growth factor-beta isoform expression in mature human healthy and carious molar teeth","volume":"32","author":"Sloan","year":"2000","journal-title":"Histochem J"},{"key":"10.1016\/j.joen.2017.02.009_bib33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/08959374010150011601","article-title":"Expression of TGF-beta receptors I and II in the human dental pulp by in situ hybridization","volume":"15","author":"Sloan","year":"2001","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2017.02.009_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1600-0722.2006.00343.x","article-title":"Caries-induced changes in the expression of pulpal neuropeptide Y","volume":"114","author":"El Karim","year":"2006","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2017.02.009_bib35","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.archoralbio.2006.04.009","article-title":"Vasoactive intestinal polypeptide (VIP) and VPAC1 receptor in adult human dental pulp in relation to caries","volume":"51","author":"El Karim","year":"2006","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.joen.2007.10.022","article-title":"Interleukin-8 is increased in gingival crevicular fluid from patients with acute pulpitis","volume":"34","author":"Karapanou","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2172-12-9","article-title":"Caries induced cytokine network in the odontoblast layer of human teeth","volume":"12","author":"Horst","year":"2011","journal-title":"BMC Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib38","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0099-2399(06)81213-6","article-title":"Effect of injury on pulpal levels of immunoreactive substance P and immunoreactive calcitonin gene-related peptide","volume":"18","author":"Grutzner","year":"1992","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib39","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0003-9969(96)00052-0","article-title":"Expression of genes for bone morphogenetic proteins and receptors in human dental pulp","volume":"41","author":"Gu","year":"1996","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib40","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S8756-3282(01)00612-3","article-title":"Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis","volume":"29","author":"Shi","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.joen.2017.02.009_bib41","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/01.DON.0000134203.65706.8F","article-title":"Expression of insulin-like growth factor-1 receptor in human pulp tissue","volume":"30","author":"Caviedes-Bucheli","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/8756-3282(94)90268-2","article-title":"Expression of bone morphogenetic protein genes in the human dental pulp cells","volume":"15","author":"Takeda","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.joen.2017.02.009_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0099-2399(87)80043-2","article-title":"An ultrastructural investigation of the human apical pulp in irreversible pulpitis: I\u2014nerves","volume":"13","author":"Mendoza","year":"1987","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib44","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0099-2399(85)80039-X","article-title":"A radioimmunoassay determination of the concentrations of prostaglandins E2 and F2alpha in painful and asymptomatic human dental pulps","volume":"11","author":"Cohen","year":"1985","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0099-2399(06)81864-9","article-title":"Determination and relationship of C-reactive protein in human dental pulps and in serum","volume":"17","author":"Proctor","year":"1991","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0099-2399(06)81139-8","article-title":"Antibodies in normal and diseased pulps reactive with microorganisms isolated from deep caries","volume":"18","author":"Hahn","year":"1992","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0099-2399(97)80184-7","article-title":"Detection of human IL-2 in normal and inflamed dental pulps","volume":"23","author":"Rauschenberger","year":"1997","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-9657.1999.tb00744.x","article-title":"Detection of interleukin-6 in human dental pulp and periapical lesions","volume":"15","author":"Barkhordar","year":"1999","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2017.02.009_bib49","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S1079-2104(99)70118-6","article-title":"Increased interleukin-8 expression in inflamed human dental pulps","volume":"88","author":"Huang","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib50","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1034\/j.1600-0722.2000.00924.x","article-title":"Substance P expression in human tooth pulp in relation to caries and pain experience","volume":"108","author":"Rodd","year":"2000","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2017.02.009_bib51","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1046\/j.1365-2591.2002.00451.x","article-title":"Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in pulp tissue from painful and healthy human teeth","volume":"35","author":"Awawdeh","year":"2002","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib52","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00004770-200209000-00006","article-title":"Evaluating IL-2 levels in human pulp tissue","volume":"28","author":"Anderson","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1034\/j.1600-0722.2002.21347.x","article-title":"Matrix metalloproteinase levels and gelatinolytic activity in clinically healthy and inflamed human dental pulps","volume":"110","author":"Gusman","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2017.02.009_bib54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00004770-200204000-00013","article-title":"Tissue levels of matrix metalloproteinases in pulps and periapical lesions","volume":"28","author":"Shin","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib55","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0188-4409(02)00396-X","article-title":"Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps","volume":"33","author":"Pezelj-Ribaric","year":"2002","journal-title":"Arch Med Res"},{"key":"10.1016\/j.joen.2017.02.009_bib56","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00004770-200201000-00005","article-title":"Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps","volume":"28","author":"Artese","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00004770-200304000-00009","article-title":"Tissue levels of immunoreactive substance P are increased in patients with irreversible pulpitis","volume":"29","author":"Bowles","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib58","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.0143-2885.2004.00758.x","article-title":"Transforming growth factor-beta 1 (TGF-beta 1) expression in normal healthy pulps and in those with irreversible pulpitis","volume":"37","author":"Piattelli","year":"2004","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib59","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00004770-200404000-00004","article-title":"Expression of calcitonin gene-related peptide (CGRP) in irreversible acute pulpitis","volume":"30","author":"Caviedes-Bucheli","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib60","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/01.don.0000143414.22112.57","article-title":"Expression of macrophage inflammatory protein 3alpha in human inflamed dental pulp tissue","volume":"31","author":"Nakanishi","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib61","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2591.2006.01093.x","article-title":"Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp","volume":"39","author":"Caviedes-Bucheli","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib62","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1365-2591.2006.01189.x","article-title":"Substance P receptor expression in healthy and inflamed human pulp tissue","volume":"40","author":"Caviedes-Bucheli","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib63","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1747-4477.2009.00160.x","article-title":"The relationship of pulp polyp with the presence and concentration of immunoglobulin E, histamine, interleukin-4 and interleukin-12","volume":"35","author":"Sattari","year":"2009","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib64","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1590\/S1678-77572009000500031","article-title":"Interleukin-1 beta and interleukin-8 in healthy and inflamed dental pulps","volume":"17","author":"Silva","year":"2009","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2017.02.009_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joen.2010.10.003","article-title":"A first study on the usefulness of matrix metalloproteinase 9 from dentinal fluid to indicate pulp inflammation","volume":"37","author":"Zehnder","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib66","first-page":"113","article-title":"Relation between pulpal neuropeptides and dental caries","volume":"5","author":"Kangarlou Haghighi","year":"2010","journal-title":"Iran Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.joen.2011.10.005","article-title":"Dentin matrix protein-1 activates dental pulp fibroblasts","volume":"38","author":"Abd-Elmeguid","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib68","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.joen.2012.11.011","article-title":"Evaluation of gelatinases, tissue inhibitor of matrix metalloproteinase-2, and myeloperoxidase protein in healthy and inflamed human dental pulp tissue","volume":"39","author":"Accorsi-Mendon\u00e7a","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib69","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.joen.2012.12.035","article-title":"Osteocalcin expression in pulp inflammation","volume":"39","author":"Abd-Elmeguid","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib70","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.joen.2015.10.020","article-title":"A prospective clinical pilot study on the level of matrix metalloproteinase-9 in dental pulpal blood as a marker for the state of inflammation in the pulp tissue","volume":"42","author":"Mente","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib71","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1043-4666(03)00116-9","article-title":"Cytokine gene expression: part of host defence in pulpitis","volume":"22","author":"Zehnder","year":"2003","journal-title":"Cytokine"},{"key":"10.1016\/j.joen.2017.02.009_bib72","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2591.2007.01215.x","article-title":"Irreversible but not reversible pulpitis is associated with up-regulation of tumour necrosis factor-alpha gene expression in human pulp","volume":"40","author":"Kokkas","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.02.009_bib73","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.don.0000164851.55389.4e","article-title":"The upregulation of matrix metalloproteinase-9 in inflamed human dental pulps","volume":"31","author":"Tsai","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/754069","article-title":"Overexpression of receptor for advanced glycation end products and high-mobility group box 1 in human dental pulp inflammation","volume":"2014","author":"Tancharoen","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2017.02.009_bib75","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.joen.2007.01.001","article-title":"Innate immune responses of the dental pulp to caries","volume":"33","author":"Hahn","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib76","doi-asserted-by":"crossref","first-page":"347649","DOI":"10.1155\/2015\/347649","article-title":"Is pulp inflammation a prerequisite for pulp healing and regeneration?","volume":"11","author":"Goldberg","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2017.02.009_bib77","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.yexcr.2013.03.018","article-title":"Nemotic human dental pulp fibroblasts promote human dental pulp stem cells migration","volume":"319","author":"Zhai","year":"2013","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.joen.2017.02.009_bib78","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1399-302X.1995.tb00145.x","article-title":"Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure","volume":"10","author":"Tani-Ishii","year":"1995","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib79","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0022034509334070","article-title":"TNF-alpha promotes an odontoblastic phenotype in dental pulp cells","volume":"88","author":"Paula-Silva","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.02.009_bib80","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10735-015-9630-7","article-title":"High dose of TNF-\u03b1 suppressed osteogenic differentiation of human dental pulp stem cells by activating the Wnt\/\u03b2-catenin signaling","volume":"46","author":"Qin","year":"2015","journal-title":"J Mol Histol"},{"key":"10.1016\/j.joen.2017.02.009_bib81","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1365-2184.2011.00769.x","article-title":"Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells","volume":"44","author":"Huang","year":"2011","journal-title":"Cell Prolif"},{"key":"10.1016\/j.joen.2017.02.009_bib82","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.joen.2012.04.005","article-title":"The effects of tumor necrosis factor-\u03b1 on mineralization of human dental apical papilla cells","volume":"38","author":"Yang","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.02.009_bib83","doi-asserted-by":"crossref","first-page":"e113419","DOI":"10.1371\/journal.pone.0113419","article-title":"Chronic inflammation and angiogenic signaling axis impairs differentiation of dental-pulp stem cells","volume":"9","author":"Boyle","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2017.02.009_bib84","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jlb.41.3.196","article-title":"Receptor binding and activation of polymorphonuclear neutrophils by tumor necrosis factor-alpha","volume":"41","author":"Shalaby","year":"1987","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib85","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4049\/jimmunol.135.3.2069","article-title":"Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors","volume":"135","author":"Shalaby","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib86","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.4049\/jimmunol.136.11.4220","article-title":"Stimulation of neutrophils by tumor necrosis factor","volume":"136","author":"Klebanoff","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib87","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.4049\/jimmunol.166.5.3476","article-title":"Promotion of neutrophil apoptosis by TNF-alpha","volume":"166","author":"Salamone","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2017.02.009_bib88","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2017.02.009_bib89","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2741\/2161","article-title":"The dual personalities of matrix metalloproteinases in inflammation","volume":"12","author":"Le","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.joen.2017.02.009_bib90","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2353\/ajpath.2009.080705","article-title":"Matrix metalloproteinase-3 accelerates wound healing following dental pulp injury","volume":"175","author":"Zheng","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joen.2017.02.009_bib91","doi-asserted-by":"crossref","first-page":"e52523","DOI":"10.1371\/journal.pone.0052523","article-title":"The anti-inflammatory effects of matrix metalloproteinase-3 on irreversible pulpitis of mature erupted teeth","volume":"7","author":"Eba","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2017.02.009_bib92","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.earlhumdev.2010.03.007","article-title":"Increased expression of matrix metalloproteinase-9 and hepatocyte growth factor in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus","volume":"86","author":"Okamoto","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.joen.2017.02.009_bib93","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1600-051X.1996.tb01814.x","article-title":"Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients","volume":"23","author":"Ingman","year":"1996","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2017.02.009_bib94","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1034\/j.1600-051x.2000.027005366.x","article-title":"Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients","volume":"27","author":"Chen","year":"2000","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2017.02.009_bib95","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1600-0765.2006.00897.x","article-title":"Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test","volume":"41","author":"M\u00e4ntyl\u00e4","year":"2006","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.joen.2017.02.009_bib96","first-page":"67","article-title":"Assessment of matrix metalloproteinases-8 and -9 in gingival crevicular fluid of smokers and non-smokers with chronic periodontitis using ELISA","volume":"6","author":"Victor","year":"2014","journal-title":"J Int Oral Health"},{"key":"10.1016\/j.joen.2017.02.009_bib97","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1165\/ajrcmb.20.3.3311","article-title":"Human neutrophils secrete gelatinase B in\u00a0vitro and in\u00a0vivo in response to endotoxin and proinflammatory mediators","volume":"20","author":"Pugin","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib98","first-page":"309","article-title":"Dental pulp conditions in relation to carious lesions","volume":"20","author":"Baume","year":"1970","journal-title":"Int Dent J"},{"key":"10.1016\/j.joen.2017.02.009_bib99","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-9657.1987.tb00619.x","article-title":"Tissue response to dental caries","volume":"3","author":"Langeland","year":"1987","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2017.02.009_bib100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0003-9969(91)90072-3","article-title":"Fluid and protein flux across the pulpodentine complex of the dog in\u00a0vivo","volume":"36","author":"Maita","year":"1991","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib101","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0003-9969(94)90043-4","article-title":"Determination of plasma proteins in dentinal fluid from cavities prepared in healthy young human teeth","volume":"39","author":"Knutsson","year":"1994","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.02.009_bib102","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0300-5712(93)90133-B","article-title":"Inhibition of serum albumin flux across exposed dentine following conditioning with GLUMA primer, glutaraldehyde or potassium oxalates","volume":"21","author":"Bergenholtz","year":"1993","journal-title":"J Dent"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239917302492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239917302492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T17:28:37Z","timestamp":1750267717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239917302492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":102,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0099239917302492"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2017.02.009","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2017.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}