{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:53:43Z","timestamp":1777571623698,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.joen.2017.06.012","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T21:16:17Z","timestamp":1503695777000},"page":"S57-S64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"S","title":["Regenerative Endodontics for Adult Patients"],"prefix":"10.1016","volume":"43","author":[{"given":"Ling","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahng G.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qimei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sainan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuedong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqi","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy J.","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2017.06.012_bib1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2591.2007.01322.x","article-title":"Outcome of primary root canal treatment: systematic review of the literature - part 1. Effects of study characteristics on probability of success","volume":"40","author":"Ng","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.06.012_bib2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2591.2008.01484.x","article-title":"Outcome of primary root canal treatment: systematic review of the literature \u2013 part 2. Influence of clinical factors","volume":"41","author":"Ng","year":"2008","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.06.012_bib3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.14219\/jada.archive.2012.0208","article-title":"Outcomes of endodontic therapy in general practice: a study by the Practitioners Engaged in Applied Research and Learning Network","volume":"143","author":"Bernstein","year":"2012","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2017.06.012_bib4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jdent.2015.01.013","article-title":"Three-year outcomes of root canal treatment: mining an insurance database","volume":"43","author":"Raedel","year":"2015","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2017.06.012_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tripleo.2003.07.006","article-title":"Success rate of endodontic treatment of teeth with vital and nonvital pulps. A meta-analysis","volume":"97","author":"Kojima","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib6","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1365-2591.2008.01484.x","article-title":"Outcome of secondary root canal treatment: a systematic review of the literature","volume":"41","author":"Ng","year":"2008","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.06.012_bib7","unstructured":"American Association of Endodontists. Regenerative Endodontics. Available at: http:\/\/www.aae.org\/regeneration\/. Accessed September 1, 2106."},{"key":"10.1016\/j.joen.2017.06.012_bib8","unstructured":"American Association of Endodontics. Endodontic facts. Available at: http:\/\/www.aae.org\/about-aae\/news-room\/endodontic-facts.aspx. Accessed September 1,\u00a02016."},{"key":"10.1016\/j.joen.2017.06.012_bib9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5395\/rde.2014.39.4.258","article-title":"Microorganism penetration in dentinal tubules of instrumented and retreated root canal walls. In\u00a0vitro SEM study","volume":"39","author":"Al-Nazhan","year":"2014","journal-title":"Restor Dent Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/00004770-200102000-00002","article-title":"Viable bacteria in root dentinal tubules of teeth with apical periodontitis","volume":"27","author":"Peters","year":"2001","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cden.2010.01.002","article-title":"The use of the operating microscope in endodontics","volume":"54","author":"Carr","year":"2010","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joen.2017.06.012_bib12","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.joen.2012.04.010","article-title":"One- versus two-visit endodontic treatment of teeth with apical periodontitis: a histobacteriologic study","volume":"38","author":"Vera","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib13","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joen.2013.04.027","article-title":"One-visit versus two-visit root canal treatment: effectiveness in the removal of endotoxins and cultivable bacteria","volume":"39","author":"Xavier","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.joen.2014.12.019","article-title":"Role of angiogenesis in endodontics: contributions of stem cells and proangiogenic and antiangiogenic factors to dental pulp regeneration","volume":"41","author":"Saghiri","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0099-2399(06)80483-8","article-title":"Are endodontically treated teeth more brittle?","volume":"18","author":"Sedgley","year":"1992","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib16","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.joen.2008.05.001","article-title":"Efficacy of revascularization to induce apexification\/apexogensis in infected, nonvital, immature teeth: a pilot clinical study","volume":"34","author":"Shah","year":"2008","journal-title":"J Endod"},{"issue":"Suppl","key":"10.1016\/j.joen.2017.06.012_bib17","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1016\/j.joen.2012.11.019","article-title":"Considerations for regeneration procedures","volume":"39","author":"Law","year":"2013","journal-title":"J Endod"},{"issue":"Suppl","key":"10.1016\/j.joen.2017.06.012_bib18","first-page":"170","article-title":"Guideline on pulp therapy for primary and young permanent teeth","volume":"30","year":"2008","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2017.06.012_bib19","unstructured":"American Association of Endodontists. Endodontic treatment statistics. Available at: http:\/\/www.aae.org\/about-aae\/news-room\/endodontic-treatment-statistics.aspx. Accessed September 1, 2016."},{"key":"10.1016\/j.joen.2017.06.012_bib20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.joen.2013.04.029","article-title":"Regenerative endodontic treatment of permanent teeth after completion of root development: a report of 2 cases","volume":"39","author":"Paryani","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib21","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.joen.2014.07.027","article-title":"Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy","volume":"40","author":"Saoud","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.joen.2015.09.015","article-title":"Treatment of mature permanent teeth with necrotic pulps and apical periodontitis using regenerative endodontic procedures: a case series","volume":"42","author":"Saoud","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3109\/00016356109043395","article-title":"The role of the blood clot in endodontic therapy. An experimental histologic study","volume":"19","author":"Ostby","year":"1961","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.joen.2017.06.012_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-9657.2011.01044.x","article-title":"Recommendations for using regenerative endodontic procedures in permanent immature traumatized teeth","volume":"28","author":"Garcia-Godoy","year":"2012","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2017.06.012_bib25","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.joen.2013.02.004","article-title":"The critical apical diameter to obtain regeneration of the pulp tissue after tooth transplantation, replantation, or regenerative endodontic treatment","volume":"39","author":"Laureys","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.stem.2012.08.010","article-title":"Stem cells in the face: tooth regeneration and beyond","volume":"11","author":"Mao","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.joen.2017.06.012_bib27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.joen.2015.08.026","article-title":"Regenerative endodontic treatment of an immature necrotic molar with arrested root development by using recombinant human platelet-derived growth factor: a case report","volume":"42","author":"Zhujiang","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib28","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1089\/ten.tea.2010.0181","article-title":"Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing","volume":"16","author":"Kim","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2017.06.012_bib29","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/iej.12087","article-title":"Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells","volume":"46","author":"Zhu","year":"2013","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.06.012_bib30","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.joen.2014.03.020","article-title":"Histologic comparison between platelet-rich plasma and blood clot in regenerative endodontic treatment: an animal study","volume":"40","author":"Zhang","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib31","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.joen.2013.04.032","article-title":"Clinical, radiographic, and histological observation of a human immature permanent tooth with chronic apical abscess after revitalization treatment","volume":"39","author":"Shimizu","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib32","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.joen.2015.03.012","article-title":"Histologic and immunohistochemical findings of a human immature permanent tooth with apical periodontitis after regenerative endodontic treatment","volume":"41","author":"Lei","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib33","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.joen.2014.05.010","article-title":"Immunohistochemical and histochemical analysis of newly formed tissues in root canal space transplanted with dental pulp stem cells plus platelet-rich plasma","volume":"40","author":"Zhu","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.joen.2013.12.025","article-title":"Histologic examinations of teeth treated with 2 scaffolds: a pilot animal investigation","volume":"40","author":"Torabinejad","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.joen.2015.10.019","article-title":"Exploiting the bioactive properties of the dentin-pulp complex in regenerative endodontics","volume":"42","author":"Smith","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib36","doi-asserted-by":"crossref","DOI":"10.1177\/2041731415586318","article-title":"Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair","volume":"6","author":"Lee","year":"2015","journal-title":"J Tissue Eng"},{"key":"10.1016\/j.joen.2017.06.012_bib37","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1371\/journal.pone.0000079","article-title":"Mesenchymal stem cell-mediated functional tooth regeneration in swine","volume":"1","author":"Sonoyama","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2017.06.012_bib38","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.joen.2008.03.001","article-title":"The hidden treasure in apical papilla: the potential role in pulp\/dentin regeneration and bioroot engineering","volume":"34","author":"Huang","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib39","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0022034509340867","article-title":"Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine","volume":"88","author":"Huang","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.06.012_bib40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tice.2016.08.008","article-title":"Comparison of stem cell behaviors between indigenous high and low-CD24 percentage expressing cells of stem cells from apical papilla (SCAPs)","volume":"48","author":"Aguilar","year":"2016","journal-title":"Tissue Cell"},{"key":"10.1016\/j.joen.2017.06.012_bib41","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1002\/stem.211","article-title":"CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells","volume":"27","author":"Pruszak","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.joen.2017.06.012_bib42","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1089\/ten.tea.2009.0518","article-title":"Stem\/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in\u00a0vivo model","volume":"16","author":"Huang","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2017.06.012_bib43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.joen.2007.03.012","article-title":"Tooth slice-based models for the study of human dental pulp angiogenesis","volume":"33","author":"Goncalves","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.5966\/sctm.2012-0132","article-title":"A novel combinatorial therapy with pulp stem cells and granulocyte colony-stimulating factor for total pulp regeneration","volume":"2","author":"Iohara","year":"2013","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.joen.2017.06.012_bib45","doi-asserted-by":"crossref","first-page":"9036","DOI":"10.1016\/j.biomaterials.2013.08.011","article-title":"The use of granulocyte-colony stimulating factor induced mobilization for isolation of dental pulp stem cells with high regenerative potential","volume":"34","author":"Murakami","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2017.06.012_bib46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cytogfr.2009.10.012","article-title":"Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration","volume":"20","author":"Nakashima","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"issue":"Suppl","key":"10.1016\/j.joen.2017.06.012_bib47","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.joen.2014.01.014","article-title":"Cell-free approaches for dental pulp tissue engineering","volume":"40","author":"Galler","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.06.012_bib48","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.cden.2012.05.005","article-title":"Regenerative endodontics: barriers and strategies for clinical translation","volume":"56","author":"Mao","year":"2012","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joen.2017.06.012_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/etp.12037","article-title":"Dentin and dental pulp regeneration by the patient's endogenous cells","volume":"28","author":"Kim","year":"2013","journal-title":"Endod Topics"},{"key":"10.1016\/j.joen.2017.06.012_bib50","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0140-6736(10)60668-X","article-title":"Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study","volume":"376","author":"Lee","year":"2010","journal-title":"Lancet"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239917307653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239917307653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T20:12:44Z","timestamp":1659384764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239917307653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0099239917307653"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2017.06.012","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regenerative Endodontics for Adult Patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2017.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}