{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:54:03Z","timestamp":1787504043125,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100002569","name":"American Association of Endodontists Foundation Research","doi-asserted-by":"publisher","award":["500774"],"award-info":[{"award-number":["500774"]}],"id":[{"id":"10.13039\/100002569","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Academy of Endodontics Endowment"},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","award":["928133"],"award-info":[{"award-number":["928133"]}],"id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.joen.2017.08.021","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T14:49:08Z","timestamp":1510843748000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bioactivity of Photoactivated Functionalized Nanoparticles Assessed in Lipopolysaccharide-contaminated Root Canals In\u00a0Vivo"],"prefix":"10.1016","volume":"44","author":[{"given":"Annie","family":"Shrestha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimon","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin D.","family":"Torneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Kishen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2017.08.021_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2591.2006.01099.x","article-title":"On the causes of persistent apical periodontitis: a review","volume":"39","author":"Nair","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.08.021_bib2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1365-2591.2006.01121.x","article-title":"In\u00a0vivo evaluation of microbial reduction after chemo-mechanical preparation of human root canals containing necrotic pulp tissue","volume":"39","author":"Vianna","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2017.08.021_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0099-2399(75)80244-5","article-title":"Endotoxin content in endodontically involved teeth","volume":"1","author":"Schein","year":"1975","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/cc0500755","article-title":"Structure-activity relationships in lipopolysaccharide neutralizers: design, synthesis, and biological evaluation of a 540-membered amphipathic bisamide library","volume":"8","author":"Burns","year":"2006","journal-title":"J Comb Chem"},{"key":"10.1016\/j.joen.2017.08.021_bib5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0099-2399(06)80057-9","article-title":"Alteration of biological properties of bacterial lipopolysaccharide by calcium hydroxide treatment","volume":"20","author":"Safavi","year":"1994","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1399-302X.2007.00379.x","article-title":"Effect of root canal procedures on endotoxins and endodontic pathogens","volume":"22","author":"Vianna","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2017.08.021_bib7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1099\/jmm.0.45976-0","article-title":"Quantification of endotoxins in necrotic root canals from symptomatic and asymptomatic teeth","volume":"54","author":"Jacinto","year":"2005","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.joen.2017.08.021_bib8","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.joen.2014.01.019","article-title":"Scaffolds to control inflammation and facilitate dental pulp regeneration","volume":"40","author":"Colombo","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/0022034516671499","article-title":"Effect of residual bacteria on the outcome of pulp regeneration in\u00a0vivo","volume":"96","author":"Verma","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.08.021_bib10","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.joen.2017.01.023","article-title":"Effect of bacterial biofilm on the osteogenic differentiation of stem cells of apical papilla","volume":"43","author":"Vishwanat","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib11","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.joen.2013.07.018","article-title":"Human stem cells from the apical papilla response to bacterial lipopolysaccharide exposure and anti-inflammatory effects of nuclear factor I C","volume":"39","author":"Zhang","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1006\/cyto.1997.0262","article-title":"IL-6 and IL-8 production by human bone marrow stromal cells","volume":"10","author":"Rougier","year":"1998","journal-title":"Cytokine"},{"key":"10.1016\/j.joen.2017.08.021_bib13","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.joen.2011.08.027","article-title":"Dentin conditioning codetermines cell fate in regenerative endodontics","volume":"37","author":"Galler","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib14","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.joen.2008.09.001","article-title":"The comparison of the effect of endodontic irrigation on cell adherence to root canal dentin","volume":"34","author":"Ring","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib15","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1021\/cr030441b","article-title":"Chitosan chemistry and pharmaceutical perspectives","volume":"104","author":"Kumar","year":"2004","journal-title":"Chem Rev"},{"key":"10.1016\/j.joen.2017.08.021_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nano.2013.10.010","article-title":"Photoactivated rose bengal functionalized chitosan nanoparticles produce antibacterial\/biofilm activity and stabilize dentin-collagen","volume":"10","author":"Shrestha","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.joen.2017.08.021_bib17","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.joen.2014.03.009","article-title":"Antibiofilm efficacy of photosensitizer-functionalized bioactive nanoparticles on multispecies biofilm","volume":"40","author":"Shrestha","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib18","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.joen.2014.12.007","article-title":"Photoactivated polycationic bioactive chitosan nanoparticles inactivate bacterial endotoxins","volume":"41","author":"Shrestha","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib19","first-page":"272","article-title":"Endotoxic activities of lipopolysaccharides of microorganisms isolated from an infected root canal in Macaca cynomolgus","volume":"85","author":"Dahlen","year":"1977","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.joen.2017.08.021_bib20","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.joen.2012.04.015","article-title":"Efficacy of endodontic treatment for endotoxin reduction in primarily infected root canals and evaluation of cytotoxic effects","volume":"38","author":"Oliveira","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1067\/moe.2003.20","article-title":"Cell and tissue reactions to mineral trioxide aggregate and Portland cement","volume":"95","author":"Saidon","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0099-2399(81)80003-9","article-title":"Intraosseous implantation for biological evaluation of endodontic materials","volume":"7","author":"Olsson","year":"1981","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joen.2013.10.008","article-title":"Quantification of endotoxins in infected root canals and acute apical abscess exudates: monitoring the effectiveness of root canal procedures in the reduction of endotoxins","volume":"40","author":"Sousa","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.archoralbio.2013.11.008","article-title":"Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells","volume":"59","author":"Kato","year":"2014","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2017.08.021_bib25","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.joen.2012.11.025","article-title":"Treatment options: biological basis of regenerative endodontic procedures","volume":"39","author":"Hargreaves","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib26","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1600-9657.2010.00912.x","article-title":"Dentin xenografts to experimental bone defects in rabbit tibia are ankylosed and undergo osseous replacement","volume":"26","author":"Andersson","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2017.08.021_bib27","first-page":"7986","article-title":"In\u00a0vitro tests of the validity of singlet oxygen luminescence measurements as a dose metric in photodynamic therapy","volume":"63","author":"Niedre","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.joen.2017.08.021_bib28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/0030-4220(94)90047-7","article-title":"Taxonomy, ecology, and pathogenicity of the root canal flora","volume":"78","author":"Sundqvist","year":"1994","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2017.08.021_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.joen.2010.10.009","article-title":"Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure","volume":"37","author":"Lovelace","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib30","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.joen.2008.03.001","article-title":"The hidden treasure in apical papilla: the potential role in pulp\/dentin regeneration and bioroot engineering","volume":"34","author":"Huang","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib31","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00004770-200404000-00003","article-title":"Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?","volume":"30","author":"Banchs","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib32","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.joen.2012.06.025","article-title":"Drawbacks and unfavorable outcomes of regenerative endodontic treatments of necrotic immature teeth: a literature review and report of a case","volume":"38","author":"Nosrat","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib33","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.joen.2011.08.025","article-title":"Immunohistological characterization of newly formed tissues after regenerative procedure in immature dog teeth","volume":"37","author":"Yamauchi","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2017.08.021_bib34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tripleo.2009.08.028","article-title":"Oral bacterial extracts facilitate early osteogenic\/dentinogenic differentiation in human dental pulp-derived cells","volume":"109","author":"Abe","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239917309652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239917309652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T21:05:26Z","timestamp":1535231126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239917309652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0099239917309652"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2017.08.021","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioactivity of Photoactivated Functionalized Nanoparticles Assessed in Lipopolysaccharide-contaminated Root Canals In\u00a0Vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2017.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}