{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:58:52Z","timestamp":1786993132217,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771064"],"award-info":[{"award-number":["81771064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371106"],"award-info":[{"award-number":["81371106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81271099"],"award-info":[{"award-number":["81271099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.joen.2017.12.023","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T18:35:07Z","timestamp":1521138907000},"page":"786-791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["FoxO3a Regulates Inflammation-induced Autophagy in Odontoblasts"],"prefix":"10.1016","volume":"44","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2017.12.023_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0300-5712(95)90655-2","article-title":"Pulpo-dentinal complex revisited","volume":"23","author":"Goldberg","year":"1995","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2017.12.023_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1155\/2015\/230251","article-title":"Dental pulp defence and repair mechanisms in dental caries","volume":"2015","author":"Farges","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2017.12.023_bib3","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fphys.2013.00326","article-title":"Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria","volume":"4","author":"Farges","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.joen.2017.12.023_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/0022034514553815","article-title":"Dual role of autophagy in lipopolysaccharide-induced preodontoblastic cells","volume":"94","author":"Pei","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.12.023_bib5","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.cell.2013.11.019","article-title":"Autophagy-mediated tumor promotion","volume":"155","author":"Guo","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.joen.2017.12.023_bib6","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4161\/auto.24273","article-title":"Autophagy: regulation and role in development","volume":"9","author":"Hale","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.joen.2017.12.023_bib7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/aps.2012.184","article-title":"Why should autophagic flux be assessed?","volume":"34","author":"Zhang","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.joen.2017.12.023_bib8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.joen.2017.12.023_bib9","doi-asserted-by":"crossref","first-page":"e917","DOI":"10.1038\/cddis.2013.421","article-title":"Measurement of autophagy flux in the nervous system in\u00a0vivo","volume":"4","author":"Castillo","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.joen.2017.12.023_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1460-9568.2010.07500.x","article-title":"Autophagy, inflammation and neurodegenerative disease","volume":"33","author":"Alirezaei","year":"2011","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.joen.2017.12.023_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.intimp.2013.11.001","article-title":"Autophagy in inflammation, infection, neurodegeneration and cancer","volume":"18","author":"Arroyo","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.joen.2017.12.023_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4161\/auto.22831","article-title":"IFNB1\/interferon-beta-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function","volume":"9","author":"Ambjorn","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.joen.2017.12.023_bib13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10735-013-9518-3","article-title":"Localization of Beclin1 in mouse developing tooth germs: possible implication of the interrelation between autophagy and apoptosis","volume":"44","author":"Yang","year":"2013","journal-title":"J Mol Histol"},{"key":"10.1016\/j.joen.2017.12.023_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/0022034513495874","article-title":"The amazing odontoblast: activity, autophagy, and aging","volume":"92","author":"Couve","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.12.023_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/15548627.2015.1034410","article-title":"Transcriptional and epigenetic regulation of autophagy in aging","volume":"11","author":"Lapierre","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.joen.2017.12.023_bib16","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1089\/ars.2011.4410","article-title":"Autophagy regulation and integration with cell signaling","volume":"17","author":"Hamacher-Brady","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.joen.2017.12.023_bib17","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.joen.2017.12.023_bib18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.4331\/wjbc.v5.i3.346","article-title":"FoxO3a and disease progression","volume":"5","author":"Nho","year":"2014","journal-title":"World J Biol Chem"},{"key":"10.1016\/j.joen.2017.12.023_bib19","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.4103\/0366-6999.167314","article-title":"Expression of transcription factor FOXO3a is decreased in patients with ulcerative colitis","volume":"128","author":"Min","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.joen.2017.12.023_bib20","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1349-7006.2010.01503.x","article-title":"Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin","volume":"101","author":"Shiota","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.joen.2017.12.023_bib21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3892\/ijo.2014.2771","article-title":"Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression","volume":"46","author":"Liu","year":"2015","journal-title":"Int J Oncol"},{"key":"10.1016\/j.joen.2017.12.023_bib22","doi-asserted-by":"crossref","first-page":"23058","DOI":"10.18632\/oncotarget.5492","article-title":"Regulation of Bim in health and disease","volume":"6","author":"Sionov","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.joen.2017.12.023_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.niox.2013.04.001","article-title":"Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol","volume":"32","author":"Xia","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.joen.2017.12.023_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature11895","article-title":"FOXO3A directs a protective autophagy program in haematopoietic stem cells","volume":"494","author":"Warr","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.joen.2017.12.023_bib25","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2007.11.004","article-title":"FoxO3 coordinately activates protein degradation by the autophagic\/lysosomal and proteasomal pathways in atrophying muscle cells","volume":"6","author":"Zhao","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.joen.2017.12.023_bib26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in\u00a0vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.joen.2017.12.023_bib27","doi-asserted-by":"crossref","first-page":"L552","DOI":"10.1152\/ajplung.00079.2015","article-title":"Reduced FoxO3a expression causes low autophagy in idiopathic pulmonary fibrosis fibroblasts on collagen matrices","volume":"309","author":"Im","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.joen.2017.12.023_bib28","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0188-4409(02)00396-X","article-title":"Detection of tumor necrosis factor alpha in normal and inflamed human dental pulps","volume":"33","author":"Pezelj-Ribaric","year":"2002","journal-title":"Arch Med Res"},{"key":"10.1016\/j.joen.2017.12.023_bib29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11626-012-9576-y","article-title":"Establishment and characterization of a tamoxifen-mediated reversible immortalized mouse dental papilla cell line","volume":"49","author":"Lin","year":"2013","journal-title":"In\u00a0Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.joen.2017.12.023_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1177\/0022034516633639","article-title":"Increased apoptosis of inflamed odontoblasts is associated with CD47 loss","volume":"95","author":"Wang","year":"2016","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.12.023_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/0022034510393347","article-title":"Autophagic activity and aging in human odontoblasts","volume":"90","author":"Couve","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2017.12.023_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"Levine","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.joen.2017.12.023_bib33","doi-asserted-by":"crossref","first-page":"28319","DOI":"10.1074\/jbc.M109.024406","article-title":"FoxO transcription factors promote autophagy in cardiomyocytes","volume":"284","author":"Sengupta","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2017.12.023_bib34","doi-asserted-by":"crossref","first-page":"29864","DOI":"10.1074\/jbc.M502149200","article-title":"Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia","volume":"280","author":"Abid","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2017.12.023_bib35","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1042\/BST0340722","article-title":"FOXO transcription factors: key regulators of cell fate","volume":"34","author":"Lam","year":"2006","journal-title":"Biochem Soc Trans"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918300049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918300049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T04:53:26Z","timestamp":1535000006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239918300049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0099239918300049"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2017.12.023","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FoxO3a Regulates Inflammation-induced Autophagy in Odontoblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2017.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}