{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:59:49Z","timestamp":1762390789594},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.joen.2018.01.004","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T12:58:12Z","timestamp":1518872292000},"page":"683-688","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anesthetic Efficacy of a Combination of 4% Prilocaine\/2% Lidocaine with Epinephrine for the Inferior Alveolar Nerve Block: A Prospective, Randomized, Double-blind Study"],"prefix":"10.1016","volume":"44","author":[{"given":"Olivia","family":"Cook","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Nusstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Drum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Al","family":"Reader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Draper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2018.01.004_bib1","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.14219\/jada.archive.2001.0054","article-title":"Pain on injection of prilocaine plain vs. lidocaine with epinephrine. A prospective double-blind study","volume":"132","author":"Wahl","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib2","first-page":"52","article-title":"Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration","volume":"46","author":"Kramp","year":"1999","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2018.01.004_bib3","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.14219\/jada.archive.2002.0115","article-title":"Injection pain of bupivacaine with epinephrine vs. prilocaine plain","volume":"133","author":"Wahl","year":"2002","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib4","first-page":"168","article-title":"Injection pain of prilocaine plain, mepivacaine plain, articaine with epinephrine, and lidocaine with epinephrine","volume":"54","author":"Wahl","year":"2006","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2018.01.004_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0099-2399(06)80510-8","article-title":"An evaluation of 4% prilocaine and 3% mepivacaine compared with 2% lidocaine (1:100,000 epinephrine) for inferior alveolar nerve block","volume":"19","author":"McLean","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3959(84)90835-2","article-title":"An experimental basis for revising the graphic rating scale for pain","volume":"19","author":"Heft","year":"1984","journal-title":"Pain"},{"key":"10.1016\/j.joen.2018.01.004_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joen.2014.09.010","article-title":"Evaluation of the Gow-Gates and Vazirani-Akinosi techniques in patients with symptomatic irreversible pulpitis: a prospective randomized study","volume":"41","author":"Click","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib8","series-title":"Premedication, Local and General Anesthesia in Dentistry","author":"Jorgensen","year":"1967"},{"key":"10.1016\/j.joen.2018.01.004_bib9","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.joen.2014.04.015","article-title":"Does the combination of 3% mepivacaine plain plus 2% lidocaine with epinephrine improve anesthesia and reduce the pain of anesthetic injection for the inferior alveolar nerve block? A prospective, randomized, double-blind study","volume":"40","author":"Lammers","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0300-5712(81)90061-0","article-title":"Prilocaine - an investigation into its use in the presence of inflammation and in combination with lignocaine","volume":"9","author":"Rood","year":"1981","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2018.01.004_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1399-6576.1982.tb01812.x","article-title":"Effects of commercial (pH approximately 3.5) and freshly prepared (pH approximately 6.5) lidocaine-adrenaline solutions on tissue pH","volume":"26","author":"Wennberg","year":"1982","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.joen.2018.01.004_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/bja\/61.2.154","article-title":"Buffering capacity of normal and inflamed tissues following the injection of local anaesthetic solutions","volume":"61","author":"Punnia-Moorthy","year":"1988","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.joen.2018.01.004_bib13","first-page":"372","article-title":"Anesthetic efficacy of different volumes of lidocaine with epinephrine for inferior alveolar nerve blocks","volume":"50","author":"Nusstein","year":"2002","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2018.01.004_bib14","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.14219\/jada.archive.2008.0338","article-title":"Comparing anesthetic efficacy of articaine versus lidocaine as a supplemental buccal infiltration of the mandibular first molar after an inferior alveolar nerve block","volume":"139","author":"Haase","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2591.2008.01507.x","article-title":"Articaine buccal infiltration enhances the effectiveness of lidocaine inferior alveolar nerve block","volume":"42","author":"Kanaa","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.01.004_bib16","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.joen.2010.03.004","article-title":"Anesthetic efficacy of articaine for combination labial plus lingual infiltrations versus labial infiltration in the mandibular lateral incisor","volume":"36","author":"Nuzum","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0099-2399(96)80083-5","article-title":"Anesthetic efficacy of the intraosseous injection after an inferior alveolar nerve block","volume":"22","author":"Dunbar","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S1079-2104(99)70210-6","article-title":"Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin","volume":"87","author":"Guglielmo","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1079-2104(00)80019-0","article-title":"Anesthetic efficacy and heart rate effects of the intraosseous injection of 3% mepivacaine after an inferior alveolar nerve block","volume":"89","author":"Gallatin","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1079-2104(00)70120-X","article-title":"Anesthetic efficacy and heart rate effects of the intraosseous injection of 1.5% etidocaine (1:200,000 epinephrine) after an inferior alveolar nerve block","volume":"89","author":"Stabile","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0099-2399(96)80267-6","article-title":"The anesthetic efficacy of the periodontal ligament injection after an inferior alveolar nerve block","volume":"22","author":"Childers","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib22","series-title":"Successful Local Anesthesia for Restorative Dentistry and Endodontics","first-page":"19","author":"Reader","year":"2017"},{"key":"10.1016\/j.joen.2018.01.004_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0099-2399(89)80091-3","article-title":"An evaluation of volumes and concentrations of lidocaine in human inferior alveolar nerve block","volume":"15","author":"Vreeland","year":"1989","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0099-2399(06)80849-6","article-title":"An evaluation of the incisive nerve block and combination inferior alveolar and incisive nerve blocks in mandibular anesthesia","volume":"18","author":"Nist","year":"1992","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib25","first-page":"9","article-title":"Anesthetic efficacy of a combination of hyaluronidase and lidocaine with epinephrine in inferior alveolar nerve blocks","volume":"48","author":"Ridenour","year":"2001","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2018.01.004_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.don.0000140576.36513.cb","article-title":"A comparison of articaine and lidocaine for inferior alveolar nerve blocks","volume":"31","author":"Mikesell","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib27","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1016\/j.joen.2008.09.005","article-title":"The anesthetic efficacy of diphenhydramine and the combination diphenhydramine\/lidocaine for the inferior alveolar nerve block","volume":"34","author":"Willett","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib28","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.joen.2014.08.001","article-title":"Anesthetic comparisons of 4% concentrations of articaine, lidocaine and prilocaine as primary buccal infiltrations of the mandibular first molar: a prospective randomized, double-blind study","volume":"40","author":"Nydegger","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib29","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1213\/00000539-198706000-00015","article-title":"Sodium bicarbonate attenuates pain on skin infiltration with lidocaine, with or without epinephrine","volume":"66","author":"McKay","year":"1987","journal-title":"Anesth Analg"},{"key":"10.1016\/j.joen.2018.01.004_bib30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.joen.2014.10.001","article-title":"Effect of operator and subject gender on injection pain: a randomized double-blind study","volume":"41","author":"Perry","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.01.004_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.14219\/jada.archive.2001.0152","article-title":"Articaine hydrochloride: a study of the safety of a new amide local anesthetic","volume":"132","author":"Malamed","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib32","doi-asserted-by":"crossref","first-page":"826","DOI":"10.14219\/jada.archive.1999.0306","article-title":"When patients become cyanotic: Acquired methemoglobinemia","volume":"130","author":"Wilburn-Goo","year":"1999","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib33","first-page":"319","article-title":"21-year retrospective study of reports of paresthesia following local anesthetic administration","volume":"61","author":"Haas","year":"1995","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib34","first-page":"627","article-title":"Incidence of local anesthetic-induced neuropathies in Ontario from 1994\u20131998","volume":"79","author":"Miller","year":"2000","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2018.01.004_bib35","first-page":"579","article-title":"Retrospective review of voluntary reports of nonsurgical paresthesia in dentistry","volume":"75","author":"Gaffen","year":"2009","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.joen.2018.01.004_bib36","doi-asserted-by":"crossref","first-page":"836","DOI":"10.14219\/jada.archive.2010.0281","article-title":"Occurrence of paresthesia after dental local anesthetic administration in the United States","volume":"141","author":"Garisto","year":"2010","journal-title":"J Am Dent Assoc"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918300177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918300177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T01:24:05Z","timestamp":1535073845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239918300177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0099239918300177"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2018.01.004","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anesthetic Efficacy of a Combination of 4% Prilocaine\/2% Lidocaine with Epinephrine for the Inferior Alveolar Nerve Block: A Prospective, Randomized, Double-blind Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2018.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}