{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:31:17Z","timestamp":1777048277233,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.joen.2018.02.022","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T13:13:37Z","timestamp":1524057217000},"page":"992-996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Human Dental Pulp Cells Express Cellular Markers for Inflammation and Hard Tissue Formation in Response to Bacterial Information"],"prefix":"10.1016","volume":"44","author":[{"given":"Akina","family":"Sugiuchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousuke","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Furusawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9165-4194","authenticated-orcid":false,"given":"Shu","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2018.02.022_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2341\/06-000","article-title":"Buonocore Memorial Lecture","volume":"31","author":"N\u00f6r","year":"2006","journal-title":"Oper Dent"},{"key":"10.1016\/j.joen.2018.02.022_bib2","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.joen.2014.07.009","article-title":"Effects of WNT10A on proliferation and differentiation of human dental pulp cells","volume":"40","author":"Zhang","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib3","first-page":"771","article-title":"Pulp-dentin biology in restorative dentistry. Part 5: clinical management and tissue changes associated with wear and trauma","volume":"32","author":"Mjor","year":"2001","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2018.02.022_bib4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/j.0022-0337.2003.67.6.tb03668.x","article-title":"Vitality of the dentin-pulp complex in health and disease: growth factors as key mediators","volume":"67","author":"Smith","year":"2003","journal-title":"J Dent Educ"},{"key":"10.1016\/j.joen.2018.02.022_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tripleo.2009.08.028","article-title":"Oral bacterial extracts facilitate early osteogenic\/dentinogenic differentiation in human dental pulp-derived cells","volume":"109","author":"Abe","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1600-9657.2000.016006269.x","article-title":"Comparison of profiles of key periodontal pathogens in periodontium and endodontium","volume":"16","author":"Rupf","year":"2000","journal-title":"Endod Dental Traumatol"},{"key":"10.1016\/j.joen.2018.02.022_bib7","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ni1004-971","article-title":"The interface between innate and adaptive immunity","volume":"5","author":"Hoebe","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joen.2018.02.022_bib8","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.joen.2007.05.018","article-title":"Expression of Toll-like receptor 2 and 4 in dental pulp","volume":"33","author":"Mutoh","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib9","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.joen.2014.03.015","article-title":"TLR4 activation by lipopolysaccharide and Streptococcus mutans induces differential regulation of proliferation and migration in human dental pulp stem cells","volume":"40","author":"Liu","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ydbio.2009.07.015","article-title":"Wnt\/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development","volume":"334","author":"Chen","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.joen.2018.02.022_bib11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.cell.2009.11.035","article-title":"Wnt signaling and the polarity of the primary body axis","volume":"139","author":"Petersen","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.joen.2018.02.022_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.nbd.2009.09.003","article-title":"Wnt signaling in development and disease","volume":"38","author":"Freese","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.joen.2018.02.022_bib13","doi-asserted-by":"crossref","first-page":"a008078","DOI":"10.1101\/cshperspect.a008078","article-title":"Wnt signaling and injury repair","volume":"4","author":"Whyte","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.joen.2018.02.022_bib14","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2741\/e201","article-title":"Role of the Wnt signaling pathway in bone and tooth","volume":"2","author":"Tamura","year":"2010","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.joen.2018.02.022_bib15","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-2591.2010.01693.x","article-title":"Wnt5a promotes differentiation of human dental papilla cells","volume":"43","author":"Peng","year":"2010","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.02.022_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.yexcr.2014.05.006","article-title":"IL-1beta-induced, matrix metalloproteinase-3-regulated proliferation of embryonic stem cell-derived odontoblastic cells is mediated by the Wnt5 signaling pathway","volume":"328","author":"Ozeki","year":"2014","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.joen.2018.02.022_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.joen.2013.09.011","article-title":"Lipopolysaccharide enhances Wnt5a expression through toll-like receptor 4, myeloid differentiating factor 88, phosphatidylinositol 3-OH kinase\/AKT and nuclear factor kappa B pathways in human dental pulp stem cells","volume":"40","author":"He","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.archoralbio.2007.02.006","article-title":"Immortalization and characterization of human dental pulp cells with odontoblastic differentiation","volume":"52","author":"Kitagawa","year":"2007","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2018.02.022_bib19","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1128\/IAI.68.12.6785-6789.2000","article-title":"Cytokine induction by Streptococcus mutans and pulpal pathogenesis","volume":"68","author":"Hahn","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.joen.2018.02.022_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/bmme.1996.0079","article-title":"Stimulation of interleukin-1beta-independent interleukin-6 production in human dental pulp cells by lipopolysaccharide","volume":"59","author":"Hosoya","year":"1996","journal-title":"Biochem Mol Med"},{"key":"10.1016\/j.joen.2018.02.022_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00004770-200402000-00006","article-title":"Proinflammatory cytokine profiles in pulp fibroblasts stimulated with lipopolysaccharide and methyl mercaptan","volume":"30","author":"Coil","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.joen.2018.02.022_bib23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2443.2003.00662.x","article-title":"The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a\/JNK signalling pathway","volume":"8","author":"Oishi","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.joen.2018.02.022_bib24","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0925-4773(99)00095-7","article-title":"Expression of Wnt signalling pathway genes during tooth development","volume":"85","author":"Sarkar","year":"1999","journal-title":"Mech Dev"},{"key":"10.1016\/j.joen.2018.02.022_bib25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jbmr.1488","article-title":"WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production","volume":"27","author":"Rauner","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2018.02.022_bib26","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2005-12-5046","article-title":"The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation","volume":"108","author":"Blumenthal","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.joen.2018.02.022_bib27","doi-asserted-by":"crossref","first-page":"e34434","DOI":"10.1371\/journal.pone.0034434","article-title":"Modulation of Wnt5a expression by periodontopathic bacteria","volume":"7","author":"Nanbara","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2018.02.022_bib28","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1073\/pnas.050574297","article-title":"Expression and function of wingless and frizzled homologs in rheumatoid arthritis","volume":"97","author":"Sen","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.joen.2018.02.022_bib29","doi-asserted-by":"crossref","first-page":"21028","DOI":"10.1074\/jbc.M113.546523","article-title":"Wnt5a promotes inflammatory responses via nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinase (MAPK) pathways in human dental pulp cells","volume":"289","author":"Zhao","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2018.02.022_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000063930","article-title":"Pulpal responses to caries and dental repair","volume":"36","author":"Smith","year":"2002","journal-title":"Caries Res"},{"key":"10.1016\/j.joen.2018.02.022_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/154411130201300207","article-title":"Invasion of dentinal tubules by oral bacteria","volume":"13","author":"Love","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2018.02.022_bib32","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.joen.2006.05.003","article-title":"Molecular analysis of Filifactor alocis, Tannerella forsythia, and treponema denticola associated with primary endodontic infections and failed endodontic treatment","volume":"32","author":"Gomes","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib33","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.joen.2012.02.014","article-title":"Changes in proliferation and osteogenic differentiation of stem cells from deep caries in\u00a0vitro","volume":"38","author":"Ma","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2591.2012.02096.x","article-title":"LPS induces IL-8 expression through TLR4, MyD88, NF-kappaB and MAPK pathways in human dental pulp stem cells","volume":"46","author":"He","year":"2013","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.02.022_bib35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0099-2399(06)80437-1","article-title":"Effects of lipopolysaccharides on human dental pulp cells","volume":"21","author":"Nakane","year":"1995","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.02.022_bib36","doi-asserted-by":"crossref","first-page":"29717","DOI":"10.1074\/jbc.M502929200","article-title":"Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2018.02.022_bib37","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1177\/0022034509342873","article-title":"Runx2, osx, and dspp in tooth development","volume":"88","author":"Chen","year":"2009","journal-title":"J Dent Res"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918301353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918301353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T22:55:10Z","timestamp":1604184910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239918301353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0099239918301353"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2018.02.022","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Dental Pulp Cells Express Cellular Markers for Inflammation and Hard Tissue Formation in Response to Bacterial Information","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2018.02.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}