{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:05:52Z","timestamp":1770753952379,"version":"3.50.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100002569","name":"American Association of Endodontists Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.joen.2018.10.014","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T11:01:25Z","timestamp":1547722885000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Investigating Potential Correlations between Endodontic Pathology and Cardiovascular Diseases Using Epidemiological and Genetic Approaches"],"prefix":"10.1016","volume":"45","author":[{"given":"Maria","family":"Messing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Chaves de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Cavalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna Kumar","family":"Kookal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Walji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-6735","authenticated-orcid":false,"given":"Ariadne","family":"Letra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2018.10.014_bib1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0030-4220(65)90166-0","article-title":"The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats","volume":"20","author":"Kakehashi","year":"1965","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2018.10.014_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11883-006-0072-2","article-title":"Nonconventional genetic risk factors for cardiovascular disease","volume":"8","author":"Tymchuk","year":"2006","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.joen.2018.10.014_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/iej.12710","article-title":"Association between apical periodontitis and cardiovascular diseases: a systematic review of the literature","volume":"50","author":"Berlin-Broner","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.10.014_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jebdp.2014.07.003","article-title":"Chronic apical periodontitis is more common in subjects with coronary artery disease","volume":"14","author":"Caplan","year":"2014","journal-title":"J Evid Based Dent Pract"},{"key":"10.1016\/j.joen.2018.10.014_bib5","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.joen.2016.07.007","article-title":"Association between systemic diseases and apical periodontitis","volume":"42","author":"Khalighinejad","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib6","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.joen.2014.08.013","article-title":"An overview on biologic medications and their possible role in apical periodontitis","volume":"40","author":"Cotti","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib7","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.joen.2013.06.014","article-title":"Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis","volume":"39","author":"Gomes","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12944-015-0156-5","article-title":"Lipids and lipoproteins and inflammatory markers in patients with chronic apical periodontitis","volume":"14","author":"Kimak","year":"2015","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.joen.2018.10.014_bib9","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00784-013-1156-3","article-title":"The association of chronic apical periodontitis and endodontic therapy with atherosclerosis","volume":"18","author":"Petersen","year":"2014","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2018.10.014_bib10","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/iej.12567","article-title":"Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients","volume":"49","author":"Vidal","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.10.014_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijcard.2010.08.011","article-title":"Can a chronic dental infection be considered a cause of cardiovascular disease? A review of the literature","volume":"148","author":"Cotti","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.joen.2018.10.014_bib12","first-page":"527","article-title":"Apical periodontitis and atherosclerosis: is there a link? Review of the literature and potential mechanism of linkage","volume":"48","author":"Berlin-Broner","year":"2017","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2018.10.014_bib13","first-page":"1269","article-title":"Duplicate patient records--implication for missed laboratory results","volume":"2012","author":"Joffe","year":"2012","journal-title":"AMIA Annu Symp Proc"},{"key":"10.1016\/j.joen.2018.10.014_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/iej.12611","article-title":"Pulp sensibility and vitality tests for diagnosing pulpal health in permanent teeth: a critical review","volume":"50","author":"Alghaithy","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.10.014_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1601-1546.2004.00082.x","article-title":"Radiographic manifestations of periapical inflammatory lesions","volume":"8","author":"Gr\u00f6ndahl","year":"2004","journal-title":"Endod Topics"},{"key":"10.1016\/j.joen.2018.10.014_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-9657.1986.tb00119.x","article-title":"The periapical index: a scoring system for radiographic assessment of apical periodontitis","volume":"2","author":"Orstavik","year":"1986","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2018.10.014_bib17","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.joen.2016.03.011","article-title":"Association of radiographically diagnosed apical periodontitis and cardiovascular disease: a hospital records-based study","volume":"42","author":"An","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.joen.2018.10.014_bib19","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.14219\/jada.archive.2009.0311","article-title":"The relationship between self-reported history of endodontic therapy and coronary heart disease in the Atherosclerosis Risk in Communities Study","volume":"140","author":"Caplan","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2018.10.014_bib20","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.joen.2009.01.012","article-title":"Association between chronic dental infection and acute myocardial infarction","volume":"35","author":"Willershausen","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ng.3768","article-title":"Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk","volume":"49","author":"Warren","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.joen.2018.10.014_bib22","doi-asserted-by":"crossref","first-page":"e006465","DOI":"10.1161\/JAHA.117.006465","article-title":"The impact of heterozygous KCNK3 mutations associated with pulmonary arterial hypertension on channel function and pharmacological recovery","volume":"6","author":"Bohnen","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.joen.2018.10.014_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/HYPERTENSIONAHA.116.07564","article-title":"KCNK3 variants are associated with hyperaldosteronism and hypertension","volume":"68","author":"Manichaikul","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.joen.2018.10.014_bib24","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1358\/dot.2005.41.11.917342","article-title":"The role of chronic infection and inflammation in the pathogenesis of cardiovascular and cerebrovascular disease","volume":"41","author":"Diomedi","year":"2005","journal-title":"Drugs Today"},{"key":"10.1016\/j.joen.2018.10.014_bib25","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/0022034516660509","article-title":"Association of endodontic lesions with coronary artery disease","volume":"95","author":"Liljestrand","year":"2016","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2018.10.014_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/00016350310005510","article-title":"Endodontic variables and coronary heart disease","volume":"61","author":"Frisk","year":"2003","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.joen.2018.10.014_bib27","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.joen.2015.03.007","article-title":"Association of functional gene polymorphism with apical periodontitis","volume":"41","author":"Aminoshariae","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib28","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.joen.2010.08.004","article-title":"Hypertension and dental periapical condition","volume":"36","author":"Segura-Egea","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib29","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.joen.2011.03.004","article-title":"Relationship between smoking and endodontic variables in hypertensive patients","volume":"37","author":"Segura-Egea","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.10.014_bib30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ng.3405","article-title":"Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation","volume":"47","author":"Kato","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.joen.2018.10.014_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/35058574","article-title":"Potassium leak channels and the KCNK family of two-P-domain subunits","volume":"2","author":"Goldstein","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.joen.2018.10.014_bib32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/8084","article-title":"Inhalational anesthetics activate two-pore-domain background K+ channels","volume":"2","author":"Patel","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.joen.2018.10.014_bib33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12920-018-0373-7","article-title":"Genetic interaction effects reveal lipid-metabolic and inflammatory pathways underlying common metabolic disease risks","volume":"11","author":"Woo","year":"2018","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.joen.2018.10.014_bib34","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3389\/fimmu.2017.01395","article-title":"Genes critical for developing periodontitis: lessons from mouse models","volume":"8","author":"de Vries","year":"2017","journal-title":"Front Immunol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918307489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918307489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T21:39:11Z","timestamp":1565213951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239918307489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0099239918307489"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2018.10.014","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating Potential Correlations between Endodontic Pathology and Cardiovascular Diseases Using Epidemiological and Genetic Approaches","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2018.10.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}