{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:07:22Z","timestamp":1784804842671,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.joen.2018.11.017","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T09:28:19Z","timestamp":1550914099000},"page":"302-309.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis"],"prefix":"10.1016","volume":"45","author":[{"given":"Jinxin","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijun","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieni","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongtao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2018.11.017_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/08959374940080022001","article-title":"Microbial ecology of dental plaque and its significance in health and disease","volume":"8","author":"Marsh","year":"1994","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2018.11.017_bib2","doi-asserted-by":"crossref","first-page":"e92940","DOI":"10.1371\/journal.pone.0092940","article-title":"Bacterial profile of dentine caries and the impact of pH on bacterial population diversity","volume":"9","author":"Kianoush","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.joen.2018.11.017_bib3","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1128\/JCM.42.7.3023-3029.2004","article-title":"Molecular analysis of the microflora associated with dental caries","volume":"42","author":"Munson","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib4","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1128\/JCM.43.2.843-849.2005","article-title":"Molecular analysis of microbial diversity in advanced caries","volume":"43","author":"Chhour","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2591.1992.tb00941.x","article-title":"Bacterial invasion of non-exposed dental pulp","volume":"25","author":"Hoshino","year":"1992","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2018.11.017_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1590\/1678-775720150448","article-title":"In\u00a0vivo model for microbial invasion of tooth root dentinal tubules","volume":"24","author":"Brittan","year":"2016","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2018.11.017_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0030-4220(66)90143-5","article-title":"The relationship of bacterial penetration and pulpal pathosis in carious teeth","volume":"22","author":"Reeves","year":"1966","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2018.11.017_bib8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0030-4220(94)90178-3","article-title":"Microbiologic factors in endodontology","volume":"78","author":"Seltzer","year":"1994","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2018.11.017_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0099-2399(81)80122-7","article-title":"Inflammatory response of the dental pulp to bacterial irritation","volume":"7","author":"Bergenholtz","year":"1981","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.11.017_bib10","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1128\/JCM.40.5.1698-1704.2002","article-title":"Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis","volume":"40","author":"Martin","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib11","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.joen.2009.09.032","article-title":"Identify and define all diagnostic terms for pulpal health and disease states","volume":"35","author":"Levin","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.11.017_bib12","doi-asserted-by":"crossref","first-page":"e47722","DOI":"10.1371\/journal.pone.0047722","article-title":"Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis","volume":"7","author":"Gross","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.joen.2018.11.017_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1399-302X.2006.00270.x","article-title":"Molecular analysis of bacteria in asymptomatic and symptomatic endodontic infections","volume":"21","author":"Sakamoto","year":"2006","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2018.11.017_bib14","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.joen.2017.03.019","article-title":"Pyrosequencing analysis of cryogenically ground samples from primary and secondary\/persistent endodontic infections","volume":"43","author":"Keskin","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.11.017_bib15","doi-asserted-by":"crossref","first-page":"e0154653","DOI":"10.1371\/journal.pone.0154653","article-title":"Microbiome of deep dentinal caries lesions in teeth with symptomatic irreversible pulpitis","volume":"11","author":"R\u00f4\u00e7as","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2018.11.017_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0099-2399(06)81037-X","article-title":"Correlation between thermal sensitivity and microorganisms isolated from deep carious dentin","volume":"19","author":"Hahn","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.11.017_bib17","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.joen.2015.05.013","article-title":"Advanced caries microbiota in teeth with irreversible pulpitis","volume":"41","author":"Rocas","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.11.017_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1399-302X.1993.tb00539.x","article-title":"The association of carious dentin microflora with tissue changes in human pulpitis","volume":"8","author":"Massey","year":"1993","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2018.11.017_bib19","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.joen.2009.09.029","article-title":"AAE Consensus Conference on Diagnostic Terminology: background and perspectives","volume":"35","author":"Glickman","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2018.11.017_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0022034516639271","article-title":"managing carious lesions: consensus recommendations on carious tissue removal","volume":"28","author":"Schwendicke","year":"2016","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2018.11.017_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jobm.201600358","article-title":"Comparative analysis of bacteria associated with different mosses by 16S rRNA and 16S rDNA sequencing","volume":"57","author":"Tian","year":"2017","journal-title":"J Basic Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib22","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","article-title":"Defining the normal bacterial flora of the oral cavity","volume":"43","author":"Aas","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1534\/genetics.110.114983","article-title":"Statistical design and analysis of RNA sequencing data","volume":"185","author":"Auer","year":"2010","journal-title":"Genetics"},{"issue":"Suppl 1","key":"10.1016\/j.joen.2018.11.017_bib24","first-page":"507","article-title":"Role of intradental A- and C-type nerve fibres in dental pain mechanisms","volume":"88","author":"Narhi","year":"1992","journal-title":"Proc Finn Dent Soc"},{"issue":"Suppl","key":"10.1016\/j.joen.2018.11.017_bib25","doi-asserted-by":"crossref","first-page":"87S","DOI":"10.1016\/0003-9969(94)90193-7","article-title":"Interactions between neural and hydrodynamic mechanisms in dentine and pulp","volume":"39","author":"Matthews","year":"1994","journal-title":"Arch Oral Biol"},{"issue":"Suppl","key":"10.1016\/j.joen.2018.11.017_bib26","doi-asserted-by":"crossref","first-page":"23S","DOI":"10.1016\/0003-9969(94)90184-8","article-title":"The neurophysiological basis and the role of inflammatory reactions in dentine hypersensitivity","volume":"39","author":"Narhi","year":"1994","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2018.11.017_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1747-4477.2003.tb00538.x","article-title":"Carious pulpitis: microbiological and histopathological considerations","volume":"29","author":"Martin","year":"2003","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2018.11.017_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0003-9969(91)90077-8","article-title":"Microbiological studies of carious dentine from human teeth with irreversible pulpitis","volume":"36","author":"Hahn","year":"1991","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2018.11.017_bib29","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1128\/JCM.01410-07","article-title":"Bacteria of dental caries in primary and permanent teeth in children and young adults","volume":"46","author":"Aas","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1128\/JCM.40.3.1001-1009.2002","article-title":"Molecular analysis of bacterial species associated with childhood caries","volume":"40","author":"Becker","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2018.11.017_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/iai.17.1.55-61.1977","article-title":"Sucrose metabolism by prominent members of the flora isolated from cariogenic and non-cariogenic dental plaques","volume":"17","author":"Minah","year":"1977","journal-title":"Infect Immun"},{"key":"10.1016\/j.joen.2018.11.017_bib32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1128\/iai.6.5.723-729.1972","article-title":"Ecology of human oral lactobacilli","volume":"6","author":"Van Houte","year":"1972","journal-title":"Infect Immun"},{"key":"10.1016\/j.joen.2018.11.017_bib33","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/mr.50.4.353-380.1986","article-title":"Role of Streptococcus mutans in human dental decay","volume":"50","author":"Loesche","year":"1986","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.joen.2018.11.017_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1399-302X.1993.tb00581.x","article-title":"Coaggregation of oral lactobacilli with streptococci from the oral cavity","volume":"8","author":"Willcox","year":"1993","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2018.11.017_bib35","first-page":"76","article-title":"Dental plaque as a biofilm: The significance of pH in health and caries","volume":"30","author":"Marsh","year":"2009","journal-title":"Compend Contin Educ Dent"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918308306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239918308306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:46:37Z","timestamp":1758829597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239918308306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0099239918308306"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2018.11.017","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiome of Deep Dentinal Caries from Reversible Pulpitis to Irreversible Pulpitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2018.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}