{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:07:45Z","timestamp":1791652065854,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.joen.2019.02.025","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T17:42:19Z","timestamp":1558028539000},"page":"840-847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Success of Direct Pulp Capping Using Mineral Trioxide Aggregate and Calcium Hydroxide in Mature Permanent Molars with Pulps Exposed during Carious Tissue Removal: 1-year Follow-up"],"prefix":"10.1016","volume":"45","author":[{"given":"Komal","family":"Suhag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigyasa","family":"Duhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sangwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2019.02.025_bib1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0030-4220(65)90166-0","article-title":"The effects of surgical exposures of dental pulps in germfree and conventional laboratory rats","volume":"20","author":"Kakehashi","year":"1965","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2019.02.025_bib2","series-title":"Pathways of the Pulp","article-title":"Vital pulp therapy","author":"Bogen","year":"2006"},{"key":"10.1016\/j.joen.2019.02.025_bib3","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.joen.2017.06.031","article-title":"Direct pulp capping with calcium hydroxide, mineral trioxide aggregate, and biodentine in permanent young teeth with caries: a\u00a0randomized clinical trial","volume":"43","author":"Brizuela","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib4","series-title":"American Association of Endodontists Glossary of Endodontic Terms","year":"2016"},{"key":"10.1016\/j.joen.2019.02.025_bib5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joen.2010.12.004","article-title":"Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review","volume":"37","author":"Aguilar","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib6","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.joen.2014.07.028","article-title":"Direct pulp capping after a carious exposure versus root canal treatment: a cost-effectiveness analysis","volume":"40","author":"Schwendicke","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.14219\/jada.archive.2008.0160","article-title":"Direct pulp capping with mineral trioxide aggregate: an observational study","volume":"139","author":"Bogen","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2019.02.025_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.joen.2013.09.017","article-title":"Gene expression and cytokine release during odontogenic differentiation of human dental pulp stem cells induced by 2 endodontic biomaterials","volume":"40","author":"Asgary","year":"2014","journal-title":"J Endod"},{"issue":"Suppl 7","key":"10.1016\/j.joen.2019.02.025_bib9","doi-asserted-by":"crossref","first-page":"16S","DOI":"10.1177\/0022034513484336","article-title":"Comparison of CaOH with MTA for Direct Pulp\u00a0Capping: A PBRN Randomized Clinical Trial","volume":"92","author":"Hilton","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2019.02.025_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2591.1997.tb00690.x","article-title":"TNF-alpha release in monocytes after exposure to calcium hydroxide treated Escherichia coli LPS","volume":"30","author":"Barthel","year":"1997","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2019.02.025_bib11","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1016\/j.biomaterials.2005.12.020","article-title":"The effect of calcium hydroxide on solubilisation of bio-active dentine matrix components","volume":"27","author":"Graham","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2019.02.025_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jbm.a.31558","article-title":"The formation of tertiary dentin after pulp capping with a calcium phosphate cement, loaded with PLGA microparticles containing TGF-\u03b21","volume":"85","author":"Zhang","year":"2008","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joen.2019.02.025_bib13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004770-200009000-00010","article-title":"Pulp capping of carious exposures: treatment outcome after 5 and 10 years: a retrospective study","volume":"26","author":"Barthel","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib14","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/0030-4220(62)90416-4","article-title":"Pulp cap study","volume":"15","author":"Armstrong","year":"1965","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2341\/09-132-0","article-title":"Keys to clinical success with pulp capping: a review of the literature","volume":"34","author":"Hilton","year":"2009","journal-title":"Oper Dent"},{"key":"10.1016\/j.joen.2019.02.025_bib16","first-page":"4","article-title":"Tunnel defects in dentin bridges: their formation following direct pulp capping","volume":"21","author":"Cox","year":"1996","journal-title":"Oper Dent"},{"key":"10.1016\/j.joen.2019.02.025_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.joen.2012.11.034","article-title":"Prognostic factors for clinical outcomes according to time after direct pulp capping","volume":"39","author":"Cho","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.joen.2015.01.007","article-title":"Clinical outcomes for teeth treated with electro spun poly (\u03b5-caprolactone) fiber meshes\/mineral trioxide aggregate direct pulp capping","volume":"41","author":"Lee","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib19","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/00004770-200312000-00007","article-title":"Mineral trioxide aggregate (MTA) solubility and porosity with different water\u2013to\u2013powder ratios","volume":"29","author":"Fridland","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0099-2399(06)80326-2","article-title":"Dye leakage of four root end filling materials: effects of blood contamination","volume":"20","author":"Torabinejad","year":"1994","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0099-2399(06)81004-6","article-title":"Comparative investigation of marginal adaptation of mineral trioxide aggregate and other commonly used root-end filling materials","volume":"21","author":"Torabinejad","year":"1995","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib22","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/iej.12719","article-title":"Capping carious exposures in adults: a randomized controlled trial investigating mineral trioxide aggregate vs. calcium hydroxide","volume":"50","author":"Kundzina","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2019.02.025_bib23","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.joen.2014.07.019","article-title":"Treatment outcome of mineral trioxide aggregate or calcium hydroxide direct pulp capping: long-term results","volume":"40","author":"Mente","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib24","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.14219\/jada.archive.2006.0116","article-title":"The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study","volume":"137","author":"Al-Hiyasat","year":"2006","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2019.02.025_bib25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2591.2006.01180.x","article-title":"Quality guidelines for endodontic treatment consensus report of the European Society of Endodontology","volume":"39","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2019.02.025_bib26","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.joen.2010.02.024","article-title":"Mineral trioxide aggregate or calcium hydroxide direct pulp capping: an analysis of the clinical treatment outcome","volume":"36","author":"Mente","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.17796\/jcpd.37.4.l3176v7602558853","article-title":"Determining treatability of primary teeth with pulpal exposure","volume":"37","author":"Dogan","year":"2013","journal-title":"J Clin Pediatr Dent"},{"key":"10.1016\/j.joen.2019.02.025_bib28","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.joen.2015.02.024","article-title":"Outcome of direct pulp capping with mineral trioxide aggregate: a prospective study","volume":"41","author":"Marques","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00784-016-1798-z","article-title":"Prognostic factors in direct pulp capping with mineral trioxide aggregate or calcium hydroxide: 2- to 6-year follow-up","volume":"21","author":"Caliskan","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2019.02.025_bib30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.dental.2004.08.008","article-title":"Adverse effects of human pulps after direct pulp capping with the different components from a total-etch, three-step adhesive system","volume":"21","author":"Accorinte Mde","year":"2005","journal-title":"Dent Mater"},{"key":"10.1016\/j.joen.2019.02.025_bib31","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00784-009-0326-9","article-title":"Long-term evaluation of direct pulp capping-Treatment outcomes over an average period of 6.1 years","volume":"14","author":"Dammaschke","year":"2010","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2019.02.025_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-9657.1985.tb00555.x","article-title":"A retrospective study of direct pulp capping with calcium hydroxide compounds","volume":"1","author":"Horsted","year":"1985","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2019.02.025_bib33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0099-2399(96)80017-3","article-title":"A clinical study of direct pulp capping applied to carious-exposed pulps","volume":"22","author":"Matsuo","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib34","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.joen.2018.08.004","article-title":"Outcomes of vital pulp therapy using mineral\u00a0trioxide aggregate or Biodentine: a prospective randomized clinical trial","volume":"44","author":"Awawdeh","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0099-2399(78)80153-8","article-title":"A clinical report on partial pulpotomy and capping with calcium hydroxide in permanent incisors with complicated crown fracture","volume":"4","author":"Cvek","year":"1978","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF03262577","article-title":"Calcium hydroxide vs mineral trioxide aggregates\u00a0for partial pulpotomy of permanent molars with deep caries","volume":"8","author":"Qudeimat","year":"2007","journal-title":"Eur Arch Paediatr Dent"},{"key":"10.1016\/j.joen.2019.02.025_bib37","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-0722.2010.00731.x","article-title":"Treatment of deep caries lesions in adults: randomized clinical trials comparing stepwise vs. direct complete excavation, and direct pulp capping vs. partial pulpotomy","volume":"118","author":"Bjorndal","year":"2010","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2019.02.025_bib38","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.joen.2015.03.015","article-title":"A randomized controlled study of the use of ProRoot mineral trioxide aggregate and Endocem as direct pulp capping materials: 3-month versus 1-year outcomes","volume":"41","author":"Jang","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0022034516639271","article-title":"Managing carious lesions: consensus recommendations on carious tissue removal","volume":"28","author":"Schwendicke","year":"2016","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2019.02.025_bib40","first-page":"261","article-title":"An in\u00a0vivo evaluation of hemorrhage control using sodium hypochlorite and direct capping with a one- or two-component adhesive system in exposed nonhuman primate pulps","volume":"33","author":"Hafez","year":"2002","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2019.02.025_bib41","first-page":"85","article-title":"Clinical and histological evaluation of white ProRoot MTA in direct pulp capping","volume":"19","author":"Iwamoto","year":"2006","journal-title":"Am J Dent"},{"key":"10.1016\/j.joen.2019.02.025_bib42","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1600-0714.1983.tb00348.x","article-title":"Protein synthesis in\u00a0vitro, in the presence of Ca(OH)2 containing pulp-capping medicaments","volume":"12","author":"Hanks","year":"1983","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.joen.2019.02.025_bib43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0099-2399(89)80074-3","article-title":"pH values of pulp-capping agents","volume":"15","author":"Ida","year":"1989","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.02.025_bib44","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.joen.2009.04.023","article-title":"Outcomes of nonsurgical retreatment and endodontic surgery: a systematic review","volume":"35","author":"Torabinejad","year":"2009","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991930202X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991930202X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T17:31:46Z","timestamp":1562002306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923991930202X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S009923991930202X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2019.02.025","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Success of Direct Pulp Capping Using Mineral Trioxide Aggregate and Calcium Hydroxide in Mature Permanent Molars with Pulps Exposed during Carious Tissue Removal: 1-year Follow-up","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2019.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}