{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:51:40Z","timestamp":1790085100080,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.joen.2019.06.014","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T17:01:05Z","timestamp":1565197265000},"page":"1200-1208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Differences in Inflammation and Bone Resorption between Apical Granulomas, Radicular Cysts, and Dentigerous Cysts"],"prefix":"10.1016","volume":"45","author":[{"given":"Manuel","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Ries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"B\u00fcttner-Herold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol-Immanuel","family":"Geppert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Kesting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Wehrhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2019.06.014_bib1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.joen.2007.02.006","article-title":"Proliferation of epithelial cell rests, formation of apical cysts, and regression of apical cysts after periapical wound healing","volume":"33","author":"Lin","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.06.014_bib2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.joen.2014.01.010","article-title":"Immunoexpression of transforming growth factor beta and interferon gamma in radicular and dentigerous cysts","volume":"40","author":"de Moraes","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.06.014_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12105-014-0585-x","article-title":"Odontogenic tumors, WHO 2005: where do we go from here?","volume":"8","author":"Wright","year":"2014","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.joen.2019.06.014_bib4","first-page":"CD005511","article-title":"Endodontic procedures for retreatment of periapical lesions","author":"Del Fabbro","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.joen.2019.06.014_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1067\/moe.2001.116813","article-title":"Study of the expression of CD68+ macrophages and CD8+ T cells in human granulomas and periapical cysts","volume":"92","author":"Rodini","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2019.06.014_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/eji.200636910","article-title":"New vistas on macrophage differentiation and activation","volume":"7","author":"Mantovani","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.joen.2019.06.014_bib7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jacc.2011.01.048","article-title":"Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue","volume":"58","author":"Hirata","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.joen.2019.06.014_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.joen.2019.06.014_bib9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jcms.2014.01.035","article-title":"Small oral squamous cell carcinomas with nodal lymphogenic metastasis show increased infiltration of M2 polarized macrophages--an immunohistochemical analysis","volume":"42","author":"Weber","year":"2014","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.joen.2019.06.014_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00784-017-2123-1","article-title":"Macrophage polarization differs between apical granulomas, radicular cysts, and dentigerous cysts","volume":"22","author":"Weber","year":"2018","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2019.06.014_bib11","doi-asserted-by":"crossref","first-page":"615486","DOI":"10.1155\/2015\/615486","article-title":"Mechanisms of bone resorption in periodontitis","volume":"2015","author":"Hienz","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.joen.2019.06.014_bib12","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.2741\/4547","article-title":"Dynamic monitoring of monocyte HLA-DR expression for the diagnosis, prognosis, and prediction of sepsis","volume":"22","author":"Zhuang","year":"2017","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.joen.2019.06.014_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12791","article-title":"Decidual CD68(+) HLA-DR(+) CD163(-) M1 macrophages increase in miscarriages with normal fetal chromosome","volume":"79","author":"Shimada","year":"2018","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.joen.2019.06.014_bib14","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.3892\/mmr.2016.4998","article-title":"Altered function of monocytes\/macrophages in patients with autoimmune hepatitis","volume":"13","author":"Lin","year":"2016","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.joen.2019.06.014_bib15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/leu.2015.231","article-title":"Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation","volume":"30","author":"Seldon","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.joen.2019.06.014_bib16","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.4049\/jimmunol.1302929","article-title":"Dendritic cell maturation and survival are differentially regulated by TNFR1 and TNFR2","volume":"193","author":"Maney","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2019.06.014_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/jcpe.12636","article-title":"Contribution of biomechanical forces to inflammation-induced bone resorption","volume":"44","author":"Nogueira","year":"2017","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2019.06.014_bib18","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.archoralbio.2011.05.009","article-title":"Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts","volume":"56","author":"de Moraes","year":"2011","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2019.06.014_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/BOR.0000000000000449","article-title":"Inflammation in bone physiology and pathology","volume":"30","author":"Adamopoulos","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.joen.2019.06.014_bib20","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.3892\/mmr.2017.7625","article-title":"High-dose PMA with RANKL and MCSF induces THP1 cell differentiation into human functional osteoclasts in\u00a0vitro","volume":"16","author":"Li","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.joen.2019.06.014_bib21","series-title":"Janeway's Immunobiology","author":"Murphy","year":"2016"},{"key":"10.1016\/j.joen.2019.06.014_bib22","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/infdis\/jix444","article-title":"Homeostatic expansion of CD4+ T cells promotes cortical and trabecular bone loss, whereas CD8+ T cells induce trabecular bone loss only","volume":"216","author":"Weitzmann","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.joen.2019.06.014_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/MED.0000000000000103","article-title":"T-cells and B-cells in osteoporosis","volume":"21","author":"Weitzmann","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1016\/j.joen.2019.06.014_bib24","doi-asserted-by":"crossref","first-page":"E2481","DOI":"10.3390\/ijms18112481","article-title":"Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis","volume":"18","author":"Iacobini","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joen.2019.06.014_bib25","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1186\/s12885-017-3920-2","article-title":"Galectin 3 expression in primary oral squamous cell carcinomas","volume":"17","author":"Weber","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.joen.2019.06.014_bib26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jbspin.2016.02.029","article-title":"Galectin-3: a key player in arthritis","volume":"84","author":"Hu","year":"2017","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.joen.2019.06.014_bib27","first-page":"CD005517","article-title":"Materials for retrograde filling in root canal therapy","volume":"12","author":"Ma","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.joen.2019.06.014_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/sj.ebd.6401284","article-title":"Limited evidence on best material for retrograde root fillings","volume":"19","author":"Ay","year":"2018","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.joen.2019.06.014_bib29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bdj.2014.205","article-title":"Contemporary obturation of the root canal system","volume":"216","author":"Tomson","year":"2014","journal-title":"Br Dent J"},{"key":"10.1016\/j.joen.2019.06.014_bib30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12903-016-0276-y","article-title":"Single-visit endodontic treatment of mature teeth with chronic apical abscesses using mineral trioxide aggregate cement: a randomized clinical trial","volume":"16","author":"Alsulaimani","year":"2016","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.joen.2019.06.014_bib31","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/iej.12843","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part II: other clinical applications and complications","volume":"51","author":"Torabinejad","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2019.06.014_bib32","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.joen.2009.09.010","article-title":"Mineral trioxide aggregate: a comprehensive literature review--part II: leakage and biocompatibility investigations","volume":"36","author":"Torabinejad","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.06.014_bib33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.joen.2013.11.011","article-title":"M2 macrophages participate in the biological tissue healing reaction to mineral trioxide aggregate","volume":"40","author":"Ito","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2019.06.014_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.oraloncology.2015.11.001","article-title":"Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas","volume":"52","author":"Weber","year":"2016","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joen.2019.06.014_bib35","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/bjc.2015.212","article-title":"Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas--an immunohistochemical study","volume":"113","author":"Weber","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1016\/j.joen.2019.06.014_bib36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/iej.12303","article-title":"Anti-inflammatory effects of glutamine on LPS-stimulated human dental pulp cells correlate with activation of MKP-1 and attenuation of the MAPK and NF-kappaB pathways","volume":"48","author":"Kim","year":"2015","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2019.06.014_bib37","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1590\/1807-3107bor-2017.vol31.0106","article-title":"Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts","volume":"31","author":"Silva","year":"2017","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2019.06.014_bib38","first-page":"2677","article-title":"The expression of PD-1 and LAG-3 in periapical lesions","volume":"10","author":"Wang","year":"2018","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.joen.2019.06.014_bib39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri.2017.108","article-title":"The diverse functions of the PD1 inhibitory pathway","volume":"18","author":"Sharpe","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.joen.2019.06.014_bib40","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.archoralbio.2012.02.005","article-title":"Immunohistochemical analysis of FoxP3+ cells in periapical granulomas and radicular cysts","volume":"57","author":"Peixoto","year":"2012","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2019.06.014_bib41","doi-asserted-by":"crossref","first-page":"9089610","DOI":"10.1155\/2016\/9089610","article-title":"The alternative faces of macrophage generate osteoclasts","volume":"2016","author":"Lampiasi","year":"2016","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.joen.2019.06.014_bib42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000365788","article-title":"Treatment of bone metastases in urologic malignancies","volume":"93","author":"Froehner","year":"2014","journal-title":"Urol Int"},{"key":"10.1016\/j.joen.2019.06.014_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jbo.2015.06.001","article-title":"Are adjuvant bisphosphonates now standard of care of women with early stage breast cancer? A debate from the Canadian Bone and the Oncologist New Updates meeting","volume":"4","author":"Jacobs","year":"2015","journal-title":"J Bone Oncol"},{"key":"10.1016\/j.joen.2019.06.014_bib44","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/jop.12036","article-title":"Immunoexpression of RANK, RANKL, OPG, VEGF, and vWF in radicular and dentigerous cysts","volume":"42","author":"de Moraes","year":"2013","journal-title":"J Oral Pathol Med"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239919305047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239919305047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:47:20Z","timestamp":1758829640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239919305047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0099239919305047"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2019.06.014","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences in Inflammation and Bone Resorption between Apical Granulomas, Radicular Cysts, and Dentigerous Cysts","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2019.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}