{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:06:34Z","timestamp":1790755594057,"version":"4.1.0"},"reference-count":111,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jendodon.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.joen.2020.06.037","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T05:52:40Z","timestamp":1600321960000},"page":"S161-S174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"S","title":["Clinical Perspectives of Pulp Regeneration"],"prefix":"10.1016","volume":"46","author":[{"given":"Gottfried","family":"Schmalz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Widbiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin M.","family":"Galler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2020.06.037_bib1","first-page":"125","article-title":"Treatment options: apexogenesis and apexification","volume":"35","author":"Shabahang","year":"2013","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2020.06.037_bib2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.joen.2016.02.007","article-title":"Apical closure in apexification: a review and case report of apexification treatment of an immature permanent tooth with biodentine","volume":"42","author":"Vidal","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jfma.2016.01.010","article-title":"Comparison of mineral trioxide aggregate and calcium hydroxide for apexification of immature permanent teeth: a systematic review and meta-analysis","volume":"115","author":"Lin","year":"2016","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.joen.2020.06.037_bib4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/iej.12843","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part II: other clinical applications and complications","volume":"51","author":"Torabinejad","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-9657.1992.tb00228.x","article-title":"Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha. A retrospective clinical study","volume":"8","author":"Cvek","year":"1992","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2020.06.037_bib6","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/iej.13159","article-title":"Biomechanical performance of an immature maxillary central incisor after revitalization: a finite element analysis","volume":"52","author":"Bucchi","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/0022034517733967","article-title":"Schwann cell phenotype changes in aging human dental pulp","volume":"97","author":"Couve","year":"2018","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/08990229309028828","article-title":"Effects of tooth pulp deafferentation on brainstem neurons of the rat trigeminal subnucleus oralis","volume":"10","author":"Kwan","year":"1993","journal-title":"Somatosens Mot Res"},{"key":"10.1016\/j.joen.2020.06.037_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/08990229509093662","article-title":"Central projections of identified trigeminal primary afferents after molar pulp deafferentation in adult rats","volume":"12","author":"Shortland","year":"1995","journal-title":"Somatosens Mot Res"},{"key":"10.1016\/j.joen.2020.06.037_bib10","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-385198-7.00007-2","article-title":"Peripheral and central mechanisms of orofacial inflammatory pain","volume":"97","author":"Sessle","year":"2011","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.joen.2020.06.037_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1744806917715173","article-title":"Molecular, cellular and behavioral changes associated with pathological pain signaling occur after dental pulp injury","volume":"13","author":"Lee","year":"2017","journal-title":"Mol Pain"},{"key":"10.1016\/j.joen.2020.06.037_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1034\/j.1600-0447.2002.21236.x","article-title":"Quantitative analysis of substance P, neurokinin A and calcitonin gene-related peptide in gingival crevicular fluid associated with painful human teeth","volume":"110","author":"Awawdeh","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2020.06.037_bib13","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/jcpe.12781","article-title":"The innate host response in caries and periodontitis","volume":"44","author":"Meyle","year":"2017","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2020.06.037_bib14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joen.2007.01.002","article-title":"Update on the adaptive immune responses of the dental pulp","volume":"33","author":"Hahn","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/230251","article-title":"Dental pulp defence and repair mechanisms in dental caries","author":"Farges","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2020.06.037_bib16","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/joor.12423","article-title":"Assessment of treatment failure in endodontic therapy","volume":"43","author":"Bergenholtz","year":"2016","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joen.2020.06.037_bib17","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0099-2399(13)00231-8","article-title":"Scope of endodontics: regenerative endodontics","volume":"39","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/iej.12629","article-title":"European Society of Endodontology position statement: revitalization procedures","volume":"49","author":"Galler","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib19","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.joen.2018.09.007","article-title":"Comprehensive characterization of 2 immature teeth treated with regenerative endodontic procedures","volume":"44","author":"Austah","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cden.2016.08.004","article-title":"Regenerative endodontic procedures: clinical outcomes","volume":"61","author":"Diogenes","year":"2017","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joen.2020.06.037_bib21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.joen.2019.02.021","article-title":"Neurotrophic proteins in dentin and their effect on trigeminal sensory neurons","volume":"45","author":"Widbiller","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.17796\/1053-4625-43.5.1","article-title":"Pulp revascularization or apexification for the treatment of immature necrotic permanent teeth: systematic review and meta-analysis","volume":"43","author":"Nicoloso","year":"2019","journal-title":"J Clin Pediatr Dent"},{"key":"10.1016\/j.joen.2020.06.037_bib23","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.joen.2017.06.029","article-title":"Regenerative endodontic treatment or mineral trioxide aggregate apical plug in teeth with necrotic pulps and open apices: a systematic review and meta-analysis","volume":"43","author":"Torabinejad","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib24","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.joen.2017.04.018","article-title":"Regenerative endodontic therapy in the management of nonvital immature permanent teeth: a systematic review-outcome evaluation and meta-analysis","volume":"43","author":"Tong","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00016357.2015.1069394","article-title":"The effectiveness of pulp revascularization in root formation of necrotic immature permanent teeth: a systematic review","volume":"74","author":"Antunes","year":"2016","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.joen.2020.06.037_bib26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.joen.2019.04.005","article-title":"Regenerative endodontic procedures in necrotic mature teeth with periapical radiolucencies: a preliminary randomized clinical study","volume":"45","author":"Arslan","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib27","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.joen.2017.06.023","article-title":"Regenerative endodontics versus apexification in immature permanent teeth with apical periodontitis: a prospective randomized controlled study","volume":"43","author":"Lin","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.joen.2016.10.030","article-title":"Treatment outcomes of apexification or revascularization in nonvital immature permanent teeth: a retrospective study","volume":"43","author":"Silujjai","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.joen.2013.10.027","article-title":"Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols","volume":"40","author":"Nagy","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib30","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00784-015-1555-8","article-title":"Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study","volume":"20","author":"Meschi","year":"2016","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2020.06.037_bib31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/0022034516671499","article-title":"Effect of residual bacteria on the outcome of pulp regeneration in\u00a0vivo","volume":"96","author":"Verma","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib32","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.joen.2018.09.005","article-title":"Effect of residual dental pulp tissue on regeneration of dentin-pulp complex: an in\u00a0vivo investigation","volume":"44","author":"Torabinejad","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib33","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.joen.2017.06.010","article-title":"Microbial factors and antimicrobial strategies in dental pulp regeneration","volume":"43","author":"Fouad","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib34","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.joen.2017.08.037","article-title":"Effect of different treatment options on biomechanics of immature teeth: a finite element stress analysis study","volume":"44","author":"Belli","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib35","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1590\/1807-3107bor-2018.vol32.0075","article-title":"Pulp canal obliteration after traumatic injuries in permanent teeth - scientific fact or fiction?","volume":"32","author":"Bastos","year":"2018","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2020.06.037_bib36","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.joen.2019.07.005","article-title":"Outcome of partial pulpotomy in cariously exposed posterior permanent teeth: a systematic review and meta-analysis","volume":"45","author":"Elmsmari","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib37","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.joen.2015.04.012","article-title":"Direct pulp capping with calcium hydroxide or mineral trioxide aggregate: a meta-analysis","volume":"41","author":"Li","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/edt.12297","article-title":"Cvek pulpotomy-revisited","volume":"32","author":"Bimstein","year":"2016","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2020.06.037_bib39","first-page":"2178535","article-title":"Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial","volume":"24","author":"Uesrichai","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib40","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/iej.12897","article-title":"Interactive effects of LPS and dentine matrix proteins on human dental pulp stem cells","volume":"51","author":"Widbiller","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib41","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.4317\/jced.51305","article-title":"Dental pulp polyps contain stem cells comparable to the normal dental pulps","volume":"6","author":"Attar","year":"2014","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.joen.2020.06.037_bib42","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/jbm.a.35968","article-title":"Could the application of bioactive molecules improve vital pulp therapy success? A systematic review","volume":"105","author":"Luiz de Oliveira da Rosa","year":"2017","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.joen.2020.06.037_bib43","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.joen.2018.11.013","article-title":"Healing capacity of autologous bone marrow-derived mesenchymal stem cells on partially pulpotomized dogs' teeth","volume":"45","author":"El-Zekrid","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib44","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1177\/0022034517725523","article-title":"Implanted dental pulp cells fail to induce regeneration in partial pulpotomies","volume":"96","author":"Mangione","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib45","doi-asserted-by":"crossref","first-page":"39654","DOI":"10.1038\/srep39654","article-title":"Promotion of natural tooth repair by small molecule GSK3 antagonists","volume":"7","author":"Neves","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.joen.2020.06.037_bib46","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12903-019-0917-z","article-title":"Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis","volume":"19","author":"Chen","year":"2019","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.joen.2020.06.037_bib47","first-page":"325","article-title":"Pulp therapy for primary and immature permanent teeth","volume":"39","year":"2017","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2020.06.037_bib48","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/iej.12793","article-title":"Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs","volume":"50","author":"Wolters","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib49","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.joen.2018.03.003","article-title":"Full pulpotomy with biodentine in symptomatic young permanent teeth with carious exposure","volume":"44","author":"Taha","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/iej.12614","article-title":"Mineral trioxide aggregate pulpotomy for permanent molars with clinical signs indicative of irreversible pulpitis: a preliminary study","volume":"50","author":"Qudeimat","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib51","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/edt.12074","article-title":"Pulpal response to sensibility tests after traumatic dental injuries in permanent teeth","volume":"30","author":"Bastos","year":"2014","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2020.06.037_bib52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/0022034511405326","article-title":"Scaffolds for dental pulp tissue engineering","volume":"23","author":"Galler","year":"2011","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib53","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.joen.2018.02.011","article-title":"Cell homing for pulp tissue engineering with endogenous dentin matrix proteins","volume":"44","author":"Widbiller","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2217\/rme.09.5","article-title":"Regeneration of dental pulp after pulpotomy by transplantation of CD31(-)\/CD146(-) side population cells from a canine tooth","volume":"4","author":"Iohara","year":"2009","journal-title":"Regen Med"},{"key":"10.1016\/j.joen.2020.06.037_bib55","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1089\/ten.tec.2013.0148","article-title":"Pulp cell tracking by radionuclide imaging for dental tissue engineering","volume":"20","author":"Souron","year":"2014","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1016\/j.joen.2020.06.037_bib56","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.joen.2016.03.007","article-title":"Simvastatin promotes dental pulp stem cell-induced coronal pulp regeneration in pulpotomized teeth","volume":"42","author":"Jia","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib57","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s10266-016-0283-0","article-title":"Dental pulp tissue engineering of pulpotomized rat molars with bone marrow mesenchymal stem cells","volume":"105","author":"Ito","year":"2017","journal-title":"Odontology"},{"key":"10.1016\/j.joen.2020.06.037_bib58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/ma11010123","article-title":"Effect of exposed surface area, volume and environmental pH on the calcium ion release of three commercially available tricalcium silicate based dental cements","volume":"11","author":"Rajasekharan","year":"2018","journal-title":"Materials"},{"key":"10.1016\/j.joen.2020.06.037_bib59","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.joen.2017.06.008","article-title":"Perspectives for cell-homing approaches to engineer dental pulp","volume":"43","author":"Galler","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib60","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.joen.2017.06.003","article-title":"Signaling molecules and pulp regeneration","volume":"43","author":"Schmalz","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib61","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/iej.12954","article-title":"Regenerative endodontics: a comprehensive review","volume":"51","author":"Kim","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5624\/isd.2014.44.2.103","article-title":"Development of dental charts according to tooth development and eruption for Turkish children and young adults","volume":"44","author":"Karaday\u0131","year":"2014","journal-title":"Imaging Sci Dent"},{"key":"10.1016\/j.joen.2020.06.037_bib63","first-page":"211","article-title":"A new system of dental age assessment","volume":"45","author":"Demirjian","year":"1973","journal-title":"Hum Biol"},{"key":"10.1016\/j.joen.2020.06.037_bib64","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/joor.12474","article-title":"Age-related morphological, histological and functional changes in teeth","volume":"44","author":"Carvalho","year":"2017","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joen.2020.06.037_bib65","doi-asserted-by":"crossref","first-page":"175","DOI":"10.22203\/eCM.v037a11","article-title":"The effects of ageing on dental pulp stem cells, the tooth longevity elixir","volume":"37","author":"Iezzi","year":"2019","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.joen.2020.06.037_bib66","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.archoralbio.2019.01.012","article-title":"Cellular senescence in dental pulp stem cells","volume":"99","author":"Morsczeck","year":"2019","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2020.06.037_bib67","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/0022034513495874","article-title":"The amazing odontoblast: activity, autophagy, and aging","volume":"92","author":"Couve","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib68","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4103\/1735-3327.166187","article-title":"Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature","volume":"12","author":"Akhlaghi","year":"2015","journal-title":"Dent Res J"},{"key":"10.1016\/j.joen.2020.06.037_bib69","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.joen.2009.09.029","article-title":"AAE consensus conference on diagnostic terminology: background and perspectives","volume":"35","author":"Glickman","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib70","first-page":"d90","article-title":"Pulpitis (reversible\/irreversible)","volume":"79","author":"Dabuleanu","year":"2013","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.joen.2020.06.037_bib71","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00004770-200312000-00001","article-title":"Treatment outcome in endodontics: the Toronto study. phase 1: initial treatment","volume":"29","author":"Friedman","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib72","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2591.2007.01322.x","article-title":"Outcome of primary root canal treatment: systematic review of the literature - part 1. Effects of study characteristics on probability of success","volume":"40","author":"Ng","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib73","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.joen.2016.10.027","article-title":"Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: the retrospective study","volume":"43","author":"Linsuwanont","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib74","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.joen.2017.12.010","article-title":"Treatment outcomes of 4 vital pulp therapies in mature molars","volume":"44","author":"Asgary","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib75","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1177\/0022034513505772","article-title":"Dental pulp tissue engineering in full-length human root canals","volume":"92","author":"Rosa","year":"2013","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib76","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1177\/0022034510368647","article-title":"SHED differentiate into functional odontoblasts and endothelium","volume":"89","author":"Sakai","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib77","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2217\/rme.11.3","article-title":"Bioengineering of dental stem cells in a PEGylated fibrin gel","volume":"6","author":"Galler","year":"2011","journal-title":"Regen Med"},{"key":"10.1016\/j.joen.2020.06.037_bib78","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1089\/ten.tea.2009.0518","article-title":"Stem\/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in\u00a0vivo model","volume":"16","author":"Huang","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2020.06.037_bib79","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1089\/ten.tea.2010.0615","article-title":"Complete pulp regeneration after pulpectomy by transplantation of CD105+ stem cells with stromal cell-derived factor-1","volume":"17","author":"Iohara","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2020.06.037_bib80","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.joen.2015.11.021","article-title":"Assessment of pulp regeneration induced by stem cell therapy by magnetic resonance imaging","volume":"42","author":"Iohara","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib81","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.exger.2014.01.020","article-title":"Age-dependent decline in dental pulp regeneration after pulpectomy in dogs","volume":"52","author":"Iohara","year":"2014","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.joen.2020.06.037_bib82","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.joen.2013.02.004","article-title":"The critical apical diameter to obtain regeneration of the pulp tissue after tooth transplantation, replantation, or regenerative endodontic treatment","volume":"39","author":"Laureys","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib83","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13287-017-0506-5","article-title":"Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study","volume":"8","author":"Nakashima","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.joen.2020.06.037_bib84","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.joen.2014.01.014","article-title":"Cell-free approaches for dental pulp tissue engineering","volume":"40","author":"Galler","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib85","first-page":"133","article-title":"Dental pulp regeneration via cell homing","volume":"40","author":"Eramo","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib86","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1016\/j.joen.2017.06.012","article-title":"Regenerative endodontics for adult patients","volume":"43","author":"He","year":"2017","journal-title":"J Endod"},{"issue":"Suppl 4","key":"10.1016\/j.joen.2020.06.037_bib87","doi-asserted-by":"crossref","first-page":"e278","DOI":"10.1111\/iej.12754","article-title":"Dentine matrix proteins: isolation and effects on human pulp cells","volume":"51","author":"Widbiller","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib88","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/iej.12492","article-title":"EDTA conditioning of dentine promotes adhesion, migration and differentiation of dental pulp stem cells","volume":"49","author":"Galler","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib89","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00784-016-1824-1","article-title":"Ultrasonic activation of irrigants increases growth factor release from human dentine","volume":"21","author":"Widbiller","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2020.06.037_bib90","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/s41598-019-41144-x","article-title":"Shotgun proteomics of human dentin with different prefractionation methods","volume":"9","author":"Widbiller","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.joen.2020.06.037_bib91","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/0022034511408426","article-title":"Induced migration of dental pulp stem cells for in\u00a0vivo pulp regeneration","volume":"90","author":"Suzuki","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib92","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1089\/ten.tea.2010.0181","article-title":"Regeneration of dental-pulp-like tissue by chemotaxis-induced cell homing","volume":"16","author":"Kim","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2020.06.037_bib93","first-page":"10261","article-title":"Systemic BMSC homing in the regeneration of pulp-like tissue and the enhancing effect of stromal cell-derived factor-1 on BMSC homing","volume":"8","author":"Zhang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.joen.2020.06.037_bib94","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.joen.2013.09.022","article-title":"Fibrin gel improves tissue ingrowth and cell differentiation in human immature premolars implanted in rats","volume":"40","author":"Ruangsawasdi","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib95","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/ten.tea.2016.0227","article-title":"Effects of stem cell factor on cell homing during functional pulp regeneration in human immature teeth","volume":"23","author":"Ruangsawasdi","year":"2017","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2020.06.037_bib96","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/odi.12227","article-title":"Similar in\u00a0vitro effects and pulp regeneration in ectopic tooth transplantation by basic fibroblast growth factor and granulocyte-colony stimulating factor","volume":"21","author":"Takeuchi","year":"2015","journal-title":"Oral Dis"},{"key":"10.1016\/j.joen.2020.06.037_bib97","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/ten.tea.2016.0555","article-title":"Suitability of different natural and synthetic biomaterials for dental pulp tissue engineering","volume":"24","author":"Galler","year":"2018","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.joen.2020.06.037_bib98","doi-asserted-by":"crossref","first-page":"eaaf3227","DOI":"10.1126\/scitranslmed.aaf3227","article-title":"Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth","volume":"10","author":"Xuan","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.joen.2020.06.037_bib99","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00784-016-1805-4","article-title":"Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis","volume":"20","author":"Segura-Egea","year":"2016","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2020.06.037_bib100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/0022034513504782","article-title":"Comparison of long-term survival of implants and endodontically treated teeth","volume":"93","author":"Setzer","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.06.037_bib101","doi-asserted-by":"crossref","first-page":"S95","DOI":"10.1016\/j.joen.2017.07.012","article-title":"Microbial modulation of stem cells and future directions in regenerative endodontics","volume":"43","author":"Diogenes","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib102","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2014.12.006","article-title":"Autophagy in SDF-1\u03b1-mediated DPSC migration and pulp regeneration","volume":"44","author":"Yang","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2020.06.037_bib103","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/aej.12210","article-title":"Investigation of the regenerative potential of necrotic mature teeth following different revascularisation protocols","volume":"43","author":"Fahmy","year":"2017","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib104","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.joen.2015.09.015","article-title":"Treatment of mature permanent teeth with necrotic pulps and apical periodontitis using regenerative endodontic procedures: a case series","volume":"42","author":"Saoud","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib105","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.joen.2014.07.027","article-title":"Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy","volume":"40","author":"Saoud","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.06.037_bib106","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2591.2012.02113.x","article-title":"Should pulp chamber pulpotomy be seen as a permanent treatment? Some preliminary thoughts","volume":"46","author":"Simon","year":"2013","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.06.037_bib107","doi-asserted-by":"crossref","first-page":"e0167289","DOI":"10.1371\/journal.pone.0167289","article-title":"Biological markers for pulpal inflammation: a systematic review","volume":"11","author":"Rechenberg","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2020.06.037_bib108","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.cyto.2014.05.014","article-title":"Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis","volume":"69","author":"Rechenberg","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.joen.2020.06.037_bib109","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00784-018-2530-y","article-title":"Detection of pulsed blood flow through a molar pulp chamber and surrounding tissue in\u00a0vitro","volume":"23","author":"Kn\u00f6rzer","year":"2019","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2020.06.037_bib110","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00784-013-1115-z","article-title":"In\u00a0vitro optical detection of simulated blood pulse in a human tooth pulp model","volume":"18","author":"Niklas","year":"2014","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2020.06.037_bib111","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/0022034519862258","article-title":"Perivascular-derived mesenchymal stem cells","volume":"98","author":"Yianni","year":"2019","journal-title":"J Dent Res"}],"updated-by":[{"DOI":"10.1016\/j.joen.2020.11.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000}}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239920304489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239920304489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T02:03:21Z","timestamp":1610157801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239920304489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":111,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0099239920304489"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2020.06.037","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.joen.2020.11.011","asserted-by":"object"}]},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Perspectives of Pulp Regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2020.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}