{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:04:47Z","timestamp":1790366687995,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.joen.2020.07.008","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T03:24:49Z","timestamp":1594783489000},"page":"1438-1447.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["A Decellularized Matrix Hydrogel Derived from Human Dental Pulp Promotes Dental Pulp Stem Cell Proliferation, Migration, and Induced Multidirectional Differentiation In\u00a0Vitro"],"prefix":"10.1016","volume":"46","author":[{"given":"Junda","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongshan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2020.07.008_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1747-4477.2003.tb00538.x","article-title":"Carious pulpitis: microbiological and histopathological considerations","volume":"29","author":"Martin","year":"2003","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2020.07.008_bib2","first-page":"661","article-title":"The global burden of oral diseases and risks to oral health","volume":"83","author":"Petersen","year":"2005","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.joen.2020.07.008_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/iej.13064","article-title":"Dissecting dentine\u2013pulp injury and wound healing responses: consequences for regenerative endodontics","volume":"52","author":"Duncan","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.07.008_bib4","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.joen.2009.04.023","article-title":"Outcomes of nonsurgical retreatment and endodontic surgery: a systematic review","volume":"35","author":"Torabinejad","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.008_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-9657.1992.tb00228.x","article-title":"Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha. A retrospective clinical study","volume":"8","author":"Cvek","year":"1992","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.008_bib6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nmat3357","article-title":"Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues","volume":"11","author":"Miller","year":"2012","journal-title":"Nat Mater"},{"key":"10.1016\/j.joen.2020.07.008_bib7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cden.2017.06.009","article-title":"Advanced scaffolds for dental pulp and periodontal regeneration","volume":"61","author":"Bottino","year":"2017","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.joen.2020.07.008_bib8","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1177\/0022034514549809","article-title":"Tissue-engineering-based strategies for regenerative endodontics","volume":"93","author":"Albuquerque","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.07.008_bib9","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.3390\/ma12152347","article-title":"Polymer-based instructive scaffolds for endodontic regeneration","volume":"12","author":"Zein","year":"2019","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.joen.2020.07.008_bib10","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.joen.2008.04.009","article-title":"Dental pulp tissue engineering with stem cells from exfoliated deciduous teeth","volume":"34","author":"Cordeiro","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.008_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/0022034511405326","article-title":"Scaffolds for dental pulp tissue engineering","volume":"23","author":"Galler","year":"2011","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.joen.2020.07.008_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1021\/acsami.7b13727","article-title":"Decellularized liver matrix-modified cryogel scaffolds as potential hepatocyte carriers in bioartificial liver support systems and implantable liver constructs","volume":"10","author":"Damania","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.joen.2020.07.008_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.actbio.2018.04.001","article-title":"Hydrogel derived from porcine decellularized nerve tissue as a promising biomaterial for repairing peripheral nerve defects","volume":"73","author":"Lin","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.joen.2020.07.008_bib14","doi-asserted-by":"crossref","first-page":"118559","DOI":"10.1016\/j.bbamcr.2019.118559","article-title":"Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue","volume":"1867","author":"Alexanian","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.joen.2020.07.008_bib15","doi-asserted-by":"crossref","first-page":"116891","DOI":"10.1016\/j.lfs.2019.116891","article-title":"Synergistic effects of adipose-derived stem cells combined with decellularized myocardial matrix on the treatment of myocardial infarction in rats","volume":"239","author":"Qiao","year":"2019","journal-title":"Life Sci"},{"key":"10.1016\/j.joen.2020.07.008_bib16","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1016\/j.biomaterials.2012.06.051","article-title":"A hydrogel derived from decellularized dermal extracellular matrix","volume":"33","author":"Wolf","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2020.07.008_bib17","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1016\/j.biomaterials.2011.06.008","article-title":"The effect of decellularized bone\/bone marrow produced by high-hydrostatic pressurization on the osteogenic differentiation of mesenchymal stem cells","volume":"32","author":"Hashimoto","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2020.07.008_bib18","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.actbio.2009.02.011","article-title":"Decellularization of bovine corneas for tissue engineering applications","volume":"5","author":"Ponce M\u00e1rquez","year":"2009","journal-title":"Acta Biomater"},{"key":"10.1016\/j.joen.2020.07.008_bib19","doi-asserted-by":"crossref","first-page":"015010","DOI":"10.1088\/1748-6041\/10\/1\/015010","article-title":"Preparation and characterization of a decellularized cartilage scaffold for ear cartilage reconstruction","volume":"10","author":"Utomo","year":"2015","journal-title":"Biomed Mater"},{"key":"10.1016\/j.joen.2020.07.008_bib20","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1177\/0022034517693606","article-title":"Decellularized human dental pulp as a scaffold for regenerative endodontics","volume":"96","author":"Song","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.07.008_bib21","first-page":"9342714","article-title":"Decellularized swine dental pulp as a bioscaffold for pulp regeneration","author":"Hu","year":"2017","journal-title":"Biomed Res Int 2017"},{"key":"10.1016\/j.joen.2020.07.008_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3389\/fphys.2013.00395","article-title":"Extracellular matrix of dental pulp stem cells: applications in pulp tissue engineering using somatic MSCs","volume":"4","author":"Ravindran","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.joen.2020.07.008_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fphys.2014.00036","article-title":"Stem cell sources for tooth regeneration: current status and future prospects","volume":"5","author":"Otsu","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.joen.2020.07.008_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wisniewski","year":"2009","journal-title":"Nat Methods"},{"key":"10.1016\/j.joen.2020.07.008_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10735-007-9148-8","article-title":"Influence of TGF-beta 1 on the expression of BSP, DSP, TGF-beta 1 receptor I and Smad proteins during reparative dentinogenesis","volume":"39","author":"Hwang","year":"2008","journal-title":"J Mol Histol"},{"key":"10.1016\/j.joen.2020.07.008_bib26","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/j.0022-0337.2003.67.6.tb03668.x","article-title":"Vitality of the dentin-pulp complex in health and disease: growth factors as key mediators","volume":"67","author":"Smith","year":"2003","journal-title":"J Dent Educ"},{"key":"10.1016\/j.joen.2020.07.008_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S8756-3282(01)00683-4","article-title":"Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth","volume":"30","author":"Papagerakis","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.joen.2020.07.008_bib28","doi-asserted-by":"crossref","first-page":"1900386","DOI":"10.1002\/adfm.201900386","article-title":"Processed tissue\u2013derived extracellular matrices: tailored platforms empowering diverse therapeutic applications","volume":"30","author":"Krishtul","year":"2019","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.joen.2020.07.008_bib29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.addr.2015.11.019","article-title":"ECM and ECM-like materials - biomaterials for applications in regenerative medicine and cancer therapy","volume":"97","author":"Hinderer","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.joen.2020.07.008_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2017.12.019","article-title":"Extracellular matrix hydrogel therapies: in\u00a0vivo applications and development","volume":"68","author":"Spang","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.joen.2020.07.008_bib31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/iej.12882","article-title":"A biocompatible decellularized pulp scaffold for regenerative endodontics","volume":"51","author":"Matoug-Elwerfelli","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.07.008_bib32","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1177\/0022034518785124","article-title":"Decellularized swine dental pulp tissue for regenerative root canal therapy","volume":"97","author":"Alqahtani","year":"2018","journal-title":"J Dent Res"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239920304957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239920304957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:49:26Z","timestamp":1758829766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239920304957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0099239920304957"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2020.07.008","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Decellularized Matrix Hydrogel Derived from Human Dental Pulp Promotes Dental Pulp Stem Cell Proliferation, Migration, and Induced Multidirectional Differentiation In\u00a0Vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2020.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}