{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:02Z","timestamp":1791216482639,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.joen.2020.07.022","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T02:24:12Z","timestamp":1595903052000},"page":"1610-1615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Regenerative Endodontic Procedures for Traumatized Immature Permanent Teeth with Severe External Root Resorption and Root Perforation"],"prefix":"10.1016","volume":"46","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-3871","authenticated-orcid":false,"given":"Bill","family":"Kahler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2020.07.022_bib1","first-page":"273","article-title":"Luxation of permanent teeth due to trauma. A clinical and radiographic follow-up study of 189 injured teeth","volume":"78","author":"Andreasen","year":"1970","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.joen.2020.07.022_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-9657.1985.tb00583.x","article-title":"Prognosis of luxated permanent teeth--the development of pulp necrosis","volume":"1","author":"Andreasen","year":"1985","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.022_bib3","series-title":"Textbook and Color Atlas of Traumatic Injuries to the Teeth","author":"Andreasen","year":"2019"},{"key":"10.1016\/j.joen.2020.07.022_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-9657.1988.tb00642.x","article-title":"Root resorption \u2013 etiology, terminology and clinical manifestations","volume":"4","author":"Tronstad","year":"1988","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.022_bib5","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1600-9657.2010.00924.x","article-title":"A retrospective study of 889 injured permanent teeth","volume":"26","author":"Hecova","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.022_bib6","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.joen.2018.03.002","article-title":"Incidence of root resorption after the replantation of avulsed teeth: a meta-analysis","volume":"44","author":"Souza","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0099-2399(81)80095-7","article-title":"Relationship between surface and inflammatory root resorption and changes in the pulp after replantation of permanent incisors in monkeys","volume":"7","author":"Andreasen","year":"1981","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0022034516677539","article-title":"Cellular and moleculr pathways leading to external root resorption","volume":"96","author":"Igleias-Linares","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.07.022_bib9","doi-asserted-by":"crossref","first-page":"25103","DOI":"10.1074\/jbc.R109.041087","article-title":"Cellular and molecular mechanisms of bone remodeling","volume":"285","author":"Raggatt","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2020.07.022_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-9657.1986.tb00142.x","article-title":"Effects of calcium hydroxide treatment on periodontal healing and resorption","volume":"2","author":"Hammarstr\u00f6m","year":"1986","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.022_bib12","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.joen.2016.04.028","article-title":"Regenerative endodontic procedures for traumatized teeth after horizontal root fracture, avulsion, and perforating root resorption","volume":"42","author":"Saoud","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib13","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.joen.2015.03.019","article-title":"Revascularization technique for the treatment of external inflammatory root resorption: a report of 3 cases","volume":"41","author":"Santiago","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib14","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/iej.12515","article-title":"The use of a single-step regenerative approach for the treatment of a replanted mandibular central incisor with severe resorption","volume":"49","author":"Chaniotis","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.07.022_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.joen.2017.11.006","article-title":"Management of intruded immature maxillary central incisor with pulp necrosis and severe external root resorption by regenerative approach","volume":"44","author":"Tzanetaki","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.joen.2019.10.023","article-title":"Regenerative endodontics: a potential solution for external root resporption (case series)","volume":"46","author":"Yoshpe","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.joen.2020.07.022_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4248\/BR201301003","article-title":"Osteoclasts: new insights","volume":"1","author":"Feng","year":"2013","journal-title":"Bone Res"},{"key":"10.1016\/j.joen.2020.07.022_bib19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1600-051X.1987.tb01542.x","article-title":"Cellular colonization of denuded root surface in\u00a0vitro: cell morphology in dentin resorption and cementum repair","volume":"14","author":"Lindskog","year":"1987","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2020.07.022_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000147628","article-title":"How repair cementum becomes attached to the resorbed roots of human permanent teeth","volume":"150","author":"Bosshardt","year":"1994","journal-title":"Acta Anat (Basel)"},{"key":"10.1016\/j.joen.2020.07.022_bib21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.joen.2020.07.022_bib22","first-page":"474","article-title":"Cementum and periodontal wound heling and regeneration","volume":"13","author":"Grzesilk","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2020.07.022_bib23","series-title":"Ten Cate\u2019s Oral Biology","author":"Nanci","year":"2017"},{"key":"10.1016\/j.joen.2020.07.022_bib24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/edt.12338","article-title":"Histological assessment of regenerative endodontic treatment in animal studies with different scaffolds: a systematic review","volume":"33","author":"Altaii","year":"2017","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.022_bib25","first-page":"695","article-title":"The developmental biology of cementum","volume":"45","author":"Diekwish","year":"2001","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.joen.2020.07.022_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-9657.1995.tb00462.x","article-title":"Replantation of 400 traumatically avulsed permanent incisors. 2. Factors related to pulpal healing","volume":"11","author":"Andreasen","year":"1995","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2020.07.022_bib27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-2591.2011.01978.x","article-title":"Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis\/abscess to revascularization procedures","volume":"45","author":"Chen","year":"2012","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2020.07.022_bib28","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.joen.2017.06.018","article-title":"Revascularization-associated intracanal calcification: assessment of prevalence and contributing factors","volume":"43","author":"Song","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.joen.2010.10.009","article-title":"Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure","volume":"17","author":"Lovelace","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2020.07.022_bib30","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1177\/0022034515596527","article-title":"Delivery of apical mesenchymal stem cells into root canals of mature teeth","volume":"94","author":"Cherepa","year":"2015","journal-title":"J Dent Res"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239920305367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239920305367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:49:33Z","timestamp":1758829773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239920305367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0099239920305367"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2020.07.022","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regenerative Endodontic Procedures for Traumatized Immature Permanent Teeth with Severe External Root Resorption and Root Perforation","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2020.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}