{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:03:08Z","timestamp":1773961388713,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.joen.2021.06.008","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:00:51Z","timestamp":1623762051000},"page":"1481-1486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Instrumentation Protocols Regarding the Quality of Mesial Canal Preparation in Mandibular Molars: A Micro\u2013computed Tomographic Study"],"prefix":"10.1016","volume":"47","author":[{"given":"Flavia Darius","family":"Vivacqua","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Antonio","family":"Hungaro Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Ricci","family":"Vivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo Priori","family":"Alcalde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renan Diego","family":"Furlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clovis Monteiro","family":"Bramante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2021.06.008_bib1","first-page":"e65","article-title":"Unprepared root canal surface areas: causes, clinical implications, and therapeutic strategies","volume":"18","author":"Siqueira Junior","year":"2018","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2021.06.008_bib2","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/j.1365-2591.2010.01724.x","article-title":"Histological evaluation of the effectiveness of increased apical enlargement for cleaning the apical third of curved canals","volume":"43","author":"Fornari","year":"2010","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib3","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.joen.2016.08.012","article-title":"Efficacy of CM-Wire, M-Wire, and nickel-titanium instruments for removing filling material from curved root canals: a micro\u2013computed tomography study","volume":"42","author":"Rodrigues","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.joen.2014.06.005","article-title":"Behavior of nickel-titanium instruments manufactured with different thermal treatments","volume":"41","author":"Pereira","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.joen.2020.07.017","article-title":"Morphologic changes of apical foramen and microcrack formation after foraminal enlargement: a scanning electron microscopic and micro\u2013computed tomographic analysis","volume":"46","author":"Vieira","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.joen.2009.12.020","article-title":"Preparation of oval-shaped root canals in mandibular molars using nickel-titanium rotay instruments: a micro-computed tomography study","volume":"36","author":"Paqu\u00e9","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib7","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.joen.2012.06.024","article-title":"Effect of different apical preparation sizes on outcome of primary endodontic treatment: a randomized controlled trial","volume":"38","author":"Saini","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib8","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/iej.12873","article-title":"Effects of increased apical enlargement on the amount of unprepared areas and coronal dentine removal: a micro-computed tomography study","volume":"51","author":"Perez","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib9","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1111\/iej.13384","article-title":"The impact of minimally invasive root canal preparation strategies on the ability to shape root canals of mandibular molars","volume":"53","author":"Lima","year":"2020","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2209\/tdcpublication.55.67","article-title":"Effect of \u201capical clearing\u201d and \u201capical foramen widening\u201d on apical ramifications and bacterial load in root canals: an ex-vivo stereomicroscopic study","volume":"55","author":"Yadav","year":"2014","journal-title":"Bull Tokyo Dental Coll"},{"key":"10.1016\/j.joen.2021.06.008_bib11","first-page":"61","article-title":"The effect of size and taper of apical preparation in reducing intra-canal bacteria: a quantitative SEM study","volume":"9","author":"Akhlaghi","year":"2014","journal-title":"Iran Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib12","first-page":"9","article-title":"Influence of apical preparation size on effective conventional irrigation in the apical third: a scanning electron microscopic study","volume":"4","author":"Butcher","year":"2019","journal-title":"Eur Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib13","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.joen.2016.11.009","article-title":"The effect of foraminal enlargement of necrotic teeth with a continuous rotary system on postoperative pain: a randomized controlled trial","volume":"43","author":"Yaylali","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib14","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.joen.2014.06.020","article-title":"The effect of larger apical preparations in the danger zone of lower molars prepared using the Mtwo and Reciproc systems","volume":"40","author":"Sant\u2019Anna Junior","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib15","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.joen.2011.08.019","article-title":"Increased apical enlargement contributes to excessive dentin removal in curved root canals: a stepwise microcomputed tomography study","volume":"37","author":"ElAyouti","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0030-4220(84)90085-9","article-title":"Root canal anatomy of the human permanent teeth","volume":"58","author":"Vertucci","year":"1984","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2021.06.008_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0030-4220(71)90230-1","article-title":"A comparison of canal preparations in straight and curved canals","volume":"32","author":"Schneider","year":"1971","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2021.06.008_bib18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0099-2399(96)80221-4","article-title":"Comparison of nickel-titanium and stainless steel hand-file instrumentation using computed tomography","volume":"22","author":"Gambill","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib19","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.joen.2017.04.012","article-title":"Canal transportation, unprepared areas, and dentin removal after preparation with bt-race and protaper next systems","volume":"43","author":"Brasil","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib20","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.joen.2015.06.007","article-title":"A micro\u2013computed tomographic assessment of root canal preparation with a novel instrument, TRUShape, in mesial roots of mandibular molars","volume":"41","author":"Peters","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.joen.2019.02.012","article-title":"Microcomputed assessment of transportation, centering ratio, canal area, and volume increase after single-file rotary and reciprocating glide path instrumentation in curved root canals: a laboratory study","volume":"45","author":"Ayd\u0131n","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.joen.2019.01.020","article-title":"Determination of the initial apical canal diameter by the first file to bind or cone-beam computed tomographic measurements using micro-computed tomography as the gold standard: an ex\u00a0vivo study in human cadavers","volume":"45","author":"Campello AF","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib23","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.joen.2017.02.004","article-title":"Influence of the apical preparation size and the irrigant type on bacterial reduction in root canal-treated teeth with apical periodontitis","volume":"43","author":"Rodrigues","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2327854","article-title":"Relationship between the apical preparation diameter and the apical seal: an in\u00a0vitro study","volume":"10","author":"Laslami","year":"2018","journal-title":"Int J Dent"},{"key":"10.1016\/j.joen.2021.06.008_bib25","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.joen.2014.11.028","article-title":"Accumulated hard tissue debris produced during reciprocating and rotary nickel-titanium canal preparation","volume":"41","author":"De-Deus","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib26","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1177\/0300060518757607","article-title":"Micro-computed tomographic evaluation of the effect of the final apical size prepared by rotary nickel-titanium files on the removal efficacy of hard-tissue debris","volume":"46","author":"Xu","year":"2018","journal-title":"J Int Med Res"},{"key":"10.1016\/j.joen.2021.06.008_bib27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/aej.12394","article-title":"Influence of foraminal enlargement on the apical extrusion of filling material: volumetric analysis using micro-computed tomography","volume":"46","author":"Albuquerque","year":"2020","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib28","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.joen.2012.04.010","article-title":"One- versus two-visit endodontic treatment of teeth with apical periodontitis: a histobacteriologic study","volume":"38","author":"Vera","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.joen.2018.12.016","article-title":"Prevalence studies on root canal anatomy using cone-beam computed tomographic imaging: a systematic review","volume":"45","author":"Martins","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2021.06.008_bib30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/eos.12303","article-title":"Comparative evaluation of the impact of minimally invasive preparation vs. conventional straight-line preparation on tooth biomechanics: a finite element analysis","volume":"124","author":"Yuan","year":"2016","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2021.06.008_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/iej.13002","article-title":"Influence of size and taper of basic root canal preparation on root canal cleanliness: a scanning electron microscopy study","volume":"52","author":"Plotino","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-2591.2011.01872.x","article-title":"A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health","volume":"44","author":"Ng","year":"2011","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2021.06.008_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1590\/1678-77572016-0230","article-title":"Influence of NiTi alloy on the root canal shaping capabilities of the ProTaper Universal and ProTaper Gold rotary instrument systems","volume":"25","author":"Duque","year":"2017","journal-title":"J Appl Oral Sci"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239921004143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239921004143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:51:57Z","timestamp":1758829917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239921004143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0099239921004143"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2021.06.008","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of Instrumentation Protocols Regarding the Quality of Mesial Canal Preparation in Mandibular Molars: A Micro\u2013computed Tomographic Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2021.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}