{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:38:43Z","timestamp":1782495523996,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.joen.2022.02.002","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T12:46:52Z","timestamp":1644929212000},"page":"632-640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of Anti\u2013Receptor Activator of Nuclear Factor Kappa B Ligand Antibody and Zoledronic Acid on Periapical Lesion Development in Mice"],"prefix":"10.1016","volume":"48","author":[{"given":"Megumi","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2099-7293","authenticated-orcid":false,"given":"Akiko","family":"Karakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideomi","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Azetsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Chatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2022.02.002_bib1","first-page":"449","article-title":"The effects of surgical exposures of dental pulps in germfree and conventional laboratory rats","volume":"34","author":"Kakehashi","year":"1966","journal-title":"J South Calif Dent Assoc"},{"key":"10.1016\/j.joen.2022.02.002_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0003-9969(98)00089-2","article-title":"Enhanced expression of activation-associated molecules on macrophages of heterogeneous populations in expanding periapical lesions in rat molars","volume":"44","author":"Suzuki","year":"1999","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2022.02.002_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0003-9969(98)00094-6","article-title":"Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation","volume":"44","author":"Kawashima","year":"1999","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2022.02.002_bib4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/SPC.0b013e328349731c","article-title":"Denosumab: Benefits of RANK ligand inhibition in cancer patients","volume":"5","author":"Lipton","year":"2011","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.joen.2022.02.002_bib5","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.2010.31.3304","article-title":"Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma","volume":"29","author":"Henry","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.joen.2022.02.002_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/MOU.0b013e3283449e19","article-title":"Contemporary management of metastatic castration-resistant prostate cancer","volume":"21","author":"Sonpavde","year":"2011","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.joen.2022.02.002_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4158\/EP14106.OR","article-title":"Comparison of the efficacy, adverse effects, and cost of zoledronic acid and denosumab in the treatment of osteoporosis","volume":"21","author":"Sheedy","year":"2015","journal-title":"Endocr Pract"},{"key":"10.1016\/j.joen.2022.02.002_bib8","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1006\/bbrc.1999.0252","article-title":"A new member of tumor necrosis factor ligand family, ODF\/OPGL\/TRANCE\/RANKL, regulates osteoclast differentiation and function","volume":"256","author":"Takahashi","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joen.2022.02.002_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/er.2007-0014","article-title":"Receptor activator of nuclear factor \u03baB ligand and osteoprotegerin regulation of bone remodeling in health and disease","volume":"29","author":"Kearns","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.joen.2022.02.002_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","article-title":"Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.joen.2022.02.002_bib11","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1359\/jbmr.2000.15.8.1467","article-title":"Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298","volume":"15","author":"Coxon","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2022.02.002_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bone.2010.11.008","article-title":"Biochemical and molecular mechanisms of action of bisphosphonates","volume":"49","author":"Rogers","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.joen.2022.02.002_bib13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.joen.2020.10.019","article-title":"Prevalence of periapical lesions in patients with osteoporosis","volume":"47","author":"Katz","year":"2021","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.02.002_bib14","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/jbmr.2097","article-title":"RANKL inhibitors induce osteonecrosis of the jaw in mice with periapical disease","volume":"29","author":"Aghaloo","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2022.02.002_bib15","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/jbmr.1894","article-title":"Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice","volume":"28","author":"Kang","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2022.02.002_bib16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1590\/0103-6440201601558","article-title":"Effects of zoledronic acid in experimental periapical lesions in rats: An imaging and histological analysis","volume":"28","author":"Fran\u00e7a","year":"2017","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2022.02.002_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2591.2010.01703.x","article-title":"Effect of alendronate on alveolar bone resorption and angiogenesis in rats with experimental periapical lesions","volume":"43","author":"Xiong","year":"2010","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2022.02.002_bib18","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.joen.2015.04.013","article-title":"Cathepsin K inhibitor regulates inflammation and bone destruction in experimentally induced rat periapical lesions","volume":"41","author":"Suzuki","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.02.002_bib19","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1172\/JCI42528","article-title":"Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation","volume":"120","author":"Nishikawa","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2022.02.002_bib20","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.joen.2022.02.002_bib21","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1101\/gad.1119303","article-title":"Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation","volume":"17","author":"Kim","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.joen.2022.02.002_bib22","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1083\/jcb.127.6.1755","article-title":"Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage","volume":"127","author":"Katagiri","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1016\/j.joen.2022.02.002_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/00220345000790010401","article-title":"Quantification of periapical bone destruction in mice by micro-computed tomography","volume":"79","author":"Balto","year":"2000","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2022.02.002_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0065-1281(80)80021-3","article-title":"Localization of some enzymes in the periodontium of the rat molar","volume":"67","author":"Halackov\u00e1","year":"1980","journal-title":"Acta Histochem"},{"key":"10.1016\/j.joen.2022.02.002_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tripleo.2006.11.036","article-title":"Kinetics of RANKL, RANK and OPG expressions in experimentally induced rat periapical lesions","volume":"103","author":"Kawashima","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2022.02.002_bib26","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.4049\/jimmunol.134.4.2444","article-title":"Interferons as macrophage-activating factors. III. Preferential effects of interferon-\u03b3 on the interleukin 1 secretory potential of fresh or aged human monocytes","volume":"134","author":"Arenzana-Seisdedos","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2022.02.002_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1399-302X.1995.tb00145.x","article-title":"Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure","volume":"10","author":"Tani-Ishii","year":"1995","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2022.02.002_bib28","doi-asserted-by":"crossref","first-page":"19895","DOI":"10.1038\/s41598-019-56151-1","article-title":"Biological effects of anti-RANKL antibody and zoledronic acid on growth and tooth eruption in growing mice","volume":"9","author":"Isawa","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.joen.2022.02.002_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-302x.2000.150301.x","article-title":"Protective and destructive immune reactions in apical periodontitis","volume":"15","author":"M\u00e1rton","year":"2000","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2022.02.002_bib30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1517\/17425255.2015.1000860","article-title":"Denosumab for the treatment of osteoporosis","volume":"11","author":"Zaheer","year":"2015","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.joen.2022.02.002_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/RLU.0000000000002058","article-title":"Impending atypical femoral fracture in a patient of breast cancer with bone metastases receiving long-term denosumab","volume":"43","author":"Sugihara","year":"2018","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.joen.2022.02.002_bib32","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2022.02.002_bib34","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bjoms.2014.01.021","article-title":"Effect of antiresorptive drugs on bony turnover in the jaw: denosumab compared with bisphosphonates","volume":"52","author":"Ristow","year":"2014","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2022.02.002_bib35","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.joms.2014.07.004","article-title":"Bisphosphonate uptake in areas of tooth extraction or periapical disease","volume":"72","author":"Cheong","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2022.02.002_bib36","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tripleo.2003.09.006","article-title":"Endodontic retreatment strategies used by general dental practitioners","volume":"97","author":"Kvist","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923992200108X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923992200108X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:52:50Z","timestamp":1758829970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923992200108X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S009923992200108X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2022.02.002","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Anti\u2013Receptor Activator of Nuclear Factor Kappa B Ligand Antibody and Zoledronic Acid on Periapical Lesion Development in Mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2022.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}