{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:11:55Z","timestamp":1778512315227,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["NRCT5-RSA63001-13"],"award-info":[{"award-number":["NRCT5-RSA63001-13"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["DRF62-001"],"award-info":[{"award-number":["DRF62-001"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.joen.2022.05.002","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T12:11:56Z","timestamp":1652271116000},"page":"1046-1054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Prostacyclin Analog Iloprost Promotes Cementum Formation and Collagen Reattachment of Replanted Molars and Up-regulates Mineralization by Human Periodontal Ligament Cells"],"prefix":"10.1016","volume":"48","author":[{"given":"Sonntana","family":"Seang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichakorn","family":"Chenboonthai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natnicha","family":"Nisaeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araya","family":"Teantongdee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saharat","family":"Jamsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanunchida","family":"Changgnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanika","family":"Yoongkiew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somchai","family":"Yodsanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paksinee","family":"Kamolratanakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sermporn","family":"Thaweesapphithak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thantrira","family":"Pornthaveetus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Everts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanaphum","family":"Osathanont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chalida Nakalekha","family":"Limjeerajarus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2022.05.002_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-9657.2011.01003.x","article-title":"Avulsion of permanent teeth: theory to practice","volume":"27","author":"Trope","year":"2011","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2022.05.002_bib2","first-page":"101","article-title":"A time-related study of periodontal healing and root resorption activity after replantation of mature permanent incisors in monkeys","volume":"4","author":"Andreasen","year":"1980","journal-title":"Swed Dent J"},{"key":"10.1016\/j.joen.2022.05.002_bib3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1600-9657.2010.00914.x","article-title":"Viability of fibroblasts in a novel probiotic storage media","volume":"26","author":"Caglar","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2022.05.002_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0022034512469026","article-title":"Deficiency in acellular cementum and periodontal attachment in bsp null mice","volume":"92","author":"Foster","year":"2012","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2022.05.002_bib5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0031-6997(25)06759-6","article-title":"Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin","volume":"30","author":"Moncada","year":"1978","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.joen.2022.05.002_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-7120-5-41","article-title":"Acute hemodynamic effect of inhaled iloprost in pulmonary artery hypertension evaluated with echocardiography","volume":"5","author":"Loureiro","year":"2007","journal-title":"Cardiovasc Ultrasound"},{"key":"10.1016\/j.joen.2022.05.002_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1183\/09031936.00097107","article-title":"Prostacyclin therapies for the treatment of pulmonary arterial hypertension","volume":"31","author":"Gomberg-Maitland","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.joen.2022.05.002_bib8","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.joen.2019.03.020","article-title":"Prostacyclin analog promotes human dental pulp cell migration via a matrix metalloproteinase 9\u2013related pathway","volume":"45","author":"Seang","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.05.002_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10266-017-0307-4","article-title":"The effect of iloprost on cell proliferation and angiogenesis-related gene expression in human periodontal ligament cells","volume":"106","author":"Jearanaiphaisarn","year":"2018","journal-title":"Odontology"},{"key":"10.1016\/j.joen.2022.05.002_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.joen.2018.02.001","article-title":"Iloprost induces dental pulp angiogenesis in a growth factor\u2013free 3-dimensional organ culture system","volume":"44","author":"Seang","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.05.002_bib11","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.joen.2014.07.002","article-title":"Iloprost induces tertiary dentin formation","volume":"40","author":"Limjeerajarus","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.05.002_bib12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.joen.2013.10.025","article-title":"Iloprost up-regulates vascular endothelial growth factor expression in human dental pulp cells in\u00a0vitro and enhances pulpal blood flow in\u00a0vivo","volume":"40","author":"Limjeerajarus","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.05.002_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2334\/josnusd.17-0368","article-title":"Prolonged release of iloprost enhances pulpal blood flow and dentin bridge formation in a rat model of mechanical tooth pulp exposure","volume":"61","author":"Limjeerajarus","year":"2019","journal-title":"J Oral Sci"},{"key":"10.1016\/j.joen.2022.05.002_bib14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00004770-200312000-00006","article-title":"Effect of dexamethasone on root resorption after delayed replantation of rat tooth","volume":"29","author":"Keum","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.05.002_bib15","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro\u2013computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2022.05.002_bib16","doi-asserted-by":"crossref","first-page":"20140322","DOI":"10.1259\/dmfr.20140322","article-title":"Comparison of mandibular bone microarchitecture between micro-CT and CBCT images","volume":"44","author":"Panmekiate","year":"2015","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.joen.2022.05.002_bib17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1387\/ijdb.11669371","article-title":"The developmental biology of cementum","volume":"45","author":"Diekwisch","year":"2004","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.joen.2022.05.002_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0757.1997.tb00095.x","article-title":"Dental cementum: the dynamic tissue covering of the root","volume":"13","author":"Bosshardt","year":"1997","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.joen.2022.05.002_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ijos.2012.57","article-title":"Methods for studying tooth root cementum by light microscopy","volume":"4","author":"Foster","year":"2012","journal-title":"In J Oral Sci"},{"key":"10.1016\/j.joen.2022.05.002_bib20","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1016\/j.biomaterials.2010.05.024","article-title":"The biomechanical characteristics of the bone-periodontal ligament-cementum complex","volume":"31","author":"Ho","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2022.05.002_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1902\/jop.1980.51.7.386","article-title":"Ultrastructure of regenerating junctional epithelium in the monkey","volume":"51","author":"Braga","year":"1980","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2022.05.002_bib22","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/jcpe.13371","article-title":"Formation and regeneration of a Wnt-responsive junctional epithelium","volume":"47","author":"Yuan","year":"2020","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2022.05.002_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.22203\/eCM.v033a03","article-title":"Relevance of osteoclast-specific enzyme activities in cell-based in\u00a0vitro resorption assays","volume":"33","author":"Bernhardt","year":"2017","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.joen.2022.05.002_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1097-0185(199606)245:2<327::AID-AR15>3.0.CO;2-R","article-title":"Periodontal ligament cell populations: the central role of fibroblasts in creating a unique tissue","volume":"245","author":"Lekic","year":"1996","journal-title":"Anat Rec"},{"key":"10.1016\/j.joen.2022.05.002_bib25","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1177\/00220345900690100801","article-title":"Formation of acellular root cementum in to dental and non-dental hard tissues in the rat","volume":"69","author":"Beertsen","year":"1990","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2022.05.002_bib26","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0099-2399(98)80166-0","article-title":"Reparative dentin formation in rat molars after direct pulp capping with growth factors","volume":"24","author":"Hu","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.05.002_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/(SICI)1097-0185(199606)245:2<267::AID-AR12>3.0.CO;2-N","article-title":"Cementogenesis reviewed: a comparison between human premolars and rodent molars","volume":"245","author":"Bosshardt","year":"1996","journal-title":"Anat Rec"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239922003405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239922003405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:34:33Z","timestamp":1778510073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239922003405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0099239922003405"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2022.05.002","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Prostacyclin Analog Iloprost Promotes Cementum Formation and Collagen Reattachment of Replanted Molars and Up-regulates Mineralization by Human Periodontal Ligament Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2022.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}