{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:39:47Z","timestamp":1770701987588,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.joen.2022.12.005","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T19:52:04Z","timestamp":1670961124000},"page":"262-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Risk for Acute Periapical Abscesses in Multiple Sclerosis Patients and the Possible Association with Epstein-Barr Virus"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-4260","authenticated-orcid":false,"given":"Ilan","family":"Rotstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-8149","authenticated-orcid":false,"given":"Joseph","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2022.12.005_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/cdoe.12512","article-title":"A systematic review of oral health in people with multiple sclerosis","volume":"48","author":"Manchery","year":"2020","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.joen.2022.12.005_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/bmb\/ldq017","article-title":"Multiple sclerosis: a practical overview for clinicians","volume":"95","author":"Rejdak","year":"2010","journal-title":"Br Med Bull"},{"key":"10.1016\/j.joen.2022.12.005_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1474-4422(20)30432-4","article-title":"Paediatric multiple sclerosis and antibody-associated demyelination: clinical, imaging, and biological considerations for diagnosis and care","volume":"20","author":"Fadda","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.joen.2022.12.005_bib4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1177\/1352458516634871","article-title":"Aging and multiple sclerosis","volume":"19","author":"Sanai","year":"2016","journal-title":"Mult Scler J"},{"key":"10.1016\/j.joen.2022.12.005_bib5","first-page":"402","article-title":"Multiple sclerosis and aging","volume":"15","author":"Louapre","year":"2017","journal-title":"Geriatr Psychol Neuropsychiatr Vieil"},{"key":"10.1016\/j.joen.2022.12.005_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12883-018-1026-3","article-title":"Pediatric multiple sclerosis: a review","volume":"18","author":"Alroughani","year":"2018","journal-title":"BMC Neurol"},{"key":"10.1016\/j.joen.2022.12.005_bib7","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1172\/JCI73408","article-title":"Enhanced sphin- gosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility","volume":"124","author":"Cruz-Orengo","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2022.12.005_bib8","first-page":"22","article-title":"Symptomatic management and rehabilitation in multiple sclerosis","volume":"71","author":"Thompson","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.joen.2022.12.005_bib9","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1515\/revneuro-2017-0011","article-title":"Cognitive impairment in multiple sclerosis\u2014a review of current knowledge and recent research","volume":"28","author":"Grzegorski","year":"2017","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.joen.2022.12.005_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrneurol.2016.187","article-title":"Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis","volume":"13","author":"Olsson","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.joen.2022.12.005_bib11","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1177\/1352458512453362","article-title":"Bone health and multiple sclerosis","volume":"18","author":"Dobson","year":"2012","journal-title":"Mult Scler"},{"key":"10.1016\/j.joen.2022.12.005_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/sj.bdj.4800255a","article-title":"Multiple sclerosis, dental caries and fillings: a case-control study","volume":"187","author":"McGrother","year":"1999","journal-title":"Br Dent J"},{"key":"10.1016\/j.joen.2022.12.005_bib13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/ene.12103","article-title":"Association between multiple sclerosis and chronic periodontitis: a population-based pilot study","volume":"20","author":"Sheu","year":"2013","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.joen.2022.12.005_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/cdoe.12263","article-title":"How do Australians living with MS experience oral health and accessing dental care? A focus group study","volume":"45","author":"Pateman","year":"2016","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.joen.2022.12.005_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41432-021-0159-1","article-title":"Is there an association between multiple sclerosis and oral health?","volume":"22","author":"Al-Ansari","year":"2021","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.joen.2022.12.005_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jns.2016.01.013","article-title":"Epstein-Barr virus and multiple sclerosis. From evidence to therapeutic strategies","volume":"361","author":"Fern\u00e1ndez-Men\u00e9ndez","year":"2016","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.joen.2022.12.005_bib17","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/1744666X.2021.1847642","article-title":"The role of Epstein-Barr virus in the etiology of multiple sclerosis: a current review","volume":"16","author":"Ruprecht","year":"2020","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.joen.2022.12.005_bib18","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.joen.2022.12.005_bib19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJM200008173430707","article-title":"Epstein-Barr virus infection","volume":"343","author":"Cohen","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joen.2022.12.005_bib20","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/jclinpath-2019-205822","article-title":"Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors","volume":"72","author":"Kerr","year":"2019","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.joen.2022.12.005_bib21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/odi.12656","article-title":"Epstein-Barr virus in the pathogenesis of oral cancers","volume":"24","author":"Guidry","year":"2018","journal-title":"Oral Dis"},{"key":"10.1016\/j.joen.2022.12.005_bib22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/cre2.435","article-title":"Human papillomavirus, Epstein-Barr virus, and Candida albicans co-infection in oral leukoplakia with different degrees of dysplasia","volume":"7","author":"Erira","year":"2021","journal-title":"Clin Exp Dent Res"},{"key":"10.1016\/j.joen.2022.12.005_bib23","doi-asserted-by":"crossref","first-page":"e0258109","DOI":"10.1371\/journal.pone.0258109","article-title":"Association between Epstein-Barr virus and periodontitis: a meta-analysis","volume":"16","author":"Maulani","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2022.12.005_bib24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/v13020250","article-title":"Epstein-Barr Virus and Peri-Implantitis: a Systematic Review and Meta-Analysis","volume":"13","author":"Roca-Millan","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.joen.2022.12.005_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1034\/j.1399-302X.2003.00079.x","article-title":"Cytomegalovirus and Epstein-Barr virus are associated with symptomatic periapical pathosis","volume":"18","author":"Sabeti","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2022.12.005_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1034\/j.1399-302X.2003.00055.x","article-title":"Cytomegalovirus and Epstein-Barr virus DNA transcription in endodontic symptomatic lesions","volume":"18","author":"Sabeti","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2022.12.005_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.joen.2008.09.017","article-title":"Herpesviruses in endodontic pathoses: association of Epstein-Barr virus with irreversible pulpitis and apical periodontitis","volume":"35","author":"Li","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib28","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.joen.2010.06.008","article-title":"Prevalence and activity of Epstein-Barr virus and human cytomegalovirus in symptomatic and asymptomatic apical periodontitis lesions","volume":"36","author":"Hern\u00e1di","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib29","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.joen.2015.08.027","article-title":"Human cytomegalovirus and Epstein-Barr virus genotypes in apical periodontitis lesions","volume":"41","author":"Jakovljevic","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib30","doi-asserted-by":"crossref","first-page":"e0121548","DOI":"10.1371\/journal.pone.0121548","article-title":"Epstein-Barr virus infection in chronically inflamed periapical granulomas","volume":"10","author":"Makino","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2022.12.005_bib31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s10266-015-0200-y","article-title":"Viruses in pulp and periapical inflammation: a review","volume":"104","author":"Hern\u00e1ndez Vigueras","year":"2016","journal-title":"Odontology"},{"key":"10.1016\/j.joen.2022.12.005_bib32","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.joen.2020.08.015","article-title":"Diabetes mellitus and periapical abscess: a cross-sectional Study","volume":"46","author":"Saleh","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib33","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.adaj.2021.01.005","article-title":"The association of apical periodontitis and type 2 diabetes mellitus: a large hospital network cross-sectional case-controlled study","volume":"152","author":"Yip","year":"2021","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2022.12.005_bib34","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.joen.2019.03.003","article-title":"Association of apical periodontitis with cardiovascular disease via noninvasive assessment of endothelial function and subclinical atherosclerosis","volume":"45","author":"Chauhan","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib35","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1177\/1352458510368985","article-title":"Osteoporosis in multiple sclerosis","volume":"16","author":"Hearn","year":"2010","journal-title":"Mult Scler"},{"key":"10.1016\/j.joen.2022.12.005_bib36","first-page":"5","article-title":"Osteoporosis in multiple sclerosis: a frequent, serious, and under-recognized problem","volume":"2","author":"Herndon","year":"2000","journal-title":"In J MS Care"},{"key":"10.1016\/j.joen.2022.12.005_bib37","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1007\/s00198-011-1644-8","article-title":"Bone health in multiple sclerosis","volume":"22","author":"Gibson","year":"2011","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.joen.2022.12.005_bib38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.joen.2020.10.019","article-title":"Prevalence of periapical lesions in patients with osteoporosis","volume":"47","author":"Katz","year":"2021","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tripleo.2005.04.010","article-title":"Oral implications of osteoporosis","volume":"100","author":"Dervis","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/1352458506070605","article-title":"Interferon-beta modulates bone-associated cytokines and osteoclast precursor activity in multiple sclerosis patients","volume":"12","author":"Weinstock-Guttman","year":"2006","journal-title":"Mult Scler"},{"key":"10.1016\/j.joen.2022.12.005_bib41","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.joen.2011.09.026","article-title":"Significance of human cytomegalovirus and Epstein-Barr virus in inducing cytokine expression in periapical lesions","volume":"38","author":"Sabeti","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00004770-200305000-00002","article-title":"Cytomegalovirus and Epstein-Barr virus active infection in periapical lesions of teeth with intact crowns","volume":"29","author":"Sabeti","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2022.12.005_bib43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00004770-200402000-00001","article-title":"Herpesviral-bacterial coinfection in periapical pathosis","volume":"30","author":"Sabeti","year":"2004","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239922008287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239922008287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:53:57Z","timestamp":1758830037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239922008287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0099239922008287"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2022.12.005","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Risk for Acute Periapical Abscesses in Multiple Sclerosis Patients and the Possible Association with Epstein-Barr Virus","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2022.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}