{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:54:52Z","timestamp":1793987692427,"version":"4.8.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["PROINPEP 249495-2019"],"award-info":[{"award-number":["PROINPEP 249495-2019"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["PROINPEP 254801-2020"],"award-info":[{"award-number":["PROINPEP 254801-2020"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"publisher","award":["PROSNI 2017-2021"],"award-info":[{"award-number":["PROSNI 2017-2021"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.joen.2023.07.001","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T20:54:11Z","timestamp":1688763251000},"page":"1090-1098","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Serum Levels of Cytokines in Acute Apical Abscess: A Longitudinal Observational Study"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-4186","authenticated-orcid":false,"given":"Claudia Azucena","family":"Palafox-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-4362","authenticated-orcid":false,"given":"Alvaro","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Celeste","family":"Salazar-Camarena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gerardo","family":"Gasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-7846","authenticated-orcid":false,"given":"Luciano Tavares Angelo","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Francisco","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Garc\u00eda-Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1488-0366","authenticated-orcid":false,"given":"Carlos","family":"Estrela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Annahi","family":"Menchaca-Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2023.07.001_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190469","article-title":"Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis","volume":"13","author":"R\u00f4\u00e7as","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2023.07.001_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/CMR.00082-12","article-title":"Microbiology and treatment of acute apical abscesses","volume":"26","author":"Siqueira","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.joen.2023.07.001_bib3","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.3402\/jom.v3i0.5304","article-title":"Review of osteoimmunology and the host response in endodontic and periodontal lesions","volume":"3","author":"Graves","year":"2011","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.joen.2023.07.001_bib4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/154411130401500604","article-title":"Pathogenesis of apical periodontitis and the causes of endodontic failures","volume":"15","author":"Nair","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2023.07.001_bib5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1034\/j.1600-0447.2002.11227.x","article-title":"Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats","volume":"110","author":"Lin","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2023.07.001_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.joen.2016.01.022","article-title":"Multiple apical periodontitis influences serum levels of cytokines and nitric oxide","volume":"42","author":"Cintra","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib7","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/iej.12196","article-title":"The role of IL-6 on apical periodontitis: a systematic review","volume":"47","author":"Azuma","year":"2014","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.07.001_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-0722.2000.108003195.x","article-title":"Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry","volume":"108","author":"Walker","year":"2000","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2023.07.001_bib9","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.joen.2012.02.021","article-title":"Correlation between clinical\/radiographic features and inflammatory cytokine networks produced by macrophages stimulated with endodontic content","volume":"38","author":"Martinho","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib10","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S1079-2104(03)00067-2","article-title":"Immunolocalization of interleukin 4, interleukin 6, and lymphotoxin \u03b1 in dental granulomas","volume":"96","author":"Rosa de S\u00e1","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2007\/38210","article-title":"Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions","volume":"2007","author":"Brekalo Pr\u0161o","year":"2007","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2023.07.001_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1034\/j.1399-302X.2003.180102.x","article-title":"Interleukin-6 and granulocyte-macrophage colony-stimulating factor in apical periodontitis: correlation with clinical and histologic findings of the involved teeth","volume":"18","author":"Radics","year":"2003","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2023.07.001_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2591.1992.tb01154.x","article-title":"Influence of surgical treatment of periapical lesions on serum and blood levels of inflammatory mediators","volume":"25","author":"Marton","year":"1992","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.07.001_bib14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joen.2023.07.001_bib15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s10266-021-00636-x","article-title":"Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions","volume":"109","author":"Cintra","year":"2021","journal-title":"Odontology"},{"key":"10.1016\/j.joen.2023.07.001_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/iej.13789","article-title":"Impact of systemic health on treatment outcomes in endodontics","volume":"56","author":"Segura-Egea","year":"2023","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.07.001_bib17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.joen.2016.01.018","article-title":"Cytokine expression in patients hospitalized for severe odontogenic infection in Brazil","volume":"42","author":"Sette-Dias","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib18","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.joen.2017.08.015","article-title":"AAE position statement: AAE guidance on the use of systemic antibiotics in endodontics","volume":"43","author":"Document","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.joen.2018.11.014","article-title":"Elevated systemic inflammatory burden and cardiovascular risk in young adults with endodontic apical lesions","volume":"45","author":"Garrido","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2591.2007.01272.x","article-title":"Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses","volume":"40","author":"De S\u00e1","year":"2007","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.07.001_bib21","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.joen.2019.07.017","article-title":"Apical periodontitis is associated with elevated concentrations of inflammatory mediators in peripheral blood: a systematic review and meta-analysis","volume":"45","author":"Georgiou","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib22","first-page":"1","article-title":"Glossary of Endodontic Terms 2016","volume":"10","year":"2020","journal-title":"Gloss Endod Terms"},{"key":"10.1016\/j.joen.2023.07.001_bib23","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"Eke","year":"2012","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2023.07.001_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-9657.1986.tb00119.x","article-title":"The periapical index: a scoring system for radiographic assessment of apical periodontitis","volume":"2","author":"\u00d8rstavik","year":"1986","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2023.07.001_bib25","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1128\/IAI.68.8.4746-4751.2000","article-title":"Interleukin-1 receptor signaling rather than that of tumor necrosis factor is critical in protecting the host from the severe consequences of a polymicrobe anaerobic infection","volume":"68","author":"GD","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.joen.2023.07.001_bib26","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.joen.2015.11.012","article-title":"Immune-inflammatory cell profile and receptor activator of nuclear factor kappa B ligand\/osteoprotegerin expression in persistent apical periodontitis after root canal retreatment failure","volume":"42","author":"Estrela","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib27","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.joen.2014.08.013","article-title":"An overview on biologic medications and their possible role in apical periodontitis","volume":"40","author":"Cotti","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib28","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.joen.2011.09.006","article-title":"Association of endodontic infection with detection of an initial lesion to the cardiovascular system","volume":"37","author":"Cotti","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.07.001_bib29","first-page":"586","article-title":"Serum interleukin-6 as a serologic marker of chronic periapical lesions; a case-control study","volume":"4","author":"Bakhtiari","year":"2010","journal-title":"HealthMED"},{"issue":"4","key":"10.1016\/j.joen.2023.07.001_bib30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/iej.13879","article-title":"TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: association with apical periodontitis","volume":"56","author":"Cruz","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.07.001_bib31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/aej.12072","article-title":"Pro-inflammatory cytokine levels in human apical periodontitis: correlation with clinical and histological findings","volume":"41","author":"Jakovljevic","year":"2015","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2023.07.001_bib32","doi-asserted-by":"crossref","first-page":"S294","DOI":"10.1086\/513856","article-title":"Cytokines as endogenous pyrogens","volume":"179","author":"Dinarello","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.joen.2023.07.001_bib33","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00784-017-2222-z","article-title":"Endodontic infections increase leukocyte and lymphocyte levels in the blood","volume":"22","author":"Samuel","year":"2018","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2023.07.001_bib34","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1182\/blood.V80.8.2012.2012","article-title":"Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products","volume":"80","author":"Colotta","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.joen.2023.07.001_bib35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10238-014-0315-4","article-title":"Association of interleukin-10 promoter haplotypes with disease susceptibility and IL-10 levels in Mexican patients with systemic lupus erythematosus","volume":"15","author":"Palafox-S\u00e1nchez","year":"2015","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.joen.2023.07.001_bib36","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.4049\/jimmunol.165.7.3626","article-title":"IL-10, but Not IL-4, suppresses infection-stimulated bone resorption in\u00a0vivo","volume":"165","author":"Sasaki","year":"2000","journal-title":"J Immunol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239923003928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239923003928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:05:04Z","timestamp":1777478704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239923003928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0099239923003928"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2023.07.001","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of Serum Levels of Cytokines in Acute Apical Abscess: A Longitudinal Observational Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2023.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}