{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:54:08Z","timestamp":1787982848971,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.joen.2023.08.013","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T11:15:34Z","timestamp":1692962134000},"page":"1480-1486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Symptomatic Irreversible Pulpitis Induces Increased Levels of Human NLRP3 in Gingival Crevicular Fluid Compared to Saliva: A Case Control Observational Study"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-6689","authenticated-orcid":false,"given":"Dax","family":"Abraham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-9486","authenticated-orcid":false,"given":"Arundeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-3237","authenticated-orcid":false,"given":"Anjana","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2023.08.013_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00004770-200003000-00012","article-title":"Pulpal pain diagnosis-a review","volume":"26","author":"Bender","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1747-4477.2000.tb00144.x","article-title":"Reversible and irreversible painful pulpitides: diagnosis and treatment","volume":"26","author":"Bender","year":"2000","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2023.08.013_bib3","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0030-4220(63)90201-9","article-title":"The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp","volume":"16","author":"Seltzer","year":"1963","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2023.08.013_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2591.1980.tb00834.x","article-title":"Clinical signs and symptoms in pulp disease","volume":"13","author":"Dummer","year":"1980","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.08.013_bib5","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/00220345650440041301","article-title":"Dental pulp hemogram","volume":"44","author":"Guthrie","year":"1965","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2023.08.013_bib6","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.joen.2017.02.009","article-title":"Pulp inflammation diagnosis from clinical to inflammatory mediators: a systematic review","volume":"43","author":"Zanini","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/00016358309162331","article-title":"Vascular reactions in the dental pulp during inflammation","volume":"41","author":"T\u00f8nder","year":"1983","journal-title":"Acta Odontol Scand"},{"issue":"Suppl 1","key":"10.1016\/j.joen.2023.08.013_bib8","first-page":"387","article-title":"Effects of selected inflammatory mediators on blood flow and vascular permeability in the dental pulp","volume":"88","author":"Kim","year":"1992","journal-title":"Proc Finn Dent Soc"},{"key":"10.1016\/j.joen.2023.08.013_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jdent.2010.05.016","article-title":"Inflammation-regeneration interplay in the dentine-pulp complex","volume":"38","author":"Cooper","year":"2010","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2023.08.013_bib10","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/j.joen.2017.06.011","article-title":"Inflammation and regeneration in the dentin-pulp complex: net gain or net loss?","volume":"43","author":"Cooper","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00441-015-2118-7","article-title":"Activation of the NLRP3\/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts","volume":"361","author":"Jiang","year":"2015","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.joen.2023.08.013_bib12","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3389\/fimmu.2019.02538","article-title":"Pharmacological inhibitors of the NLRP3 inflammasome","volume":"10","author":"Zahid","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.joen.2023.08.013_bib13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.joen.2023.08.013_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1590\/S1678-77572009000500031","article-title":"Interleukin-1 beta and interleukin-8 in healthy and inflamed dental pulps","volume":"17","author":"Silva","year":"2009","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2023.08.013_bib15","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.joen.2020.06.008","article-title":"Dysregulation of inflammasomes in human dental pulp cells exposed to porphyromonas gingivalis and Fusobacterium nucleatum","volume":"46","author":"Aral","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib16","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"22","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.joen.2023.08.013_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/imr.12296","article-title":"Regulation of inflammasome activation","volume":"265","author":"Man","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.joen.2023.08.013_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2008.02.005","article-title":"The NLR gene family: a standard nomenclature","volume":"28","author":"Ting","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.joen.2023.08.013_bib19","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.joen.2012.09.023","article-title":"NLRP3 is expressed in human dental pulp cells and tissues","volume":"38","author":"Song","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib20","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1902\/jop.2017.170244","article-title":"Salivary levels of NLRP3 inflammasome-related proteins as potential biomarkers of periodontal clinical status","volume":"88","author":"Isaza-Guzm\u00e1n","year":"2017","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2023.08.013_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/jisp.jisp_5_21","article-title":"Comparative evaluation of the levels of nod-like receptor family pyrin domain-containing protein (NLRP) 3 in saliva of subjects with chronic periodontitis and healthy controls","volume":"26","author":"Mitra","year":"2022","journal-title":"J Indian Soc Periodontol"},{"key":"10.1016\/j.joen.2023.08.013_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cobeha.2019.01.007","article-title":"Salivary biomarkers in psychoneuroimmunology","volume":"28","author":"Engeland","year":"2019","journal-title":"Curr Opin Behav Sci"},{"key":"10.1016\/j.joen.2023.08.013_bib23","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3390\/molecules26051208","article-title":"Gingival crevicular fluid (GCF): a diagnostic tool for the detection of periodontal health and diseases","volume":"26","author":"Fatima","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.joen.2023.08.013_bib24","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017724","article-title":"Effect of combined periodontal-orthodontic treatment on NOD-like receptor protein 3 and high mobility group box-1 expressions in patients with periodontitis and its clinical significance","volume":"98","author":"Yu","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.joen.2023.08.013_bib25","article-title":"Effectiveness of diagnosing pulpitis: a systematic review","author":"Donnermeyer","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2023.08.013_bib26","first-page":"25","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"19","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joen.2023.08.013_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/febs.13133","article-title":"Structural mechanisms of inflammasome assembly","volume":"282","author":"Lu","year":"2015","journal-title":"FEBS J"},{"key":"10.1016\/j.joen.2023.08.013_bib28","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/0022034509341779","article-title":"Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts","volume":"88","author":"Hirao","year":"2009","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2023.08.013_bib29","first-page":"15","article-title":"Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives","volume":"8","author":"Ozaki","year":"2015","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.joen.2023.08.013_bib30","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.joen.2020.07.013","article-title":"Comparison of neurokinin A, substance P, interleukin 8, and matrix metalloproteinase-8 changes in pulp tissue and gingival crevicular fluid samples of healthy and symptomatic irreversible pulpitis teeth","volume":"46","author":"Akbal Dincer","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/00004770-200201000-00005","article-title":"Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps","volume":"28","author":"Artese","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2023.08.013_bib32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0099-2399(96)80242-1","article-title":"Neurogenic inflammation and tooth pulp innervation pattern in sympathectomized rats","volume":"22","author":"Komorowski","year":"1996","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239923005071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239923005071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:55:46Z","timestamp":1758830146000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239923005071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0099239923005071"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2023.08.013","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Symptomatic Irreversible Pulpitis Induces Increased Levels of Human NLRP3 in Gingival Crevicular Fluid Compared to Saliva: A Case Control Observational Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2023.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}