{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:04:56Z","timestamp":1766869496130,"version":"3.37.3"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.joen.2024.01.018","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T16:19:08Z","timestamp":1706890748000},"page":"499-505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation Between Proinflammatory Cytokine Expression and Clinical Data in Apical Granuloma"],"prefix":"10.1016","volume":"50","author":[{"given":"Renata C.V.","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana T.M.","family":"Porpino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilton","family":"Dessaune-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique S.","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina M.M.C.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Provenzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio R.","family":"Pires","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 F.","family":"Siqueira Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Armada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2024.01.018_bib1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.joen.2016.03.008","article-title":"Cellular profile and expression of immunologic markers in chronic apical periodontitis from hiv-infected patients undergoing highly active antiretroviral therapy","volume":"42","author":"Gama","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib2","first-page":"54","article-title":"Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities","volume":"2","author":"Karamifar","year":"2020","journal-title":"Eur Endod J"},{"key":"10.1016\/j.joen.2024.01.018_bib3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joen.2021.03.007","article-title":"Tumor necrosis factor alpha 2308 g\/a single-nucleotide polymorphism and apical periodontitis: an updated systematic review and metaanalysis","volume":"47","author":"Jakovljevic","year":"2021","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00784-021-04083-4","article-title":"Systemic burden and cardiovascular risk to porphyromonas species in apical periodontitis","volume":"26","author":"Jim\u00e9nez","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.01.018_bib5","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.sdentj.2021.07.005","article-title":"Apical periodontitis promotes insulin resistance and alters adaptive immunity markers in rats","volume":"33","author":"Pereira","year":"2021","journal-title":"Saudi Dent J"},{"key":"10.1016\/j.joen.2024.01.018_bib6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s10266-020-00534-8","article-title":"The importance of inflammatory biomarkers, IL-6 and PAPP-A, in the evaluation of asymptomatic apical periodontitis","volume":"109","author":"Sirin","year":"2021","journal-title":"Odontology"},{"key":"10.1016\/j.joen.2024.01.018_bib7","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/iej.13467","article-title":"The global prevalence of apical periodontitis: a systematic review and meta-analysis","volume":"54","author":"Tib\u00farcio-Machado","year":"2021","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.01.018_bib8","doi-asserted-by":"crossref","first-page":"e20220316","DOI":"10.1590\/1678-7757-2022-0316","article-title":"Macrophage M1 polarization mediated via the IL-6\/STAT3 pathway contributes to apical periodontitis induced by porphyromonas gingivalis","volume":"30","author":"Chen","year":"2022","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2024.01.018_bib9","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.2174\/1381612822666160216145107","article-title":"Interrelationship between periapical lesion and systemic metabolic disorders","volume":"22","author":"Sasaki","year":"2016","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.joen.2024.01.018_bib10","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.joen.2018.09.002","article-title":"Immunohistochemical analysis of cyclooxygenase-2 and tumor necrosis factor alpha in periapical lesions","volume":"44","author":"\u00c1lvares","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1590\/1807-3107bor-2018.vol32.0069","article-title":"Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology","volume":"32","author":"Gomes","year":"2018","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.01.018_bib12","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/iej.13350","article-title":"Relationship between apical periodontitis and atherosclerosis: lipid profile and histological study","volume":"53","author":"Conti","year":"2020","journal-title":"Int Endod J"},{"issue":"1","key":"10.1016\/j.joen.2024.01.018_bib13","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1590\/1807-3107BOR-2016.vol30.0034","article-title":"Analysis of interleukin 17A in periapical abscess and granuloma lesions","volume":"30","author":"Ferreira","year":"2016","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.01.018_bib14","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.joen.2013.03.001","article-title":"The expression of macrophage migration inhibitory factor is correlated with receptor activator of nuclear factor kappa B ligand in induced rat periapical lesions","volume":"39","author":"Liu","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib15","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.joms.2013.05.023","article-title":"Immunohistochemical detection of receptor activator nuclear kB ligand and osteoprotegerin in odontogenic cysts and tumors","volume":"71","author":"Matos","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2024.01.018_bib16","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.joen.2014.03.024","article-title":"Immunoexpression of interleukin 17 in apical periodontitis","volume":"40","author":"Ajuz","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.joen.2013.09.037","article-title":"Distribution of mast cells and macrophages and expression of interleukin-6 in periapical cysts","volume":"40","author":"Bracks","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/aej.12072","article-title":"Pro-inflammatory cytokine levels in human apical periodontitis: correlation with clinical and histological findings","volume":"41","author":"Jakovljevic","year":"2015","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2024.01.018_bib19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.joen.2016.01.022","article-title":"Multiple apical periodontitis influences serum levels of cytokines and nitric oxide","volume":"42","author":"Cintra","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib20","doi-asserted-by":"crossref","first-page":"e20170455","DOI":"10.1590\/1678-7757-2017-0455","article-title":"Pro-inflammatory and anti-inflammatory cytokine expression in post-treatment apical periodontitis","volume":"26","author":"Dessaune-Neto","year":"2018","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2024.01.018_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00016357.2018.1521005","article-title":"Inflammatory profile of chronic apical periodontitis: a literature review","volume":"77","author":"Braz-Silva","year":"2019","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"10.1016\/j.joen.2024.01.018_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41368-019-0049-y","article-title":"Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis","volume":"11","author":"Davanian","year":"2019","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.joen.2024.01.018_bib23","doi-asserted-by":"crossref","first-page":"e093","DOI":"10.1590\/1807-3107bor-2019.vol33.0093","article-title":"Cytokines and chemokines associated with Treg\/Th17 response in chronic inflammatory periapical disease","volume":"33","author":"De Toledo","year":"2019","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.01.018_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8325380","article-title":"Production of soluble receptor activator of nuclear factor kappa-\u03b2 ligand and osteoprotegerin by apical periodontitis cells in culture and their modulation by cytokines","volume":"2019","author":"Duka","year":"2019","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joen.2024.01.018_bib25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.joen.2021.04.026","article-title":"Influence of bacterial profiles in cytokine and clinical features of endodontic disease","volume":"47","author":"Martinho","year":"2021","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib26","article-title":"Correlation between transforming growth factor- \u03b2 and periapical lesions in patients with chronic apical periodontitis","volume":"2022","author":"Li","year":"2022","journal-title":"J Healthc Eng"},{"key":"10.1016\/j.joen.2024.01.018_bib27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.joen.2011.12.010","article-title":"T-Lymphocyte and cytokine expression in human inflammatory periapical lesions","volume":"38","author":"de Brito","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib28","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.joen.2011.12.029","article-title":"Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion","volume":"38","author":"Silva","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.joen.2015.03.025","article-title":"Expression and distribution of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and osteoprotegerin in periradicular cysts","volume":"41","author":"Armada","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib30","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.joen.2014.12.021","article-title":"C-Reactive protein expression is up-regulated in apical lesions of endodontic origin in association with interleukin-6","volume":"41","author":"Garrido","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/0103-6440202205113","article-title":"Genetic, cellular and molecular aspects involved in apical periodontitis","volume":"33","author":"Petean","year":"2022","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2024.01.018_bib32","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.joen.2012.02.021","article-title":"Correlation between clinical\/radiographic features and inflammatory cytokine networks produced by macrophages stimulated with endodontic content","volume":"38","author":"Martinho","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joen.2014.09.028","article-title":"Clinical influence of different intracanal medications on Th-1 type and Th-2 type cytokine responses in apical periodontitis","volume":"41","author":"Martinho","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-302x.2000.150301.x","article-title":"Protective and destructive immune reactions in apical periodontitis","volume":"15","author":"Marton","year":"2000","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2024.01.018_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.joen.2018.10.015","article-title":"Notch signaling pathway in apical periodontitis: correlation with bone resorption regulators and proinflammatory cytokines","volume":"45","author":"Nikolic","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib36","first-page":"213","article-title":"TNF-Alpha and IL-6: the link between immune and bone system","volume":"21","author":"Wang","year":"2020","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.joen.2024.01.018_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2007\/38210","article-title":"Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions","volume":"20","author":"Prso","year":"2007","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.joen.2024.01.018_bib38","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1600-0714.2009.00788.x","article-title":"Production of proinflammatory and immunoregulatory cytokines by inflammatory cells from periapical lesions in culture","volume":"38","author":"Gazivoda","year":"2009","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.joen.2024.01.018_bib39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molimm.2009.01.011","article-title":"Proinflammatory and immunoregulatory mechanisms in periapical lesions","volume":"47","author":"Colic","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.joen.2024.01.018_bib40","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2591.2006.01180.x","article-title":"Quality guidelines for endodontic treatment: consensus report of the European Society of Endodontology","volume":"39","author":"European Society of","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.01.018_bib41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00004770-200006000-00007","article-title":"Immunolocalization of macrophages and transforming growth factor-beta 1 in induced rat periapical lesions","volume":"26","author":"Lin","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00918135","article-title":"Transforming growth factor beta (TGF-beta) in inflammation: a cause and a cure","volume":"12","author":"Wahl","year":"1992","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.joen.2024.01.018_bib43","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S1079-2104(03)00059-3","article-title":"Cytokines in periapical lesions: the effect of lineolid treatment","volume":"96","author":"Danin","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib44","first-page":"458","article-title":"Changes in TGF-\u03b21 levels in gingival crevicular fluid and serum associated periodontal inflammation in humans and dogs","volume":"26","author":"Skaleric","year":"1997","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2024.01.018_bib45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0099-2399(99)80322-7","article-title":"Eosinophil-derived transforming growth factors (TGF-alpha and TGF-beta1) in human perirradicular lesions","volume":"25","author":"Tyler","year":"1999","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib46","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1365-2222.2006.02606.x","article-title":"Regulation of the T cell response","volume":"36","author":"Romagnani","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.joen.2024.01.018_bib47","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/jb\/mvq043","article-title":"Cellular and molecular basis for the regulation of inflammation by TGF-beta","volume":"147","author":"Yoshimura","year":"2010","journal-title":"J Biochem"},{"key":"10.1016\/j.joen.2024.01.018_bib48","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1590\/1807-3107bor-2017.vol31.0051","article-title":"Immunohistochemical expression of TGF-\u03b21 and MMP-9 in periapical lesions","volume":"31","author":"\u00c1lvares","year":"2017","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.01.018_bib49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1600-0714.2009.00863.x","article-title":"Distinct Th1, Th2 and T reg cytokines balance in chronic periapical granulomas and radicular cysts","volume":"39","author":"Teixeira-Salum","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.joen.2024.01.018_bib50","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.joen.2008.10.022","article-title":"Immunohistochemical localization of IL-17 in induced rat periapical lesions","volume":"35","author":"Xiong","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib51","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.joen.2010.03.020","article-title":"T-Helper cell type 17\/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas","volume":"36","author":"Mar\u00e7al","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib52","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.joen.2011.08.007","article-title":"Cytokine analysis in lesions refractory to endodontic treatment","volume":"37","author":"Henriques","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.01.018_bib53","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/iej.13112","article-title":"The presence and involvement of interleukin-17 in apical periodontitis","volume":"52","author":"Xiong","year":"2019","journal-title":"Int Endod J"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923992400061X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923992400061X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T02:01:45Z","timestamp":1711504905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923992400061X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S009923992400061X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2024.01.018","relation":{},"ISSN":["0099-2399"],"issn-type":[{"type":"print","value":"0099-2399"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Correlation Between Proinflammatory Cytokine Expression and Clinical Data in Apical Granuloma","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2024.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}