{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:51:12Z","timestamp":1784422272284,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.joen.2024.02.018","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T04:03:03Z","timestamp":1709265783000},"page":"827-834","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Radiotherapy and Taper of Root Canal Preparation on the Biomechanical Behavior of Mesial Roots of Mandibular Molars"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-0370","authenticated-orcid":false,"given":"Guilherme","family":"Pauletto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Machado","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeu","family":"Baumhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Kalil","family":"Rocha Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alexandre","family":"Souza Bier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2024.02.018_bib1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.soc.2015.03.001","article-title":"Epidemiology of head and neck cancer","volume":"24","author":"Rettig","year":"2015","journal-title":"Surg Oncol Clin N Am"},{"key":"10.1016\/j.joen.2024.02.018_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.coms.2018.06.001","article-title":"Epidemiology and demographics of the head and neck cancer population","volume":"30","author":"Cohen","year":"2018","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.joen.2024.02.018_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/14737140.2018.1446832","article-title":"An update on radiation therapy in head and neck cancers","volume":"18","author":"Mazzola","year":"2018","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.joen.2024.02.018_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/154411130301400305","article-title":"Oral sequelae of head and neck radiotherapy","volume":"14","author":"Vissink","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2024.02.018_bib5","first-page":"448","article-title":"Oral adverse effects of head and neck radiotherapy: literature review and suggestion of a clinical oral care guideline for irradiated patients","volume":"19","author":"Tolentino Ede","year":"2011","journal-title":"J Appl Oral Sci"},{"key":"10.1016\/j.joen.2024.02.018_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/0022034509351251","article-title":"Effect of gamma irradiation on ultimate tensile strength of enamel and dentin","volume":"89","author":"Soares","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2024.02.018_bib7","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jdent.2014.05.011","article-title":"Radiation therapy alters microhardness and microstructure of enamel and dentin of permanent human teeth","volume":"42","author":"Gon\u00e7alves","year":"2014","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2024.02.018_bib8","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1590\/1807-3107BOR-2016.vol30.0009","article-title":"Effect of high energy X-ray irradiation on the nano-mechanical properties of human enamel and dentine","volume":"30","author":"Liang","year":"2016","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.02.018_bib9","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s00784-016-1731-5","article-title":"Effect of gamma irradiation on the wear behavior of human tooth dentin","volume":"20","author":"Qing","year":"2016","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.02.018_bib10","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.oraloncology.2005.03.011","article-title":"Radiation caries\u2013radiogenic destruction of dental collagen","volume":"41","author":"Springer","year":"2005","journal-title":"Oral Oncol"},{"key":"10.1016\/j.joen.2024.02.018_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/etp.12089","article-title":"Biomechanics of fractures in endodontically treated teeth","volume":"33","author":"Kishen","year":"2015","journal-title":"Endod Topics"},{"key":"10.1016\/j.joen.2024.02.018_bib12","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.dental.2019.02.015","article-title":"Relationship between canal enlargement and fracture load of root dentin sections","volume":"35","author":"Munari","year":"2019","journal-title":"Dent Mater"},{"key":"10.1016\/j.joen.2024.02.018_bib13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/iej.13750","article-title":"Present status and future directions: minimally invasive root canal preparation and periradicular surgery","volume":"55","author":"Neelakantan","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.02.018_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1601-1546.2006.00201.x","article-title":"Mechanisms and risk factors for fracture predilection in endodontically treated teeth","volume":"13","author":"Kishen","year":"2006","journal-title":"Endod Top"},{"key":"10.1016\/j.joen.2024.02.018_bib15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.joen.2016.12.009","article-title":"Clinical and radiographic characteristics of vertical root fractures in endodontically and nonendodontically treated teeth","volume":"43","author":"Liao","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib16","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.joen.2021.06.002","article-title":"The effect of root canal preparation size and taper of middle mesial canals on fracture resistance of the mandibular molar teeth: an in\u00a0vitro study","volume":"47","author":"K\u0131l\u0131\u00e7","year":"2021","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib17","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/iej.12556","article-title":"Influence of therapeutic cancer radiation on the bond strength of an epoxy- or an MTA-based sealer to root dentine","volume":"49","author":"Martins","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.02.018_bib18","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/iej.12945","article-title":"Longevity of bond strength of resin cements to root dentine after radiation therapy","volume":"51","author":"Yamin","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.02.018_bib19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00784-017-2165-4","article-title":"Influence of radiotherapy on the dentin properties and bond strength","volume":"22","author":"Rodrigues","year":"2018","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.02.018_bib20","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.joen.2020.05.019","article-title":"Middle mesial canal preparation enhances the risk of fracture in mesial root of mandibular molars","volume":"46","author":"Kele\u015f","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib21","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0022-3913(99)70103-4","article-title":"Clinically relevant approach to failure testing of all-ceramic restorations","volume":"81","author":"Kelly","year":"1999","journal-title":"J Prosthet Dent"},{"key":"10.1016\/j.joen.2024.02.018_bib22","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.joen.2017.07.013","article-title":"Influence of endodontic treatment and retreatment on the fatigue failure load, numbers of cycles for failure, and survival rates of human canine teeth","volume":"43","author":"Missau","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/aej.12782","article-title":"Effect of the progressive taper enlargement of buccal root canals of three-rooted maxillary molars: a stepwise micro-CT study","volume":"49","author":"Barbosa","year":"2023","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2024.02.018_bib24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.joen.2018.04.004","article-title":"Biomechanical properties of first maxillary molars with different endodontic cavities: a finite element analysis","volume":"44","author":"Jiang","year":"2018","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib25","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.joen.2021.03.008","article-title":"Influence of progressive versus minimal canal preparations on the fracture resistance of mandibular molars: a 3-dimensional finite element analysis","volume":"47","author":"Smoljan","year":"2021","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib26","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.joen.2023.09.014","article-title":"Finite element analysis of fracture resistance of mandibular molars with different access cavity designs","volume":"49","author":"Rahmatian","year":"2023","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/0103-6440202305101","article-title":"Impact of radiotherapy on the morphological and compositional structure of intra-radicular dentin","volume":"34","author":"Martini","year":"2023","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2024.02.018_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000457806","article-title":"Postradiation Matrix Metalloproteinase-20 Expression and its impact on dental micromorphology and radiation-related caries","volume":"51","author":"Gomes-Silva","year":"2017","journal-title":"Caries Res"},{"key":"10.1016\/j.joen.2024.02.018_bib29","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s00784-018-2373-6","article-title":"Radiotherapy alters the composition, structural and mechanical properties of root dentin in\u00a0vitro","volume":"22","author":"Velo","year":"2018","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.02.018_bib30","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1365-2591.2011.01920.x","article-title":"Effect of gamma irradiation and restorative material on the biomechanical behaviour of root filled premolars","volume":"44","author":"Soares","year":"2011","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.02.018_bib31","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00784-020-03378-2","article-title":"The effect of radiotherapy delivery time and obturation materials on the fracture resistance of mandibular premolars","volume":"25","author":"Aktemur T\u00fcrker","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.02.018_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105607","article-title":"A brief review on fatigue test of ceramic and some related matters in dentistry","volume":"138","author":"Valandro","year":"2023","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.joen.2024.02.018_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00004770-200308000-00008","article-title":"Patterns of vertical root fracture: factors affecting stress distribution in the root canal","volume":"29","author":"Lertchirakarn","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.02.018_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/aej.12472","article-title":"The effect of taper and apical preparation size on fracture resistance of roots","volume":"47","author":"Do\u011fanay Y\u0131ld\u0131z","year":"2021","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2024.02.018_bib35","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/iej.12540","article-title":"Resistance to vertical root fracture of root filled teeth using different conceptual approaches to canal preparation","volume":"49","author":"Prado","year":"2016","journal-title":"Int Endod J"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924001249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924001249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T09:58:31Z","timestamp":1716026311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239924001249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0099239924001249"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2024.02.018","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Radiotherapy and Taper of Root Canal Preparation on the Biomechanical Behavior of Mesial Roots of Mandibular Molars","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2024.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}