{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:49:29Z","timestamp":1793047769280,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.joen.2024.06.012","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T14:06:53Z","timestamp":1719583613000},"page":"1370-1380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Tooth Loss is a Risk Factor for Cardiovascular Disease Mortality: A Systematic Review with Meta-analyses"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-9988","authenticated-orcid":false,"given":"Anita","family":"Aminoshariae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nosrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Jakovljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Ja\u0107imovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Narasimhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkateshbabu","family":"Nagendrababu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2024.06.012_bib1","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 Update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2024.06.012_bib2","article-title":"Tooth loss and risk of cardiovascular disease and stroke: a dose-response meta analysis of prospective cohort studies","volume":"13","author":"Cheng","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2024.06.012_bib6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ijcard.2017.07.036","article-title":"Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart disease","volume":"245","author":"Vedin","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.joen.2024.06.012_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpor.2017.08.003","article-title":"Association between missing tooth count and mortality: a systematic review","volume":"62","author":"Koka","year":"2018","journal-title":"J Prosthodont Res"},{"key":"10.1016\/j.joen.2024.06.012_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-95865-z","article-title":"Oral health and all-cause, cardiovascular disease, and respiratory mortality in older people in the UK and USA","volume":"11","author":"Kotronia","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.joen.2024.06.012_bib9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1177\/0022034511414423","article-title":"Oral health and cancer, cardiovascular, and respiratory mortality of Japanese","volume":"90","author":"Aida","year":"2011","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2024.06.012_bib10","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12903-021-01934-0","article-title":"Number of teeth is associated with all-cause and disease-specific mortality","volume":"21","author":"Yu","year":"2021","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.joen.2024.06.012_bib11","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.930112","article-title":"Periodontitis and number of teeth in the risk of coronary heart disease: an updated meta-analysis","volume":"27","author":"Gao","year":"2021","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.joen.2024.06.012_bib12","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1902\/jop.2010.090680","article-title":"Number of teeth as a predictor of cardiovascular mortality in a cohort of 7,674 subjects followed for 12 years","volume":"81","author":"Holmlund","year":"2010","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2024.06.012_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0022034518814829","article-title":"Tooth loss predicts myocardial infarction, heart failure, stroke, and death","volume":"98","author":"Lee","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2024.06.012_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.621626","article-title":"Lower number of teeth is related to higher risks for ACVD and death-systematic review and meta-analyses of survival data","volume":"8","author":"Beukers","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.joen.2024.06.012_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00784-011-0625-9","article-title":"The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? a systematic review and meta-analysis","volume":"16","author":"Polzer","year":"2012","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.06.012_bib16","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181773","article-title":"The relationship between tooth loss and mortality from all causes, cardiovascular diseases, and coronary heart disease in the general population: systematic review and dose-response meta-analysis of prospective cohort studies","volume":"39","author":"Peng","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.joen.2024.06.012_bib17","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.joen.2016.07.007","article-title":"Association between systemic diseases and apical periodontitis","volume":"42","author":"Khalighinejad","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.06.012_bib18","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1007\/s00784-020-03596-8","article-title":"The impact of cardiovascular disease and endodontic outcome: a systematic review of longitudinal studies","volume":"24","author":"Aminoshariae","year":"2020","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.joen.2024.06.012_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00784-019-03094-6","article-title":"The association between smoking and periapical periodontitis: a systematic review","volume":"24","author":"Aminoshariae","year":"2020","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.joen.2024.06.012_bib20","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.joen.2015.03.007","article-title":"Association of functional gene polymorphism with apical periodontitis","volume":"41","author":"Aminoshariae","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.06.012_bib21","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/iej.13364","article-title":"Association between cardiovascular diseases and apical periodontitis: an umbrella review","volume":"53","author":"Jakovljevic","year":"2020","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.06.012_bib22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/iej.13756","article-title":"Single nucleotide polymorphisms as a predisposing factor for the development of apical periodontitis-an umbrella review","volume":"55","author":"Jakovljevic","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.06.012_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1902\/annals.1998.3.1.175","article-title":"Possible explanations for the tooth loss and cardiovascular disease relationship","volume":"3","author":"Joshipura","year":"1998","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.joen.2024.06.012_bib24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1177\/0022034515586352","article-title":"Missing teeth predict incident cardiovascular events, diabetes, and death","volume":"94","author":"Liljestrand","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2024.06.012_bib25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.adaj.2021.11.009","article-title":"Edentulism is associated with increased risk of all-cause mortality in adult men","volume":"153","author":"Bond","year":"2022","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2024.06.012_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jcpe.12192","article-title":"Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort","volume":"41","author":"Janket","year":"2014","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2024.06.012_bib27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/iej.13634","article-title":"Endodontic inflammatory disease: a risk indicator for a first myocardial infarction","volume":"55","author":"Sebring","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.06.012_bib28","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s40520-019-01446-6","article-title":"Association between periodontal disease and tooth loss and mortality in an elderly Chinese population","volume":"32","author":"Qi","year":"2020","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.joen.2024.06.012_bib29","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.joen.2024.06.012_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13643-020-01542-z","article-title":"PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews","volume":"10","author":"Rethlefsen","year":"2021","journal-title":"Syst Rev"},{"key":"10.1016\/j.joen.2024.06.012_bib31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jclinepi.2016.01.021","article-title":"PRESS peer review of electronic search strategies: 2015 guideline statement","volume":"75","author":"McGowan","year":"2016","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.joen.2024.06.012_bib32","series-title":"Proceedings of the 18th International Conference on Evaluation and Assessment in Software Engineering","first-page":"1","article-title":"Guidelines for snowballing in systematic literature studies and a replication in software engineering","volume":"2014","author":"Wohlin","year":"2014"},{"key":"10.1016\/j.joen.2024.06.012_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.joen.2024.06.012_bib34","author":"Wells"},{"key":"10.1016\/j.joen.2024.06.012_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/cdoe.12095","article-title":"Associations of number of teeth with risks for all-cause mortality and cause-specific mortality in middle-aged and elderly men in the northern part of Japan: the iwate-KENCO study","volume":"42","author":"Ando","year":"2014","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.joen.2024.06.012_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1741-2358.2003.00032.x","article-title":"Oral health status, C-reactive protein and mortality--a 10 year follow-up study","volume":"20","author":"Ajwani","year":"2003","journal-title":"Gerodontology"},{"key":"10.1016\/j.joen.2024.06.012_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1194054","article-title":"Tooth loss, denture use, and all-cause and cause-specific mortality in older adults: a community cohort study","volume":"11","author":"Dai","year":"2023","journal-title":"Front Public Health"},{"key":"10.1016\/j.joen.2024.06.012_bib38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2188\/jea.JE20180243","article-title":"Number of teeth and all-cause and cancer mortality in a Japanese Community: the Takayama study","volume":"30","author":"Goto","year":"2020","journal-title":"J Epidemiol"},{"key":"10.1016\/j.joen.2024.06.012_bib39","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/ije\/dyac072","article-title":"Tooth count, untreated caries and mortality in US adults: a population-based cohort study","volume":"51","author":"Liu","year":"2022","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.joen.2024.06.012_bib40","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/JPER.23-0277","article-title":"Association between missing teeth number and all-cause and cardiovascular mortality: NHANES 1999-2004 and 2009-2014","volume":"95","author":"Shen","year":"2023","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2024.06.012_bib41","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/ije\/dyx056","article-title":"Oral health and mortality in the Golestan cohort study","volume":"46","author":"Vogtmann","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.joen.2024.06.012_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030797","article-title":"Tooth loss and cardiovascular disease mortality risk--results from the Scottish health survey","volume":"7","author":"Watt","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2024.06.012_bib43","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/CIRCULATIONAHA.123.065770","article-title":"Fractional flow reserve-guided PCI or coronary bypass surgery for 3-vessel coronary artery disease: 3-year follow-up of the FAME 3 trial","volume":"148","author":"Zimmermann","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2024.06.012_bib44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1056\/NEJM199602293340903","article-title":"Three-year follow-up after implantation of metallic coronary-artery stents","volume":"334","author":"Kimura","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joen.2024.06.012_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/eurheartj\/ehn516","article-title":"Long-term benefit-risk balance of drug-eluting vs. bare-metal stents in daily practice: does stent diameter matter? three-year follow-up of BASKET","volume":"30","author":"Pfisterer","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.joen.2024.06.012_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.amjcard.2012.02.040","article-title":"Impact of routine angiographic follow-up after percutaneous coronary intervention with drug-eluting stents in the SPIRIT III randomized trial at three years","volume":"110","author":"Lansky","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.joen.2024.06.012_bib47","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/jamacardio.2022.3203","article-title":"Long-term effects of P2Y12 inhibitor monotherapy after percutaneous coronary intervention: 3-year follow-up of the SMART-CHOICE randomized clinical trial","volume":"7","author":"Choi","year":"2022","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.joen.2024.06.012_bib49","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics-2018 update: a report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2024.06.012_bib50","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/iej.12468","article-title":"Apical Periodontitis and incident cardiovascular events in the Baltimore longitudinal study of ageing","volume":"49","author":"Gomes","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.06.012_bib51","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/CIRCULATIONAHA.107.711507","article-title":"Age-dependent associations between chronic periodontitis\/edentulism and risk of coronary heart disease","volume":"117","author":"Dietrich","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2024.06.012_bib52","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.2174\/0929867324666170428103206","article-title":"Diet and cardiovascular disease: effects of foods and nutrients in classical and emerging cardiovascular risk factors","volume":"26","author":"Badimon","year":"2019","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.joen.2024.06.012_bib53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.lfs.2018.10.063","article-title":"Interaction between gut microbiome and cardiovascular disease","volume":"214","author":"Peng","year":"2018","journal-title":"Life Sci"},{"key":"10.1016\/j.joen.2024.06.012_bib54","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.3390\/ijms22115876","article-title":"Oral microbiome in relation to periodontitis severity and systemic inflammation","volume":"22","author":"Plachokova","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joen.2024.06.012_bib55","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/iej.12772","article-title":"Lower risk for cardiovascular mortality for patients with root filled teeth in a Finnish population","volume":"50","author":"Meurman","year":"2017","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.06.012_bib56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/154411130201300306","article-title":"Nutrition as a mediator in the relation between oral and systemic disease: associations between specific measures of adult oral health and nutrition outcomes","volume":"13","author":"Ritchie","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2024.06.012_bib57","doi-asserted-by":"crossref","first-page":"442","DOI":"10.5114\/ceji.2018.81356","article-title":"The impact of periodontal treatment on inflammatory markers and cellular parameters associated with atherosclerosis in patients after myocardial infarction","volume":"43","author":"G\u00f3rski","year":"2018","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.joen.2024.06.012_bib58","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12882-015-0101-x","article-title":"Periodontal disease, chronic kidney disease and mortality: results from the third national health and nutrition examination survey","volume":"16","author":"Ricardo","year":"2015","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.joen.2024.06.012_bib59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/jcpe.12650","article-title":"Risk factors in periodontology: a conceptual framework","volume":"44","author":"Bouchard","year":"2017","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2024.06.012_bib60","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/jre.13061","article-title":"Periodontitis and edentulism as risk indicators for mortality: results from a prospective cohort study with 20 years of follow-up","volume":"58","author":"Antonoglou","year":"2023","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.joen.2024.06.012_bib61","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004518","article-title":"History of periodontitis diagnosis and edentulism as predictors of cardiovascular disease, stroke, and mortality in postmenopausal women","volume":"6","author":"LaMonte","year":"2017","journal-title":"J Am Heart Assoc"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924003649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924003649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T04:10:02Z","timestamp":1728533402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239924003649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0099239924003649"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2024.06.012","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tooth Loss is a Risk Factor for Cardiovascular Disease Mortality: A Systematic Review with Meta-analyses","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2024.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}