{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:56:25Z","timestamp":1789048585092,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010382","name":"European Society of Endocrinology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021792","name":"British Endodontic Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.joen.2024.11.009","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T20:37:44Z","timestamp":1732307864000},"page":"140-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Links between Nosocomial Endodontic Infections and Bacteremia Associated with Apical Periodontitis and Endodontic Treatment"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-2025","authenticated-orcid":false,"given":"Abdulaziz","family":"Bakhsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Moyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mannocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Proctor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0334-4119","authenticated-orcid":false,"given":"Sadia","family":"Niazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2024.11.009_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/CMR.00028-08","article-title":"Microbiology of odontogenic bacteremia: beyond endocarditis","volume":"22","author":"Parahitiyawa","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.joen.2024.11.009_bib2","article-title":"The incidence and prognosis of patients with bacteremia","volume":"62","author":"Nielsen","year":"2015","journal-title":"Dan Med J"},{"key":"10.1016\/j.joen.2024.11.009_bib3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0099-2399(76)80010-6","article-title":"The incidence of bacteremias related to endodontic procedures. I. nonsurgical endodontics","volume":"2","author":"Baumgartner","year":"1976","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib4","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1128\/jcm.28.10.2205-2209.1990","article-title":"Detection and quantitation by lysis-filtration of bacteremia after different oral surgical procedures","volume":"28","author":"Heimdahl","year":"1990","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2024.11.009_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.14219\/jada.archive.1980.0334","article-title":"Late infections in patients with prostheses for total replacement of joints: implications for the dental practitioner","volume":"101","author":"Mulligan","year":"1980","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2024.11.009_bib6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1600-051X.1984.tb02211.x","article-title":"Plaque and systemic disease: a reappraisal of the focal infection concept","volume":"11","author":"Thoden van Velzen","year":"1984","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.joen.2024.11.009_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-9657.1995.tb00476.x","article-title":"Bacteremia in conjunction with endodontic therapy","volume":"11","author":"Debelian","year":"1995","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2024.11.009_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-9657.1992.tb00253.x","article-title":"Profiling of propionibacterium acnes recovered from root canal and blood during and after endodontic treatment","volume":"8","author":"Debelian","year":"1992","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2024.11.009_bib9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jdent.2004.09.008","article-title":"Detection of bacteraemias during non-surgicalroot canal treatment","volume":"33","author":"Savarrio","year":"2005","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2024.11.009_bib10","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1600-0722.1996.tb00139.x","article-title":"Electrophoresis of whole-cell soluble proteins of microorganisms isolated from bacteremias in endodontic therapy","volume":"104","author":"Debelian","year":"1996","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2024.11.009_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/anae.1997.0108","article-title":"Ribotyping of bacteria from root canal and blood of patients receiving endodontic therapy","volume":"3","author":"Debelian","year":"1997","journal-title":"Anaerobe"},{"key":"10.1016\/j.joen.2024.11.009_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.mimet.2009.09.012","article-title":"Metagenomic study of the oral microbiota by illumina high-throughput sequencing","volume":"79","author":"Lazarevic","year":"2009","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.joen.2024.11.009_bib13","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.joen.2016.05.016","article-title":"Glove contamination during endodontic treatment is one of the sources of nosocomial endodontic propionibacterium acnes infections","volume":"42","author":"Niazi","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.joen.2022.01.007","article-title":"Assessing the iatrogenic contribution to contamination during root canal treatment","volume":"48","author":"Zahran","year":"2022","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib15","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1128\/JCM.01326-10","article-title":"Propionibacterium acnes and staphylococcus epidermidis isolated from refractory endodontic lesions are opportunistic pathogens","volume":"48","author":"Niazi","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.joen.2024.11.009_bib16","author":"Dore"},{"key":"10.1016\/j.joen.2024.11.009_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.joen.2024.11.009_bib18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.joen.2024.11.009_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baq013","article-title":"The human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information","volume":"2010","author":"Chen","year":"2010","journal-title":"Database"},{"key":"10.1016\/j.joen.2024.11.009_bib20","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.joen.2024.11.009_bib21","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.joen.2016.05.013","article-title":"Bacteremia after endodontic procedures in patients with heart disease: culture and molecular analyses","volume":"42","author":"Reis","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib22","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1286-4579(00)00391-9","article-title":"The oral cavity as a reservoir of bacterial pathogens for focal infections","volume":"2","author":"Gendron","year":"2000","journal-title":"Microb Infect"},{"key":"10.1016\/j.joen.2024.11.009_bib23","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3390\/medicina58070931","article-title":"Association between endodontic infection, its treatment and systemic health: a narrative review","volume":"58","author":"Niazi","year":"2022","journal-title":"Medicina"},{"key":"10.1016\/j.joen.2024.11.009_bib24","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1111\/iej.13605","article-title":"The impact of an enhanced infection control protocol on molar root canal treatment outcome - a randomized clinical trial","volume":"54","author":"Zahran","year":"2021","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.11.009_bib25","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1177\/0022034510370026","article-title":"Analyzing endodontic infections by deep coverage pyrosequencing","volume":"89","author":"Li","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2024.11.009_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/1471-2164-13-345","article-title":"Microbial transformation from normal oral microbiota to acute endodontic infections","volume":"13","author":"Hsiao","year":"2012","journal-title":"BMC Genom"},{"key":"10.1016\/j.joen.2024.11.009_bib27","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1365-2591.2011.02006.x","article-title":"Ecology of the microbiome of the infected root canal system: a comparison between apical and coronal root segments","volume":"45","author":"Ozok","year":"2012","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.11.009_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084960","article-title":"Comparison of the bacterial composition and structure in symptomatic and asymptomatic endodontic infections associated with root-filled teeth using pyrosequencing","volume":"8","author":"Anderson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2024.11.009_bib29","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.joen.2017.03.019","article-title":"Pyrosequencing analysis of cryogenically ground samples from primary and secondary\/persistent endodontic infections","volume":"43","author":"Keskin","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib30","first-page":"24","article-title":"Microbial flora of root canals of pulpally-infected teeth: enterococcus faecalis a prevalent species","volume":"3","author":"Gajan","year":"2009","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"10.1016\/j.joen.2024.11.009_bib31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/iej.13640","article-title":"Potential relationship between clinical symptoms and the root canal microbiomes of root filled teeth based on the next-generation sequencing","volume":"55","author":"Hou","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.11.009_bib32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archinternmed.2008.603","article-title":"Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis\u2013Prospective Cohort Study","volume":"169","author":"Murdoch","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.joen.2024.11.009_bib33","doi-asserted-by":"crossref","first-page":"e963","DOI":"10.1161\/CIR.0000000000000969","article-title":"Prevention of Viridans Group streptococcal infective endocarditis: a scientific statement from the American Heart Association","volume":"143","author":"Wilson","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2024.11.009_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/CIRCULATIONAHA.112.095281","article-title":"Incidence of infective endocarditis caused by viridans group streptococci before and after publication of the 2007 American Heart Association's endocarditis prevention guidelines","volume":"126","author":"DeSimone","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.joen.2024.11.009_bib35","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.mayocp.2015.04.019","article-title":"Incidence of infective endocarditis due to viridans group streptococci before and after the 2007 American Heart Association\u2019s prevention guidelines: an extended evaluation of the Olmsted county, Minnesota, population and nationwide inpatient sample","volume":"90","author":"DeSimone","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.joen.2024.11.009_bib36","first-page":"11","article-title":"Systemic infections cause exaggerated local inflammation in atherosclerotic coronary arteries: clues to the triggering effect of acute infections on acute coronary syndromes","volume":"34","author":"Madjid","year":"2007","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.joen.2024.11.009_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232112906","article-title":"The role of inflammation in cardiovascular disease","volume":"23","author":"Henein","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joen.2024.11.009_bib38","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s00784-016-1739-x","article-title":"Isolation of propionibacterium acnes among the microbiota of primary endodontic infections with and without intraoral communication","volume":"20","author":"Niazi","year":"2016","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.joen.2024.11.009_bib39","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.joen.2017.06.036","article-title":"Bacterial contamination of endodontic materials before and after clinical storage","volume":"43","author":"Saeed","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib40","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.joen.2005.09.017","article-title":"Bacterial count comparisons on examination gloves from freshly opened boxes versus nearly empty boxes and from examination gloves before treatment versus after dental dam isolation","volume":"32","author":"Luckey","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.11.009_bib41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1034\/j.1600-9657.2000.016005191.x","article-title":"Assessment of periradicular microbiota by DNA-DNA hybridization","volume":"16","author":"Sunde","year":"2000","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2024.11.009_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162887","article-title":"Microbiome in the apical root canal system of teeth with post-treatment apical periodontitis","volume":"11","author":"Siqueira","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.joen.2024.11.009_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1469-0691.2009.02703.x","article-title":"Infective endocarditis due to propionibacterium species","volume":"15","author":"Sohail","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.joen.2024.11.009_bib44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10096-017-3172-8","article-title":"Prosthetic valve endocarditis caused by propionibacterium species: a national registry-based study of 51 Swedish cases","volume":"37","author":"Lindell","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.joen.2024.11.009_bib45","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/icvts\/ivw087","article-title":"Prosthetic valve endocarditis due to propionibacterium acnes","volume":"23","author":"van Valen","year":"2016","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.joen.2024.11.009_bib46","first-page":"25","article-title":"Infective endocarditis: acne to zoonoses on the valve, an A to Z perspective","volume":"29","author":"Boyle","year":"2022","journal-title":"Br J Cardiol"},{"key":"10.1016\/j.joen.2024.11.009_bib47","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0002-9343(05)80067-1","article-title":"Native valve staphylococcus epidermidis endocarditis: report of seven cases and review of the literature","volume":"90","author":"Arber","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.joen.2024.11.009_bib48","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/524666","article-title":"Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis","volume":"46","author":"Chu","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924005983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924005983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T22:39:02Z","timestamp":1738622342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239924005983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0099239924005983"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2024.11.009","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Links between Nosocomial Endodontic Infections and Bacteremia Associated with Apical Periodontitis and Endodontic Treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2024.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}