{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:13:34Z","timestamp":1790194414496,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/211.458\/2021"],"award-info":[{"award-number":["E-26\/211.458\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.joen.2024.12.009","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T17:58:03Z","timestamp":1735063083000},"page":"303-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the Potential of Nitrofurantoin for Infection Control in Regenerative Endodontics: In\u00a0Vitro Study"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-9968","authenticated-orcid":false,"given":"Fabiano Palmeira","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-4349","authenticated-orcid":false,"given":"Olney","family":"Vieira-da-Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4425-5008","authenticated-orcid":false,"given":"Pantaleo","family":"Scelza Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5977-6964","authenticated-orcid":false,"given":"Solange Silva","family":"Samar\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-4220","authenticated-orcid":false,"given":"Sandro Junio de Oliveira","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-931X","authenticated-orcid":false,"given":"S\u00e9rgio Henrique","family":"Seabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-3034","authenticated-orcid":false,"given":"Gabriel Bonan","family":"Taveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-4755","authenticated-orcid":false,"given":"Miriam Fatima Zaccaro","family":"Scelza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2024.12.009_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/iej.13731","article-title":"Present status and future directions of intracanal medicaments","volume":"55 Suppl 3","author":"Ordinola-Zapata","year":"2022","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2022.104278","article-title":"Cytocompatibility and antimicrobial activity of a novel endodontic irrigant combining citric acid and chlorhexidine","volume":"125","author":"Scelza","year":"2022","journal-title":"J Dent"},{"key":"10.1016\/j.joen.2024.12.009_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2591.1996.tb01173.x","article-title":"In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline","volume":"29","author":"Hoshino","year":"1996","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1807-3107bor-2018.vol32.0065","article-title":"Unprepared root canal surface areas: causes, clinical implications, and therapeutic strategies","volume":"32","author":"Siqueira Junior","year":"2018","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.12.009_bib5","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.3390\/ma14164418","article-title":"Prognosis of regenerative endodontic procedures in mature teeth: a systematic review and meta-analysis of clinical and radiographic parameters","volume":"14","author":"Scelza","year":"2021","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.joen.2024.12.009_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/2050168420963302","article-title":"Regenerative endodontic procedures, disinfectants and outcomes: a systematic review","volume":"9","author":"Kharchi","year":"2020","journal-title":"Prim Dent J"},{"key":"10.1016\/j.joen.2024.12.009_bib7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.adaj.2016.01.009","article-title":"Regenerative endodontics a way forward","volume":"147","author":"Diogenes","year":"2016","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2024.12.009_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S0099-2399(97)80314-7","article-title":"Determination of the p-monochlorophenol residue in the calcium hydroxide + p-monochlorophenol combination used as an intracanal dressing in pulpless teeth of dogs with induced chronic periapical lesion","volume":"23","author":"Alencar","year":"1997","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.joen.2024.12.009_bib11","first-page":"ZD41","article-title":"Multidisciplinary approach in management of a large cystic lesion in anterior maxilla - a case report","volume":"9","author":"Diwan","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.joen.2024.12.009_bib12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4103\/JCD.JCD_117_17","article-title":"Comparative evaluation of coronal discoloration induced by two triple antibiotic revascularization protocols when used at varying depths of temporary sealing material at the end of varying time periods","volume":"21","author":"Jagdale","year":"2018","journal-title":"J Conserv Dent"},{"issue":"1 Suppl","key":"10.1016\/j.joen.2024.12.009_bib13","first-page":"230","article-title":"Evaluation of the cytotoxicity of two types of triple antibiotic paste on human permanent dental apical papilla stem cells: an in\u00a0vitro in\u00a0vitro study","volume":"23","author":"Rafatjou","year":"2022","journal-title":"J Dent (Shiraz)"},{"key":"10.1016\/j.joen.2024.12.009_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/antibiotics3010039","article-title":"Role of old antibiotics in the era of antibiotic resistance. Highlighted nitrofurantoin for the treatment of lower urinary tract infections","volume":"3","author":"Munoz-Davila","year":"2014","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.joen.2024.12.009_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/jac\/33.suppl_A.23","article-title":"Nitrofurantoin: mechanism of action and implications for resistance development in common uropathogens","volume":"33","author":"McOsker","year":"1994","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.joen.2024.12.009_bib16","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World medical association declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","author":"World Medical","year":"2013","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.joen.2024.12.009_bib17","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00784-018-2345-x","article-title":"Effectiveness of ultrasonically activated irrigation on root canal disinfection: a systematic review of in\u00a0vitro studies","volume":"22","author":"Nagendrababu","year":"2018","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2024.12.009_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4012\/dmj.2016-102","article-title":"Antibacterial efficacy of several intracanal medicaments for endodontic therapy","volume":"36","author":"Valverde","year":"2017","journal-title":"Dent Mater J"},{"key":"10.1016\/j.joen.2024.12.009_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/php.12869","article-title":"Antimicrobial photodynamic therapy associated with conventional endodontic treatment: a clinical and molecular microbiological study","volume":"94","author":"da Silva","year":"2018","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.joen.2024.12.009_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.tripleo.2004.03.027","article-title":"Effect of three different time periods of irrigation with EDTA-T, EDTA, and citric acid on smear layer removal","volume":"98","author":"Scelza","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib21","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1016\/j.tripleo.2008.04.002","article-title":"Bactericidal activity of phosphoric acid, citric acid, and EDTA solutions against enterococcus faecalis","volume":"106","author":"Arias-Moliz","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib22","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"CLSI","year":"2024"},{"key":"10.1016\/j.joen.2024.12.009_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1055\/s-2006-957563","article-title":"A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria","volume":"64","author":"Eloff","year":"1998","journal-title":"Planta Med"},{"key":"10.1016\/j.joen.2024.12.009_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2021.101543","article-title":"New and simplified method for drug combination studies by checkerboard assay","volume":"8","author":"Bellio","year":"2021","journal-title":"MethodsX"},{"key":"10.1016\/j.joen.2024.12.009_bib25","doi-asserted-by":"crossref","first-page":"5451","DOI":"10.1128\/AEM.65.12.5451-5458.1999","article-title":"Permeabilization of fungal membranes by plant defensins inhibits fungal growth","volume":"65","author":"Thevissen","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.joen.2024.12.009_bib26","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0030-4220(65)90166-0","article-title":"The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats","volume":"20","author":"Kakehashi","year":"1965","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2024.12.009_bib27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1365-2591.1997.00092.x","article-title":"Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis","volume":"30","author":"Sj\u00f6gren","year":"1997","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib28","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/0810761","article-title":"Molecular and cultural analysis of the microflora associated with endodontic infections","volume":"81","author":"Munson","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2024.12.009_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2591.2003.00603.x","article-title":"Microorganisms from canals of root-filled teeth with periapical lesions","volume":"36","author":"Pinheiro","year":"2003","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1365-2591.2007.01323.x","article-title":"Outcome of primary root canal treatment: systematic review of the literature -- part 2. Influence of clinical factors","volume":"41","author":"Ng","year":"2008","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2591.1998.t01-1-00111.x","article-title":"Microbiological status of root-filled teeth with apical periodontitis","volume":"31","author":"Molander","year":"1998","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib32","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.tripleo.2004.09.006","article-title":"Denaturing gradient gel electrophoresis analysis of bacterial communities associated with failed endodontic treatment","volume":"98","author":"R\u00f4\u00e7as","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib33","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1016\/j.jmb.2016.05.006","article-title":"Polymicrobial\u2013host interactions during infection","volume":"428","author":"Tay","year":"2016","journal-title":"J Mol Biol"},{"key":"10.1016\/j.joen.2024.12.009_bib34","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/08927014.2013.816298","article-title":"Multi-species biofilms defined from drinking water microorganisms provide increased protection against chlorine disinfection","volume":"29","author":"Schwering","year":"2013","journal-title":"Biofouling"},{"key":"10.1016\/j.joen.2024.12.009_bib35","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.joen.2022.07.004","article-title":"Microbiome changes during regenerative endodontic treatment using different methods of disinfection","volume":"48","author":"Fouad","year":"2022","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib36","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/iej.13050","article-title":"Biofilm model systems for root canal disinfection: a literature review","volume":"52","author":"Swimberghe","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/joor.12474","article-title":"Age-related morphological, histological and functional changes in teeth","volume":"44","author":"Carvalho","year":"2017","journal-title":"J Oral Rehabil"},{"key":"10.1016\/j.joen.2024.12.009_bib38","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0099-2399(84)80204-6","article-title":"Scanning electron microscopic investigation of the smeared layer on root canal walls","volume":"10","author":"Mader","year":"1984","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jemt.22976","article-title":"Evaluation of 17% EDTA and 10% citric acid in smear layer removal and tubular dentin sealer penetration","volume":"81","author":"Machado","year":"2018","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.joen.2024.12.009_bib40","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/ijms18040713","article-title":"Effect of the biofilm age and starvation on acid tolerance of biofilm formed by streptococcus mutans isolated from caries-active and caries-free adults","volume":"18","author":"Jiang","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joen.2024.12.009_bib41","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/iej.12913","article-title":"Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review","volume":"51","author":"Montero-Miralles","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jds.2019.06.005","article-title":"The discoloration effect of diluted minocycline containing triple antibiotic gel used in revascularization","volume":"15","author":"Sabrah","year":"2020","journal-title":"J Dent Sci"},{"key":"10.1016\/j.joen.2024.12.009_bib43","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41429-021-00444-z","article-title":"Fosfomycin and nitrofurantoin: classic antibiotics and perspectives","volume":"74","author":"dos Santos","year":"2021","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.joen.2024.12.009_bib44","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1089\/mdr.2019.0044","article-title":"Susceptibility of nitrofurantoin and fosfomycin against outpatient urinary isolates of multidrug-resistant enterococci over a period of 10 years from India","volume":"26","author":"Das","year":"2020","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.joen.2024.12.009_bib45","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/14656566.2018.1479397","article-title":"Combatting resistant enterococcal infections: a pharmacotherapy review","volume":"19","author":"Mercuro","year":"2018","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.joen.2024.12.009_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1079-2104(03)00353-6","article-title":"Polymerase chain reaction\u2013based analysis of microorganisms associated with failed endodontic treatment","volume":"97","author":"Siqueira","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.joen.2011.02.006","article-title":"Relationship of biofilm formation and gelE gene expression in enterococcus faecalis recovered from root canals in patients requiring endodontic retreatment","volume":"37","author":"Wang","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.resmic.2010.09.018","article-title":"Characterization of virulence factors and clonal diversity of enterococcus faecalis isolates from treated dental root canals","volume":"162","author":"Zoletti","year":"2011","journal-title":"Res Microbiol"},{"key":"10.1016\/j.joen.2024.12.009_bib49","doi-asserted-by":"crossref","DOI":"10.1177\/20503121231220794","article-title":"The effectiveness of single antibiotic paste nitrofurantoin V\/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis\u2014a randomized controlled trial","volume":"12","author":"Abbasi","year":"2024","journal-title":"SAGE Open Med"},{"key":"10.1016\/j.joen.2024.12.009_bib50","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2017.vol31.0108","article-title":"Culture-dependent approaches to explore the prevalence of root canal pathogens from endodontic infections","volume":"31","author":"Pourhajibagher","year":"2017","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.joen.2024.12.009_bib51","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S1079-2104(03)00166-5","article-title":"Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments against Enterococcus faecalis in\u00a0vitro","volume":"96","author":"Basrani","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib52","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00004770-200210000-00003","article-title":"Biofilm formation in medicated root canals","volume":"28","author":"Distel","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-9657.2009.00834.x","article-title":"The effects of short-term calcium hydroxide application on the strength of dentine","volume":"26","author":"Sahebi","year":"2010","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2024.12.009_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.36347\/sjds.2022.v09i01.004","article-title":"The effects of short-term calcium hydroxide application on the strength of dentine","volume":"9","author":"Hedgire","year":"2022","journal-title":"Sch J Dent Sci"},{"key":"10.1016\/j.joen.2024.12.009_bib55","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4103\/JCDE.JCDE_172_24","article-title":"Comparative evaluation of antibacterial efficacy of nitrofurantoin, chitosan, and calcium hydroxide in combination with propylene glycol as an intracanal medicament against endodontic pathogen \u2013 an in\u00a0vitro study","volume":"27","author":"Ugalmugale","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib56","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/iej.13093","article-title":"Inflammatory potential of monospecies biofilm matrix components","volume":"52","author":"Ramirez","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib57","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1038\/s41598-022-11780-x","article-title":"Effect of calcium hydroxide on morphology and physicochemical properties of enterococcus faecalis biofilm","volume":"12","author":"Momenijavid","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.joen.2024.12.009_bib58","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1073\/pnas.73.10.3386","article-title":"Nitrofurans, a group of synthetic antibiotics, with a new mode of action: discrimination of specific messenger RNA classes","volume":"73","author":"Herrlich","year":"1976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joen.2024.12.009_bib59","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1055\/s-0039-3401369","article-title":"Cytotoxicity evaluation of minimum antibacterial values of different medicaments used in endodontic regenerative procedures","volume":"13","author":"Khoshkhounejad","year":"2019","journal-title":"Eur J Dent"},{"key":"10.1016\/j.joen.2024.12.009_bib60","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/aej.12437","article-title":"Optimal antimicrobial concentration of mixed antibiotic pastes in eliminating Enterococcus faecalis from root dentin","volume":"47","author":"Dewi","year":"2021","journal-title":"Aust Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib61","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/jemt.23192","article-title":"Antimicrobial activity of intracanal medications against both enterococcus faecalis and Candida albicans biofilm","volume":"82","author":"Zancan","year":"2019","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.joen.2024.12.009_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.joen.2012.10.004","article-title":"Antimicrobial activity of triantibiotic paste, 2% chlorhexidine gel, and calcium hydroxide on an intraoral-infected dentin biofilm model","volume":"39","author":"Ordinola-Zapata","year":"2013","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib63","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.joen.2020.06.032","article-title":"Antimicrobial therapeutics in regenerative endodontics: a scoping review","volume":"46","author":"Ribeiro","year":"2020","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2024.12.009_bib64","first-page":"1","article-title":"A review on triple antibiotic paste as a suitable material used in regenerative endodontics","volume":"13","author":"Mohammadi","year":"2018","journal-title":"Iran Endod J"},{"key":"10.1016\/j.joen.2024.12.009_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/2128473","article-title":"Assessment of nitrofurantoin as an experimental intracanal medicament in endodontics","volume":"2020","author":"Alrahman","year":"2020","journal-title":"Biomed Res Int"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924006915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239924006915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T23:42:04Z","timestamp":1741909324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239924006915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0099239924006915"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2024.12.009","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the Potential of Nitrofurantoin for Infection Control in Regenerative Endodontics: In\u00a0Vitro Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2024.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}