{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:54:33Z","timestamp":1793224473527,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002425","name":"Governo Brasil","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.joen.2025.12.006","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T16:10:48Z","timestamp":1766247048000},"page":"653-657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Placement and Removal of Calcium Hydroxide and a Bioceramic Medication in Type-II Mesial Molar Canals: A Micro-computed Tomographic Study"],"prefix":"10.1016","volume":"52","author":[{"given":"Pilar A.","family":"Araya-Cumsille","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita A.","family":"Toloza-Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina C.","family":"Brasil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda A.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea F.","family":"Campello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9922-8202","authenticated-orcid":false,"given":"Fl\u00e1vio R.F.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela N.","family":"R\u00f4\u00e7as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Jos\u00e9 F.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2025.12.006_bib1","series-title":"Treatment of Endodontic Infections","author":"Siqueira","year":"2022"},{"key":"10.1016\/j.joen.2025.12.006_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2591.1999.00275.x","article-title":"Mechanisms of antimicrobial activity of calcium hydroxide: a critical review","volume":"32","author":"Siqueira","year":"1999","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2025.12.006_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0099-2399(98)80151-9","article-title":"Influence of different vehicles on the antibacterial effects of calcium hydroxide","volume":"24","author":"Siqueira","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1590\/S0103-64402010000400004","article-title":"Calcium hydroxide intracanal dressing removal with different rotary instruments and irrigating solutions: a scanning electron microscopy study","volume":"21","author":"Kuga","year":"2010","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2025.12.006_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2591.2005.01049.x","article-title":"Removal efficacy of various calcium hydroxide\/chlorhexidine medicaments from the root canal","volume":"39","author":"Lambrianidis","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2025.12.006_bib6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/iej.12374","article-title":"Micro-CT evaluation of calcium hydroxide removal through passive ultrasonic irrigation associated with or without an additional instrument","volume":"48","author":"Silva","year":"2015","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2025.12.006_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fdmed.2024.1451275","article-title":"Novel temporary endodontic medication based on calcium silicate strategy: a biological and physicochemical study","volume":"5","author":"El Hachem","year":"2024","journal-title":"Front Dent Med"},{"key":"10.1016\/j.joen.2025.12.006_bib8","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1590\/0103-6440202003376","article-title":"A new calcium silicate-based root canal dressing: physical and chemical properties, cytotoxicity and dentinal tubule penetration","volume":"31","author":"Villa","year":"2020","journal-title":"Braz Dent J"},{"key":"10.1016\/j.joen.2025.12.006_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/ma11010123","article-title":"Effect of exposed surface area, volume and environmental pH on the calcium ion release of three commercially available tricalcium silicate based dental cements","volume":"11","author":"Rajasekharan","year":"2018","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.joen.2025.12.006_bib10","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/iej.13502","article-title":"Antibacterial activity, cytocompatibility and effect of Bio-C temp bioceramic intracanal medicament on osteoblast biology","volume":"54","author":"Guerreiro","year":"2021","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2025.12.006_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.joen.2024.11.016","article-title":"Intracanal antibacterial effects of a bioceramic medication compared with calcium hydroxide pastes in different vehicles","volume":"51","author":"Campello","year":"2025","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/JCDE.JCDE_74_24","article-title":"Comparative evaluation of the antibacterial efficacy of two experimental calcium silicate-based intracanal medicaments: an in-vitro study","volume":"27","author":"Patri","year":"2024","journal-title":"J Conserv Dent Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib13","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.4317\/jced.62609","article-title":"Bioceramic dressing and its influence on intratubular penetration and bond strength of endodontic sealers","volume":"17","author":"Rodrigues","year":"2025","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.joen.2025.12.006_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00004770-200202000-00012","article-title":"Influence of calcium hydroxide dressing on the obturation of simulated lateral canals","volume":"28","author":"Goldberg","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib15","doi-asserted-by":"crossref","first-page":"374","DOI":"10.14744\/eej.2024.35219","article-title":"Calcium silicate-based intracanal medication: physicochemical properties and effectiveness of techniques for removing medication from the human root canal","volume":"9","author":"Lopes","year":"2024","journal-title":"Eur Endod J"},{"key":"10.1016\/j.joen.2025.12.006_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/iej.12316","article-title":"Efficacy of different irrigation techniques in the removal of calcium hydroxide from a simulated internal root resorption cavity","volume":"48","author":"Topcuoglu","year":"2015","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2025.12.006_bib17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.joen.2014.07.033","article-title":"Efficacy of 3 different irrigation systems on removal of calcium hydroxide from the root canal: a scanning electron microscopic study","volume":"41","author":"Alturaiki","year":"2015","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12903-023-03450-9","article-title":"Micro-computed tomography analysis of calcium hydroxide delivery efficacy in C-shaped canal system of mandibular second molars","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.joen.2025.12.006_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69849-8","article-title":"Efficacy of various techniques in calcium silicate-based intracanal medicament removal: a micro-CT analysis","volume":"14","author":"Almohareb","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.joen.2025.12.006_bib20","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.joen.2025.05.013","article-title":"Micro-computed tomographic analysis of the efficacy of 3 techniques for removal of calcium hydroxide from the mesial canals of curved mandibular molars","volume":"51","author":"Edwards","year":"2025","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00784-024-05878-x","article-title":"Evaluation of different irrigation activation techniques for the removal of various medicaments from a simulated internal resorption cavity: an in vitro study","volume":"28","author":"Sariyilmaz","year":"2024","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.joen.2025.12.006_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joen.2010.11.019","article-title":"Efficacy of sonic and ultrasonic activation for removal of calcium hydroxide from mesial canals of mandibular molars: a microtomographic study","volume":"37","author":"Wiseman","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2025.12.006_bib23","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2591.2005.01035.x","article-title":"Calcium hydroxide dressings using different preparation and application modes: density and dissolution by simulated tissue pressure","volume":"38","author":"Peters","year":"2005","journal-title":"Int Endod J"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239925008106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239925008106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:37:22Z","timestamp":1775306242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239925008106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0099239925008106"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2025.12.006","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placement and Removal of Calcium Hydroxide and a Bioceramic Medication in Type-II Mesial Molar Canals: A Micro-computed Tomographic Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2025.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}