{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T07:23:56Z","timestamp":1787383436955,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002665","name":"Aristotle University of Thessaloniki Research Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.joen.2026.06.001","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:34:44Z","timestamp":1781278484000},"page":"1508-1515.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of High-Performance Liquid Chromatography to Quantify Formaldehyde Release From the Chemical Interaction of Sodium Hypochlorite and EDTA"],"prefix":"10.1016","volume":"52","author":[{"given":"Konstantinos","family":"Ioannidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Katmerou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Nikolaidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kolokouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Koulaouzidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2026.06.001_bib1","first-page":"61","article-title":"Root canal irrigation\u2014a historical perspective","volume":"52","author":"Sedgley","year":"2004","journal-title":"J Hist Dent"},{"key":"10.1016\/j.joen.2026.06.001_bib2","series-title":"Formation of Toxic Disinfection By-Products During Chemomechanical Preparation of Infected Root Canals and Alternative Methods for Root Canal Disinfection (PhD Thesis)","author":"Ioannidis","year":"2020"},{"key":"10.1016\/j.joen.2026.06.001_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/iej.12595","article-title":"Mixture of alkaline tetrasodium EDTA with sodium hypochlorite promotes in vitro smear layer removal and organic matter dissolution during biomechanical preparation","volume":"50","author":"Tartari","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2026.06.001_bib4","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.joen.2011.01.018","article-title":"Influence of ethylenediaminetetraacetic acid on the active chlorine content of sodium hypochlorite solutions when mixed in various proportions","volume":"37","author":"Clarkson","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2026.06.001_bib5","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.joen.2017.03.034","article-title":"Free active chlorine in sodium hypochlorite solutions admixed with octenidine, SmearOFF, chlorhexidine, and EDTA","volume":"43","author":"Krishnan","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2026.06.001_bib6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.joen.2005.08.007","article-title":"Interaction between EDTA and sodium hypochlorite: a nuclear magnetic resonance analysis","volume":"32","author":"Grande","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2026.06.001_bib7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.dental.2019.11.011","article-title":"Ex vivo detection and quantification of apically extruded volatile compounds and disinfection by-products by SIFT-MS, during chemomechanical preparation of infected root canals","volume":"36","author":"Ioannidis","year":"2020","journal-title":"Dent Mater"},{"key":"10.1016\/j.joen.2026.06.001_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2591.2008.01514.x","article-title":"Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer","volume":"42","author":"Lottanti","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2026.06.001_bib9","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.joen.2014.07.031","article-title":"Antimicrobial activity of a sodium hypochlorite\/etidronic acid irrigant solution","volume":"40","author":"Arias-Moliz","year":"2014","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2026.06.001_bib11","volume":"88","year":"2006"},{"key":"10.1016\/j.joen.2026.06.001_bib13","series-title":"WHO Guidelines for Indoor Air Quality: Selected Pollutants","first-page":"103","article-title":"3. Formaldehyde","year":"2010"},{"key":"10.1016\/j.joen.2026.06.001_bib14","first-page":"19","article-title":"Separation science and technology: 2 - key concepts of HPLC in pharmaceutical analysis","volume":"6","author":"Ornaf","year":"2005","journal-title":"Sep Sci Tech"},{"issue":"Suppl 1","key":"10.1016\/j.joen.2026.06.001_bib15","first-page":"127","article-title":"Determination of formaldehyde in squid by high performance liquid chromatography","volume":"16","author":"Li","year":"2007","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.joen.2026.06.001_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/cssc.202402371","article-title":"Production of novel dental resin monomers using dimethacrylated oligoesters derived from chemically recycling PET waste","volume":"18","author":"Karkanis","year":"2025","journal-title":"ChemSusChem"},{"key":"10.1016\/j.joen.2026.06.001_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.joen.2015.12.024","article-title":"Does para-chloroaniline really form after mixing sodium hypochlorite and chlorhexidine?","volume":"42","author":"Orhan","year":"2016","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2026.06.001_bib19","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.dental.2023.07.006","article-title":"Controlled drug delivery from metronidazole-containing bioactive endodontic cements","volume":"39","author":"Balbinot","year":"2023","journal-title":"Dent Mater"},{"key":"10.1016\/j.joen.2026.06.001_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/1305-7456.175691","article-title":"Investigation of eluted monomers from resin-based root canal sealer by high-performance liquid chromatography analysis","volume":"10","author":"Omurlu","year":"2016","journal-title":"Eur J Dent"},{"key":"10.1016\/j.joen.2026.06.001_bib21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/iej.13974","article-title":"Treatment of pulpal and apical disease: the European Society of Endodontology (ESE) S3-level clinical practice guideline","volume":"56 Suppl 3","author":"Duncan","year":"2023","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2026.06.001_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2591.2009.01625.x","article-title":"The effect of sodium hypochlorite and ethylenediaminetetraacetic acid irrigation, individually and in alternation, on tooth surface strain","volume":"43","author":"Rajasingham","year":"2010","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2026.06.001_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jmbbm.2007.04.002","article-title":"Fatigue of mineralized tissues: cortical bone and dentin","volume":"1","author":"Kruzic","year":"2008","journal-title":"J Mech Beh Biomed Mater"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239926003067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239926003067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:40:26Z","timestamp":1787380826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239926003067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0099239926003067"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2026.06.001","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of High-Performance Liquid Chromatography to Quantify Formaldehyde Release From the Chemical Interaction of Sodium Hypochlorite and EDTA","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2026.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Association of Endodontists.","name":"copyright","label":"Copyright"}]}}