{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:34:30Z","timestamp":1788971670096,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gynecology Obstetrics and Human Reproduction"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jogoh.2019.07.010","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T10:51:12Z","timestamp":1562410272000},"page":"101614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The results of new low dose fractional CO2 Laser \u2013 A prospective clinical study in France"],"prefix":"10.1016","volume":"49","author":[{"given":"Jan","family":"Marin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Lipa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jogoh.2019.07.010_bib0005","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/GME.0000000000000329","article-title":"Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the international society for the study of women\u2019s sexual health and the North American Menopause Society","volume":"21","author":"Portman","year":"2014","journal-title":"Menopause"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0010","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00192-017-3282-y","article-title":"Laser therapy as a treatment modality for genitourinary syndrome of menopause: a critical appraisal of evidence","volume":"28","author":"Arunkalaivanan","year":"2017","journal-title":"Int Urogynecol J"},{"issue":"1","key":"10.1016\/j.jogoh.2019.07.010_bib0015","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10103-014-1677-2","article-title":"Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment","volume":"30","author":"Zerbinati","year":"2014","journal-title":"Lasers Med Sci"},{"issue":"8","key":"10.1016\/j.jogoh.2019.07.010_bib0020","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/GME.0000000000000401","article-title":"Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study","volume":"22","author":"Salvatore","year":"2015","journal-title":"Menopause"},{"issue":"1","key":"10.1016\/j.jogoh.2019.07.010_bib0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3889\/oamjms.2018.058","article-title":"Early regenerative modifications of human postmenopausal atrophic vaginal mucosa following fractional CO2 laser treatment","volume":"6","author":"Salvatore","year":"2018","journal-title":"Open Access Maced J Med Sci"},{"issue":"6","key":"10.1016\/j.jogoh.2019.07.010_bib0030","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/gyn.2016.0099","article-title":"Fractional CO 2 laser treatment for vaginal atrophy and Vulvar lichen sclerosus","volume":"32","author":"Baggish","year":"2016","journal-title":"J Gynecol Surg"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0035","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s10103-018-2471-3","article-title":"Fractional CO2 laser for genitourinary syndrome of menopause in breast cancer survivors: clinical, immunological, and microbiological aspects","volume":"33","author":"Becorpi","year":"2018","journal-title":"Lasers Med Sci"},{"issue":"2","key":"10.1016\/j.jogoh.2019.07.010_bib0040","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/13697137.2014.975197","article-title":"Sexual function after fractional microablative CO2 laser in women with vulvovaginal atrophy","volume":"18","author":"Salvatore","year":"2015","journal-title":"Climacteric"},{"issue":"3","key":"10.1016\/j.jogoh.2019.07.010_bib0045","first-page":"6","article-title":"Atrophie vulvovaginale et laser fractionn\u00e9 CO2","volume":"183","author":"Elia","year":"2015","journal-title":"Genesis"},{"issue":"3","key":"10.1016\/j.jogoh.2019.07.010_bib0050","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/074880681102800309","article-title":"Vaginal Fractional CO2 Laser: A Minimally Invasive Option for Vaginal Rejuvenation","volume":"28","author":"Gaspar","year":"2011","journal-title":"Am. J. Cosmet. Surg."},{"issue":"3","key":"10.1016\/j.jogoh.2019.07.010_bib0055","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.maturitas.2014.12.006","article-title":"Vulvo-vaginal atrophy: a new treatment modality using thermo-ablative fractional CO2laser","volume":"80","author":"Perino","year":"2015","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.jogoh.2019.07.010_bib0060","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.maturitas.2015.07.020","article-title":"Update on management of genitourinary syndrome of menopause: a practical guide","volume":"82","author":"Palacios","year":"2015","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.jogoh.2019.07.010_bib0065","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.maturitas.2012.06.009","article-title":"EMAS clinical guide: low-dose vaginal estrogens for postmenopausal vaginal atrophy","volume":"73","author":"Rees","year":"2012","journal-title":"Maturitas"},{"issue":"4 Supplement","key":"10.1016\/j.jogoh.2019.07.010_bib0070","doi-asserted-by":"crossref","first-page":"P4-11-06","DOI":"10.1158\/1538-7445.SABCS15-P4-11-06","article-title":"Abstract P4-11-06: feasibility of a non-hormonal vaginal moisturizer in postmenopausal cancer survivors","volume":"76","author":"Carter","year":"2016","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.jogoh.2019.07.010_bib0075","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5301\/je.5000184","article-title":"Microablative fractional CO2 laser improves dyspareunia related to vulvovaginal atrophy: a pilot study","volume":"6","author":"Salvatore","year":"2014","journal-title":"J Endometr Pelvic Pain Disord"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.maturitas.2016.09.012","article-title":"Microablative fractional CO2-laser therapy and the genitourinary syndrome of menopause: an observational study","volume":"94","author":"Pitsouni","year":"2016","journal-title":"Maturitas"},{"issue":"8","key":"10.1016\/j.jogoh.2019.07.010_bib0085","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s10103-017-2293-8","article-title":"Microablative fractional CO2laser for the genitourinary syndrome of menopause: power of 30 or 40 W?","volume":"32","author":"Pitsouni","year":"2017","journal-title":"Lasers Med Sci"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0090","series-title":"Fundamentals of Biostatistics","first-page":"221","article-title":"Sample size for before-after study (Paired T-test) | Sample Size Calculators","author":"UCSF Clinical and Translational Science Institute","year":"1995"},{"issue":"2","key":"10.1016\/j.jogoh.2019.07.010_bib0095","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/bimj.4710350205","article-title":"Fundamentals of Biostatistics, third edition. PWS-Kent, Boston 1990","volume":"35","author":"Sanchez","year":"1993","journal-title":"Biom J"},{"issue":"1","key":"10.1016\/j.jogoh.2019.07.010_bib0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0002-9378(96)70243-0","article-title":"The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction","volume":"175","author":"Bump","year":"1996","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.jogoh.2019.07.010_bib0105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/009262300278597","article-title":"The female sexual function index (Fsfi): a multidimensional self-report instrument for the assessment of female sexual function","volume":"26","author":"Rosen","year":"2000","journal-title":"J Sex Marital Ther"},{"issue":"4","key":"10.1016\/j.jogoh.2019.07.010_bib0110","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.maturitas.2015.08.001","article-title":"Genitourinary syndrome of menopause and the use of laser therapy","volume":"82","author":"Hutchinson-Colas","year":"2015","journal-title":"Maturitas"},{"issue":"10-11","key":"10.1016\/j.jogoh.2019.07.010_bib0115","first-page":"729","article-title":"CO2LASER for the treatment of vaginal symptoms of genitourinary syndrome of menopause","volume":"46","author":"Jardin","year":"2018","journal-title":"Gynecol Obstet Fertil Senol"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0120","article-title":"FDA warns against use of energy-based devices to perform vaginal \u2018Rejuvenation\u2019 or vaginal cosmetic procedures","author":"U.S. Food and Drug Administration","year":"2018","journal-title":"FDA Safety Communications"},{"issue":"2","key":"10.1016\/j.jogoh.2019.07.010_bib0125","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/ajo.12735","article-title":"The evidence for laser treatments to the vulvo-vagina: making sure we do not repeat past mistakes","volume":"58","author":"Song","year":"2018","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"1","key":"10.1016\/j.jogoh.2019.07.010_bib0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/GME.0000000000000955","article-title":"Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO 2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women","volume":"25","author":"Cruz","year":"2018","journal-title":"Menopause"},{"issue":"9","key":"10.1016\/j.jogoh.2019.07.010_bib0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.5694\/mja18.00187","article-title":"No TitleThe first published randomised controlled trial of laser treatment for vaginal atrophy raises serious questions","volume":"209","author":"Buttini","year":"2018","journal-title":"Med J Aust"},{"issue":"10","key":"10.1016\/j.jogoh.2019.07.010_bib0140","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/GME.0000000000000700","article-title":"An assessment of the safety and efficacy of a fractional CO2 laser system for the treatment of vulvovaginal atrophy","volume":"23","author":"Sokol","year":"2016","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.jogoh.2019.07.010_bib0145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/13697137.2017.1319815","article-title":"Fractional CO2laser therapy: a new challenge for vulvovaginal atrophy in postmenopausal women","volume":"20","author":"Siliquini","year":"2017","journal-title":"Climacteric"},{"issue":"5","key":"10.1016\/j.jogoh.2019.07.010_bib0150","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/13697137.2016.1212006","article-title":"The effect of microablative fractional CO 2 laser on vaginal flora of postmenopausal women","volume":"19","author":"Athanasiou","year":"2016","journal-title":"Climacteric"},{"issue":"5","key":"10.1016\/j.jogoh.2019.07.010_bib0155","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3109\/13697137.2015.1045485","article-title":"Vaginal Erbium Laser: the second-generation thermotherapy for the genitourinary syndrome of menopause","volume":"18","author":"Gambacciani","year":"2015","journal-title":"Climacteric"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0160","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.maturitas.2017.07.007","article-title":"CO2-laser for the genitourinary syndrome of menopause. How many laser sessions?","volume":"104","author":"Athanasiou","year":"2017","journal-title":"Maturitas"},{"issue":"9","key":"10.1016\/j.jogoh.2019.07.010_bib0165","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/lsm.22416","article-title":"Novel minimally invasive laser treatment of urinary incontinence in women","volume":"7","author":"Ogrinc","year":"2015","journal-title":"Lasers Surg Med"},{"issue":"Suppl 1","key":"10.1016\/j.jogoh.2019.07.010_bib0170","first-page":"32","article-title":"Er:yag laser treatment for early stages of stress urinary incontinence (SUI) in women: a controlled clinical trial","volume":"17","author":"Ivan","year":"2014","journal-title":"Climacteric"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0175","article-title":"Laser thermotherapy in pelvic floor dysfunction, randomised placebo controled study","author":"Lukanovic","year":"2014","journal-title":"Neurourol. urodynamics."},{"key":"10.1016\/j.jogoh.2019.07.010_bib0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejogrb.2017.03.036","article-title":"Safety and long-term efficacy of fractional CO2 laser treatment in women suffering from genitourinary syndrome of menopause","volume":"213","author":"Behnia-Willison","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"10.1016\/j.jogoh.2019.07.010_bib0185","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/GME.0000000000000761","article-title":"Vaginal erbium laser as second-generation thermotherapy for the genitourinary syndrome of menopause: a pilot study in breast cancer survivors","volume":"24","author":"Gambacciani","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.jogoh.2019.07.010_bib0190","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000329338","article-title":"Vaginal rugation rejuvenation (restoration): a new surgical technique for an acquired sensation of wide\/Smooth Vagina","volume":"73","author":"Ostrzenski","year":"2012","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"10.1016\/j.jogoh.2019.07.010_bib0195","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/13697137.2018.1436538","article-title":"Long-term effects of vaginal erbium laser in the treatment of genitourinary syndrome of menopause","volume":"21","author":"Gambacciani","year":"2018","journal-title":"Climacteric"},{"issue":"12","key":"10.1016\/j.jogoh.2019.07.010_bib0200","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.jsxm.2016.10.006","article-title":"Fractional CO2Laser treatment of the vestibule for patients with vestibulodynia and genitourinary syndrome of menopause: a pilot study","volume":"13","author":"Murina","year":"2016","journal-title":"J Sex Med"},{"issue":"9","key":"10.1016\/j.jogoh.2019.07.010_bib0205","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/GME.0b013e3182a15aa1","article-title":"2013 position statement of the North American Menopause Society","volume":"20","author":"Management of symptomatic vulvovaginal atrophy","year":"2013","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.jogoh.2019.07.010_bib0210","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00404-016-4118-6","article-title":"Fractional CO2laser for vulvovaginal atrophy (VVA) dyspareunia relief in breast cancer survivors","volume":"294","author":"Pieralli","year":"2016","journal-title":"Arch Gynecol Obstet"}],"container-title":["Journal of Gynecology Obstetrics and Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468784719302028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468784719302028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:55:50Z","timestamp":1762854950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468784719302028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2468784719302028"],"URL":"https:\/\/doi.org\/10.1016\/j.jogoh.2019.07.010","relation":{},"ISSN":["2468-7847"],"issn-type":[{"value":"2468-7847","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The results of new low dose fractional CO2 Laser \u2013 A prospective clinical study in France","name":"articletitle","label":"Article Title"},{"value":"Journal of Gynecology Obstetrics and Human Reproduction","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jogoh.2019.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101614"}}