{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T04:30:47Z","timestamp":1794457847752,"version":"4.9.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gynecology Obstetrics and Human Reproduction"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jogoh.2020.102006","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T17:29:19Z","timestamp":1606152559000},"page":"102006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The efficacy of different insulin-sensitizing agents on treatment outcomes in patients with polycystic ovary syndrome who underwent in-vitro fertilization: A retrospective, record-based, comparative study"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-5320","authenticated-orcid":false,"given":"Asl\u0131","family":"Yaylal\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bakacak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-0939","authenticated-orcid":false,"given":"Zeyneb","family":"Bakacak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jogoh.2020.102006_bib0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jogoh.2020.102006_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/ENDO:30:1:3","article-title":"Diagnostic criteria for polycystic ovarian syndrome","volume":"30","author":"Broekmans","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.jogoh.2020.102006_bib0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJM199608293350909","article-title":"Insulin and the polycystic ovary syndrome","volume":"335","author":"Utiger","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jogoh.2020.102006_bib0020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0015-0282(03)00734-9","article-title":"The importance of insulin resistance in polycystic ovary syndrome","volume":"80","author":"Goodarzi","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jogoh.2020.102006_bib0025","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humupd\/dmn015","article-title":"Follicle dynamics and anovulation in polycystic ovary syndrome","volume":"14","author":"Franks","year":"2008","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.jogoh.2020.102006_bib0030","doi-asserted-by":"crossref","first-page":"482","DOI":"10.5603\/EP.2017.0050","article-title":"Metformin - a new old drug","volume":"68","author":"Wr\u00f3bel","year":"2017","journal-title":"Endokrynol Pol"},{"key":"10.1016\/j.jogoh.2020.102006_bib0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/1471-0528.12070","article-title":"Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials","volume":"120","author":"Palomba","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.jogoh.2020.102006_bib0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mehy.2017.01.012","article-title":"Should metformin be included in fertility treatment of PCOS patients?","volume":"100","author":"Haas","year":"2017","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jogoh.2020.102006_bib0045","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/09513590903366996","article-title":"Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women","volume":"26","author":"Raffone","year":"2010","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jogoh.2020.102006_bib0050","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/humrep\/17.6.1591","article-title":"Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality","volume":"17","author":"Chiu","year":"2002","journal-title":"Hum Rep"},{"key":"10.1016\/j.jogoh.2020.102006_bib0055","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/humrep\/deg113","article-title":"Effects of myo-inositol on the in-vitro maturation and subsequent development of mouse oocytes","volume":"18","author":"Chiu","year":"2003","journal-title":"Hum Rep"},{"key":"10.1016\/j.jogoh.2020.102006_bib0060","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.fertnstert.2008.01.088","article-title":"Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial","volume":"91","author":"Papaleo","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jogoh.2020.102006_bib0065","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/humrep\/deh248","article-title":"Metformin treatment before IVF\/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study","volume":"19","author":"Kj\u00f8tr\u00f8d","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jogoh.2020.102006_bib0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jogoh.2020.102006_bib0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.fertnstert.2017.06.026","article-title":"Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline","volume":"108","author":"Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine","year":"2017","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jogoh.2020.102006_bib0080","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/1471-0528.12070","article-title":"Effects of metformin in women with polycystic ovary syndrome treated with gonadotrophins for in vitro fertilisation and intracytoplasmic sperm injection cycles: a systematic review and meta-analysis of randomised controlled trials","volume":"120","author":"Palomba","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.jogoh.2020.102006_bib0085","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/BF01204248","article-title":"A correlation of the outcome of clinical in vitro fertilization with the inositol content and embryotrophic properties of human serum","volume":"9","author":"Chiu","year":"1992","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.jogoh.2020.102006_bib0090","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.fertnstert.2008.01.088","article-title":"Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial","volume":"91","author":"Papaleo","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jogoh.2020.102006_bib0095","article-title":"Inositol for subfertile women with polycystic ovary syndrome","volume":"12","author":"Showell","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jogoh.2020.102006_bib0100","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/09513590.2018.1549656","article-title":"Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial","volume":"35","author":"Agrawal","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jogoh.2020.102006_bib0105","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1080\/09513590.2018.1540570","article-title":"Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial","volume":"35","author":"Shokrpour","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jogoh.2020.102006_bib0110","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00404-019-05064-5","article-title":"The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole","volume":"299","author":"Pourghasem","year":"2019","journal-title":"Arch Gynecol Obstet"}],"container-title":["Journal of Gynecology Obstetrics and Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468784720303767?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468784720303767?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T17:47:09Z","timestamp":1749577629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468784720303767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S2468784720303767"],"URL":"https:\/\/doi.org\/10.1016\/j.jogoh.2020.102006","relation":{},"ISSN":["2468-7847"],"issn-type":[{"value":"2468-7847","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The efficacy of different insulin-sensitizing agents on treatment outcomes in patients with polycystic ovary syndrome who underwent in-vitro fertilization: A retrospective, record-based, comparative study","name":"articletitle","label":"Article Title"},{"value":"Journal of Gynecology Obstetrics and Human Reproduction","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jogoh.2020.102006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102006"}}