{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:50:09Z","timestamp":1790275809848,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.joim.2018.03.001","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T23:45:44Z","timestamp":1520379944000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties"],"prefix":"10.1016","volume":"16","author":[{"given":"Eric Wei Chiang","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu Kuin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Tuck","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joim.2018.03.001_b0005","doi-asserted-by":"crossref","first-page":"9049","DOI":"10.7314\/APJCP.2014.15.21.9049","article-title":"Molecular mechanisms of casticin action: an update on its antitumor functions","volume":"15","author":"Rasul","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.joim.2018.03.001_b0010","series-title":"Plant resources of South-East Asia No. 12(1): medicinal and poisonous plants 1","first-page":"497","author":"de Padua","year":"1999"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0015","first-page":"75","article-title":"Phytoconstituents and biological activities of Vitex\u2014a review","volume":"5","author":"Ganapaty","year":"2005","journal-title":"J Nat Remed"},{"key":"10.1016\/j.joim.2018.03.001_b0020","unstructured":"eFloras.org. Vitex Linn. (1994). [2017-09-01]. http:\/\/flora.huh.harvard.edu\/china\/PDF\/PDF17\/vitex.pdf."},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0025","first-page":"1","article-title":"Pharmacological and phytochemical evidences for the extracts from plants of the genus Vitex\u2014a review","volume":"2","author":"Meena","year":"2010","journal-title":"Int J Pharm Clin Res"},{"issue":"14","key":"10.1016\/j.joim.2018.03.001_b0030","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/0973-7847.120522","article-title":"The genus Vitex: a review","volume":"7","author":"Rani","year":"2013","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.joim.2018.03.001_b0035","unstructured":"The Plant List 2013. Vitex. Version 1.1. [2017-11-20]. http:\/\/www.theplantlist.org\/tpl1.1\/search?q=vitex."},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0040","first-page":"107","article-title":"Medicinal plants of sandy shores: a short review on Vitex trifolia L. and Ipomoea pes-caprae (L.)","volume":"7","author":"Chan","year":"2016","journal-title":"R Br Indian J Nat Prod Resour"},{"issue":"11","key":"10.1016\/j.joim.2018.03.001_b0045","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1248\/cpb.34.4829","article-title":"Studies on the constituents of Vitex rotundifolia L","volume":"34","author":"Kondo","year":"1986","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0050","first-page":"167","article-title":"Chemical constituents of the fruits of Vitex trifolia L","volume":"21","author":"Zeng","year":"1996","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.joim.2018.03.001_b0055","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1515\/znc-2004-7-810","article-title":"Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia","volume":"59","author":"Yoshioka","year":"2004","journal-title":"Z Naturforsch C"},{"key":"10.1016\/j.joim.2018.03.001_b0060","first-page":"582","article-title":"Studies on flavonoid constituents of Vitex trifolia L. var. simplicifolia Cham","volume":"20","author":"Chen","year":"2008","journal-title":"Tian Ran Chan Wu Yan Jiu Yu Kai Fa"},{"key":"10.1016\/j.joim.2018.03.001_b0065","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s13765-012-2027-3","article-title":"Cytotoxic compounds from the fruits of Vitex rotundifolia against human cancer cell lines","volume":"55","author":"Kim","year":"2012","journal-title":"J Korean Soc Appl Biol Chem"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0070","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0944-7113(00)80058-6","article-title":"Pharmacological activities of Vitex agnus-castus extracts in vitro","volume":"7","author":"Meier","year":"2000","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.joim.2018.03.001_b0075","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.fitote.2010.12.003","article-title":"Phytoconstituents from Vitex agnus-castus fruits","volume":"82","author":"Chen","year":"2011","journal-title":"Fitoterapia"},{"issue":"6","key":"10.1016\/j.joim.2018.03.001_b0080","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.3892\/ijo.2013.2133","article-title":"Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines","volume":"43","author":"Kikuchi","year":"2013","journal-title":"Int J Oncol"},{"issue":"9","key":"10.1016\/j.joim.2018.03.001_b0085","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ptr.2639","article-title":"Atta-ur-Rahman. Anti-inflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus","volume":"23","author":"Choudhary","year":"2009","journal-title":"Phytother Res"},{"issue":"11","key":"10.1016\/j.joim.2018.03.001_b0090","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/ptr.2492","article-title":"Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus","volume":"23","author":"Mesaik","year":"2009","journal-title":"Phytother Res"},{"key":"10.1016\/j.joim.2018.03.001_b0095","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1039\/jr9610002523","article-title":"Constituents of Vitex agnus-castus seeds. Part I. Casticin","volume":"73","author":"Beli\u010d","year":"1961","journal-title":"J Chem Soc"},{"issue":"6","key":"10.1016\/j.joim.2018.03.001_b0100","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1021\/np0300784","article-title":"Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo","volume":"66","author":"Diaz","year":"2003","journal-title":"J Nat Prod"},{"issue":"9","key":"10.1016\/j.joim.2018.03.001_b0105","first-page":"1241","article-title":"Analysis of flavonoids and iridoids in Vitex negundo by HPLC-PDA and method validation","volume":"8","author":"Roy","year":"2013","journal-title":"Nat Prod Commun"},{"issue":"9","key":"10.1016\/j.joim.2018.03.001_b0110","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/S0031-9422(00)97976-7","article-title":"Antimicrobial flavonoids from Psiadia trinervia and their methylated and acetylated derivatives","volume":"28","author":"Wang","year":"1989","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0115","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0031-9422(90)80037-H","article-title":"Sesquiterpenes and flavonoids from Tessaria species","volume":"29","author":"Guerreiro","year":"1990","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.joim.2018.03.001_b0120","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ptr.2650080614","article-title":"Trypanocidal components of Pluchea quitoc L","volume":"8","author":"Zani","year":"1994","journal-title":"Phytother Res"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0125","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/jf040231f","article-title":"Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo","volume":"53","author":"Kao","year":"2005","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jep.2005.04.033","article-title":"In vivo immunomodulating activity of wood extracts from Clausena excavata Burm. f","volume":"102","author":"Manosroi","year":"2005","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0135","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.canlet.2005.11.017","article-title":"The flavonoid casticin has multiple mechanisms of tumour cytotoxicity action","volume":"242","author":"Ha\u00efdara","year":"2006","journal-title":"Cancer Lett"},{"issue":"4","key":"10.1016\/j.joim.2018.03.001_b0140","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s11373-006-9081-y","article-title":"Hepatoprotective effect of total flavonoids from Laggera alata against carbon tetrachloride-induced injury in primary cultured neonatal rat hepatocytes and in rats with hepatic damage","volume":"13","author":"Wu","year":"2006","journal-title":"J Biomed Sci"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0145","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jnr.22218","article-title":"Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes","volume":"88","author":"Spohr","year":"2010","journal-title":"J Neurosci Res"},{"issue":"19","key":"10.1016\/j.joim.2018.03.001_b0150","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1080\/10826076.2011.589094","article-title":"Preparative isolation and purification of four flavonoids from Daphne genkwa Sieb. et Zucc. by high-speed counter-current chromatography","volume":"34","author":"Xie","year":"2011","journal-title":"J Liq Chromatogr Relat Technol"},{"issue":"1\u20132","key":"10.1016\/j.joim.2018.03.001_b0155","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chroma.2007.02.105","article-title":"Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography","volume":"1151","author":"Han","year":"2007","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.joim.2018.03.001_b0160","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bse.2016.02.016","article-title":"Phenolics from Tanacetum sinaicum (Fresen.) Delile ex Bremer & Humphries (Asteraceae)","volume":"65","author":"Marzouk","year":"2016","journal-title":"Biochem Syst Ecol"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0165","first-page":"206","article-title":"Content determination of vitexicarpin in different organs of Vitex trifolia L. var. simplicifolia Cham","volume":"31","author":"Sun","year":"2012","journal-title":"Yi Yao Dao Bao"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1076\/phbi.39.1.57.5950","article-title":"Quantitative high performance liquid chromatographic analysis of casticin in the fruits of Vitex agnus-castus","volume":"39","author":"Hoberg","year":"2001","journal-title":"Pharm Biol"},{"issue":"12","key":"10.1016\/j.joim.2018.03.001_b0175","doi-asserted-by":"crossref","first-page":"P300","DOI":"10.1055\/s-0030-1264598","article-title":"Casticin and rotundifuran content of subcritical Vitex agnus-castus CO2 fruit extracts compared with classical Soxhlet extracts","volume":"76","author":"Mele","year":"2010","journal-title":"Planta Med"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/intimm\/dxs102","article-title":"Vitex rotundifolia L. prevented airway eosinophilic inflammation and airway remodelling in an ovalbumin-induced asthma mouse model","volume":"25","author":"Bae","year":"2012","journal-title":"Int Immunol"},{"issue":"12","key":"10.1016\/j.joim.2018.03.001_b0185","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/bmc.2724","article-title":"Metabolism studies of casticin in rats using HPLC-ESI-MS(n)","volume":"26","author":"Ling","year":"2012","journal-title":"Biomed Chromatogr"},{"issue":"4","key":"10.1016\/j.joim.2018.03.001_b0190","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/10286020310001625085","article-title":"Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2\/M phase and induce apoptosis in mammalian cancer cells","volume":"7","author":"Li","year":"2005","journal-title":"J Asian Nat Prod Res"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0195","first-page":"27","article-title":"Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway","volume":"40","author":"Wang","year":"2005","journal-title":"Yao Xue Xue Bao"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2004.01.012","article-title":"G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from viticis fructus (Vitex rotundifolia Linn.)","volume":"208","author":"Kobayakawa","year":"2004","journal-title":"Cancer Lett"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0205","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10330-011-0711-0","article-title":"Proliferation inhibition of human cervical cancer HeLa cells by casticin in vitro","volume":"10","author":"Xie","year":"2011","journal-title":"Chinese-German J Clin Oncol"},{"issue":"8","key":"10.1016\/j.joim.2018.03.001_b0210","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00277-008-0677-3","article-title":"Casticin induces leukemic cell death through apoptosis and mitotic catastrophe","volume":"88","author":"Shen","year":"2009","journal-title":"Ann Hematol"},{"issue":"10","key":"10.1016\/j.joim.2018.03.001_b0215","first-page":"703","article-title":"Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell","volume":"90","author":"Song","year":"2010","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"38","key":"10.1016\/j.joim.2018.03.001_b0220","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.3748\/wjg.v17.i38.4298","article-title":"Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells","volume":"17","author":"Yang","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.joim.2018.03.001_b0225","doi-asserted-by":"crossref","first-page":"e58855","DOI":"10.1371\/journal.pone.0058855","article-title":"Casticin potentiates trail-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress","volume":"8","author":"Zhou","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0230","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1271\/bbb.63.896","article-title":"Antiproliferative activity of flavonoids on several cancer lines","volume":"63","author":"Kawaii","year":"1999","journal-title":"Biosci Biotechnol Biochem"},{"issue":"10","key":"10.1016\/j.joim.2018.03.001_b0235","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0278-6915(00)00079-X","article-title":"Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells","volume":"38","author":"Ko","year":"2000","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0240","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/abbs\/gms013","article-title":"Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase","volume":"44","author":"Zeng","year":"2012","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"6","key":"10.1016\/j.joim.2018.03.001_b0245","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1159\/000350098","article-title":"Casticin induces human glioma cell death through apoptosis and mitotic arrest","volume":"31","author":"Liu","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.joim.2018.03.001_b0250","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3329\/bjp.v11i1.24578","article-title":"Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase","volume":"11","author":"Song","year":"2016","journal-title":"Bangladesh J Pharmacol"},{"issue":"6","key":"10.1016\/j.joim.2018.03.001_b0255","first-page":"412","article-title":"Casticin induces apoptosis and mitotic arrest in pancreatic carcinoma PANC-1 cells","volume":"6","author":"Ding","year":"2012","journal-title":"Afr J Pharm Pharmacol"},{"issue":"12","key":"10.1016\/j.joim.2018.03.001_b0260","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.7314\/APJCP.2012.13.12.6369","article-title":"Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2\/M phase arrest","volume":"13","author":"Meng","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"10.1016\/j.joim.2018.03.001_b0265","first-page":"426","article-title":"Effect of casticin on the growth of human ovarian carcinoma HO-8910 cells xenografts in nude mice","volume":"21","author":"Bai","year":"2011","journal-title":"Zhongguo Xian Dai Yi Xue Za Zhi"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0270","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3892\/or.2012.2127","article-title":"Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells","volume":"29","author":"Tang","year":"2013","journal-title":"Oncol Rep"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0275","first-page":"149","article-title":"Effects of casticin on the growth and apoptosis of colon carcinoma cell line SW480","volume":"39","author":"Yuan","year":"2011","journal-title":"Zhongnan Yi Xue Ke Xue Za Zhi"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0280","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1995-7645(13)60041-3","article-title":"Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells","volume":"6","author":"Zhou","year":"2013","journal-title":"Asian Pac J Trop Med"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0285","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3892\/etm.2014.1934","article-title":"Activation of the apoptosis signal\u2013regulating kinase 1\/c\u2013Jun N\u2013terminal kinase pathway is involved in the casticin\u2013induced apoptosis of colon cancer cells","volume":"8","author":"Qu","year":"2014","journal-title":"Exp Ther Med"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0290","first-page":"9","article-title":"Role of apoptosis signal-regulating kinase 1 activation in casticin-induced apoptosis of colon cancer cells","volume":"9","author":"Huang","year":"2012","journal-title":"Hunan Shi Fan Da Xue Xue Bao (Yi Xue Ban)"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0295","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3892\/or.2012.2076","article-title":"Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma","volume":"29","author":"He","year":"2013","journal-title":"Oncol Rep"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0300","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3892\/ol.2013.1258","article-title":"Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a","volume":"5","author":"Jiang","year":"2013","journal-title":"Oncol Lett"},{"issue":"12","key":"10.1016\/j.joim.2018.03.001_b0305","first-page":"898","article-title":"Casticin induces breast cancer cell apoptosis by inhibition of FoxM1","volume":"22","author":"Liu","year":"2012","journal-title":"Zhongguo Ai Zheng Za Zhi"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0310","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.3892\/ol.2014.1911","article-title":"Casticin induces breast cancer cell apoptosis by inhibiting the expression of fork-head box protein M1","volume":"7","author":"Liu","year":"2014","journal-title":"Oncol Lett"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0315","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3892\/ol.2014.1899","article-title":"Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through down-regulating Twist","volume":"7","author":"He","year":"2014","journal-title":"Oncol Lett"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0320","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1142\/S0192415X1650035X","article-title":"Casticin induced apoptosis in A375.S2 human melanoma cells through the inhibition of NF-\u03baB and mitochondria-dependent pathways in vitro and inhibited human melanoma xenografts in a mouse model in vivo","volume":"44","author":"Shiue","year":"2016","journal-title":"Am J Chin Med"},{"issue":"9","key":"10.1016\/j.joim.2018.03.001_b0325","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/tox.22417","article-title":"Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K\/AKT and NF-\u03baB signalling pathways","volume":"32","author":"Shih","year":"2017","journal-title":"Environ Toxicol"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0330","first-page":"106","article-title":"Effects of casticin on the apoptosis and methylation of DAPK gene in cervical cancer HeLa cells","volume":"2","author":"Zhao","year":"2012","journal-title":"Zhong Liu Yao Xue"},{"issue":"1","key":"10.1016\/j.joim.2018.03.001_b0335","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3329\/bjp.v10i1.20975","article-title":"Vitexicarpin inhibits overexpression of GNAO1 and plays a role in gastric cancer cell proliferation and apoptosis","volume":"10","author":"Wang","year":"2015","journal-title":"Bangladesh J Pharmacol"},{"issue":"25","key":"10.1016\/j.joim.2018.03.001_b0340","first-page":"1874","article-title":"Vitexicarpin induces apoptosis-independent mitotic arrest in U87 glioblastoma cells","volume":"6","author":"Wang","year":"2012","journal-title":"Afr J Pharm Pharmacol"},{"issue":"8","key":"10.1016\/j.joim.2018.03.001_b0345","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1002\/tox.22381","article-title":"Casticin induced apoptotic cell death and altered associated gene expression in human colon cancer colo 205 cells","volume":"32","author":"Shang","year":"2017","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.joim.2018.03.001_b0350","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12935-016-0377-3","article-title":"Casticin induces apoptosis and G0\/G1 cell cycle arrest in gallbladder cancer cells","volume":"17","author":"Song","year":"2017","journal-title":"Cancer Cell Int"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0355","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/tox.22497","article-title":"Casticin impairs cell growth and induces cell apoptosis via cell cycle arrest in human oral cancer SCC-4 cells","volume":"33","author":"Chou","year":"2017","journal-title":"Environ Toxicol"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0360","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3892\/etm.2016.4003","article-title":"Casticin inhibits the activity of transcription factor Sp1 and the methylation of RECK in MGC803 gastric cancer cells","volume":"13","author":"Yang","year":"2017","journal-title":"Exp Ther Med"},{"issue":"6","key":"10.1016\/j.joim.2018.03.001_b0365","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1055\/s-2006-957511","article-title":"Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro","volume":"64","author":"You","year":"1998","journal-title":"Planta Med"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0370","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3736\/jcim20070520","article-title":"In vivo effect of casticin on acute inflammation","volume":"5","author":"Lin","year":"2007","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0375","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s10753-011-9349-x","article-title":"Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells","volume":"35","author":"Lee","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.joim.2018.03.001_b0380","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jep.2014.10.046","article-title":"Casticin inhibits COX-2 and iNOS expression via suppression of NF-\u03baB and MAPK signalling in lipopolysaccharide-stimulated mouse macrophages","volume":"158","author":"Liou","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"21","key":"10.1016\/j.joim.2018.03.001_b0385","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1016\/j.bmcl.2013.08.004","article-title":"Anti-inflammatory constituents from the fruits of Vitex rotundifolia","volume":"23","author":"Lee","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"issue":"2","key":"10.1016\/j.joim.2018.03.001_b0390","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.intimp.2015.07.041","article-title":"Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model","volume":"28","author":"Lee","year":"2015","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0395","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jep.2011.01.014","article-title":"Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-\u03baB inactivation","volume":"136","author":"Koh","year":"2011","journal-title":"J Ethnopharmacol"},{"issue":"11","key":"10.1016\/j.joim.2018.03.001_b0400","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1055\/s-2002-35650","article-title":"Tracheo-spasmolytic activity of viteosin-A and vitexicarpin isolated from Vitex trifolia","volume":"68","author":"Alam","year":"2002","journal-title":"Planta Med"},{"issue":"10","key":"10.1016\/j.joim.2018.03.001_b0405","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.phymed.2007.01.008","article-title":"Antinociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents","volume":"14","author":"Hu","year":"2007","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.joim.2018.03.001_b0410","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/aps.2010.178","article-title":"Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro","volume":"31","author":"Ye","year":"2010","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.joim.2018.03.001_b0415","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bcp.2010.09.013","article-title":"Opioidergic mechanisms underlying the actions of Vitex agnus-castus L","volume":"81","author":"Webster","year":"2011","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1016\/j.joim.2018.03.001_b0420","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1211\/jpp.59.9.0016","article-title":"Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of pre-menstrual syndrome","volume":"59","author":"Hu","year":"2007","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.joim.2018.03.001_b0425","first-page":"278405","article-title":"Vitexicarpin acts as a novel angiogenesis inhibitor and its target network","volume":"2013","author":"Zhang","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"24","key":"10.1016\/j.joim.2018.03.001_b0430","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1080\/14786419.2017.1303696","article-title":"Anti-angiogenic activity and phytochemical screening of fruit fractions from Vitex agnus castus","volume":"31","author":"Certo","year":"2017","journal-title":"Nat Prod Res"},{"issue":"5","key":"10.1016\/j.joim.2018.03.001_b0435","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3892\/mmr.2012.1040","article-title":"Drug screening study using glioma stem-like cells","volume":"6","author":"Feng","year":"2012","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.joim.2018.03.001_b0440","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejphar.2016.07.035","article-title":"Casticin inhibits lipopolysaccharide-induced acute lung injury in mice","volume":"789","author":"Wang","year":"2016","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0445","first-page":"2879","article-title":"Casticin attenuates rheumatoid arthritis through PKC-NF-\u03baB signalling in vitro and in vivo","volume":"9","author":"Li","year":"2016","journal-title":"Int J Clin Exper Pathol"},{"key":"10.1016\/j.joim.2018.03.001_b0450","doi-asserted-by":"crossref","first-page":"56267","DOI":"10.18632\/oncotarget.17453","article-title":"Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-\u03b2\/Smad signalling pathway","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.joim.2018.03.001_b0455","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s004040000123","article-title":"Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS)","volume":"264","author":"Berger","year":"2000","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.joim.2018.03.001_b0460","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1136\/bmj.322.7279.134","article-title":"Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study","volume":"322","author":"Schellenberg","year":"2001","journal-title":"BMJ"},{"issue":"14","key":"10.1016\/j.joim.2018.03.001_b0465","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.phymed.2012.08.006","article-title":"Dose-dependent efficacy of the Vitex agnus castus extract Ze 440 in patients suffering from premenstrual syndrome","volume":"19","author":"Schellenberg","year":"2012","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.joim.2018.03.001_b0470","first-page":"562","article-title":"Bone KM. Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials","volume":"79","author":"van Die","year":"2013","journal-title":"Planta Med"},{"issue":"4","key":"10.1016\/j.joim.2018.03.001_b0475","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/00002018-200528040-00004","article-title":"Vitex agnus castus: a systematic review of adverse events","volume":"28","author":"Daniele","year":"2005","journal-title":"Drug Saf"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496418300360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496418300360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T20:13:58Z","timestamp":1719864838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095496418300360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":95,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S2095496418300360"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2018.03.001","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2018.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}