{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:54:54Z","timestamp":1787241294904,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004621","name":"Kerman University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.joim.2020.02.008","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T20:21:09Z","timestamp":1583180469000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of a Plantago ovata-based herbal compound in prevention and treatment of oral mucositis in patients with breast cancer receiving chemotherapy: A double-blind, randomized, controlled crossover trial"],"prefix":"10.1016","volume":"18","author":[{"given":"Fatemeh Sadat","family":"Hasheminasab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mehdi","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizallah","family":"Dehghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Sharififar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Setayesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Sasanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Tasbandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Raeiszadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9 Suppl 4","key":"10.1016\/j.joim.2020.02.008_b0005","first-page":"3","article-title":"Pathobiology of oral mucositis: novel insights and opportunities","volume":"5","author":"Sonis","year":"2007","journal-title":"J Support Oncol"},{"issue":"10","key":"10.1016\/j.joim.2020.02.008_b0010","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/cncr.28592","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","volume":"120","author":"Lalla","year":"2014","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.joim.2020.02.008_b0015","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.oraloncology.2009.08.006","article-title":"Mucositis: the impact, biology and therapeutic opportunities of oral mucositis","volume":"45","author":"Sonis","year":"2009","journal-title":"Oral Oncol"},{"issue":"S9","key":"10.1016\/j.joim.2020.02.008_b0020","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/cncr.20163","article-title":"Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis","volume":"100","author":"Rubenstein","year":"2004","journal-title":"Cancer"},{"issue":"9 Suppl","key":"10.1016\/j.joim.2020.02.008_b0025","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis","year":"2004","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.joim.2020.02.008_b0030","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/hed.20162","article-title":"Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis","volume":"27","author":"Duncan","year":"2005","journal-title":"Head Neck"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/s1679-45082018rw4007","article-title":"Chemotherapy protocols and incidence of oral mucositis. An integrative review","volume":"16","author":"Curra","year":"2018","journal-title":"Einstein (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/1874079001104010007","article-title":"Oral mucositis, pain and xerostomia in 135 head and neck cancer patients receiving radiotherapy with or without chemotherapy","volume":"4","author":"Nicolatou-Galitis","year":"2011","journal-title":"Open Cancer J"},{"issue":"Suppl 5","key":"10.1016\/j.joim.2020.02.008_b0045","doi-asserted-by":"crossref","first-page":"v139","DOI":"10.1093\/annonc\/mdv202","article-title":"Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up","volume":"26","author":"Peterson","year":"2015","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.joim.2020.02.008_b0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S2095-4964(17)60333-9","article-title":"Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia: a randomized, open-label, active-controlled trial","volume":"15","author":"Heydarirad","year":"2017","journal-title":"J Integr Med"},{"issue":"11","key":"10.1016\/j.joim.2020.02.008_b0055","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2174\/1389201017666160808094008","article-title":"An updated review of natural products intended to prevent or treat oral mucositis in patients undergoing radio-chemotherapy","volume":"17","author":"Panahi","year":"2016","journal-title":"Curr Pharm Biotechnol"},{"issue":"9","key":"10.1016\/j.joim.2020.02.008_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5812\/ijcm.8642","article-title":"Efficacy of a Persian medicine herbal compound (Alcea digitata Alef and Malva sylvestris L.) on prevention of radiation induced acute mucositis in patients with head and neck cancer: a pilot study","volume":"10","author":"Rezaeipour","year":"2017","journal-title":"Int J Cancer Manag"},{"issue":"2","key":"10.1016\/j.joim.2020.02.008_b0065","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jep.2012.01.024","article-title":"Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch","volume":"140","author":"Mandegary","year":"2012","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"10.1016\/j.joim.2020.02.008_b0070","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3109\/13880209.2014.957784","article-title":"Leishmanicidal and cytotoxic activities of Nigella sativa and its active principle, thymoquinone","volume":"53","author":"Mahmoudvand","year":"2015","journal-title":"Pharm Biol"},{"issue":"4","key":"10.1016\/j.joim.2020.02.008_b0075","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4103\/0972-9062.147862","article-title":"Evaluation of antileishmanial activity and cytotoxicity of the extracts of Berberis vulgaris and Nigella sativa against Leishmania tropica","volume":"51","author":"Mahmoudvand","year":"2014","journal-title":"J Vector Borne Dis"},{"key":"10.1016\/j.joim.2020.02.008_b0080","series-title":"WHO global atlas of traditional, complementary and alternative medicine","author":"Bodeker","year":"2005"},{"key":"10.1016\/j.joim.2020.02.008_b0085","series-title":"Popular medicinal plants of Iran","author":"Amin","year":"1991"},{"key":"10.1016\/j.joim.2020.02.008_b0090","unstructured":"Azam Khan M. Exir azam. Tehran: Institute of Medical History, Islamic Medicine and Complementary Medicine; 2008: 8\u201336 [Persian]"},{"key":"10.1016\/j.joim.2020.02.008_b0095","unstructured":"Sina A. The canon of medicine. Translated by Sharafkandi A. Tehran: Soroush Publication; 1997: 431\u20133 [Persian]."},{"issue":"20","key":"10.1016\/j.joim.2020.02.008_b0100","first-page":"5172","article-title":"Assessment of antioxidative activities of extracts from selected Plantago species","volume":"5","author":"Mahmood","year":"2011","journal-title":"J Med Plant Res"},{"key":"10.1016\/j.joim.2020.02.008_b0105","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ijbiomac.2018.06.139","article-title":"Physicochemical characterization, antioxidant and anti-proliferative activities of a polysaccharide extracted from psyllium (P. ovata) leaves","volume":"118","author":"Patel","year":"2018","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"10.1016\/j.joim.2020.02.008_b0110","doi-asserted-by":"crossref","DOI":"10.1515\/jcim-2015-0075","article-title":"Cytokine changes in gastric and colonic epithelial cell in response to Planta ovata extract","volume":"14","author":"Yakoob","year":"2017","journal-title":"J Complement Integr Med"},{"issue":"2","key":"10.1016\/j.joim.2020.02.008_b0115","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3923\/ijp.2010.117.122","article-title":"Antibacterial effect of ethanolic and methanolic extracts of Plantago ovata and Oliveria decumbens endemic in Iran against some pathogenic bacteria","volume":"6","author":"Motamedi","year":"2010","journal-title":"Int J Pharmacol"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bj.2018.01.001","article-title":"Antiulcer and hepatoprotective effects of aqueous extract of Plantago ovata seed on indomethacin-ulcerated rats","volume":"41","author":"Bagheri","year":"2018","journal-title":"Biomed J"},{"issue":"8","key":"10.1016\/j.joim.2020.02.008_b0125","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1926","article-title":"Bulk agent Plantago ovata after Milligan-Morgan hemorrhoidectomy with Ligasure\u2122","volume":"20","author":"Kecmanovic","year":"2006","journal-title":"Phytother Res"},{"issue":"7","key":"10.1016\/j.joim.2020.02.008_b0130","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2174\/1871530319666190206213420","article-title":"A randomized controlled trial of a herbal compound for improving metabolic parameters in diabetic patients with uncontrolled dyslipidemia","volume":"19","author":"Ghorbani","year":"2019","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"5","key":"10.1016\/j.joim.2020.02.008_b0135","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/ajcn\/nqy115","article-title":"Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets, non-HDL cholesterol and apolipoprotein B: a systematic review and meta-analysis of randomized controlled trials","volume":"108","author":"Jovanovski","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.joim.2020.02.008_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ctim.2018.07.004","article-title":"Effects of psyllium vs. placebo on constipation, weight, glycemia, and lipids: a randomized trial in patients with type 2 diabetes and chronic constipation","volume":"40","author":"Noureddin","year":"2018","journal-title":"Complement Ther Med"},{"issue":"7","key":"10.1016\/j.joim.2020.02.008_b0145","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.amjcard.2018.06.040","article-title":"Meta-analysis of usefulness of psyllium fiber as adjuvant antilipid therapy to enhance cholesterol lowering efficacy of statins","volume":"122","author":"Brum","year":"2018","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.joim.2020.02.008_b0150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3390\/ijms20020433","article-title":"The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls","volume":"20","author":"Jalanka","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joim.2020.02.008_b0155","series-title":"Quality control methods for herbal materials","author":"World Health Organization","year":"2011"},{"issue":"28","key":"10.1016\/j.joim.2020.02.008_b0160","doi-asserted-by":"crossref","first-page":"764","DOI":"10.5897\/JMPR2013.5197","article-title":"Identification of bio-active components in leaf extracts of Aloe vera, Ocimum tenuiflorum (Tulasi) and Tinospora cordifolia (Amrutballi)","volume":"9","author":"Vastrad","year":"2015","journal-title":"J Med Plant Res"},{"issue":"4","key":"10.1016\/j.joim.2020.02.008_b0165","first-page":"22","article-title":"Phytochemical analysis and free radical scavenging potential of herbal and medicinal plant extracts","volume":"2","author":"Soni","year":"2013","journal-title":"J Pharmacogn Phytochem"},{"issue":"11","key":"10.1016\/j.joim.2020.02.008_b0170","first-page":"228","article-title":"Phytochemical constituents of some selected medicinal plants","volume":"3","author":"Njoku","year":"2009","journal-title":"AJPAC"},{"key":"10.1016\/j.joim.2020.02.008_b0175","series-title":"Remington: the science and practice of pharmacy","author":"Troy","year":"2006"},{"issue":"3","key":"10.1016\/j.joim.2020.02.008_b0180","first-page":"317","article-title":"Bioassay screening of the essential oil and various extracts from 4 spices medicinal plants","volume":"22","author":"Sharififar","year":"2009","journal-title":"Pak J Pharm Sci"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2288-4-26","article-title":"Random allocation software for parallel group randomized trials","volume":"4","author":"Saghaei","year":"2004","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0190","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-8140(02)00104-4","article-title":"A randomized, double-blind, placebo-controlled trial of concomitant pilocarpine with head and neck irradiation for prevention of radiation-induced xerostomia","volume":"64","author":"Haddad","year":"2002","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.joim.2020.02.008_b0195","first-page":"135","article-title":"Validation of a Persian version of the oral health impact profile (OHIP-14)","volume":"39","author":"Navabi","year":"2010","journal-title":"Iran J Public Health"},{"issue":"7","key":"10.1016\/j.joim.2020.02.008_b0200","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1601-0825.2010.01681.x","article-title":"New thoughts on the initiation of mucositis","volume":"16","author":"Sonis","year":"2010","journal-title":"Oral Dis"},{"issue":"4","key":"10.1016\/j.joim.2020.02.008_b0205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"10.1016\/j.joim.2020.02.008_b0210","first-page":"2075","article-title":"Emerging evidence on the pathobiology of mucositis","volume":"21","author":"Al-Dasooqi","year":"2013","journal-title":"Support Care Cancer"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2008-2231-21-18","article-title":"Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study","volume":"21","author":"Babaee","year":"2013","journal-title":"Daru"},{"key":"10.1016\/j.joim.2020.02.008_b0220","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejon.2017.11.006","article-title":"Efficacy of Plantago major, chlorhexidine 0.12% and sodium bicarbonate 5% solution in the treatment of oral mucositis in cancer patients with solid tumour: A feasibility randomised triple-blind phase III clinical trial","volume":"32","author":"Cabrera-Jaime","year":"2018","journal-title":"Eur J Oncol Nurs"},{"issue":"4","key":"10.1016\/j.joim.2020.02.008_b0225","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3109\/13880209.2014.928330","article-title":"Medicinal plants contain mucilage used in traditional Persian medicine (TPM)","volume":"53","author":"Ameri","year":"2015","journal-title":"Pharm Biol"},{"issue":"3","key":"10.1016\/j.joim.2020.02.008_b0230","first-page":"1387","article-title":"The pharmaceutical importance of Althaea officinalis and Althaea rosea: a review","volume":"5","author":"Al-Snafi","year":"2013","journal-title":"Int J Pharm Tech Res"},{"issue":"1","key":"10.1016\/j.joim.2020.02.008_b0235","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jep.2009.09.050","article-title":"Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro","volume":"127","author":"Deters","year":"2010","journal-title":"J Ethnopharmacol"},{"issue":"11","key":"10.1016\/j.joim.2020.02.008_b0240","first-page":"3165","article-title":"Systematic review of basic oral care for the management of oral mucositis in cancer patients","volume":"21","author":"McGuire","year":"2013","journal-title":"Support Care Cancer"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496420300327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496420300327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:48:37Z","timestamp":1761864517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095496420300327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S2095496420300327"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2020.02.008","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of a Plantago ovata-based herbal compound in prevention and treatment of oral mucositis in patients with breast cancer receiving chemotherapy: A double-blind, randomized, controlled crossover trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2020.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Shanghai Changhai Hospital. Published by ELSEVIER B.V.","name":"copyright","label":"Copyright"}]}}