{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:33:22Z","timestamp":1771486402388,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503632"],"award-info":[{"award-number":["81503632"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.joim.2021.08.003","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T11:49:35Z","timestamp":1629287375000},"page":"418-427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K\/AKT pathway"],"prefix":"10.1016","volume":"19","author":[{"given":"Tong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-lan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao-jiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-fu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.joim.2021.08.003_b0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","article-title":"Asia-pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update","volume":"11","author":"Omata","year":"2017","journal-title":"Hepatol Int"},{"issue":"12","key":"10.1016\/j.joim.2021.08.003_b0010","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015","volume":"3","author":"Akinyemiju","year":"2017","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.joim.2021.08.003_b0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jhep.2015.08.028","article-title":"Hepatocellular carcinoma and lifestyles","volume":"64","author":"Saran","year":"2016","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.joim.2021.08.003_b0020","doi-asserted-by":"crossref","first-page":"djv329","DOI":"10.1093\/jnci\/djv329","article-title":"Development and application of a lifestyle score for prevention of lethal prostate cancer","volume":"108","author":"Kenfield","year":"2016","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"10.1016\/j.joim.2021.08.003_b0025","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1038\/bjc.2014.77","article-title":"The association between physical activity and bladder cancer: systematic review and meta-analysis","volume":"110","author":"Keimling","year":"2014","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.joim.2021.08.003_b0030","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s10549-012-2396-7","article-title":"Physical activity and risk of breast cancer: a meta-analysis of prospective studies","volume":"137","author":"Wu","year":"2013","journal-title":"Breast Cancer Res Treat"},{"issue":"20","key":"10.1016\/j.joim.2021.08.003_b0035","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1001\/jama.293.20.2479","article-title":"Physical activity and survival after breast cancer diagnosis","volume":"293","author":"Holmes","year":"2005","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.joim.2021.08.003_b0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1615\/CritRevEukaryotGeneExpr.2016016490","article-title":"Aerobic exercise modulates the free fatty acids and inflammatory response during obesity and cancer cachexia","volume":"26","author":"Teixeira","year":"2016","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1016\/j.joim.2021.08.003_b0045","doi-asserted-by":"crossref","unstructured":"Lu T, Denehy L, Cao Y, Cong Q, Wu E, Granger CL, et al. A 12-week multi-modal exercise program: feasibility of combined exercise and simplified 8-Style Tai Chi following lung cancer surgery. Integr Cancer Ther 2020; 19:1534735420952887.","DOI":"10.1177\/1534735420952887"},{"issue":"6","key":"10.1016\/j.joim.2021.08.003_b0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.trecan.2017.04.007","article-title":"Exercise and the hallmarks of cancer","volume":"3","author":"Ruiz-Casado","year":"2017","journal-title":"Trends Cancer"},{"issue":"4","key":"10.1016\/j.joim.2021.08.003_b0055","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1042\/BST20160466","article-title":"Exercise protects from cancer through regulation of immune function and inflammation","volume":"45","author":"Hojman","year":"2017","journal-title":"Biochem Soc Trans"},{"issue":"9","key":"10.1016\/j.joim.2021.08.003_b0060","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1056\/NEJMcibr1606456","article-title":"Muscling in on cancer","volume":"375","author":"Phimister","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.joim.2021.08.003_b0065","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1096\/fj.11-196543","article-title":"Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer","volume":"26","author":"Rehman","year":"2012","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.joim.2021.08.003_b0070","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.molcel.2015.01.002","article-title":"Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth","volume":"57","author":"Kashatus","year":"2015","journal-title":"Mol Cell"},{"key":"10.1016\/j.joim.2021.08.003_b0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ceb.2016.02.001","article-title":"Regulators of mitochondrial dynamics in cancer","volume":"39","author":"Senft","year":"2016","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"10.1016\/j.joim.2021.08.003_b0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbrc.2012.03.118","article-title":"Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells","volume":"421","author":"Inoue-Yamauchi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joim.2021.08.003_b0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/164_2016_38","article-title":"Mitochondrial fission in human diseases","volume":"240","author":"Serasinghe","year":"2017","journal-title":"Handb Exp Pharmacol"},{"issue":"3","key":"10.1016\/j.joim.2021.08.003_b0090","first-page":"1010","article-title":"Suppression of DRP1-mediated mitophagy increases the apoptosis of hepatocellular carcinoma cells in the setting of chemotherapy","volume":"43","author":"Ma","year":"2020","journal-title":"Oncol Rep"},{"issue":"7","key":"10.1016\/j.joim.2021.08.003_b0095","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41389-020-00251-5","article-title":"Suppressing DRP1-mediated mitochondrial fission and mitophagy increases mitochondrial apoptosis of hepatocellular carcinoma cells in the setting of hypoxia","volume":"9","author":"Lin","year":"2020","journal-title":"Oncogenesis"},{"key":"10.1016\/j.joim.2021.08.003_b0100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.yjmcc.2016.01.023","article-title":"Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db\/db mice","volume":"92","author":"Veeranki","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"W1","key":"10.1016\/j.joim.2021.08.003_b0105","doi-asserted-by":"crossref","first-page":"W98","DOI":"10.1093\/nar\/gkx247","article-title":"GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses","volume":"45","author":"Tang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.joim.2021.08.003_b0110","doi-asserted-by":"crossref","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM, Lindskog C, Oksvold P, Mardinoglu A, et al. Proteomics. tissue-based map of the human proteome. Science 2015; 347(6220):1260419.","DOI":"10.1126\/science.1260419"},{"key":"10.1016\/j.joim.2021.08.003_b0115","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.12659\/MSM.913377","article-title":"Effect of aerobic exercise on serum metabolites in mice with hepatocellular carcinoma after surgery","volume":"25","author":"Zhao","year":"2019","journal-title":"Med Sci Monit"},{"issue":"6","key":"10.1016\/j.joim.2021.08.003_b0120","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41401-019-0343-4","article-title":"Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacol Sin"},{"issue":"24","key":"10.1016\/j.joim.2021.08.003_b0125","doi-asserted-by":"crossref","first-page":"10202","DOI":"10.1158\/0008-5472.CAN-10-2607","article-title":"A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients","volume":"70","author":"Roessler","year":"2010","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.joim.2021.08.003_b0130","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/hep.21622","article-title":"Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma","volume":"45","author":"Wurmbach","year":"2007","journal-title":"Hepatology"},{"issue":"40","key":"10.1016\/j.joim.2021.08.003_b0135","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1038\/onc.2012.494","article-title":"Mitochondrial dynamics regulates migration and invasion of breast cancer cells","volume":"32","author":"Zhao","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.joim.2021.08.003_b0140","doi-asserted-by":"crossref","unstructured":"Wan YY, Zhang JF, Yang ZJ, Jiang LP, Wei YF, Lai QN, et al. Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251cells. Oncol Rep 2014; 32(2):619\u201326.","DOI":"10.3892\/or.2014.3235"},{"issue":"4","key":"10.1016\/j.joim.2021.08.003_b0145","first-page":"284","article-title":"Effect of various types of muscle contraction with different running conditions on mouse humerus morphology","volume":"11","author":"Ozone","year":"2021","journal-title":"Life (Basel)"},{"issue":"8","key":"10.1016\/j.joim.2021.08.003_b0150","doi-asserted-by":"crossref","first-page":"E964","DOI":"10.1152\/ajpendo.00270.2013","article-title":"Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state","volume":"305","author":"Jamart","year":"2013","journal-title":"Am J Physio Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.joim.2021.08.003_b0155","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3892\/mmr.2021.12068","article-title":"Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K\/AKT signaling pathways","volume":"23","author":"Song","year":"2021","journal-title":"Mol Med Rep"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496421000686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496421000686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:51:43Z","timestamp":1761864703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095496421000686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S2095496421000686"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2021.08.003","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2021.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by ELSEVIER B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}