{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:18:43Z","timestamp":1791908323758,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.joim.2022.02.005","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T01:48:42Z","timestamp":1645408122000},"page":"204-212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Progress in the design and quality control of placeboes for clinical trials of traditional Chinese medicine"],"prefix":"10.1016","volume":"20","author":[{"given":"Ning","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.joim.2022.02.005_b0005","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/09637486.2017.1283682","article-title":"Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of Aronia juice for food intervention studies","volume":"68","author":"Kardum","year":"2017","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.joim.2022.02.005_b0010","unstructured":"Wang HW. Systematic evaluation of placebo in clinical trials of new traditional Chinese medicine. Shenyang: Liaoning University of Traditional Chinese Medicine; 2014 [Chinese with abstract in English]."},{"issue":"1","key":"10.1016\/j.joim.2022.02.005_b0015","first-page":"100","article-title":"Recommendations for reporting randomized controlled trials of herbal interventions: explanation and description","volume":"21","author":"Tian","year":"2021","journal-title":"Zhongguo Xun Zheng Yi Xue Za Zhi"},{"issue":"11","key":"10.1016\/j.joim.2022.02.005_b0020","first-page":"52","article-title":"On the character odor and efficacy odor of traditional Chinese medicine","volume":"32","author":"Xie","year":"2013","journal-title":"Neimenggu Zhong Yi Yao"},{"issue":"2","key":"10.1016\/j.joim.2022.02.005_b0025","first-page":"228","article-title":"Research status and prospect of odor identification of traditional Chinese medicine","volume":"22","author":"Xu","year":"2011","journal-title":"Zhong Yao Xin Yao Yu Lin Chuang Yao Li"},{"issue":"23","key":"10.1016\/j.joim.2022.02.005_b0030","first-page":"222","article-title":"Study on the preparation method and effect evaluation of placebo in large-scale double-blind clinical trial","volume":"10","author":"Yang","year":"2014","journal-title":"Ya Tai Chuan Tong Yi Yao"},{"issue":"12","key":"10.1016\/j.joim.2022.02.005_b0035","first-page":"91","article-title":"Objective evaluation on placebo of Huoxiang Zhengqi Granules","volume":"20","author":"Wang","year":"2014","journal-title":"Zhongguo Shi Yan Fang Ji Xue Za Zhi"},{"issue":"12","key":"10.1016\/j.joim.2022.02.005_b0040","first-page":"2013","article-title":"Preparation method and effect evaluation of placebo of traditional Chinese medicine Sicao Tongmai capsule","volume":"17","author":"Jin","year":"2014","journal-title":"Zhongguo Yao Shi"},{"issue":"1","key":"10.1016\/j.joim.2022.02.005_b0045","first-page":"78","article-title":"Application and related mechanism of electronic tongue technology in traditional Chinese medicine","volume":"19","author":"Bai","year":"2021","journal-title":"Zhong Nan Yao Xue"},{"issue":"20","key":"10.1016\/j.joim.2022.02.005_b0050","first-page":"4884","article-title":"Preparation and simulation effect evaluation of placeboes for Ginkgo Folium dropping pills","volume":"50","author":"Sun","year":"2019","journal-title":"Zhong Cao Yao"},{"issue":"9","key":"10.1016\/j.joim.2022.02.005_b0055","first-page":"1876","article-title":"The current situation and thinking of the identification of \u201csmell\u201d of traditional Chinese medicine","volume":"16","author":"Yang","year":"2014","journal-title":"Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua"},{"issue":"12","key":"10.1016\/j.joim.2022.02.005_b0060","doi-asserted-by":"crossref","first-page":"939","DOI":"10.7326\/0003-4819-137-12-200212170-00006","article-title":"Treatment of the common cold with unrefined echinacea. A randomized, double-blind, placebo-controlled trial","volume":"137","author":"Barrett","year":"2002","journal-title":"Ann Intern Med"},{"issue":"7","key":"10.1016\/j.joim.2022.02.005_b0065","first-page":"825","article-title":"Odour correlation study during preparation process of Gastrodiae Rhizoma Formula Granule","volume":"44","author":"Wang","year":"2013","journal-title":"Zhong Cao Yao"},{"issue":"11","key":"10.1016\/j.joim.2022.02.005_b0070","first-page":"1254","article-title":"Research progress in placebo design and quality control of traditional Chinese medicine for clinical trials","volume":"27","author":"Wu","year":"2018","journal-title":"Zhongguo Xin Yao Za Zhi"},{"key":"10.1016\/j.joim.2022.02.005_b0075","unstructured":"National Medical Products Administration. Standard for quality management of drug clinical trials. (2003-08) [2022-01-24]. https:\/\/www.nmpa.gov.cn\/xxgk\/fgwj\/bmgzh\/20030806010101443.html."},{"key":"10.1016\/j.joim.2022.02.005_b0080","unstructured":"National Medical Products Administration. General principles of clinical research on new Chinese medicine. (2015-11) [2022\u201301\u201324]. https:\/\/www.nmpa.gov.cn\/directory\/web\/nmpa\/xxgk\/ggtg\/qtggtg\/20151103120001444.html."},{"issue":"4","key":"10.1016\/j.joim.2022.02.005_b0085","first-page":"237","article-title":"Application characteristics and existing problems of placebo in clinical trials of traditional Chinese medicine","volume":"32","author":"Zhang","year":"2015","journal-title":"Zhongguo Yao Wu Ping Jia"},{"issue":"12","key":"10.1016\/j.joim.2022.02.005_b0090","first-page":"47","article-title":"Placebo and placebo effect","volume":"27","author":"Wang","year":"1996","journal-title":"Xin Yi Xue"},{"issue":"9","key":"10.1016\/j.joim.2022.02.005_b0095","first-page":"25","article-title":"Examples of traditional Chinese medicine and prescriptions with psychological implications in naming","volume":"29","author":"Qin","year":"2008","journal-title":"Yunnan Zhong Yi Zhong Yao Za Zhi"},{"issue":"7","key":"10.1016\/j.joim.2022.02.005_b0100","first-page":"656","article-title":"Study on the preparation of placebo in clinical trials of traditional Chinese medicine","volume":"29","author":"Tang","year":"2009","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"15","key":"10.1016\/j.joim.2022.02.005_b0105","first-page":"1294","article-title":"Preparation method and quality evaluation of traditional Chinese medicine compound placebo","volume":"56","author":"Huang","year":"2015","journal-title":"Zhong Yi Za Zhi"},{"issue":"12","key":"10.1016\/j.joim.2022.02.005_b0110","first-page":"966","article-title":"A preliminary study on the preparation of placebo in clinical trials of traditional Chinese medicine","volume":"30","author":"Wang","year":"2003","journal-title":"Liaoning Zhong Yi Za Zhi"},{"issue":"3","key":"10.1016\/j.joim.2022.02.005_b0115","first-page":"255","article-title":"Large double-blind clinical trial placebo preparation method and effect evaluation study","volume":"22","author":"Wang","year":"2011","journal-title":"Zhong Yao Xin Yao Yu Lin Chuang Yao Li"},{"issue":"10","key":"10.1016\/j.joim.2022.02.005_b0120","first-page":"2188","article-title":"Preparation of herbal medicine decoction placebo and efficacy evaluation","volume":"41","author":"Song","year":"2014","journal-title":"Liaoning Zhong Yi Za Zhi"},{"key":"10.1016\/j.joim.2022.02.005_b0125","unstructured":"Luo D. Study on placebo evaluation and preparation process of traditional Chinese medicine granules. Chengdu: Chengdu University of Traditional Chinese Medicine; 2012 [Chinese with abstract in English]."},{"issue":"2","key":"10.1016\/j.joim.2022.02.005_b0130","first-page":"108","article-title":"Preparation and evaluation of TCM granules placebo used in double-blind clinical trials","volume":"22","author":"Yan","year":"2020","journal-title":"Shi Pin Yu Yao Pin"},{"issue":"15","key":"10.1016\/j.joim.2022.02.005_b0135","first-page":"1421","article-title":"Quality standard of Huoling Shengji Granules placebo","volume":"30","author":"Guo","year":"2021","journal-title":"Shi Pin Yu Yao Pin"},{"issue":"5","key":"10.1016\/j.joim.2022.02.005_b0140","first-page":"734","article-title":"Study on the preparation and evaluation of Shenbawei Capsule","volume":"17","author":"Jin","year":"2014","journal-title":"Zhongguo Yao Shi"},{"issue":"8","key":"10.1016\/j.joim.2022.02.005_b0145","first-page":"676","article-title":"Randomized controlled double-blind trial of Shufeng Jiedu Capsule in treating acute upper respiratory tract infection with wind-heat syndrome","volume":"56","author":"Xu","year":"2015","journal-title":"Zhong Yi Za Zhi"},{"issue":"11","key":"10.1016\/j.joim.2022.02.005_b0150","first-page":"1235","article-title":"Preparation method and effect evaluation of Yiye Anti-influenza Capsule placebo","volume":"50","author":"Ji","year":"2020","journal-title":"Xinjiang Yi Xue"},{"issue":"6","key":"10.1016\/j.joim.2022.02.005_b0155","first-page":"45","article-title":"Randomized placebo-controlled study of Zhigan Pill in treating non-alcoholic fatty liver disease with phlegm and stasis","volume":"48","author":"Zhu","year":"2014","journal-title":"Shanghai Zhong Yi Yao Za Zhi"},{"issue":"8","key":"10.1016\/j.joim.2022.02.005_b0160","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s11655-016-2538-6","article-title":"A preparation model of Chinese medicine decoction placebo","volume":"23","author":"Bian","year":"2017","journal-title":"Chin J Integr Med"},{"issue":"8","key":"10.1016\/j.joim.2022.02.005_b0165","first-page":"1631","article-title":"Placebo study in the randomized clinical trials of Chinese decoction","volume":"11","author":"Wang","year":"2016","journal-title":"Shi Jie Zhong Yi Yao"},{"issue":"5","key":"10.1016\/j.joim.2022.02.005_b0170","first-page":"12","article-title":"Discussion on usage of TCM placebo based on clinical trials of new drugs in TCM","volume":"28","author":"Lyu","year":"2021","journal-title":"Zhongguo Zhong Yi Yao Xin Xi Za Zhi"},{"issue":"4","key":"10.1016\/j.joim.2022.02.005_b0175","first-page":"1165","article-title":"Discussion about the placebo choice of quality control in randomized controlled trial clinical study of traditional Chinese medicine","volume":"29","author":"Han","year":"2014","journal-title":"Zhonghua Zhong Yi Yao Za Zhi"},{"key":"10.1016\/j.joim.2022.02.005_b0180","doi-asserted-by":"crossref","first-page":"753942","DOI":"10.1155\/2015\/753942","article-title":"A novel method for the discrimination of Semen Arecae and its processed products by using computer vision, electronic nose, and electronic tongue","volume":"2015","author":"Xu","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.joim.2022.02.005_b0185","first-page":"36","article-title":"Electronic tongue for pharmaceutical analytics: quantification of tastes and masking effects","volume":"380","author":"Andrey","year":"2004","journal-title":"Anal Bioanal Chem"},{"issue":"11","key":"10.1016\/j.joim.2022.02.005_b0190","first-page":"1163","article-title":"Evaluation and thinking of simulation effect of placebo on new drug clinical trials of traditional Chinese medicines","volume":"18","author":"Lu","year":"2018","journal-title":"Zhongguo Xun Zheng Yi Xue Za Zhi"},{"issue":"10","key":"10.1016\/j.joim.2022.02.005_b0195","first-page":"900","article-title":"Study on placebo of traditional Chinese medicine","volume":"35","author":"Li","year":"2013","journal-title":"Guo Ji Zhong Yi Zhong Yao Za Zhi"},{"issue":"22","key":"10.1016\/j.joim.2022.02.005_b0200","first-page":"4648","article-title":"Application of computer color matching technology in placebo color simulation of Ruyi Jinhuang Powder","volume":"48","author":"Fan","year":"2017","journal-title":"Zhong Cao Yao"},{"key":"10.1016\/j.joim.2022.02.005_b0205","unstructured":"Han Y. Application of electronic nose in Atractylodes lancea (Thunb.) DC. quality evaluation. Beijing: Beijing University of Chinese Medicine; 2011 [Chinese with abstract in English]."},{"issue":"2","key":"10.1016\/j.joim.2022.02.005_b0210","first-page":"154","article-title":"Discrimination of traditional Chinese medicinal materials with different tastes based on electronic tongue","volume":"38","author":"Du","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.joim.2022.02.005_b0215","unstructured":"Li XF, He QL, Yang H, Li ZL, Wang J. The application of electronic tongue in evaluating the taste-masking effect of Rheum palmatum L. Granule. Chengdu Zhong Yi Yao Da Xue Xue Bao 2011; 34(2): 80\u20132, 91 [Chinese with abstract in English]."},{"issue":"6","key":"10.1016\/j.joim.2022.02.005_b0220","first-page":"2365","article-title":"Thinking on quality evaluation for traditional Chinese medicine placebo","volume":"32","author":"Li","year":"2017","journal-title":"Zhonghua Zhong Yi Yao Za Zhi"},{"issue":"8","key":"10.1016\/j.joim.2022.02.005_b0225","first-page":"356","article-title":"Application of cytotoxicology technology in food safety","volume":"30","author":"Lu","year":"2009","journal-title":"Shi Pin Gong Ye Ke Ji"},{"issue":"7","key":"10.1016\/j.joim.2022.02.005_b0230","first-page":"1309","article-title":"The impact of pharmaceutical excipients on the drug safety","volume":"32","author":"Yang","year":"2012","journal-title":"Yao Wu Fen Xi Za Zi"},{"key":"10.1016\/j.joim.2022.02.005_b0235","unstructured":"Guan DQ. Study on the production process and quality standard of placebo in clinical trials of traditional Chinese medicine. Nanjing: Nanjing University of Chinese Medicine; 2006 [Chinese with abstract in English]."},{"key":"10.1016\/j.joim.2022.02.005_b0240","article-title":"Application of placebo-controlled design in clinical trials of new Chinese medicine","author":"Bi","year":"2009","journal-title":"Chengdu: Chengdu University of Traditional Chinese Medicine"},{"issue":"7","key":"10.1016\/j.joim.2022.02.005_b0245","first-page":"1415","article-title":"A randomized, placebo-controlled study of Fangfeng Tongsheng granules in the treatment of subacute eczema","volume":"40","author":"Zhao","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.joim.2022.02.005_b0250","unstructured":"Li JP. Randomized, double-blind, placebo-controlled clinical study of Bushen Huoxue Granules in treating postmenopausal osteoporosis. Beijing: China Academy of Chinese Medical Sciences; 2012 [Chinese with abstract in English]."},{"issue":"3","key":"10.1016\/j.joim.2022.02.005_b0255","first-page":"65","article-title":"Analysis on the application and safety of additives in sweetmeat","volume":"22","author":"Li","year":"2021","journal-title":"Xian Dai Shi Pin"},{"issue":"18","key":"10.1016\/j.joim.2022.02.005_b0260","first-page":"36","article-title":"Preparation and safety control of edible flavor and fragrance","volume":"23","author":"Wang","year":"2021","journal-title":"Shi Pin An Quan Dao Kan"},{"issue":"17","key":"10.1016\/j.joim.2022.02.005_b0265","first-page":"121","article-title":"Simultaneous determination of 10 pigments in food by high-performance liquid chromatography","volume":"38","author":"Feng","year":"2019","journal-title":"Xian Dai Shi Pin"},{"key":"10.1016\/j.joim.2022.02.005_b0270","first-page":"6637326","article-title":"Similarity evaluation on the compound TCM formulation \u201cHuoling Shengji Granule\u201d and its placebo by intelligent sensory evaluation technologies and the human sensory evaluation method based on critical quality attributes","volume":"2021","author":"Wu","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.joim.2022.02.005_b0275","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12906-019-2722-2","article-title":"Placebo design in WHO-registered trials of Chinese herbal medicine need improvements","volume":"19","author":"Zhang","year":"2019","journal-title":"BMC Complement Altern Med"},{"issue":"3","key":"10.1016\/j.joim.2022.02.005_b0280","first-page":"485","article-title":"Objective and quantitative thinking on the evaluation of traditional Chinese medicine placebo","volume":"16","author":"Wang","year":"2014","journal-title":"Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua"},{"issue":"8","key":"10.1016\/j.joim.2022.02.005_b0285","first-page":"1115","article-title":"History and development of experimental design for placebo effect studies","volume":"19","author":"Zhang","year":"2011","journal-title":"Xin Li Ke Xue Jin Zhan"},{"issue":"3","key":"10.1016\/j.joim.2022.02.005_b0290","first-page":"313","article-title":"Meta-analysis of the placebo effects on insomnia treated with herbal medicine","volume":"12","author":"Chen","year":"2017","journal-title":"Shi Jie Zhong Xi Yi Jie He Za Zhi"},{"issue":"3","key":"10.1016\/j.joim.2022.02.005_b0295","first-page":"20","article-title":"Food coloring and its safety analysis","volume":"4","author":"Yu","year":"2002","journal-title":"Wuhu Zhi Ye Ji Shu Xue Yuan Xue Bao"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496422000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496422000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:51:57Z","timestamp":1761864717000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095496422000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S2095496422000267"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2022.02.005","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress in the design and quality control of placeboes for clinical trials of traditional Chinese medicine","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2022.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}