{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:20:12Z","timestamp":1790889612687,"version":"4.1.0"},"reference-count":179,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.joim.2024.09.003","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T01:46:17Z","timestamp":1726883177000},"page":"621-636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin"],"prefix":"10.1016","volume":"22","author":[{"given":"Xin-yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-sheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0005","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/molecules21060703","article-title":"Characterization and enhanced antioxidant activity of the cysteinyl \u03b2-cyclodextrin-baicalein inclusion complex","volume":"21","author":"Kim","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.joim.2024.09.003_b0010","first-page":"1673","article-title":"The stimulatory activities of baicalein and baicalin compounds derived from Scutellaria baicalensis on insulin secretion in vitro","volume":"554\u2013556","author":"Li","year":"2012","journal-title":"Adv Mater Res"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0015","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2174\/1570163811310030005","article-title":"Baicalein-phospholipid complex: a novel drug delivery technology for phytotherapeutics","volume":"10","author":"Rawat","year":"2013","journal-title":"Curr Drug Discov Technol"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0020","first-page":"157","article-title":"In vivo antivirus effect of baicalein on influenza A virus","volume":"26","author":"Wu","year":"2009","journal-title":"Guangzhou Zhong Yi Yao Da Xue Xue Bao"},{"key":"10.1016\/j.joim.2024.09.003_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.joim.2024.09.003_b0030","series-title":"Dictionary of traditional Chinese medicine","first-page":"2805","author":"Nanjing University of Chinese Medicine","year":"2006"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12906-023-03885-1","article-title":"Baicalein alleviates fibrosis and inflammation in systemic sclerosis by regulating B-cell abnormalities","volume":"23","author":"Peng","year":"2023","journal-title":"BMC Complement Med Ther"},{"issue":"11","key":"10.1016\/j.joim.2024.09.003_b0040","first-page":"3141","article-title":"Comprehensive quality evaluation of Scutellaria baicalensis Georgi by determination of multi-component content","volume":"56","author":"Xu","year":"2021","journal-title":"Yao Xue Xue Bao"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0045","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3390\/microorganisms9050893","article-title":"Baicalein and baicalin inhibit SARS-CoV-2 RNA-dependent-RNA polymerase","volume":"9","author":"Zandi","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.joim.2024.09.003_b0050","series-title":"Chinese pharmacopoeia, volume 1","first-page":"314","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF00567050","article-title":"The flavonoids of Scutellaria galericulata","volume":"11","author":"Popova","year":"1975","journal-title":"Chem Nat Compd"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0060","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.hermed.2013.02.001","article-title":"Identity issues surrounding American skullcap (Scutellaria lateriflora) and an optimized high performance liquid chromatography method to authenticate commercially available products","volume":"3","author":"Brock","year":"2013","journal-title":"J Herb Med"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1142\/S0192415X96000050","article-title":"The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin","volume":"24","author":"Lin","year":"1996","journal-title":"Am J Chin Med"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0070","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.fitote.2011.04.006","article-title":"Antioxidant flavonoids from the seed of Oroxylum indicum","volume":"82","author":"Yan","year":"2011","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0075","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/molecules23010223","article-title":"Protective mechanism of the antioxidant baicalein toward hydroxyl radical-treated bone marrow-derived mesenchymal stem cells","volume":"23","author":"Tian","year":"2018","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.joim.2024.09.003_b0080","first-page":"1587","article-title":"Antibacterial activity and mechanism of baicalein","volume":"47","author":"Yun","year":"2012","journal-title":"Yao Xue Xue Bao"},{"issue":"17","key":"10.1016\/j.joim.2024.09.003_b0085","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.3390\/molecules28176340","article-title":"Exploration of baicalein-core derivatives as potent antifungal agents: SAR and mechanism insights","volume":"28","author":"Zhou","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.joim.2024.09.003_b0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.micpath.2015.07.006","article-title":"In vitro antifungal activity of baicalin against Candida albicans biofilms via apoptotic induction","volume":"87","author":"Wang","year":"2015","journal-title":"Microb Pathog"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0095","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.intimp.2014.09.005","article-title":"The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4\/NF-\u03baB pathway activation","volume":"23","author":"Cui","year":"2014","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"10.1016\/j.joim.2024.09.003_b0100","first-page":"19","article-title":"Study on quality-efficiency evaluation of Scutellaria baicalensis from different origins based on content constituent characteristics of flavonoids and in vitro antiviral activity","volume":"31","author":"Li","year":"2020","journal-title":"Zhongguo Yao Fang"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0105","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/jcb.24445","article-title":"Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1\/2 signaling","volume":"114","author":"Zong","year":"2013","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joim.2024.09.003_b0110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejmech.2017.03.004","article-title":"Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders","volume":"131","author":"Dinda","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.joim.2024.09.003_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105387","article-title":"Baicalin mediated regulation of key signaling pathways in cancer","volume":"164","author":"Singh","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.joim.2024.09.003_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.583200","article-title":"Regulatory mechanisms of baicalin in cardiovascular diseases: a review","volume":"11","author":"Xin","year":"2020","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0125","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s43440-021-00227-1","article-title":"Pharmacological properties of baicalin on liver diseases: a narrative review","volume":"73","author":"Yang","year":"2021","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.joim.2024.09.003_b0130","unstructured":"U.S. Centers for Disease Control and Prevention. About COVID-19. (2024-06-13) [2024-07-11]. https:\/\/www.cdc.gov\/covid\/about\/?CDC_AAref_Val=https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/your-health\/about-covid-19.html."},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0135","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11427-010-0006-7","article-title":"Development of a high-throughput assay for the HIV-1 integrase disintegration reaction","volume":"53","author":"He","year":"2010","journal-title":"Sci China Life Sci"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0166-3542(97)00069-7","article-title":"Baicalin, an inhibitor of HIV-1 production in vitro","volume":"37","author":"Kitamura","year":"1998","journal-title":"Antiviral Res"},{"key":"10.1016\/j.joim.2024.09.003_b0145","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/750803","article-title":"Baicalein, ethyl acetate, and chloroform extracts of Scutellaria baicalensis inhibit the neuraminidase activity of pandemic 2009 H1N1 and seasonal influenza A viruses","volume":"2013","author":"Hour","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"8","key":"10.1016\/j.joim.2024.09.003_b0150","first-page":"541","article-title":"Antiviral effects of major constituents of Huangqin (Radix Scutellariae) on influenza A virus (FM1) in vitro","volume":"33","author":"Wu","year":"2010","journal-title":"Beijing Zhong Yi Yao Da Xue Xue Bao"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0155","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/jac\/dkt534","article-title":"Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses","volume":"69","author":"Nayak","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0160","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1248\/bpb.33.238","article-title":"Inhibitory effects of baicalein on the influenza virus in vivo is determined by baicalin in the serum","volume":"33","author":"Xu","year":"2010","journal-title":"Biol Pharm Bull"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0165","first-page":"955","article-title":"In vitro experimental study of anti-respiratory syncytial virus effect on Jinxin Oral Liquid transitional ingredients of blood","volume":"28","author":"Du","year":"2013","journal-title":"Zhonghua Zhong Yi Yao Za Zhi"},{"key":"10.1016\/j.joim.2024.09.003_b0170","doi-asserted-by":"crossref","DOI":"10.1038\/srep35851","article-title":"Baicalin from Scutellaria baicalensis blocks respiratory syncytial virus (RSV) infection and reduces inflammatory cell infiltration and lung injury in mice","volume":"6","author":"Shi","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.joim.2024.09.003_b0175","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1038\/srep05452","article-title":"Baicalin, a metabolite of baicalein with antiviral activity against dengue virus","volume":"4","author":"Moghaddam","year":"2014","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0180","doi-asserted-by":"crossref","first-page":"21221","DOI":"10.1038\/s41598-021-98949-y","article-title":"Antiviral activity of silymarin and baicalein against dengue virus","volume":"11","author":"Low","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.joim.2024.09.003_b0185","unstructured":"Expert Commission of Consensus of Baicalin for Liver Disease. Consensus of use of baicalin for treatment of liver diseases. Zhongguo Gan Zang Bing Za Zhi Dian Zi Ban 2021;13(4):5\u20138. [Chinese with abstract in English]."},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101032","article-title":"The protective effect of baicalin on duck hepatitis A virus type 1-induced duck hepatic mitochondria dysfunction by activating nuclear erythroid 2-related factor 2\/antioxidant responsive element signaling pathway","volume":"100","author":"Su","year":"2021","journal-title":"Poult Sci"},{"issue":"11","key":"10.1016\/j.joim.2024.09.003_b0195","doi-asserted-by":"crossref","first-page":"e577","DOI":"10.1002\/ctm2.577","article-title":"Baicalein resensitizes tamoxifen-resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia-inducible factor-1\u03b1","volume":"11","author":"Chen","year":"2021","journal-title":"Clin Transl Med"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0200","first-page":"364","article-title":"A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan","volume":"19","author":"Xu","year":"2021","journal-title":"Chin J Nat Med"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0205","article-title":"Baicalein resensitizes multidrug-resistant Gram-negative pathogens to doxycycline","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiol Spectr"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0210","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0215","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00044-021-02826-2","article-title":"A review of natural products, their effects on SARS-CoV-2 and their utility as lead compounds in the discovery of drugs for the treatment of COVID-19","volume":"31","author":"Chapman","year":"2022","journal-title":"Med Chem Res"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0220","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s43450-021-00182-1","article-title":"Antiviral properties of baicalin: a concise review","volume":"31","author":"Li","year":"2021","journal-title":"Rev Bras Farmacogn"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0225","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12250-017-4108-2","article-title":"Herpesviruses: epidemiology, pathogenesis, and interventions","volume":"32","author":"Lan","year":"2017","journal-title":"Virol Sin"},{"key":"10.1016\/j.joim.2024.09.003_b0230","series-title":"Medical microbiology","article-title":"Herpesviruses","author":"Whitley","year":"1996"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0235","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41579-020-00448-w","article-title":"The structural basis of herpesvirus entry","volume":"19","author":"Connolly","year":"2021","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0240","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/archdischild-2014-306321","article-title":"Fifteen minute consultation: managing neonatal and childhood herpes encephalitis","volume":"100","author":"Le Doare","year":"2015","journal-title":"Arch Dis Child Educ Pract Ed"},{"issue":"12","key":"10.1016\/j.joim.2024.09.003_b0245","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.apsb.2020.06.008","article-title":"Inhibitory effects of baicalein against herpes simplex virus type 1","volume":"10","author":"Luo","year":"2020","journal-title":"Acta Pharm Sin B"},{"issue":"11","key":"10.1016\/j.joim.2024.09.003_b0250","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/BF02978215","article-title":"Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro","volume":"28","author":"Lyu","year":"2005","journal-title":"Arch Pharm Res"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0255","doi-asserted-by":"crossref","first-page":"1000161","DOI":"10.4172\/2161-0517.1000165","article-title":"In vitro broad antiviral function against HBV, HSV, H3N2 replication by baicalin and oroxylin A-7-O-\u03b2-d-glucoside","volume":"6","author":"An","year":"2017","journal-title":"Virol Mycol"},{"key":"10.1016\/j.joim.2024.09.003_b0260","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4028\/www.scientific.net\/AMM.140.48","article-title":"Study on anti-human herpes virus 6 effects of baicalin","volume":"140","author":"Chen","year":"2012","journal-title":"Appl Mech Mater"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0265","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1038\/s41467-021-24820-3","article-title":"Structural basis for genome packaging, retention, and ejection in human cytomegalovirus","volume":"12","author":"Li","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0270","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.placenta.2014.11.003","article-title":"Ex vivo model of congenital cytomegalovirus infection and new combination therapies","volume":"36","author":"Mor\u00e8re","year":"2015","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0275","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.antiviral.2005.08.002","article-title":"Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action","volume":"68","author":"Evers","year":"2005","journal-title":"Antiviral Res"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0280","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.antiviral.2012.09.010","article-title":"Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication","volume":"96","author":"Cotin","year":"2012","journal-title":"Antiviral Res"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0285","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11596-013-1132-9","article-title":"Effect of baicalein on the expression of VIP in extravillous cytotrophoblasts infected with human cytomegalovirus in vitro","volume":"33","author":"Qiao","year":"2013","journal-title":"J Huazhong Univ Sci Technol Med Sci"},{"key":"10.1016\/j.joim.2024.09.003_b0290","first-page":"1124","article-title":"Activity of baicalin against human cytomegalovirus in vitro and its effect on the apoptosis of human embryo lung fibroblasts infected with human cytomegalovirus","volume":"36","author":"Liu","year":"2017","journal-title":"Yi Yao Dao Bao"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0295","first-page":"223","article-title":"Regulation of baicalin on learning, memory function and apoptosis in hippocampus of mice nervous system infected with cytomegalovirus","volume":"36","author":"Zhao","year":"2020","journal-title":"Bing Du Xue Bao"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0300","first-page":"675","article-title":"Effect of baicalin on expression of Th1\/Th2 cell specific transcription factors TBX21\/GATA-3 in MCMV-infected mice","volume":"43","author":"Huang","year":"2014","journal-title":"Hua Zhong Ke Ji Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.joim.2024.09.003_b0305","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.biopha.2018.03.114","article-title":"Baicalein inhibits growth of Epstein\u2013Barr virus-positive nasopharyngeal carcinoma by repressing the activity of EBNA1 Q-promoter","volume":"102","author":"Zhang","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0310","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0315","first-page":"F55","article-title":"Papillomavirus infections\u2014a major cause of human cancers","volume":"1288","author":"zur Hausen","year":"1996","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0320","first-page":"1350031","article-title":"Inhibitory activity of natural active compounds against human papilloma virus pseudovirus and novel dosage form for use therewith","volume":"25","author":"Shih","year":"2013","journal-title":"Biomed Eng"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0325","doi-asserted-by":"crossref","first-page":"17083","DOI":"10.1038\/nrdp.2017.83","article-title":"Rotavirus infection","volume":"3","author":"Crawford","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.joim.2024.09.003_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173927","article-title":"The anti-rotavirus effect of baicalin via the gluconeogenesis-related p-JNK-PDK1-AKT-SIK2 signaling pathway","volume":"897","author":"Song","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.joim.2024.09.003_b0335","series-title":"Taxonomic guide to infectious diseases","first-page":"237","article-title":"Group IV viruses: single-stranded (+) sense RNA","author":"Berman","year":"2012"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0340","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2004.03.003","article-title":"In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds","volume":"31","author":"Chen","year":"2004","journal-title":"J Clin Virol"},{"issue":"11","key":"10.1016\/j.joim.2024.09.003_b0345","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.5012\/bkcs.2013.34.11.3187","article-title":"Inhibition of SARS coronavirus helicase by baicalein","volume":"34","author":"Keum","year":"2013","journal-title":"Bull Korean Chem Soc"},{"issue":"9","key":"10.1016\/j.joim.2024.09.003_b0350","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41401-020-0483-6","article-title":"Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients","volume":"41","author":"Su","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.joim.2024.09.003_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114538","article-title":"Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method","volume":"209","author":"Zhu","year":"2022","journal-title":"J Pharm Biomed Anal"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0360","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1080\/14756366.2020.1801672","article-title":"Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro","volume":"35","author":"Jo","year":"2020","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.joim.2024.09.003_b0365","doi-asserted-by":"crossref","first-page":"502","DOI":"10.12688\/f1000research.24218.1","article-title":"Coronavirus disease 2019 drug discovery through molecular docking","volume":"9","author":"Singh","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.joim.2024.09.003_b0370","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbrc.2022.04.086","article-title":"Crystal structure of SARS-CoV 3C-like protease with baicalein","volume":"611","author":"Feng","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joim.2024.09.003_b0375","doi-asserted-by":"crossref","DOI":"10.1177\/1178633721994605","article-title":"Inhibition of ACE2 expression by ascorbic acid alone and its combinations with other natural compounds","volume":"14","author":"Ivanov","year":"2021","journal-title":"Infect Dis (Auckl)"},{"issue":"21","key":"10.1016\/j.joim.2024.09.003_b0380","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1021\/acs.jafc.1c02050","article-title":"Epigallocatechin gallate inhibits the uridylate-specific endoribonuclease Nsp15 and efficiently neutralizes the SARS-CoV-2 strain","volume":"69","author":"Hong","year":"2021","journal-title":"J Agric Food Chem"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0385","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s11418-021-01596-w","article-title":"The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro","volume":"76","author":"Ngwe Tun","year":"2022","journal-title":"J Nat Med"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0390","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-020-00353-x","article-title":"Baicalein inhibits SARS-CoV-2\/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner","volume":"5","author":"Huang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.joim.2024.09.003_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114302","article-title":"The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro","volume":"183","author":"Song","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.joim.2024.09.003_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153315","article-title":"Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19","volume":"85","author":"Zhao","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.joim.2024.09.003_b0405","unstructured":"World Health Organization. Japanese encephalitis. (2024-08-06) [2024-08-21]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/japanese-encephalitis."},{"issue":"12","key":"10.1016\/j.joim.2024.09.003_b0410","doi-asserted-by":"crossref","first-page":"16785","DOI":"10.3390\/ijms131216785","article-title":"Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus","volume":"13","author":"Johari","year":"2012","journal-title":"Int J Mol Sci"},{"issue":"7446","key":"10.1016\/j.joim.2024.09.003_b0415","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.joim.2024.09.003_b0420","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1472-6882-12-214","article-title":"Novel antiviral activity of baicalein against dengue virus","volume":"12","author":"Zandi","year":"2012","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.joim.2024.09.003_b0425","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1472-6882-13-91","article-title":"Extract of Scutellaria baicalensis inhibits dengue virus replication","volume":"13","author":"Zandi","year":"2013","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0430","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1038\/s41598-023-32049-x","article-title":"The 8-bromobaicalein inhibited the replication of dengue and Zika viruses and targeted the dengue polymerase","volume":"13","author":"Boonyasuppayakorn","year":"2023","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0435","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25836-5","article-title":"Design, synthesis, in vitro, in silico, and SAR studies of flavone analogs towards anti-dengue activity","volume":"12","author":"Patigo","year":"2022","journal-title":"Sci Rep"},{"issue":"7720","key":"10.1016\/j.joim.2024.09.003_b0440","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41586-018-0446-y","article-title":"The emergence of Zika virus and its new clinical syndromes","volume":"560","author":"Pierson","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0445","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00705-018-4083-4","article-title":"Baicalein and baicalin as Zika virus inhibitors","volume":"164","author":"Oo","year":"2019","journal-title":"Arch Virol"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0450","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12906-023-03971-4","article-title":"Investigation of the activity of baicalein towards Zika virus","volume":"23","author":"Sawadpongpan","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.joim.2024.09.003_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2022.128863","article-title":"Synthesis of baicalein derivatives and evaluation of their antiviral activity against arboviruses","volume":"72","author":"Qian","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"issue":"7","key":"10.1016\/j.joim.2024.09.003_b0460","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3390\/v13071307","article-title":"Antivirals against the Chikungunya virus","volume":"13","author":"Battisti","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.joim.2024.09.003_b0465","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.antiviral.2016.07.009","article-title":"Antiviral activity of selected flavonoids against Chikungunya virus","volume":"133","author":"Lani","year":"2016","journal-title":"Antiviral Res"},{"key":"10.1016\/j.joim.2024.09.003_b0470","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.antiviral.2017.12.012","article-title":"Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection","volume":"150","author":"Oo","year":"2018","journal-title":"Antiviral Res"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0475","first-page":"205","article-title":"Enterovirus 71: the virus, its infections and outbreaks","volume":"33","author":"Ho","year":"2000","journal-title":"J Microbiol Immunol Infect"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0480","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12906-020-2880-2","article-title":"Antiviral activity of silymarin in comparison with baicalein against EV-A71","volume":"20","author":"Lalani","year":"2020","journal-title":"BMC Complement Med Ther"},{"issue":"8","key":"10.1016\/j.joim.2024.09.003_b0485","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.3390\/v7082841","article-title":"The antiviral effect of baicalin on Enterovirus 71 in vitro","volume":"7","author":"Li","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.joim.2024.09.003_b0490","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.virol.2015.06.006","article-title":"Recent progress in understanding coxsackievirus replication, dissemination, and pathogenesis","volume":"484","author":"Sin","year":"2015","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0495","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jviromet.2010.10.021","article-title":"A fluorescence resonance energy transfer-based fluorometer assay for screening anti-coxsackievirus B3 compounds","volume":"171","author":"Cantera","year":"2011","journal-title":"J Virol Methods"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0500","first-page":"173","article-title":"Study of characteristics of inhibition of baicalin on CoxB3 viruses in vitro","volume":"9","author":"Gao","year":"2007","journal-title":"Zhongguo Zi Ran Yi Xue Za Zhi"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0505","first-page":"474","article-title":"Inhibiting effect of baicalin on influenza, herpes simplex and CoxB3 virus infections in cultured cells","volume":"17","author":"Gao","year":"2008","journal-title":"Zhongguo Xin Yao Za Zhi"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0510","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1142\/S0192415X20500081","article-title":"Baicalin inhibits coxsackievirus B3 replication by reducing cellular lipid synthesis","volume":"48","author":"Wang","year":"2020","journal-title":"Am J Chin Med"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0515","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12257-019-0354-5","article-title":"In vitro screening of traditional Chinese medicines compounds derived with anti-encephalomyocarditis virus activities","volume":"25","author":"Zheng","year":"2020","journal-title":"Biotechnol Bioprocess Eng"},{"key":"10.1016\/j.joim.2024.09.003_b0520","series-title":"Molecular virology of human pathogenic viruses","first-page":"185","article-title":"Negative-strand RNA viruses","author":"Ryu","year":"2017"},{"key":"10.1016\/j.joim.2024.09.003_b0525","series-title":"Mandell, Douglas, and Bennett\u2019s principles and practice of infectious diseases","first-page":"1981","article-title":"Vesicular stomatitis virus and related vesiculoviruses","author":"Fine","year":"2015"},{"key":"10.1016\/j.joim.2024.09.003_b0530","series-title":"Molecular virology of human pathogenic viruses","first-page":"213","article-title":"Other negative-strand RNA viruses","author":"Ryu","year":"2017"},{"key":"10.1016\/j.joim.2024.09.003_b0535","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/263630","article-title":"Role of baicalin in anti-influenza virus A as a potent inducer of IFN-\u03b3","volume":"2015","author":"Chu","year":"2015","journal-title":"Biomed Res Int"},{"issue":"10","key":"10.1016\/j.joim.2024.09.003_b0540","first-page":"2354","article-title":"Effect of baicalin on TLR3\/TRIF signaling pathway in lung tissue of mice with influenza viral pneumonia","volume":"25","author":"Wang","year":"2014","journal-title":"Shi Zhen Guo Yi Guo Yao"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0545","first-page":"415","article-title":"A novel inhibitory mechanism of baicalein on influenza A\/FM1\/1\/47 (H1N1) virus: interference with midlate mRNA synthesis in cell culture","volume":"10","author":"Su","year":"2012","journal-title":"Chin J Nat Med"},{"key":"10.1016\/j.joim.2024.09.003_b0550","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jep.2015.11.018","article-title":"Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis","volume":"176","author":"Ji","year":"2015","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0555","first-page":"108","article-title":"Antagonism of baicalin on cell cyclical distribution and cell apoptosis in A549 cells infected with influenza A (H1N1) virus","volume":"27","author":"Zhang","year":"2011","journal-title":"Bing Du Xue Bao"},{"issue":"7","key":"10.1016\/j.joim.2024.09.003_b0560","first-page":"936","article-title":"Effect of baicalin on apoptosis induced by H1N1 virus in vitro and its mechanism","volume":"31","author":"Liu","year":"2015","journal-title":"Zhongguo Yao Li Xue Tong Bao"},{"issue":"22","key":"10.1016\/j.joim.2024.09.003_b0565","first-page":"2413","article-title":"Anti-virus effect of baicalin in vivo","volume":"32","author":"Chu","year":"2007","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0570","first-page":"1290","article-title":"Effect of baicalin on ET-1 and its receptor in lung tissue of mice with pneumonia induced by influenza A virus","volume":"30","author":"Wan","year":"2015","journal-title":"Zhonghua Zhong Yi Yao Za Zhi"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0575","first-page":"251","article-title":"Effect of baicalin on pathological improvement of lung with H1N1 infection and its mechanism","volume":"26","author":"Wang","year":"2015","journal-title":"Shi Zhen Guo Yi Guo Yao"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0580","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28790","article-title":"Baicalin inhibits influenza A (H1N1)-induced pyroptosis of lung alveolar epithelial cells via caspase-3\/GSDME pathway","volume":"95","author":"Wei","year":"2023","journal-title":"J Med Virol"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0585","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.antiviral.2011.07.008","article-title":"Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice","volume":"91","author":"Chen","year":"2011","journal-title":"Antiviral Res"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0590","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12906-023-03858-4","article-title":"Determination of the synergistic anti-influenza effect of Huangqinsu tablet and oseltamivir and investigation of mechanism of the tablet based on gut microbiota and network pharmacology","volume":"23","author":"Cui","year":"2023","journal-title":"BMC Complement Med Ther"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0595","first-page":"306","article-title":"Clinical efficacy of baicalin combined with antivirals in treatment of severe influenza A H1N1 influenza","volume":"34","author":"Su","year":"2014","journal-title":"Zhongguo Yi Yuan Yao Xue Za Zhi"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0600","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/rmv.1879","article-title":"A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action","volume":"26","author":"Yang","year":"2016","journal-title":"Rev Med Virol"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0605","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15733-7","article-title":"Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.joim.2024.09.003_b0610","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1007\/s00705-014-2192-2","article-title":"Antiviral activity of baicalin against influenza A (H1N1\/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase","volume":"159","author":"Ding","year":"2014","journal-title":"Arch Virol"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0615","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/viro.1998.9508","article-title":"Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems","volume":"252","author":"Garc\u00eda-Sastre","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.joim.2024.09.003_b0620","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4923062","article-title":"Baicalin downregulates RLRs signaling pathway to control influenza A virus infection and improve the prognosis","volume":"2018","author":"Pang","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0625","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1248\/cpb.c13-00897","article-title":"Synthesis and anti-influenza activities of novel baicalein analogs","volume":"62","author":"Chung","year":"2014","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0630","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3892\/br.2014.253","article-title":"Baicalin inhibits TLR7\/MYD88 signaling pathway activation to suppress lung inflammation in mice infected with influenza A virus","volume":"2","author":"Wan","year":"2014","journal-title":"Biomed Rep"},{"key":"10.1016\/j.joim.2024.09.003_b0635","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4028\/www.scientific.net\/AMR.345.201","article-title":"The signal pathways of immune inflammation mediated by the TLR3\/NF-\u03baB and activator protein-1 in cells infected with influenza A virus antagonized by baicalin","volume":"345","author":"Zhang","year":"2012","journal-title":"Adv Mater Res"},{"key":"10.1016\/j.joim.2024.09.003_b0640","doi-asserted-by":"crossref","first-page":"01298","DOI":"10.3389\/fphar.2020.01298","article-title":"Baicalin inhibits influenza A virus infection via promotion of M1 macrophage polarization","volume":"11","author":"Geng","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.joim.2024.09.003_b0645","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.antiviral.2014.11.003","article-title":"Baicalin inhibits autophagy induced by influenza A virus H3N2","volume":"113","author":"Zhu","year":"2015","journal-title":"Antiviral Res"},{"issue":"8","key":"10.1016\/j.joim.2024.09.003_b0650","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: new regulators of immune cell development and function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0655","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nri2957","article-title":"MicroRNAs: the fine-tuners of toll-like receptor signalling","volume":"11","author":"O'Neill","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0660","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chom.2008.05.013","article-title":"Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome","volume":"4","author":"Jopling","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0665","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ncb2054","article-title":"miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator","volume":"12","author":"Lagos","year":"2010","journal-title":"Nat Cell Biol"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0670","first-page":"5041","article-title":"Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR-146a","volume":"20","author":"Li","year":"2019","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0675","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.antiviral.2012.10.004","article-title":"Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells","volume":"97","author":"Sithisarn","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.joim.2024.09.003_b0680","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/1756-0500-7-384","article-title":"Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza A virus activity exerted by baicalein and biochanin A","volume":"7","author":"Michaelis","year":"2014","journal-title":"BMC Res Notes"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0685","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00705-011-0917-z","article-title":"Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase","volume":"156","author":"Dou","year":"2011","journal-title":"Arch Virol"},{"issue":"12","key":"10.1016\/j.joim.2024.09.003_b0690","first-page":"2055","article-title":"Effects of baicalin on transcription and duplication of RSV as well as fusion","volume":"33","author":"Xu","year":"2011","journal-title":"Zhong Cheng Yao"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0695","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s12013-014-0055-9","article-title":"Analysis of influence of baicalin joint resveratrol retention enema on the TNF-\u03b1, SIgA, IL-2, IFN-\u03b3 of rats with respiratory syncytial virus infection","volume":"70","author":"Cheng","year":"2014","journal-title":"Cell Biochem Biophys"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0700","first-page":"328","article-title":"Effects of baicalin on the expression of I-IFN and SOCS1\/3 in RSV-infected rats","volume":"33","author":"Zhang","year":"2018","journal-title":"Zhonghua Zhong Yi Yao Za Zhi"},{"key":"10.1016\/j.joim.2024.09.003_b0705","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.907047","article-title":"Baicalin induces a potent innate immune response to inhibit respiratory syncytial virus replication via regulating viral non-structural 1 and matrix RNA","volume":"13","author":"Qin","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.joim.2024.09.003_b0710","series-title":"Vaccines for biodefense and emerging and neglected diseases","first-page":"77","article-title":"Viral vectors","author":"Holman","year":"2009"},{"issue":"9","key":"10.1016\/j.joim.2024.09.003_b0715","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/jir.2008.0125","article-title":"Production of cytokines and stimulation of resistance to viral infection in human leukocytes by Scutellaria baicalensis flavones","volume":"28","author":"Blach-Olszewska","year":"2008","journal-title":"J Interferon Cytokine Res"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0720","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0006-291X(89)80097-X","article-title":"Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone","volume":"160","author":"Ono","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0725","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1990.tb15597.x","article-title":"Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases","volume":"190","author":"Ono","year":"1990","journal-title":"Eur J Biochem"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0730","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0006-2952(94)90291-7","article-title":"Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds","volume":"48","author":"Fesen","year":"1994","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0735","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1016-8478(23)17072-5","article-title":"Binding aspects of baicalein to HIV-1 integrase","volume":"12","author":"Ahn","year":"2001","journal-title":"Mol Cells"},{"issue":"12","key":"10.1016\/j.joim.2024.09.003_b0740","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1016\/j.bmc.2014.04.016","article-title":"Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF\/p75","volume":"22","author":"Li","year":"2014","journal-title":"Bioorg Med Chem"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0745","first-page":"229","article-title":"Inhibitory effects of flavonoids on human immunodeficiency virus type-1 integrase","volume":"18","author":"Tewtrakul","year":"2001","journal-title":"Wakan Iyakugaku Zasshi"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0750","first-page":"46","article-title":"Baicalein and baicalin as inhibitors of HIV-1 integrase","volume":"47","author":"Lee","year":"2003","journal-title":"Yakhak Hoechi"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0755","first-page":"119","article-title":"Inhibition of HIV infection by baicalin\u2014a flavonoid compound purified from Chinese herbal medicine","volume":"39","author":"Li","year":"1993","journal-title":"Cell Mol Biol Res"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0760","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/bbrc.2000.3485","article-title":"Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry","volume":"276","author":"Li","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joim.2024.09.003_b0765","unstructured":"World Health Organization. Hepatitis B. (2024-04-09) [2024-07-13]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b."},{"key":"10.1016\/j.joim.2024.09.003_b0770","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.antiviral.2018.04.017","article-title":"Chinese herbal extract Su-duxing had potent inhibitory effects on both wild-type and entecavir-resistant hepatitis B virus (HBV) in vitro and effectively suppressed HBV replication in mouse model","volume":"155","author":"Liu","year":"2018","journal-title":"Antiviral Res"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0775","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.antiviral.2005.07.005","article-title":"Effect of artemisinin\/artesunate as inhibitors of hepatitis B virus production in an \u201cin vitro\u201d replicative system","volume":"68","author":"Romero","year":"2005","journal-title":"Antiviral Res"},{"issue":"10","key":"10.1016\/j.joim.2024.09.003_b0780","first-page":"1258","article-title":"The inhibitory effect of oxymatrine\u2013baicalin compound on hepatitis B viral antigens secretion in HepG2.2.2.15 cells","volume":"22","author":"Cheng","year":"2006","journal-title":"Zhongguo Yao Li Xue Tong Bao"},{"issue":"32","key":"10.1016\/j.joim.2024.09.003_b0785","first-page":"5153","article-title":"Synergistic effect of a novel oxymatrine-baicalin combination against hepatitis B virus replication, \u03b1-smooth muscle actin expression and type I collagen synthesis in vitro","volume":"12","author":"Cheng","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.joim.2024.09.003_b0790","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.taap.2017.03.016","article-title":"Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs","volume":"323","author":"Huang","year":"2017","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.joim.2024.09.003_b0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115131","article-title":"Baicalin down-regulating hepatitis B virus transcription depends on the liver-specific HNF4\u03b1-HNF1\u03b1 axis","volume":"403","author":"Xia","year":"2020","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0800","first-page":"386","article-title":"Baicalin combined with interferon for treating 50 patients with chronic hepatitis B","volume":"32","author":"Song","year":"2013","journal-title":"Zhongguo Xin Yao Yu Lin Chuang Za Zhi"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0805","first-page":"218","article-title":"Effects of baicalin combined with lamivudine in treating chronic hepatitis B on cellular immunity","volume":"31","author":"Li","year":"2015","journal-title":"Zhong Yao Yao Li Yu Lin Chuang"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0810","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00011-017-1099-2","article-title":"Flavocoxid exerts a potent antiviral effect against hepatitis B virus","volume":"67","author":"Pollicino","year":"2018","journal-title":"Inflammation Res"},{"key":"10.1016\/j.joim.2024.09.003_b0815","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.907921","article-title":"Fuzheng Huayu Recipe and its active compounds inhibited HBeAg production by promoting TOMM34 gene expression in HBV-infected hepatocytes","volume":"13","author":"Xing","year":"2022","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.joim.2024.09.003_b0820","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3390\/biomedicines10040900","article-title":"Liver-targeted nanoparticles facilitate the bioavailability and anti-HBV efficacy of baicalin in vitro and in vivo","volume":"10","author":"Xu","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.joim.2024.09.003_b0825","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mib.2020.07.005","article-title":"The antiviral activities of TRIM proteins","volume":"59","author":"Koepke","year":"2021","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0830","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.immuni.2018.03.001","article-title":"A talented duo: IFIT1 and IFIT3 patrol viral RNA caps","volume":"48","author":"Choi","year":"2018","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.joim.2024.09.003_b0835","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jtcme.2023.05.009","article-title":"Baicalin inhibits the replication of the hepatitis B virus by targeting TRIM25","volume":"13","author":"Fan","year":"2023","journal-title":"J Tradit Complement Med"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0840","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00011-017-1111-x","article-title":"Baicalin in flavocoxid may act against hepatitis B virus via a pro-inflammatory pathway","volume":"67","author":"Chirumbolo","year":"2018","journal-title":"Inflamm Res"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0845","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/14756366.2021.1873977","article-title":"Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro","volume":"36","author":"Liu","year":"2021","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"11","key":"10.1016\/j.joim.2024.09.003_b0850","first-page":"1560","article-title":"Effects of combination of baicalin and ribavirin on influenza A virus infection in vitro and in vivo","volume":"27","author":"He","year":"2011","journal-title":"Zhongguo Yao Li Xue Tong Bao"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0855","first-page":"266","article-title":"Inhibitory mechanism of baicalin on H5N1 influenza virus","volume":"28","author":"Yang","year":"2016","journal-title":"Tian Ran Chan Wu Yan Jiu Yu Kai Fa"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0860","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/ijms25052935","article-title":"Inhibitory efficacy of main components of Scutellaria baicalensis on the interaction between spike protein of SARS-CoV-2 and human angiotensin-converting enzyme II","volume":"25","author":"Lin","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0865","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1038\/s41598-024-54722-5","article-title":"Synergistic inhibition effects of andrographolide and baicalin on coronavirus mechanisms by downregulation of ACE2 protein level","volume":"14","author":"Wan","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0870","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1211\/002235702522","article-title":"Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats","volume":"55","author":"Lai","year":"2003","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.joim.2024.09.003_b0875","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114052","article-title":"Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: a single-center, randomized, double-blind, placebo-controlled, single-dose phase I study","volume":"274","author":"Dong","year":"2021","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.joim.2024.09.003_b0880","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.fitote.2011.12.019","article-title":"Pharmacokinetic study of baicalein after oral administration in monkeys","volume":"83","author":"Tian","year":"2012","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1016\/j.joim.2024.09.003_b0885","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/cts.13063","article-title":"Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: a single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study","volume":"14","author":"Li","year":"2021","journal-title":"Clin Transl Sci"},{"issue":"1","key":"10.1016\/j.joim.2024.09.003_b0890","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccm.2016.11.012","article-title":"Epidemiology of viral pneumonia","volume":"38","author":"Jain","year":"2017","journal-title":"Clin Chest Med"},{"issue":"2","key":"10.1016\/j.joim.2024.09.003_b0895","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/fcp.12609","article-title":"Antiviral therapies: advances and perspectives","volume":"35","author":"Gon\u00e7alves","year":"2020","journal-title":"Fundam Clin Pharmacol"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209549642400390X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S209549642400390X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T22:31:42Z","timestamp":1734561102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S209549642400390X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":179,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S209549642400390X"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2024.09.003","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2024.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. All rights are reserved, including those for text and data mining, AI training, and similar technologies. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}