{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:20:49Z","timestamp":1789701649518,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative Medicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.joim.2025.10.004","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:40:15Z","timestamp":1760546415000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential supplement-drug interactions and bleeding in patients with cancer: A UK Biobank study"],"prefix":"10.1016","volume":"24","author":[{"given":"Chun Sing","family":"Lam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung Wai","family":"Au-Doung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Kee","family":"Koon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keary Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert Ho-Fung","family":"Loong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Chi-Ho","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Ting","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.joim.2025.10.004_b0005","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1200\/JCO.2007.13.5905","article-title":"Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review","volume":"26","author":"Velicer","year":"2008","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.joim.2025.10.004_b0010","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1186\/s12885-017-3885-1","article-title":"Dietary supplement use among cancer survivors and the general population: a nation-wide cross-sectional study","volume":"17","author":"Song","year":"2017","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.joim.2025.10.004_b0015","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jada.2007.12.005","article-title":"Dietary supplement use in individuals living with cancer and other chronic conditions: a population-based study","volume":"108","author":"Miller","year":"2008","journal-title":"J Am Diet Assoc"},{"issue":"7","key":"10.1016\/j.joim.2025.10.004_b0020","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00432-021-03594-7","article-title":"Dietary supplement use in ambulatory cancer patients: a survey on prevalence, motivation and attitudes","volume":"147","author":"Tank","year":"2021","journal-title":"J Cancer Res Clin Oncol"},{"issue":"6","key":"10.1016\/j.joim.2025.10.004_b0025","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/cncr.34055","article-title":"Dietary supplement use by individuals living with and beyond breast, prostate, and colorectal cancer: a cross-sectional survey","volume":"128","author":"Conway","year":"2022","journal-title":"Cancer"},{"key":"10.1016\/j.joim.2025.10.004_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154247","article-title":"Real-world data on herb-drug interactions in oncology: a scoping review of pharmacoepidemiological studies","volume":"103","author":"Lam","year":"2022","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.joim.2025.10.004_b0035","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/ptr.5213","article-title":"Cancer patients at risk of herb\/food supplement-drug interactions: a systematic review","volume":"28","author":"Alsanad","year":"2014","journal-title":"Phytother Res"},{"issue":"2","key":"10.1016\/j.joim.2025.10.004_b0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.21037\/apm.2017.11.01","article-title":"Bleeding in cancer patients and its treatment: a review","volume":"7","author":"Johnstone","year":"2018","journal-title":"Ann Palliat Med"},{"issue":"7","key":"10.1016\/j.joim.2025.10.004_b0045","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ajh.25494","article-title":"Bleeding incidence and risk factors among cancer patients treated with anticoagulation","volume":"94","author":"Angelini","year":"2019","journal-title":"Am J Hematol"},{"issue":"17","key":"10.1016\/j.joim.2025.10.004_b0050","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1200\/JCO.2000.18.17.3078","article-title":"Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis","volume":"18","author":"Hutten","year":"2000","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.joim.2025.10.004_b0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-022-00336-y","article-title":"Cancer-associated venous thromboembolism","volume":"8","author":"Khorana","year":"2022","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"10.1016\/j.joim.2025.10.004_b0060","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/imj.13404","article-title":"Life-threatening drug interactions: what the physician needs to know","volume":"47","author":"Day","year":"2017","journal-title":"Intern Med J"},{"issue":"12","key":"10.1016\/j.joim.2025.10.004_b0065","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s40266-017-0501-7","article-title":"Concurrent use of prescription drugs and herbal medicinal products in older adults: a systematic review","volume":"34","author":"Agbabiaka","year":"2017","journal-title":"Drugs Aging"},{"key":"10.1016\/j.joim.2025.10.004_b0070","first-page":"370","article-title":"Detecting signals of interactions between warfarin and dietary supplements in electronic health records","volume":"245","author":"Fan","year":"2017","journal-title":"Stud Health Technol Inform"},{"key":"10.1016\/j.joim.2025.10.004_b0075","first-page":"1174","article-title":"Ginkgo and warfarin interaction in a large veterans administration population","volume":"2015","author":"Stoddard","year":"2015","journal-title":"AMIA Annu Symp Proc"},{"issue":"11","key":"10.1016\/j.joim.2025.10.004_b0080","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2471\/BLT.07.045120","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"85","author":"von Elm","year":"2007","journal-title":"Bull World Health Organ"},{"issue":"3","key":"10.1016\/j.joim.2025.10.004_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.joim.2025.10.004_b0090","unstructured":"UK Biobank. Cancer data: linkage from national cancer registries. (2023-07) [2024-06-05]. https:\/\/biobank.ndph.ox.ac.uk\/showcase\/refer.cgi?id=115558."},{"key":"10.1016\/j.joim.2025.10.004_b0095","unstructured":"Norwegian Institute of Public Health. ATC\/DDD Index. (2023). [2024-06-05]. https:\/\/www.whocc.no\/atc_ddd_index\/."},{"key":"10.1016\/j.joim.2025.10.004_b0100","unstructured":"Therapeutic Research Center, LLC. NatMed Pro site. (2024) [2024-06-05]. https:\/\/naturalmedicines.therapeuticresearch.com."},{"key":"10.1016\/j.joim.2025.10.004_b0105","unstructured":"Royal Pharmaceutical Society. Medicines complete. (2023) [2024-06-05]. https:\/\/www.medicinescomplete.com\/mc\/stockley\/current\/."},{"key":"10.1016\/j.joim.2025.10.004_b0110","unstructured":"Merative US L.P. Micromedex. (2025) [2025-06-05]. http:\/\/www.micromedexsolutions.com."},{"key":"10.1016\/j.joim.2025.10.004_b0115","unstructured":"UpToDate, Inc. UpToDate\u00ae LexidrugTM. (2025) [2025-06-05]. http:\/\/online.lexi.com. Subscription required to view."},{"issue":"11","key":"10.1016\/j.joim.2025.10.004_b0120","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/cncr.33324","article-title":"Prevalence of potential interactions of medications, including herbs and supplements, before, during, and after chemotherapy in patients with breast and prostate cancer","volume":"127","author":"Lee","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.joim.2025.10.004_b0125","unstructured":"UK Biobank. First occurrence of health outcomes defined by 3-character ICD10 code. (2019-09) [2024-06-05]. https:\/\/biobank.ndph.ox.ac.uk\/ukb\/ukb\/docs\/first_occurrences_outcomes.pdf."},{"key":"10.1016\/j.joim.2025.10.004_b0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.thromres.2019.07.021","article-title":"Accuracy of ICD-10 codes for identifying hospitalizations for acute anticoagulation therapy-related bleeding events","volume":"181","author":"Joos","year":"2019","journal-title":"Thromb Res"},{"key":"10.1016\/j.joim.2025.10.004_b0135","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h246","article-title":"The association between kidney function and major bleeding in older adults with atrial fibrillation starting warfarin treatment: population based observational study","volume":"350","author":"Jun","year":"2015","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.joim.2025.10.004_b0140","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004517","article-title":"Major bleeding complications and persistence with oral anticoagulation in non-valvular atrial fibrillation: contemporary findings in real-life Danish patients","volume":"6","author":"Lamberts","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"10.1016\/j.joim.2025.10.004_b0145","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1200\/JOP.2017.020859","article-title":"Potential drug-drug and herb-drug interactions in patients with cancer: a prospective study of medication surveillance","volume":"13","author":"Ramos-Esquivel","year":"2017","journal-title":"J Oncol Pract"},{"issue":"1","key":"10.1016\/j.joim.2025.10.004_b0150","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1186\/s12885-022-10396-8","article-title":"Frequency, severity, and factors associated with clinically significant drug-drug interactions among patients with cancer attending Mbarara Regional Referral Hospital Cancer Unit, Uganda","volume":"22","author":"Luzze","year":"2022","journal-title":"BMC Cancer"},{"issue":"10","key":"10.1016\/j.joim.2025.10.004_b0155","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/aje\/kwg074","article-title":"Estimating the relative risk in cohort studies and clinical trials of common outcomes","volume":"157","author":"McNutt","year":"2003","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.joim.2025.10.004_b0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ije\/27.1.91","article-title":"Prevalence proportion ratios: estimation and hypothesis testing","volume":"27","author":"Skov","year":"1998","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.joim.2025.10.004_b0165","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"675","key":"10.1016\/j.joim.2025.10.004_b0170","doi-asserted-by":"crossref","first-page":"e711","DOI":"10.3399\/bjgp18X699101","article-title":"Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey","volume":"68","author":"Agbabiaka","year":"2018","journal-title":"Br J Gen Pract"},{"issue":"3","key":"10.1016\/j.joim.2025.10.004_b0175","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11739-016-1548-x","article-title":"Potential drug interactions with dietary and herbal supplements during hospitalization","volume":"12","author":"Levy","year":"2017","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.joim.2025.10.004_b0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.amjcard.2021.11.053","article-title":"Incidence and predictors of bleeding in patients with cancer and atrial fibrillation","volume":"167","author":"Raposeiras Roub\u00edn","year":"2022","journal-title":"Am J Cardiol"},{"issue":"4","key":"10.1016\/j.joim.2025.10.004_b0185","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s11239-020-02274-6","article-title":"Predicting the risk for major bleeding in elderly patients with venous thromboembolism using the Charlson index. Findings from the RIETE","volume":"51","author":"G\u00f3mez-Cuervo","year":"2021","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.joim.2025.10.004_b0190","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.clnesp.2023.09.919","article-title":"Association between potential supplement-drug interactions and liver diseases in patients with cancer: a large prospective cohort study","volume":"58","author":"Lam","year":"2023","journal-title":"Clin Nutr ESPEN"},{"issue":"4","key":"10.1016\/j.joim.2025.10.004_b0195","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jval.2017.09.015","article-title":"What impact does venous thromboembolism and bleeding have on cancer patients\u2019 quality of life?","volume":"21","author":"Lloyd","year":"2018","journal-title":"Value Health"},{"issue":"1","key":"10.1016\/j.joim.2025.10.004_b0200","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ahj.2011.04.015","article-title":"Bleeding, mortality, and antiplatelet therapy: results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance (CHARISMA) trial","volume":"162","author":"Berger","year":"2011","journal-title":"Am Heart J"},{"issue":"5","key":"10.1016\/j.joim.2025.10.004_b0205","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/jamaoncol.2019.0349","article-title":"Prevalence and nondisclosure of complementary and alternative medicine use in patients with cancer and cancer survivors in the United States","volume":"5","author":"Sanford","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.joim.2025.10.004_b0210","unstructured":"Terrie YC. Drug-supplement interactions: patient awareness is key. (2023-10-08) [2024-06-05]. https:\/\/www.pharmacytimes.com\/view\/drug-supplement-interactions-patient-awareness-is-key."},{"key":"10.1016\/j.joim.2025.10.004_b0215","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-244X-13-140","article-title":"Antidepressants in the treatment of depression\/depressive symptoms in cancer patients: a systematic review and meta-analysis","volume":"13","author":"Laoutidis","year":"2013","journal-title":"BMC Psychiatry"},{"issue":"2","key":"10.1016\/j.joim.2025.10.004_b0220","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","article-title":"Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies","volume":"12","author":"Mitchell","year":"2011","journal-title":"Lancet Oncol"},{"issue":"27","key":"10.1016\/j.joim.2025.10.004_b0225","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1200\/JCO.2016.68.5206","article-title":"Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline","volume":"34","author":"Paice","year":"2016","journal-title":"J Clin Oncol"},{"issue":"18","key":"10.1016\/j.joim.2025.10.004_b0230","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1200\/JCO.23.00293","article-title":"Management of anxiety and depression in adult survivors of cancer: ASCO guideline update","volume":"41","author":"Andersen","year":"2023","journal-title":"J Clin Oncol"},{"issue":"19","key":"10.1016\/j.joim.2025.10.004_b0235","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029423","article-title":"common cancer types and risk of stroke and bleeding in patients with nonvalvular atrial fibrillation: a population-based study in England","volume":"12","author":"Ajabnoor","year":"2023","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.joim.2025.10.004_b0240","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10549-021-06454-7","article-title":"Dietary supplement use and documentation in a breast cancer survivorship clinic","volume":"191","author":"Silver","year":"2022","journal-title":"Breast Cancer Res Treat"},{"issue":"10","key":"10.1016\/j.joim.2025.10.004_b0245","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/BF03261975","article-title":"Safety monitoring of herb-drug interactions: a component of pharmacovigilance","volume":"35","author":"Skalli","year":"2012","journal-title":"Drug Saf"}],"container-title":["Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496425001633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2095496425001633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:23:30Z","timestamp":1768944210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2095496425001633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2095496425001633"],"URL":"https:\/\/doi.org\/10.1016\/j.joim.2025.10.004","relation":{},"ISSN":["2095-4964"],"issn-type":[{"value":"2095-4964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential supplement-drug interactions and bleeding in patients with cancer: A UK Biobank study","name":"articletitle","label":"Article Title"},{"value":"Journal of Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joim.2025.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}